ZA918716B - 1-(2-arylethyl)-pyrrolidines - Google Patents

1-(2-arylethyl)-pyrrolidines

Info

Publication number
ZA918716B
ZA918716B ZA918716A ZA918716A ZA918716B ZA 918716 B ZA918716 B ZA 918716B ZA 918716 A ZA918716 A ZA 918716A ZA 918716 A ZA918716 A ZA 918716A ZA 918716 B ZA918716 B ZA 918716B
Authority
ZA
South Africa
Prior art keywords
arylethyl
pyrrolidines
Prior art date
Application number
ZA918716A
Other languages
English (en)
Inventor
Rudolf Gottschlich
Gottschlich Rudolf
Helmut Prucher
Prucher Helmut
Anton Haase
Haase Anton
Gerd Bartoszyk
Bartoszyk Gerd
Karl-August Ackermann
Ackermann Karl-August
Andrew Barber
Barber Andrew
Hartmut Greiner
Greiner Hartmut
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA918716B publication Critical patent/ZA918716B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
ZA918716A 1990-11-02 1991-11-01 1-(2-arylethyl)-pyrrolidines ZA918716B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4034785A DE4034785A1 (de) 1990-11-02 1990-11-02 1-(2-arylethyl)-pyrrolidine

Publications (1)

Publication Number Publication Date
ZA918716B true ZA918716B (en) 1992-08-26

Family

ID=6417469

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA918716A ZA918716B (en) 1990-11-02 1991-11-01 1-(2-arylethyl)-pyrrolidines

Country Status (10)

Country Link
EP (1) EP0483580A3 (fr)
JP (1) JPH04264067A (fr)
KR (1) KR920009791A (fr)
AU (1) AU8553891A (fr)
CA (1) CA2054648A1 (fr)
CS (1) CS332591A3 (fr)
DE (1) DE4034785A1 (fr)
HU (1) HUT61727A (fr)
PT (1) PT99383A (fr)
ZA (1) ZA918716B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4215213A1 (de) * 1992-05-09 1993-11-11 Merck Patent Gmbh Arylacetamide
WO1994018165A1 (fr) * 1993-02-12 1994-08-18 Pfizer Inc. Composes de sulfonamide utilises comme agonistes des recepteurs k d'opioides
WO1996006078A1 (fr) * 1994-08-24 1996-02-29 Pfizer Pharmaceuticals Inc. N-(2-(pyrrolidinyl-1)-1-phenylethyl)acetamides utilises en tant qu'antagonistes du recepteur kappa
DE19523502A1 (de) * 1995-06-28 1997-01-02 Merck Patent Gmbh Kappa-Opiatagonisten für entzündliche Darmerkrankungen
DE19531464A1 (de) * 1995-08-26 1997-02-27 Merck Patent Gmbh N-Methyl-N-[(1S-)-1-phenyl-2-((3S)-3-hydroxypyrrolidin 1-yl-)-ethyl]-2,2-diphenyl-acetamid
MX9701042A (es) 1996-02-07 1998-05-31 Pfizer Compuestos del acido hidroxamico.
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6303611B1 (en) * 1996-03-08 2001-10-16 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5646151A (en) * 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
TNSN97092A1 (ar) 1996-09-18 1999-12-31 Agouron Pharma مثبطات انزيم بروتيني فلزي وتركيبات صيدلانية تحتوي على تلك المثبتطات واستخدامها الصيدلاني وطرق ومركبات وسيطة مفيدة لتحضير التركيبات المذكورة.
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
CA2288828A1 (fr) * 1997-07-14 1999-01-28 Adolor Corporation Compositions pharmaceutiques anti-pruritiques contenant des agonistes de recepteurs kappa et procede de traitement du prurit a l'aide desdites compositions
DE19827633A1 (de) * 1998-04-20 1999-10-21 Merck Patent Gmbh Verfahren zur Herstellung von enantiomerenreinem N-Methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamid
EP0982297A3 (fr) * 1998-08-24 2001-08-01 Pfizer Products Inc. Procédé de préparation de dérivés de acide hydroxamique substitués par hydroxy-pyrrolidinyl, qui sont agonistes du récepteur opioid kappa
AU2002247886A1 (en) 2001-04-30 2002-11-11 Pfizer Products Inc. Process for preparing hydroxypyrrolidinyl ethylamine compounds useful as kappa agonists
CN100411618C (zh) 2002-05-17 2008-08-20 迪欧加药品公司 有效的选择性阿片受体调制剂化合物的用途
US6992193B2 (en) 2003-06-10 2006-01-31 Adolor Corporation Sulfonylamino phenylacetamide derivatives and methods of their use
DE10331723A1 (de) * 2003-07-11 2005-06-16 Merck Patent Gmbh Kappa-Agonisten
EP2636407A3 (fr) 2007-03-30 2013-11-06 Tioga Pharmaceuticals, Inc. Agonistes du récepteur opiacé kappa pour le traitement du syndrome du côlon irritable avec alternance ou à diarrhée prédominante
JP5779100B2 (ja) 2008-11-24 2015-09-16 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ 光学的に活性なｎ−ベンジル−３−ヒドロキシピロリジンの製造方法
JP6138169B2 (ja) * 2012-03-05 2017-05-31 ドクター レディズ ラボラトリーズ リミテッド κオピオイド受容体（ＫＯＲ）アゴニストとしての置換複素環式アセトアミド
JP6665189B2 (ja) * 2014-12-23 2020-03-13 ネクター セラピューティクス κオピオイド受容体に対するＮ−メチル−Ｎ−（１−フェニル−２−（１−ピロリジニル）エチル）−２−アミノフェニルアセトアミド誘導体作動薬

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT376669B (de) * 1982-11-26 1984-12-27 Laevosan Gmbh & Co Kg Verfahren zur herstellung neuer thienylessigsaeureamid-derivate und pharmazeutisch vertraeglicher saeureadditionssalze davon
GB8618188D0 (en) * 1986-07-25 1986-09-03 Ici Plc Diamine compounds
EP0261842B1 (fr) * 1986-09-17 1990-11-22 Dr. Lo. Zambeletti S.p.A. [1-(Phényl- ou benzyl)]-1,2-éthylènediamines N-1-acylées
DE3935371A1 (de) * 1988-12-23 1990-07-05 Merck Patent Gmbh Stickstoffhaltige ringverbindungen

Also Published As

Publication number Publication date
JPH04264067A (ja) 1992-09-18
DE4034785A1 (de) 1992-05-07
EP0483580A3 (en) 1992-09-02
PT99383A (pt) 1992-09-30
KR920009791A (ko) 1992-06-25
CS332591A3 (en) 1992-05-13
CA2054648A1 (fr) 1992-05-03
HU913448D0 (en) 1992-01-28
HUT61727A (en) 1993-03-01
AU8553891A (en) 1992-05-07
EP0483580A2 (fr) 1992-05-06

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