ZA92108B - Methods for preparation and use of 1alpha,24-dihydroxy vitamin d2 - Google Patents

Methods for preparation and use of 1alpha,24-dihydroxy vitamin d2

Info

Publication number: ZA92108B
Authority: ZA; South Africa
Prior art keywords: dihydroxy vitamin; proportional; preparation; converted; 1alpha
Prior art date: 1991-01-08

Application number

ZA92108A

Other languages

English (en)

Inventor

Charles W Bishop

Glenville Jones

Joyce C Knutson

Stephen Strugnell

Robert Moriarty

Raju Penmasta

Liang Guo

Original Assignee

Lunar Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-08

Filing date

1992-01-08

Publication date

1992-10-28

1992-01-08 Application filed by Lunar Corp filed Critical Lunar Corp

1992-10-28 Publication of ZA92108B publication Critical patent/ZA92108B/xx

Links

MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 title abstract 4
238000002360 preparation method Methods 0.000 title abstract 2
MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 abstract 3
229960002061 ergocalciferol Drugs 0.000 abstract 3
235000001892 vitamin D2 Nutrition 0.000 abstract 3
239000011653 vitamin D2 Substances 0.000 abstract 3
LHXJPXPNCMSHPV-KAOCCWGPSA-N (3s,9s,10r,13r,14r,17r)-17-[(e,2r,5s)-5-hydroxy-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@H](C)/C=C/[C@@](C)(O)C(C)C)CC[C@H]33)C)C3=CC=C21 LHXJPXPNCMSHPV-KAOCCWGPSA-N 0.000 abstract 2
OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 abstract 1
RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 abstract 1
HVAVRRBYXYEBNC-RKULPTJNSA-N 24-hydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/C(C)(O)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C HVAVRRBYXYEBNC-RKULPTJNSA-N 0.000 abstract 1
OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 abstract 1
DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 abstract 1
208000022458 calcium metabolism disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
208000017520 skin disease Diseases 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Diabetes (AREA)
Nutrition Science (AREA)
Hematology (AREA)
Obesity (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

ZA92108A 1991-01-08 1992-01-08 Methods for preparation and use of 1alpha,24-dihydroxy vitamin d2 ZA92108B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US63786791A	1991-01-08	1991-01-08

Publications (1)

Publication Number	Publication Date
ZA92108B true ZA92108B (en)	1992-10-28

Family

ID=24557692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA92108A ZA92108B (en)	1991-01-08	1992-01-08	Methods for preparation and use of 1alpha,24-dihydroxy vitamin d2

Country Status (14)

Country	Link
US (1)	US6211168B1 (de)
EP (2)	EP0550702B1 (de)
CN (3)	CN1032256C (de)
AT (2)	ATE240736T1 (de)
AU (1)	AU1247592A (de)
DE (2)	DE69233074T2 (de)
DK (1)	DK0550702T3 (de)
ES (2)	ES2200238T3 (de)
GR (1)	GR3030466T3 (de)
MX (1)	MX9200070A (de)
NZ (1)	NZ241255A (de)
PT (1)	PT99998B (de)
WO (1)	WO1992012165A1 (de)
ZA (1)	ZA92108B (de)

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US5602116A (en) *	1988-08-02	1997-02-11	Bone Care International, Inc.	Method for treating and preventing secondary hyperparathyroidism
US6538037B2 (en)	1991-01-08	2003-03-25	Bone Care International, Inc.	Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US20040009958A1 (en) *	1991-01-08	2004-01-15	Bone Care International, Inc.	Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
WO1994005630A1 (en) *	1992-08-28	1994-03-17	Lunar Corporation	1α,24(S)-DIHYDROXY VITAMIN D2, ITS FORMATION AND USE
US5763429A (en) *	1993-09-10	1998-06-09	Bone Care International, Inc.	Method of treating prostatic diseases using active vitamin D analogues
US6376479B1 (en)	1995-04-03	2002-04-23	Bone Care International, Inc.	Method for treating and preventing hyperparathyroidism
US6242434B1 (en) *	1997-08-08	2001-06-05	Bone Care International, Inc.	24-hydroxyvitamin D, analogs and uses thereof
US20020128240A1 (en) *	1996-12-30	2002-09-12	Bone Care International, Inc.	Treatment of hyperproliferative diseases using active vitamin D analogues
US6503893B2 (en)	1996-12-30	2003-01-07	Bone Care International, Inc.	Method of treating hyperproliferative diseases using active vitamin D analogues
US6573256B2 (en)	1996-12-30	2003-06-03	Bone Care International, Inc.	Method of inhibiting angiogenesis using active vitamin D analogues
US6566353B2 (en)	1996-12-30	2003-05-20	Bone Care International, Inc.	Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US20030129194A1 (en) *	1997-02-13	2003-07-10	Bone Care International, Inc.	Targeted therapeutic delivery of vitamin D compounds
NZ336924A (en)	1997-02-13	2001-06-29	Bone Care Int Inc	Targeted therapeutic delivery of vitamin D compounds via a Vitamin D conjugate
US6087350A (en) *	1997-08-29	2000-07-11	University Of Pittsburgh Of The Commonwealth System Of Higher Education	Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
JP2002509888A (ja) *	1998-03-27	2002-04-02	オレゴンヘルスサイエンシーズユニバーシティー	腫瘍および他の過増殖性疾患の治療におけるビタミンｄおよびその類似体
JP2002516306A (ja) *	1998-05-29	2002-06-04	ボーンケアインターナショナルインコーポレイテッド	ヒドロキシ−２５−エン−ビタミンｄ化合物の製造方法
JP2004504295A (ja)	2000-07-18	2004-02-12	ボーン　ケア　インターナショナル　インコーポレイテッド	安定化１α−ヒドロキシビタミンＤ
WO2003060094A2 (en)	2002-01-10	2003-07-24	Teva Pharmaceutical Industries Ltd.	Selective enzymatic esterification and solvolysis of epimeric vitamin d analog and separation of the epimers
US7148211B2 (en)	2002-09-18	2006-12-12	Genzyme Corporation	Formulation for lipophilic agents
US7094775B2 (en)	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) *	2004-06-30	2006-01-05	Bone Care International, Inc.	Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US20060052350A1 (en) *	2004-07-01	2006-03-09	Alexei Ploutno	Crystalline forms of 1,24(S)-dihydroxy vitamin D2
CN101607931B (zh) *	2009-07-23	2012-01-11	青岛正大海尔制药有限公司	一种骨化三醇的制备方法
CN103122009B (zh) *	2013-01-09	2015-11-25	江苏吉贝尔药业股份有限公司	两种用于合成他卡西醇支链的重要中间体化合物
CN103012463B (zh) *	2013-01-17	2016-02-10	南京理工大学	(s)-3-甲基-2-(叔丁基二甲基硅氧基)-1-溴丁烷的合成方法
CN104496871B (zh) *	2014-12-22	2016-03-09	上海皓元生物医药科技有限公司	一种他卡西醇的制备方法
CN109627279A (zh) *	2019-02-01	2019-04-16	浙江花园营养科技有限公司	一种活性维生素d3中间体的制备方法
EP3906228A4 (de)	2019-07-09	2023-02-15	Fermenta Biotech Limited	Verbessertes, kostengünstiges verfahren zur synthese von vitamin d3 und dessen analog kalzium-diol von ergosterol

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US3970676A (en) *	1974-10-29	1976-07-20	The Upjohn Company	Novel process and intermediate compounds used is preparation of -Δ5,7- steroid dienes
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US5098899A (en) *	1989-03-06	1992-03-24	Trustees Of Boston University	Method for therapeutically treating psoriatic arthritis using vitamin D analogues and metabolites

1992
- 1992-01-07 DE DE69233074T patent/DE69233074T2/de not_active Expired - Lifetime
- 1992-01-07 WO PCT/US1992/000313 patent/WO1992012165A1/en not_active Ceased
- 1992-01-07 EP EP92904947A patent/EP0550702B1/de not_active Expired - Lifetime
- 1992-01-07 DK DK92904947T patent/DK0550702T3/da active
- 1992-01-07 ES ES98110802T patent/ES2200238T3/es not_active Expired - Lifetime
- 1992-01-07 AU AU12475/92A patent/AU1247592A/en not_active Abandoned
- 1992-01-07 EP EP98110802A patent/EP0914825B1/de not_active Expired - Lifetime
- 1992-01-07 AT AT98110802T patent/ATE240736T1/de not_active IP Right Cessation
- 1992-01-07 ES ES92904947T patent/ES2134207T3/es not_active Expired - Lifetime
- 1992-01-07 AT AT92904947T patent/ATE179604T1/de not_active IP Right Cessation
- 1992-01-07 DE DE69229103T patent/DE69229103T2/de not_active Expired - Lifetime
- 1992-01-08 NZ NZ241255A patent/NZ241255A/xx not_active IP Right Cessation
- 1992-01-08 CN CN92100866A patent/CN1032256C/zh not_active Expired - Lifetime
- 1992-01-08 PT PT99998A patent/PT99998B/pt not_active IP Right Cessation
- 1992-01-08 ZA ZA92108A patent/ZA92108B/xx unknown
- 1992-01-08 MX MX9200070A patent/MX9200070A/es unknown
1995
- 1995-06-07 US US08/483,371 patent/US6211168B1/en not_active Expired - Lifetime
- 1995-11-10 CN CN95118187A patent/CN1078072C/zh not_active Expired - Lifetime
- 1995-11-10 CN CN95118188A patent/CN1071574C/zh not_active Expired - Lifetime
1999
- 1999-06-09 GR GR990401539T patent/GR3030466T3/el unknown

Also Published As

Publication number	Publication date
CN1067243A (zh)	1992-12-23
ES2200238T3 (es)	2004-03-01
DE69229103T2 (de)	1999-10-14
ES2134207T3 (es)	1999-10-01
CN1032256C (zh)	1996-07-10
EP0914825A3 (de)	1999-05-19
ATE240736T1 (de)	2003-06-15
EP0550702A1 (de)	1993-07-14
DE69233074D1 (de)	2003-06-26
NZ241255A (en)	1999-05-28
PT99998A (pt)	1993-01-29
DE69229103D1 (de)	1999-06-10
CN1143500A (zh)	1997-02-26
WO1992012165A1 (en)	1992-07-23
GR3030466T3 (en)	1999-10-29
US6211168B1 (en)	2001-04-03
CN1078072C (zh)	2002-01-23
EP0914825B1 (de)	2003-05-21
CN1071574C (zh)	2001-09-26
DK0550702T3 (da)	1999-11-01
DE69233074T2 (de)	2004-03-18
EP0550702A4 (en)	1994-06-08
PT99998B (pt)	1999-06-30
EP0914825A2 (de)	1999-05-12
AU1247592A (en)	1992-08-17
CN1133712A (zh)	1996-10-23
ATE179604T1 (de)	1999-05-15
EP0550702B1 (de)	1999-05-06
MX9200070A (es)	1992-07-01

Publication	Publication Date	Title
AU1247592A (en)	1992-08-17	Methods for preparation and use of 1alpha,24-dihydroxy vitamin d2
NO921955L (no)	1992-06-05	Nye d-vitaminforbindelser og fremgangsmaate til fremstilling av samme
HUT59313A (en)	1992-05-28	Process for producing pharmaceutical composition comprising flupirtin as active ingredient and suitable for combatting muscular tensions
IT1276253B1 (it)	1997-10-27	Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi
AU1486497A (en)	1997-05-22	1alpha,24(S)-dihydroxy vitamin D2, its formation and use
GR3020613T3 (en)	1996-10-31	Cosmetic and dermatological compositions containing an association of ceramides and linoleic acids, their preparation.
ES2085865T3 (es)	1996-06-16	Analogos de dermorfina, sus metodos de preparacion, composiciones farmaceuticas, y metodos de tratamiento terapeutico que los emplean.
DE69329887D1 (de)	2001-03-01	Thienobenzodiazepinderivate zur Behandlung von Störungen des Zentralnervensystems
WO1994005630B1 (en)	1994-04-14	1α,24(S)-DIHYDROXY VITAMIN D2, ITS FORMATION AND USE
AU649882B2 (en)	1994-06-02	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs, a process for their preparation and their use as medicaments
ATE177111T1 (de)	1999-03-15	Doppelbindungs-isomer von equilin erhalten durch säure-isomerisierung
AU8240387A (en)	1988-06-16	Basically substituted phenylacetonitriles, their preparation and drugs containing these compounds
IL107614A0 (en)	1994-02-27	Vitamin d3 analogs their preparation and pharmaceutical compositions containing them
HU9401193D0 (en)	1994-07-28	Condensed quinolyl-dihydropyridines, process for producing them and pharmaceutical compositions containing them as active components
AU6814387A (en)	1987-08-06	Phenylacetonitriles which are substituted by basic groups, their preparation and drugs containing these substances
HU9400908D0 (en)	1994-06-28	Pharmaceutical compositions for treatng skin disorders
GR3006606T3 (de)	1993-06-30
ATE147267T1 (de)	1997-01-15	Verwendung von 24,25-dihydroxyvitamin-d3 zur herstellung eines arzneimittel zur behandlung der rachitis
CA2084109A1 (en)	1993-06-11	Novel process for preparing 4-amino-5-hexanoic acid
DK0551653T3 (da)	1999-10-11	Enantiomeric pure cis-2-oxa-5,8-diazabicyclo(4.3.0)nonanes and process for their preparation
HUT54682A (en)	1991-03-28	Process for producing 13-bromine- and 13,14-dibromine-ergoline derivatives and pharmaceutical preparatives containing these compounds
ATE157008T1 (de)	1997-09-15	Aluminium-kalium-sulfat enthaltende creme und verfahren zur herstellung