ZA91948B - Novel imidazole compounds,processes for their preparation,pharmaceuticals based on these compounds and some intermediates - Google Patents

Novel imidazole compounds,processes for their preparation,pharmaceuticals based on these compounds and some intermediates

Info

Publication number: ZA91948B
Authority: ZA; South Africa
Prior art keywords: alkyl; opt; substd; compounds; heteroatom
Prior art date: 1990-02-10

Application number

ZA91948A

Other languages

English (en)

Inventor

Rolf Graeve

Graeve Rolf

Ismahan Okyayuz-Baklouti

Okyayuz-Baklouti Ismahan

Dirk Seiffge

Seiffge Dirk

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-10

Filing date

1991-02-08

Publication date

1991-10-30

1991-02-08 Application filed by Hoechst Ag filed Critical Hoechst Ag

1991-10-30 Publication of ZA91948B publication Critical patent/ZA91948B/xx

Links

150000002460 imidazoles Chemical class 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 1
239000003814 drug Substances 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 8
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 5
125000005842 heteroatom Chemical group 0.000 abstract 3
125000000623 heterocyclic group Chemical group 0.000 abstract 3
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
RVWUTALYYJTSRD-UHFFFAOYSA-N 1-methyl-n-(2-morpholin-4-ylethyl)imidazole-2-sulfonamide Chemical compound CN1C=CN=C1S(=O)(=O)NCCN1CCOCC1 RVWUTALYYJTSRD-UHFFFAOYSA-N 0.000 abstract 1
BSAUSFFXHLPDDZ-UHFFFAOYSA-N 1-methyl-n-(2-morpholin-4-ylpropyl)imidazole-4-sulfonamide Chemical compound C1COCCN1C(C)CNS(=O)(=O)C1=CN(C)C=N1 BSAUSFFXHLPDDZ-UHFFFAOYSA-N 0.000 abstract 1
101100516563 Caenorhabditis elegans nhr-6 gene Proteins 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Epoxy Resins (AREA)
Detergent Compositions (AREA)
Cosmetics (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA91948A 1990-02-10 1991-02-08 Novel imidazole compounds,processes for their preparation,pharmaceuticals based on these compounds and some intermediates ZA91948B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4004061A DE4004061A1 (de)	1990-02-10	1990-02-10	Neue imidazolverbindungen, verfahren zu deren herstellung, arzneimittel auf basis dieser verbindungen sowie einige zwischenprodukte

Publications (1)

Publication Number	Publication Date
ZA91948B true ZA91948B (en)	1991-10-30

Family

ID=6399847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA91948A ZA91948B (en)	1990-02-10	1991-02-08	Novel imidazole compounds,processes for their preparation,pharmaceuticals based on these compounds and some intermediates

Country Status (23)

Country	Link
US (2)	US5232922A (el)
EP (1)	EP0442348B1 (el)
JP (1)	JP3026847B2 (el)
KR (1)	KR910015547A (el)
CN (1)	CN1053919A (el)
AT (1)	ATE140452T1 (el)
AU (1)	AU634342B2 (el)
BR (1)	BR9100520A (el)
CA (1)	CA2035988A1 (el)
CS (1)	CS30991A2 (el)
DE (2)	DE4004061A1 (el)
DK (1)	DK0442348T3 (el)
ES (1)	ES2090150T3 (el)
FI (1)	FI910602L (el)
GR (1)	GR3020570T3 (el)
HU (1)	HU207997B (el)
IE (1)	IE910427A1 (el)
IL (1)	IL97195A0 (el)
MX (1)	MX24463A (el)
NO (1)	NO910496L (el)
NZ (1)	NZ237049A (el)
PT (1)	PT96710A (el)
ZA (1)	ZA91948B (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2338930A1 (en)	1998-07-31	2000-02-10	Hamideh Zarrinmayeh	Heterocyclic sulphonamide derivatives
EP1866298A2 (en) *	2005-03-31	2007-12-19	Takeda San Diego, Inc.	Hydroxysteroid dehydrogenase inhibitors
BR102016023153A2 (pt) *	2016-10-04	2018-05-02	Fundação Butantan	Composição, uso, e, método para tratar doenças neurodegenerativas
WO2018069237A1 (de) *	2016-10-12	2018-04-19	Basf Se	Betain (b) und verfahren zu dessen herstellung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2603649A (en) *	1950-04-04	1952-07-15	American Cyanamid Co	Heterocyclic sulfonamides and method of preparing the same
US3932444A (en) *	1972-04-28	1976-01-13	E. I. Du Pont De Nemours & Co.	4-Imidazolylsulfonylimidazoles
ATE35265T1 (de) *	1982-05-28	1988-07-15	Ciba Geigy Ag	Neue sulfonyl(thio)harnstoffe, verfahren zu deren herstellung und deren verwendung als herbizide und/oder wachstumsregulatoren.
DE3379462D1 (de) *	1982-06-01	1989-04-27	Du Pont	Herbicidal imidazole, pyrazole, thiazole and isothiazole derivatives
DE3369984D1 (en) *	1982-07-12	1987-04-09	Searle & Co	1-(1h-imidazolyl), 1-n-morpholinyl and pyridyl compounds, their preparation and pharmaceutical compositions containing them
CA1222752A (en) *	1983-05-18	1987-06-09	Beat Bohner	Sulfonylureas and sulfonylthioureas, the preparation thereof, and method of use thereof as herbicides and/or growth regulators
DE3504677A1 (de) *	1985-02-12	1986-08-14	A. Nattermann & Cie GmbH, 5000 Köln	Neue imidazol-2-yloxyalkansaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4830660A (en) *	1986-06-19	1989-05-16	Nissan Chemical Industries, Ltd.	Imidazolesulfonamide derivatives and herbicides
CA1339133C (en) *	1987-03-13	1997-07-29	Rikuo Nasu	Imidazole compounds and biocidal composition comprising the same for controlling harmful organisms
EP0284277A1 (en) *	1987-03-21	1988-09-28	AgrEvo UK Limited	Cyanoimidazole fungicides

1990
- 1990-02-10 DE DE4004061A patent/DE4004061A1/de not_active Withdrawn
1991
- 1991-02-05 DE DE59107999T patent/DE59107999D1/de not_active Expired - Lifetime
- 1991-02-05 ES ES91101497T patent/ES2090150T3/es not_active Expired - Lifetime
- 1991-02-05 EP EP91101497A patent/EP0442348B1/de not_active Expired - Lifetime
- 1991-02-05 AT AT91101497T patent/ATE140452T1/de not_active IP Right Cessation
- 1991-02-05 DK DK91101497.5T patent/DK0442348T3/da active
- 1991-02-07 BR BR919100520A patent/BR9100520A/pt unknown
- 1991-02-07 FI FI910602A patent/FI910602L/fi unknown
- 1991-02-08 KR KR1019910002129A patent/KR910015547A/ko not_active Withdrawn
- 1991-02-08 IL IL97195A patent/IL97195A0/xx unknown
- 1991-02-08 MX MX2446391A patent/MX24463A/es unknown
- 1991-02-08 CS CS91309A patent/CS30991A2/cs unknown
- 1991-02-08 IE IE042791A patent/IE910427A1/en unknown
- 1991-02-08 PT PT96710A patent/PT96710A/pt unknown
- 1991-02-08 JP JP3060750A patent/JP3026847B2/ja not_active Expired - Lifetime
- 1991-02-08 AU AU70848/91A patent/AU634342B2/en not_active Ceased
- 1991-02-08 NO NO91910496A patent/NO910496L/no unknown
- 1991-02-08 CA CA002035988A patent/CA2035988A1/en not_active Abandoned
- 1991-02-08 NZ NZ237049A patent/NZ237049A/en unknown
- 1991-02-08 HU HU91415A patent/HU207997B/hu not_active IP Right Cessation
- 1991-02-08 US US07/652,606 patent/US5232922A/en not_active Expired - Lifetime
- 1991-02-08 ZA ZA91948A patent/ZA91948B/xx unknown
- 1991-02-09 CN CN91100969A patent/CN1053919A/zh active Pending
1993
- 1993-05-07 US US08/057,887 patent/US5356922A/en not_active Expired - Lifetime
1996
- 1996-07-18 GR GR960401776T patent/GR3020570T3/el unknown

Also Published As

Publication number	Publication date
AU7084891A (en)	1991-08-15
DE4004061A1 (de)	1991-08-14
HU207997B (en)	1993-07-28
ATE140452T1 (de)	1996-08-15
DE59107999D1 (de)	1996-08-22
PT96710A (pt)	1991-10-31
US5356922A (en)	1994-10-18
FI910602A0 (fi)	1991-02-07
US5232922A (en)	1993-08-03
EP0442348A2 (de)	1991-08-21
NO910496L (no)	1991-08-12
MX24463A (es)	1993-06-01
EP0442348B1 (de)	1996-07-17
JPH04316561A (ja)	1992-11-06
KR910015547A (ko)	1991-09-30
JP3026847B2 (ja)	2000-03-27
CA2035988A1 (en)	1991-08-11
FI910602A7 (fi)	1991-08-11
DK0442348T3 (da)	1996-11-11
FI910602L (fi)	1991-08-11
HU910415D0 (en)	1991-08-28
HUT56549A (en)	1991-09-30
AU634342B2 (en)	1993-02-18
CN1053919A (zh)	1991-08-21
CS30991A2 (en)	1991-09-15
IL97195A0 (en)	1992-05-25
NO910496D0 (no)	1991-02-08
BR9100520A (pt)	1991-10-29
NZ237049A (en)	1992-10-28
IE910427A1 (en)	1991-08-14
GR3020570T3 (en)	1996-10-31
ES2090150T3 (es)	1996-10-16
EP0442348A3 (en)	1992-03-04

Publication	Publication Date	Title
GR3005586T3 (el)	1993-06-07
IL111290A (en)	1999-04-11	Uses of 2-phenyl-3-aroylbenzothiophenes in the preparation of medicaments useful in the treatment of peri-menopausal syndrome
GR3031492T3 (en)	2000-01-31	1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders
EP0285278A3 (en)	1990-05-09	Method of treating anxiety with tetrahydrobenzûc,d¨indole-6-carboxamides
ZA91948B (en)	1991-10-30	Novel imidazole compounds,processes for their preparation,pharmaceuticals based on these compounds and some intermediates
ES2059348T3 (es)	1994-11-16	Composicion farmaceutica para el tratamiento de cataratas.
IL84096A0 (en)	1988-03-31	Therapeutic agent for the treatment of peptic ulcer disease comprising a purine derivative
ZA8346B (en)	1983-10-26	Diazolylalkanols,process for their prepartion and their use as antimycotic agents
DE3687703D1 (de)	1993-03-18	Cephalosporinderivate und sie enthaltende antibiotika.
FR2539742B1 (fr)	1986-09-05	Derives amines de la pyridazine substitues en position 6 par un heterocycle ou un alicycle, lesdits derives etant actifs sur le systeme nerveux central
FR2258840A1 (en)	1975-08-22	(4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use
FR2372816A1 (fr)	1978-06-30	Benzisothiazolones et medicaments contenant ces substances
IE800900L (en)	1980-11-04	Pyrrolidinyl-benzoic acid derivatives.
ES2099093T3 (es)	1997-05-16	Uso de isocarbaciclinas para evitar o tratar enfermedades de organos.
ES8103082A1 (es)	1981-02-16	Procedimiento de preparacion de nuevos derivados pirido (3,4-e)-as-triazinos acilados y de sus sales de acicion aci-da de los mismos
KR940002268A (ko)	1994-02-17	21-클로로-프레그난 유도체
FR2280364A1 (fr)	1976-02-27	Nouveaux derives de l'acide phenylacetique, leur preparation et les medicaments qui en contiennent
NL7510483A (en)	1977-03-08	Alpha-ureido-thienylacetamido-cephalosporanic acids - with broad-spectrum antibacterial activity for oral or parenteral admin., for disinfection and as additives for animal feeds
FR2228779A1 (en)	1975-08-22	(4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use
ES2000384A6 (es)	1991-03-16	Metodo para la produccion de una composicion antiviral y antitumoral
KR890014115A (ko)	1989-10-21	4-(3-포스포노-2-프로페닐)-2-피페라진카르복실산의 신규한 용도
ES8800930A1 (es)	1987-12-01	Un metodo de preparacion de un compuesto de oxodiazina