ZA925732B - Process for purifying pentostatin - Google Patents

Process for purifying pentostatin

Info

Publication number: ZA925732B
Authority: ZA; South Africa
Prior art keywords: pentostatin; eluting; applying; water; eluate
Prior art date: 1991-07-31

Application number

ZA925732A

Other languages

English (en)

Inventor

James Clark French

Peter Mcdonnell

Howard Daniel Hollis Showalter

Colin Rath Edmunds

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-31

Filing date

1992-07-30

Publication date

1994-01-31

1992-07-30 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1994-01-31 Publication of ZA925732B publication Critical patent/ZA925732B/xx

Links

FPVKHBSQESCIEP-UHFFFAOYSA-N (8S)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Natural products C1C(O)C(CO)OC1N1C(NC=NCC2O)=C2N=C1 FPVKHBSQESCIEP-UHFFFAOYSA-N 0.000 title abstract 3
FPVKHBSQESCIEP-JQCXWYLXSA-N pentostatin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 FPVKHBSQESCIEP-JQCXWYLXSA-N 0.000 title abstract 3
229960002340 pentostatin Drugs 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
239000011324 bead Substances 0.000 abstract 2
235000013405 beer Nutrition 0.000 abstract 2
238000000855 fermentation Methods 0.000 abstract 2
230000004151 fermentation Effects 0.000 abstract 2
CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical compound C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 abstract 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 abstract 1
239000000908 ammonium hydroxide Substances 0.000 abstract 1
239000003957 anion exchange resin Substances 0.000 abstract 1
229940063013 borate ion Drugs 0.000 abstract 1
239000012607 strong cation exchange resin Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

ZA925732A 1991-07-31 1992-07-30 Process for purifying pentostatin ZA925732B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US73871591A	1991-07-31	1991-07-31

Publications (1)

Publication Number	Publication Date
ZA925732B true ZA925732B (en)	1994-01-31

Family

ID=24969187

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA925732A ZA925732B (en)	1991-07-31	1992-07-30	Process for purifying pentostatin

Country Status (15)

Country	Link
US (1)	US5463035A (ja)
EP (1)	EP0596943B1 (ja)
JP (1)	JP3141029B2 (ja)
AT (1)	ATE145404T1 (ja)
AU (1)	AU2381792A (ja)
DE (1)	DE69215375T2 (ja)
DK (1)	DK0596943T3 (ja)
ES (1)	ES2094919T3 (ja)
GR (1)	GR3022387T3 (ja)
HU (1)	HU215126B (ja)
IE (1)	IE80618B1 (ja)
MX (1)	MX9204460A (ja)
PT (1)	PT100755B (ja)
WO (1)	WO1993003048A1 (ja)
ZA (1)	ZA925732B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1439220E (pt) *	2003-01-16	2007-11-28	Adorkem Technology Spa	Biocatalisadores imobilizados utilizáveis para o fabrico de nucleósidos naturais e análogos modificados por reacções de transglicosilação enzimática
ITMI20052516A1 (it) *	2005-12-29	2007-06-30	Evultis Sa	PROCESSO PER L'ISOLAMENTO DI PèRINCIPI FARMACOLOGICAMENTE ATTIVI DI ORIGINE VEGETALE ED ANIMALE
CN101792722B (zh) *	2009-02-04	2013-04-10	杭州华东医药集团生物工程研究所有限公司	一种链霉菌及其应用
CN101798330A (zh) *	2009-02-06	2010-08-11	杭州华东医药集团生物工程研究所有限公司	一种喷司他丁的提取纯化方法
US20100261666A1 (en) *	2009-04-14	2010-10-14	The Board Of Trustees Of The University Of Illinois	Compositions and methods for the treatment of myocardial dysfunction associated with sirs or sepsis
CN102453065B (zh) *	2010-10-29	2014-12-17	上海医药工业研究院	一种去除喷司他丁发酵液中杂质的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3923785A (en) *	1974-04-22	1975-12-02	Parke Davis & Co	(R)-3-(2-deoxy-{62 -D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo{8 4,5-d{9 {8 1,3{9 diazepin-8-ol
US4713372A (en) *	1984-03-16	1987-12-15	Warner-Lambert Company	2-chloropentostatin compound having adenosine diaminase inhibitory activity
IT1182764B (it) *	1985-06-26	1987-10-05	Pietro Crocoli	Water closet, particolarmente adatto per veicoli
US4935342A (en) *	1986-12-01	1990-06-19	Syngene, Inc.	Method of isolating and purifying nucleic acids from biological samples
US4908441A (en) *	1988-07-19	1990-03-13	Warner-Lambert Company	Deoxyadenosine compounds and methods of making and using the same

1992
- 1992-07-16 DE DE69215375T patent/DE69215375T2/de not_active Expired - Lifetime
- 1992-07-16 DK DK92916090.1T patent/DK0596943T3/da active
- 1992-07-16 ES ES92916090T patent/ES2094919T3/es not_active Expired - Lifetime
- 1992-07-16 EP EP92916090A patent/EP0596943B1/en not_active Expired - Lifetime
- 1992-07-16 HU HU9400257A patent/HU215126B/hu unknown
- 1992-07-16 AT AT92916090T patent/ATE145404T1/de active
- 1992-07-16 JP JP05503590A patent/JP3141029B2/ja not_active Expired - Lifetime
- 1992-07-16 WO PCT/US1992/005946 patent/WO1993003048A1/en not_active Ceased
- 1992-07-16 AU AU23817/92A patent/AU2381792A/en not_active Abandoned
- 1992-07-30 MX MX9204460A patent/MX9204460A/es unknown
- 1992-07-30 ZA ZA925732A patent/ZA925732B/xx unknown
- 1992-07-30 IE IE922507A patent/IE80618B1/en not_active IP Right Cessation
- 1992-07-31 PT PT100755A patent/PT100755B/pt not_active IP Right Cessation
1995
- 1995-02-28 US US08/396,443 patent/US5463035A/en not_active Expired - Lifetime
1997
- 1997-01-29 GR GR960403293T patent/GR3022387T3/el unknown

Also Published As

Publication number	Publication date
ES2094919T3 (es)	1997-02-01
MX9204460A (es)	1993-04-01
JP3141029B2 (ja)	2001-03-05
PT100755A (pt)	1993-10-29
IE922507A1 (en)	1993-02-10
AU2381792A (en)	1993-03-02
EP0596943A1 (en)	1994-05-18
PT100755B (pt)	1999-07-30
GR3022387T3 (en)	1997-04-30
WO1993003048A1 (en)	1993-02-18
HU9400257D0 (en)	1994-05-30
EP0596943B1 (en)	1996-11-20
ATE145404T1 (de)	1996-12-15
DK0596943T3 (da)	1997-04-21
HUT65981A (en)	1994-08-29
DE69215375D1 (de)	1997-01-02
DE69215375T2 (de)	1997-03-13
JPH06509355A (ja)	1994-10-20
IE80618B1 (en)	1998-10-21
HU215126B (hu)	1998-09-28
US5463035A (en)	1995-10-31

Publication	Publication Date	Title
AU4521897A (en)	1998-02-12	Purified immunoglobulins
GR3022387T3 (en)	1997-04-30	Process for purifying pentostatin.
DK0712827T3 (da)	1999-09-20	Fremgangsmåde til fremstilling af D-chiro-inositol
ES8207127A1 (es)	1982-09-01	Un procedimiento para recuperar betaina de melazas
CA2166297A1 (en)	1995-01-12	Process for manufacture of 1-deamino-8-d-arginine vasopressin
IL62981A (en)	1984-01-31	Preparation of concentrated nikkomicin mixtures
AU8124494A (en)	1995-07-03	Conversion of bisnoralcohol to bisnoraldehyde
US5300653A (en)	1994-04-05	Separation method of amino acids
ES8507460A1 (es)	1985-10-01	Procedimiento para preparar esteres de alquilo c8-c20 de acido 3,5-di-terc-butil-4-hidroxibenzoico
DE69720693D1 (de)	2003-05-15	Fsh und lh trennungs- und reinigungsverfahren
MY118717A (en)	2005-01-31	Purification of hydroxylamine
ATE342269T1 (de)	2006-11-15	Herstellung von hochreiner l-ribose aus l- arabinose
AU4883493A (en)	1994-04-21	Process for the production of an alkali-metal citrate
GB1435063A (en)	1976-05-12	Preparation of beta-aminopropionitrile
Nigh et al.	1969	Substrates for fumarate hydratase
EP0892045A3 (de)	2001-02-07	Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats
French et al.	1996	Process for purifying pentostatin
MY109523A (en)	1997-02-28	Method of regenerating resin beads for use in water purification.
TW260624B (en)	1995-10-21	Process of separating tryptophan (Trp) from zymotic fluid by ion-exchange displacement chromatography
GB1201823A (en)	1970-08-12	Process for recovering glutamic acid
NZ334946A (en)	2000-09-29	Process for isolating glycomacropeptide from dairy products with a phenylalanine impurity of 0.5%w/w
ES8205742A1 (es)	1982-07-01	Un procedimiento para separar el agua de una corriente de acido acrilico acuoso.
GB1517995A (en)	1978-07-19	Method and apparatus for liquid chromatography under elevated pressure
GB1499086A (en)	1978-01-25	Process for the preparation of 4-hydroxy-l-(-)-proline
AU3455497A (en)	1998-02-10	A process for the production of crystalline aspartic acid