ZA921232B - Quinoline-containing ketoacids as leukotriene antagonists - Google Patents

Quinoline-containing ketoacids as leukotriene antagonists

Info

Publication number
ZA921232B
ZA921232B ZA921232A ZA921232A ZA921232B ZA 921232 B ZA921232 B ZA 921232B ZA 921232 A ZA921232 A ZA 921232A ZA 921232 A ZA921232 A ZA 921232A ZA 921232 B ZA921232 B ZA 921232B
Authority
ZA
South Africa
Prior art keywords
ketoacids
quinoline
leukotriene antagonists
compounds
useful
Prior art date
Application number
ZA921232A
Other languages
English (en)
Inventor
Michel L Belley
L Belley Michel
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Publication of ZA921232B publication Critical patent/ZA921232B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
ZA921232A 1991-02-21 1992-02-20 Quinoline-containing ketoacids as leukotriene antagonists ZA921232B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65893191A 1991-02-21 1991-02-21

Publications (1)

Publication Number Publication Date
ZA921232B true ZA921232B (en) 1992-10-28

Family

ID=24643302

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA921232A ZA921232B (en) 1991-02-21 1992-02-20 Quinoline-containing ketoacids as leukotriene antagonists

Country Status (17)

Country Link
EP (1) EP0500360B1 (cs)
JP (1) JPH0788361B2 (cs)
KR (1) KR920016423A (cs)
CN (1) CN1065062A (cs)
AT (1) ATE154801T1 (cs)
AU (1) AU648385B2 (cs)
CA (1) CA2061675C (cs)
CS (1) CS47192A3 (cs)
DE (1) DE69220517T2 (cs)
ES (1) ES2104821T3 (cs)
FI (1) FI920734A7 (cs)
HU (1) HU9200552D0 (cs)
IE (1) IE920499A1 (cs)
IL (1) IL100985A0 (cs)
MX (1) MX9200714A (cs)
NO (1) NO920681L (cs)
ZA (1) ZA921232B (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270324A (en) * 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
GB9216768D0 (en) * 1992-08-07 1992-09-23 Leo Pharm Prod Ltd Chemical compounds
EP0830133A1 (en) * 1995-04-28 1998-03-25 Takeda Chemical Industries, Ltd. Therapeutic composition for arthritis
WO1998008820A1 (en) * 1996-08-26 1998-03-05 Yamanouchi Pharmaceutical Co., Ltd. Benzenesulfone compounds and salts thereof
PT1037627E (pt) * 1998-07-14 2001-11-30 Alcon Lab Inc Utilizacao do acido 11-(3-dimetilaminopropilideno)-6,11-dihidrodibenz¬b,e|oxepin-2-acetico e seus sais derivados farmaceuticamente aceitaveis para a producao de um medicamento para o tratamento de doencas inflamatorias oftalmicas nao-alergicas e para a prebencao da neovascularizacao ocular
MXPA06012220A (es) 2004-04-21 2007-07-18 Teva Pharma Procesos para preparar sodio de montelukast.
ITMI20050247A1 (it) * 2005-02-18 2006-08-19 Chemi Spa Processo per la preparazione di montelukast
WO2006131782A1 (en) * 2005-06-07 2006-12-14 Glade Organics Private Limited Process for the manufacture of methyl-2-(3-(2-(7-chloro-2-quinolinyl-ethenyl)-phenyl)-3-oxopropyl) benzoate
US7812168B2 (en) 2005-07-05 2010-10-12 Teva Pharmaceutical Industries Ltd. Purification of montelukast
CN101365683A (zh) * 2005-11-18 2009-02-11 斯索恩有限公司 制备孟鲁司特及其中间体的方法
AR057909A1 (es) * 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico.
EP2059509A2 (en) * 2006-09-15 2009-05-20 Cipla Limited Process for the preparation of montelukast, and intermediates therefor
ES2320077B1 (es) * 2007-07-31 2010-02-26 Moehs Iberica, S.L. Proceso de preparacion de un antagonista de leucotrienos y de un intermedio del mismo.
CN101851196B (zh) * 2010-05-28 2011-07-27 中国科学院昆明植物研究所 2-(1h)喹啉酮衍生物,其药物组合物及其制备方法和用途
KR20140108627A (ko) * 2011-07-26 2014-09-12 썬 파마 어드밴스트 리서치 컴패니 리미티드 퀴놀린-, 퀸옥살린 또는 벤조티아졸계 시스테이닐 류코트리엔 길항물질 (ltc4)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE59889B1 (en) * 1986-02-14 1994-04-20 Merck Frosst Canada Inc 2-substituted quinoline dioic acids
EP0318093A3 (en) * 1987-11-25 1990-12-05 Merck Frosst Canada Inc. Diarylquinoline diacids and their use as medicaments
EP0349062A1 (en) * 1988-06-27 1990-01-03 Merck Frosst Canada Inc. Quinoline ether alkanoic acid
NZ233752A (en) * 1989-05-24 1993-05-26 Merck Frosst Canada Inc Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
KR920016423A (ko) 1992-09-24
NO920681L (no) 1992-08-24
IE920499A1 (en) 1992-08-26
ATE154801T1 (de) 1997-07-15
FI920734L (fi) 1992-08-22
CA2061675C (en) 2002-12-17
ES2104821T3 (es) 1997-10-16
CN1065062A (zh) 1992-10-07
CS47192A3 (en) 1992-10-14
HU9200552D0 (en) 1992-05-28
JPH0525135A (ja) 1993-02-02
MX9200714A (es) 1992-10-01
EP0500360B1 (en) 1997-06-25
DE69220517D1 (de) 1997-07-31
FI920734A7 (fi) 1992-08-22
CA2061675A1 (en) 1992-08-22
DE69220517T2 (de) 1997-12-18
NO920681D0 (no) 1992-02-20
JPH0788361B2 (ja) 1995-09-27
EP0500360A1 (en) 1992-08-26
AU648385B2 (en) 1994-04-21
IL100985A0 (en) 1992-11-15
FI920734A0 (fi) 1992-02-20
AU1111992A (en) 1992-08-27

Similar Documents

Publication Publication Date Title
LV12187A (lv) Nepiesatinatas hidroksialkiletas hinolina rindas karbonskabes
HU9402905D0 (en) Quinoline derivatives of mostly leukotriene antagonistic activity
AU1111992A (en) Quinoline-containing ketoacids as leukotriene antagonists
AU672837B2 (en) Diaryl 5,6-fusedheterocyclic acids as leukotriene antagonists
AU639612B2 (en) Hydroxyalkylquinoline ether acids as leukotriene antagonists
CA2163244A1 (en) Quinoline derivatives as leukotriene antagonists
CA2283101A1 (en) Quinoline leukotriene antagonists
EP0712407A1 (en) Aza-5,5-fused heterocyclic acids as leukotriene antagonists
MY107767A (en) Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists