ZA932914B - Phenyl sulfonamide endothelin antagonists - Google Patents

Phenyl sulfonamide endothelin antagonists

Info

Publication number: ZA932914B
Authority: ZA; South Africa
Prior art keywords: endothelin antagonists; phenyl sulfonamide; sulfonamide endothelin; hydrogen; symbols
Prior art date: 1992-05-06

Application number

ZA932914A

Other languages

English (en)

Inventor

Natesan Murugesan

John T Hunt

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-06

Filing date

1993-04-26

Publication date

1993-11-12

1993-04-26 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1993-11-12 Publication of ZA932914B publication Critical patent/ZA932914B/xx

Links

102000002045 Endothelin Human genes 0.000 title abstract 2
108050009340 Endothelin Proteins 0.000 title abstract 2
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
-1 cycloalkenylalkyl Chemical group 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA932914A 1992-05-06 1993-04-26 Phenyl sulfonamide endothelin antagonists ZA932914B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US87900092A	1992-05-06	1992-05-06

Publications (1)

Publication Number	Publication Date
ZA932914B true ZA932914B (en)	1993-11-12

Family

ID=25373236

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA932914A ZA932914B (en)	1992-05-06	1993-04-26	Phenyl sulfonamide endothelin antagonists

Country Status (22)

Country	Link
EP (1)	EP0569193B1 (de)
JP (1)	JP3286391B2 (de)
KR (1)	KR100277454B1 (de)
CN (1)	CN1066441C (de)
AT (1)	ATE149155T1 (de)
AU (1)	AU659545B2 (de)
CA (1)	CA2095174A1 (de)
CY (1)	CY2016A (de)
DE (1)	DE69308229T2 (de)
DK (1)	DK0569193T3 (de)
ES (1)	ES2100459T3 (de)
FI (1)	FI112655B (de)
GR (1)	GR3023421T3 (de)
HK (1)	HK98197A (de)
HU (1)	HU218938B (de)
IL (1)	IL105481A (de)
MX (1)	MX9302618A (de)
NO (1)	NO303065B1 (de)
NZ (1)	NZ247440A (de)
PL (1)	PL178165B1 (de)
RU (1)	RU2133742C1 (de)
ZA (1)	ZA932914B (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6124343A (en) *	1919-01-27	2000-09-26	Rhone-Poulenc Rorer Limited	Substituted phenyl compounds with a substituent having a thienyl ring
EP0301103A4 (de) *	1987-02-09	1989-07-20	Mitsui Petrochemical Ind	Formmasse für plasthalbzeugfolien und diese folie enthaltendes laminate.
US5591761A (en) *	1993-05-20	1997-01-07	Texas Biotechnology Corporation	Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5571821A (en) *	1993-05-20	1996-11-05	Texas Biotechnology Corporation	Sulfonamides and derivatives thereof that modulate the activity of endothelin
US5514691A (en) *	1993-05-20	1996-05-07	Immunopharmaceutics, Inc.	N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5962490A (en) *	1987-09-25	1999-10-05	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5594021A (en) *	1993-05-20	1997-01-14	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
US5736509A (en) *	1990-12-14	1998-04-07	Texas Biotechnology Corporation	Cyclic peptide surface feature mimics of endothelin
US5767310A (en) *	1993-03-19	1998-06-16	Merck & Co., Inc.	Phenoxyphenylacetic acid derivatives
CA2121724A1 (en)	1993-04-21	1994-10-22	Toshifumi Watanabe	Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction
US6376523B1 (en)	1994-05-20	2002-04-23	Texas Biotechnology Corporation	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6030991A (en) *	1993-05-20	2000-02-29	Texas Biotechnology Corp.	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6613804B2 (en)	1993-05-20	2003-09-02	Encysive Pharmaceuticals, Inc.	Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6342610B2 (en)	1993-05-20	2002-01-29	Texas Biotechnology Corp.	N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6541498B2 (en)	1993-05-20	2003-04-01	Texas Biotechnology	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US5686478A (en) *	1993-07-20	1997-11-11	Merck & Co. Inc.	Endothelin antagonists
ES2081250B1 (es) *	1993-07-28	1996-10-16	Squibb & Sons Inc	Antagonistas de endotelina a base de fenilsulfonamida.
US5965732A (en) *	1993-08-30	1999-10-12	Bristol-Myers Squibb Co.	Sulfonamide endothelin antagonists
AU691201B2 (en) *	1993-11-01	1998-05-14	Japat Ltd.	Endothelin receptor antagonists
US5431842A (en) *	1993-11-05	1995-07-11	The Procter & Gamble Company	Liquid detergents with ortho-substituted phenylboronic acids for inhibition of proteolytic enzyme
IL111959A (en) *	1993-12-17	2000-07-16	Tanabe Seiyaku Co	N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
GB9504854D0 (en) *	1994-03-31	1995-04-26	Zeneca Ltd	Nitrogen derivatives
GB9409618D0 (en) *	1994-05-13	1994-07-06	Zeneca Ltd	Pyridine derivatives
US5612359A (en) *	1994-08-26	1997-03-18	Bristol-Myers Squibb Company	Substituted biphenyl isoxazole sulfonamides
US5559135A (en) *	1994-09-14	1996-09-24	Merck & Co., Inc.	Endothelin antagonists bearing pyridyl amides
US5538991A (en) *	1994-09-14	1996-07-23	Merck & Co., Inc.	Endothelin antagonists bearing 5-membered heterocyclic amides
FR2724654B1 (fr) *	1994-09-16	1997-12-12	Roussel Uclaf	Nouveaux derives de l'acide gallique, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
FR2725988B1 (fr) *	1994-10-24	1997-01-24	Roussel Uclaf	Nouveaux derives de pyrazolones et pyrazoles acides, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
WO1996019455A1 (en) *	1994-12-20	1996-06-27	F. Hoffmann-La Roche Ag	Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists
US5760038A (en) *	1995-02-06	1998-06-02	Bristol-Myers Squibb Company	Substituted biphenyl sulfonamide endothelin antagonists
CA2168154A1 (en) *	1995-02-06	1996-08-07	Natesan Murugesan	Substituted biphenyl sulfonamide endothelin antagonists
DE19509950A1 (de) *	1995-03-18	1996-09-19	Merck Patent Gmbh	Endothelin-Rezeptor-Antagonisten
HUP9802034A3 (en) *	1995-04-04	2000-04-28	Encysive Pharmaceuticals Inc H	Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin and use of the compounds
US5739333A (en) *	1995-05-16	1998-04-14	Tanabe Seiyaku Co., Ltd.	Sulfonamide derivative and process for preparing the same
UA58494C2 (uk)	1995-06-07	2003-08-15	Зенека Лімітед	Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
GB9512697D0 (en) *	1995-06-22	1995-08-23	Zeneca Ltd	Heterocyclic compounds
US5846990A (en) *	1995-07-24	1998-12-08	Bristol-Myers Squibb Co.	Substituted biphenyl isoxazole sulfonamides
WO1997011942A1 (en) *	1995-09-26	1997-04-03	Shionogi & Co., Ltd.	Novel sulfonamide compounds and medicinal composition
JPH09124620A (ja)	1995-10-11	1997-05-13	Bristol Myers Squibb Co	置換ビフェニルスルホンアミドエンドセリン拮抗剤
DE19540737A1 (de)	1995-11-02	1997-05-07	Bayer Ag	Substituierte Sulfonylamino(thio)carbonylverbindungen
US5977117A (en)	1996-01-05	1999-11-02	Texas Biotechnology Corporation	Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5856507A (en) *	1997-01-21	1999-01-05	Bristol-Myers Squibb Co.	Methods for the preparation of biphenyl isoxazole sulfonamides
EP0904077A4 (de) *	1996-02-20	1999-12-22	Bristol Myers Squibb Co	Verfahren zur herstellung von biphenyl-isoxazole-sulfonamiden
US5958905A (en)	1996-03-26	1999-09-28	Texas Biotechnology Corporation	Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5939446A (en) *	1996-04-09	1999-08-17	Bristol-Myers Squibb Co.	Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
US5804585A (en)	1996-04-15	1998-09-08	Texas Biotechnology Corporation	Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
US5877193A (en) *	1996-07-19	1999-03-02	Hoffmann-La Roche Inc.	Use of N-(4-aryl-thiazol-2-yl)-sulfonamides
WO1998033781A1 (en) *	1997-01-30	1998-08-06	Bristol-Myers Squibb Company	Method for preventing or treating low renin hypertension by administering an endothelin antagonist
TW536540B (en) *	1997-01-30	2003-06-11	Bristol Myers Squibb Co	Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
US5783705A (en)	1997-04-28	1998-07-21	Texas Biotechnology Corporation	Process of preparing alkali metal salys of hydrophobic sulfonamides
AP9901643A0 (en)	1997-04-28	1999-10-02	Texas Biotechnology Corp	Sulfonamides for treatment of endothelin-mediated disorders.
IL144708A0 (en)	1999-03-19	2002-06-30	Bristol Myers Squibb Co	Methods for the preparation of biphenyl isoxazole sulfonamide derivatives
US7566452B1 (en)	1999-05-04	2009-07-28	New York University	Cancer treatment with endothelin receptor antagonists
DE60030764T2 (de) *	1999-12-15	2007-09-13	Bristol-Myers Squibb Co.	Biphenyl - sulfonamide als duale angiotensin - endothelin - rezeptor - antagonisten
HUP0203935A3 (en)	1999-12-31	2006-02-28	Encysive Pharmaceuticals Inc H	Sulfonamides and derivatives thereof that modulate the activity of endothelin, pharmaceutical compositions containing them and their use
CA2348847A1 (en) *	2000-05-31	2001-11-30	Pfizer Inc.	New isoxazole-sulfonamide endothelin antagonists
US6639082B2 (en)	2000-10-17	2003-10-28	Bristol-Myers Squibb Company	Methods for the preparation of biphenyl isoxazole sulfonamides
MXPA03008134A (es) *	2001-03-12	2004-03-10	Ono Pharmaceutical Co	Compuesto de n-fenilarilsulfonamida, medicamento que contiene el compuesto como ingrediente activo, intermediario para el compuesto y procedimientos para su produccion.
GB0219660D0 (en)	2002-08-23	2002-10-02	Astrazeneca Ab	Therapeutic use
GB0403744D0 (en)	2004-02-20	2004-03-24	Astrazeneca Ab	Chemical process
EP1807391A4 (de) *	2004-10-29	2010-01-06	Astrazeneca Ab	Neue sulfonamidderivate als glucocorticoidrezeptormodulatoren zur behandlung von entzündlichen krankheiten
CA2630718A1 (en)	2005-11-22	2007-05-31	Amgen Inc.	Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
TW200800150A (en) *	2005-12-21	2008-01-01	Organon Nv	Compounds with medicinal effects due to interaction with the glucocorticoid receptor
US7666888B2 (en)	2006-07-20	2010-02-23	Amgen Inc.	Substituted azole aromatic heterocycles as inhibitors of 11β-HSD-1
TW200829578A (en)	2006-11-23	2008-07-16	Astrazeneca Ab	Chemical compounds 537
JO2754B1 (en)	2006-12-21	2014-03-15	استرازينكا ايه بي	Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
UY31832A (es)	2008-05-20	2010-01-05	Astrazeneca Ab	Derivados de indazol sustituidos con fenilo y benzodioxinilo
HUE025013T2 (hu)	2009-01-12	2016-04-28	Pfizer Ltd	Szulfonamid-származékok
JP5872552B2 (ja)	2010-07-09	2016-03-01	ファイザー・リミテッドＰｆｉｚｅｒＬｉｍｉｔｅｄ	化学化合物
TW201512171A (zh)	2013-04-19	2015-04-01	Pfizer Ltd	化學化合物
GB201721185D0 (en)	2017-12-18	2018-01-31	Nodthera Ltd	Sulphonyl urea derivatives
GB201810092D0 (en)	2018-06-20	2018-08-08	Ctxt Pty Ltd	Compounds
GB201810581D0 (en)	2018-06-28	2018-08-15	Ctxt Pty Ltd	Compounds
PL3983387T3 (pl)	2019-06-12	2024-08-19	NodThera Limited	Pochodne sulfonylomocznika i ich zastosowania
EP3983388A1 (de) *	2019-06-12	2022-04-20	Nodthera Limited	Sulfonamidderivate und ihre verwendunge
KR102823056B1 (ko)	2019-06-18	2025-06-23	화이자 인코포레이티드	벤즈이속사졸 설폰아마이드 유도체
EP4361146A4 (de) *	2021-06-22	2025-06-18	Alchemedicine, Inc.	Verbindung, endothelin-a-rezeptorantagonist und pharmazeutische zusammensetzung
JP2025183466A (ja) *	2022-11-11	2025-12-17	株式会社アークメディスン	化合物、エンドセリンａ受容体拮抗剤、アンジオテンシンｉｉタイプ１受容体拮抗剤及び医薬組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3300488A (en) *	1963-12-23	1967-01-24	Shionogi & Co	Nu, nu'-bis [4-halogenated-5-alkyl-3-isoxazolylsulfamoyl)-phenyl]-ureas
US3422095A (en) *	1966-11-04	1969-01-14	Hoffmann La Roche	N1-and/or n4-(lower alkoxyacetyl) sulfanilamides
US5284828A (en) *	1990-05-14	1994-02-08	Fujisawa Pharmaceutical Co. Ltd.	Peptide compound and its preparation
TW270116B (de) *	1991-04-25	1996-02-11	Hoffmann La Roche
RU2086544C1 (ru) *	1991-06-13	1997-08-10	Хоффманн-Ля Рош АГ	Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
US5305312A (en) *	1992-02-07	1994-04-19	At&T Bell Laboratories	Apparatus for interfacing analog telephones and digital data terminals to an ISDN line
TW224462B (de) *	1992-02-24	1994-06-01	Squibb & Sons Inc

1993
- 1993-04-20 NZ NZ247440A patent/NZ247440A/en unknown
- 1993-04-21 IL IL10548193A patent/IL105481A/en not_active IP Right Cessation
- 1993-04-26 ZA ZA932914A patent/ZA932914B/xx unknown
- 1993-04-28 JP JP10235493A patent/JP3286391B2/ja not_active Expired - Fee Related
- 1993-04-29 AT AT93303373T patent/ATE149155T1/de not_active IP Right Cessation
- 1993-04-29 EP EP93303373A patent/EP0569193B1/de not_active Expired - Lifetime
- 1993-04-29 CA CA002095174A patent/CA2095174A1/en not_active Abandoned
- 1993-04-29 DK DK93303373.0T patent/DK0569193T3/da active
- 1993-04-29 ES ES93303373T patent/ES2100459T3/es not_active Expired - Lifetime
- 1993-04-29 DE DE69308229T patent/DE69308229T2/de not_active Expired - Fee Related
- 1993-05-04 KR KR1019930007628A patent/KR100277454B1/ko not_active Expired - Fee Related
- 1993-05-04 MX MX9302618A patent/MX9302618A/es not_active IP Right Cessation
- 1993-05-05 HU HU9301305A patent/HU218938B/hu not_active IP Right Cessation
- 1993-05-05 RU RU93004992A patent/RU2133742C1/ru not_active IP Right Cessation
- 1993-05-05 AU AU38382/93A patent/AU659545B2/en not_active Ceased
- 1993-05-05 NO NO931638A patent/NO303065B1/no not_active IP Right Cessation
- 1993-05-05 PL PL93298828A patent/PL178165B1/pl unknown
- 1993-05-06 CN CN93107073A patent/CN1066441C/zh not_active Expired - Fee Related
- 1993-05-06 FI FI932052A patent/FI112655B/fi not_active IP Right Cessation
1997
- 1997-05-15 GR GR970401070T patent/GR3023421T3/el unknown
- 1997-06-26 HK HK98197A patent/HK98197A/en not_active IP Right Cessation
1998
- 1998-02-20 CY CY201698A patent/CY2016A/xx unknown

Also Published As

Publication number	Publication date
IL105481A0 (en)	1993-08-18
JP3286391B2 (ja)	2002-05-27
CY2016A (en)	1998-02-20
IL105481A (en)	1996-12-05
DK0569193T3 (de)	1997-03-17
KR100277454B1 (ko)	2001-01-15
AU659545B2 (en)	1995-05-18
GR3023421T3 (en)	1997-08-29
FI932052A0 (fi)	1993-05-06
ES2100459T3 (es)	1997-06-16
RU2133742C1 (ru)	1999-07-27
ATE149155T1 (de)	1997-03-15
NO931638D0 (no)	1993-05-05
NO303065B1 (no)	1998-05-25
HU9301305D0 (en)	1993-09-28
DE69308229D1 (de)	1997-04-03
DE69308229T2 (de)	1997-07-17
JPH0649046A (ja)	1994-02-22
CN1066441C (zh)	2001-05-30
NZ247440A (en)	1995-04-27
EP0569193A1 (de)	1993-11-10
EP0569193B1 (de)	1997-02-26
CA2095174A1 (en)	1993-11-07
FI112655B (fi)	2003-12-31
AU3838293A (en)	1993-11-11
KR930023337A (ko)	1993-12-18
CN1084515A (zh)	1994-03-30
NO931638L (no)	1993-11-08
PL298828A1 (en)	1993-12-27
HK98197A (en)	1997-08-08
MX9302618A (es)	1994-05-31
HUT65751A (en)	1994-07-28
PL178165B1 (pl)	2000-03-31
HU218938B (hu)	2001-01-29
FI932052L (fi)	1993-11-07

Publication	Publication Date	Title
ZA932914B (en)	1993-11-12	Phenyl sulfonamide endothelin antagonists
DK0702012T3 (da)	2004-02-16	Substituerede isoxazolsulfonamider og anvendelse deraf som endothelin-antagonister
AU651922B2 (en)	1994-08-04	Sulfonamide endothelin antagonists
ZA898679B (en)	1990-08-29	Nitromethylene compounds,their preparation and their use as pesticides
DK0593595T3 (da)	2000-06-26	Derivater af inositol, præparater indeholdende dem samt deres anvendelse
EP0528034A4 (en)	1993-03-24	Remedy for asthma
ZA89431B (en)	1989-09-27	Oxadiazole compounds,their preparation and their use as pesticides
EP0785193A4 (de)	2000-04-19	Arylthiadiazol-derivate und diese enthaltende antivirale arzneimittel
GB8605032D0 (en)	1986-04-09	Fungicides
ATE46516T1 (de)	1989-10-15	Phosphonamidthioate-insektizide.
AU2057392A (en)	1993-02-25	Polyglucosides obtained from hydroxyalkylsorbitol
AP9300580A0 (en)	1995-04-14	Oxa- and thiadiazole derivatives.