ZA919079B - A process for the preparation of a 3-alkylated indole - Google Patents

A process for the preparation of a 3-alkylated indole

Info

Publication number: ZA919079B
Authority: ZA; South Africa
Prior art keywords: preparation; alkylated indole; afford; reacting; imine salt
Prior art date: 1990-12-05

Application number

ZA919079A

Other languages

English (en)

Inventor

Robert Toms Jacobs

Toms Jacobs Robert

Gerard Francois Costello

Francois Costello Gerard

Stephen Alan Brook

Alan Brook Stephen

Peter John Harrison

John Harrison Peter

Original Assignee

Ici Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-05

Filing date

1991-11-15

Publication date

1992-09-30

1991-11-15 Application filed by Ici Plc filed Critical Ici Plc

1992-09-30 Publication of ZA919079B publication Critical patent/ZA919079B/xx

Links

150000002475 indoles Chemical class 0.000 title abstract 3
-1 imine salt Chemical class 0.000 abstract 3
PFURPHRKGDQJMN-UHFFFAOYSA-N 2-(2-nitrophenyl)acetaldehyde Chemical compound [O-][N+](=O)C1=CC=CC=C1CC=O PFURPHRKGDQJMN-UHFFFAOYSA-N 0.000 abstract 2
229940100198 alkylating agent Drugs 0.000 abstract 1
239000002168 alkylating agent Substances 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
150000002081 enamines Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Ophthalmology & Optometry (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Dermatology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA919079A 1990-12-05 1991-11-15 A process for the preparation of a 3-alkylated indole ZA919079B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909026427A GB9026427D0 (en)	1990-12-05	1990-12-05	Chemical process

Publications (1)

Publication Number	Publication Date
ZA919079B true ZA919079B (en)	1992-09-30

Family

ID=10686509

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA919079A ZA919079B (en)	1990-12-05	1991-11-15	A process for the preparation of a 3-alkylated indole

Country Status (22)

Country	Link
US (1)	US5280125A (da)
EP (1)	EP0489547B1 (da)
JP (1)	JP3160040B2 (da)
KR (1)	KR100228328B1 (da)
AT (1)	ATE168998T1 (da)
AU (1)	AU652002B2 (da)
CA (1)	CA2056065C (da)
CZ (1)	CZ282019B6 (da)
DE (1)	DE69129894T2 (da)
DK (1)	DK0489547T3 (da)
ES (1)	ES2118743T3 (da)
FI (1)	FI102170B (da)
GB (1)	GB9026427D0 (da)
HU (1)	HU222123B1 (da)
IE (1)	IE913936A1 (da)
IL (1)	IL100055A (da)
NO (1)	NO175680C (da)
NZ (1)	NZ240624A (da)
PT (1)	PT99683B (da)
RU (1)	RU2054417C1 (da)
SK (1)	SK278987B6 (da)
ZA (1)	ZA919079B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9119001D0 (en) *	1991-09-05	1991-10-23	Ici Plc	Pharmaceutical agents
AU4400597A (en) *	1996-10-08	1998-05-05	Fujisawa Pharmaceutical Co., Ltd.	Indole derivatives
HN2004000536A (es) *	2003-12-16	2009-02-18	Wyeth Corp	Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
CN112457235B (zh) *	2020-12-02	2023-04-25	烟台凯博医药科技有限公司	一种7-甲基吲哚的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3732245A (en) *	1970-11-04	1973-05-08	Hoffmann La Roche	Process and intermediates for the preparation of indoles from ortho-nitrotoluenes
US3976639A (en) *	1970-11-04	1976-08-24	Hoffmann-La Roche Inc.	Intermediates for indoles
US3979410A (en) *	1974-01-21	1976-09-07	Hoffmann-La Roche Inc.	Intermediate α-acyl-β-dialkylamino-2-nitrostyrenes
US4137404A (en) *	1977-12-20	1979-01-30	Hoffmann-La Roche Inc.	Synthesis of tryptophans
US4665087A (en) *	1982-02-22	1987-05-12	Ciba-Geigy Corporation	1-(carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivatives
GB8607294D0 (en) *	1985-04-17	1986-04-30	Ici America Inc	Heterocyclic amide derivatives
GB8623429D0 (en) *	1985-10-17	1986-11-05	Ici America Inc	Carboximide derivatives
US5180728A (en) *	1989-09-25	1993-01-19	Fujisawa Pharmaceutical Company, Ltd.	Pyrimidoindole derivatives and processes for preparation thereof
GB8927981D0 (en) *	1989-12-11	1990-02-14	Ici Plc	Carbamoyl derivative
GB9026425D0 (en) *	1990-12-05	1991-01-23	Ici Plc	Process

1990
- 1990-12-05 GB GB909026427A patent/GB9026427D0/en active Pending
1991
- 1991-11-12 IE IE393691A patent/IE913936A1/en not_active IP Right Cessation
- 1991-11-14 IL IL10005591A patent/IL100055A/en active IP Right Grant
- 1991-11-15 ZA ZA919079A patent/ZA919079B/xx unknown
- 1991-11-18 NZ NZ240624A patent/NZ240624A/en not_active IP Right Cessation
- 1991-11-19 AU AU87946/91A patent/AU652002B2/en not_active Ceased
- 1991-11-22 CA CA002056065A patent/CA2056065C/en not_active Expired - Fee Related
- 1991-11-29 AT AT91311072T patent/ATE168998T1/de not_active IP Right Cessation
- 1991-11-29 DE DE69129894T patent/DE69129894T2/de not_active Expired - Fee Related
- 1991-11-29 ES ES91311072T patent/ES2118743T3/es not_active Expired - Lifetime
- 1991-11-29 EP EP91311072A patent/EP0489547B1/en not_active Expired - Lifetime
- 1991-11-29 CZ CS913633A patent/CZ282019B6/cs not_active IP Right Cessation
- 1991-11-29 SK SK3633-91A patent/SK278987B6/sk unknown
- 1991-11-29 DK DK91311072T patent/DK0489547T3/da active
- 1991-12-02 HU HU9103759A patent/HU222123B1/hu not_active IP Right Cessation
- 1991-12-04 US US07/803,315 patent/US5280125A/en not_active Expired - Fee Related
- 1991-12-04 PT PT99683A patent/PT99683B/pt not_active IP Right Cessation
- 1991-12-04 NO NO914775A patent/NO175680C/no unknown
- 1991-12-04 RU SU915010306A patent/RU2054417C1/ru not_active IP Right Cessation
- 1991-12-04 KR KR1019910022262A patent/KR100228328B1/ko not_active Expired - Fee Related
- 1991-12-05 FI FI915735A patent/FI102170B/fi not_active IP Right Cessation
- 1991-12-05 JP JP32180091A patent/JP3160040B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO175680C (no)	1994-11-16
HU913759D0 (en)	1992-02-28
NZ240624A (en)	1994-01-26
HU222123B1 (hu)	2003-04-28
IE913936A1 (en)	1992-06-17
KR100228328B1 (ko)	1999-11-01
GB9026427D0 (en)	1991-01-23
IL100055A0 (en)	1992-08-18
IL100055A (en)	1996-12-05
AU8794691A (en)	1992-06-11
ES2118743T3 (es)	1998-10-01
DE69129894T2 (de)	1998-12-10
NO175680B (no)	1994-08-08
EP0489547A1 (en)	1992-06-10
FI915735L (fi)	1992-06-06
DE69129894D1 (de)	1998-09-03
CA2056065C (en)	2003-07-29
JPH04266870A (ja)	1992-09-22
US5280125A (en)	1994-01-18
NO914775L (no)	1992-06-09
CS363391A3 (en)	1992-06-17
DK0489547T3 (da)	1999-04-26
FI915735A0 (fi)	1991-12-05
FI102170B1 (fi)	1998-10-30
RU2054417C1 (ru)	1996-02-20
NO914775D0 (no)	1991-12-04
PT99683B (pt)	1999-05-31
FI102170B (fi)	1998-10-30
SK278987B6 (sk)	1998-05-06
JP3160040B2 (ja)	2001-04-23
CZ282019B6 (cs)	1997-04-16
AU652002B2 (en)	1994-08-11
ATE168998T1 (de)	1998-08-15
CA2056065A1 (en)	1992-06-06
PT99683A (pt)	1992-10-30
EP0489547B1 (en)	1998-07-29
HUT60716A (en)	1992-10-28
KR920012029A (ko)	1992-07-25

Publication	Publication Date	Title
HU9203162D0 (en)	1992-12-28	Method for diastereoselective reductive pinacolic binding of homoquiralic alpha-amino-aldehydes
AU584861B2 (en)	1989-06-08	N-(2-Nitrophenyl)-4-aminopyrimidine derivatives, the preparation thereof and use thereof
EP0636617A3 (de)	1995-03-15	Verfahren zur Herstellung von N-(2-Hydroxyethyl)-piperazin.
PH30970A (en)	1997-12-23	Novel polyamine derivatives.
ZA873933B (en)	1987-12-02	N-(5-substituted methylene-phenyl)herbicides
JPS6475453A (en)	1989-03-22	Manufacture of amine by aminating olefin
CA2055972A1 (en)	1992-06-14	Amine modified hydrogenation of nitrile rubber
AR245108A1 (es)	1993-12-30	Derivados de n-(2-nitrofenil)-n-pirimidina-2-il-urea. su obtencion e intermediarios, composiciones herbicidas y reguladoras del crecimiento de las plantas que los contienen.
GB2185980B (en)	1990-08-15	Amine derivatives, processes for their production and their use
ZA919079B (en)	1992-09-30	A process for the preparation of a 3-alkylated indole
ZA883068B (en)	1988-12-28	Substituted tetrahydrophthalimides,processes for their preparation and their use as herbicides
PT80221B (en)	1987-02-17	Improved process for preparing benzamide derivatives useful as anticonvulsant agents
KR950011119B1 (en)	1995-09-28	Process for the manufacture of n,n-(di benzohexa trienylene)ureas
PT83253A (en)	1986-09-01	Process for preparing p-acylaminobenzamides
HUT40621A (en)	1987-01-28	Process for production of derivatives of guanidin, e.g. linoglyride and the intermediers
ES286087Y (es)	1986-10-16	Hebilla perfeccionada con mandibulas auto-apretadora para correa.
HU896745D0 (en)	1990-03-28	Process for preparation of n-(2-amino-3,5-dibrom-benzyl)-trans-4-aminocyclohexanol
FI945414A0 (fi)	1994-11-17	Menetelmä N,N-disubstituoidun aminofenolin valmistamiseksi
GR77848B (da)	1984-09-25
CS84686A1 (en)	1987-03-12	Zpusob pripravy 3 amino 5 nitro 2,1 benzisothiazolu
EP0248334A3 (en)	1990-09-26	Process for the manufacture of 2-nitro-4-sulfamyl-diphenyl amine dyes
IT8521796V0 (it)	1985-05-13	Fibbia ad aggancio rapido, particolarmente per cinturini sottogola di caschi.
EP0452504A4 (en)	1992-06-17	N-(3',4'-dimethoxycinnamoyl)anthranilic acid
IT8125591A0 (it)	1981-12-15	Procedimento di purificazione di n-alchil nitro aniline da n-nitroso ammine.
IE821075L (en)	1982-11-08	N-(0,0'-dialkyl-phenyl) alaninates