ZA936838B - Antisense polynucleotides - Google Patents

Antisense polynucleotides

Info

Publication number: ZA936838B
Authority: ZA; South Africa
Prior art keywords: antisense polynucleotides; polynucleotides; antisense
Prior art date: 1992-09-23

Application number

ZA936838A

Other languages

English (en)

Inventor

Ramaswamy Narayanan

Craig Alan Rosen

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-23

Filing date

1993-09-16

Publication date

1994-03-23

1993-09-16 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1994-03-23 Publication of ZA936838B publication Critical patent/ZA936838B/xx

Links

230000000692 anti-sense effect Effects 0.000 title 1
102000040430 polynucleotide Human genes 0.000 title 1
108091033319 polynucleotide Proteins 0.000 title 1
239000002157 polynucleotide Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

ZA936838A 1992-09-23 1993-09-16 Antisense polynucleotides ZA936838B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US95053192A	1992-09-23	1992-09-23

Publications (1)

Publication Number	Publication Date
ZA936838B true ZA936838B (en)	1994-03-23

Family

ID=25490552

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA936838A ZA936838B (en)	1992-09-23	1993-09-16	Antisense polynucleotides

Country Status (8)

Country	Link
US (1)	US5591840A (de)
EP (1)	EP0589330A3 (de)
JP (1)	JPH06209778A (de)
CN (1)	CN1084564A (de)
AU (1)	AU673537B2 (de)
CA (1)	CA2105595A1 (de)
NZ (1)	NZ248691A (de)
ZA (1)	ZA936838B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5981486A (en) *	1995-04-13	1999-11-09	Chugai Seiyaku Kabushiki Kaisha	Peptide suppressing IκBα phosphorylation
DE69636997T2 (de) *	1995-05-12	2007-07-12	Anges MG Inc., Ibaraki	HEILUNG UND VORBEUGUNG VON DURCH NF-kappaB VERURSACHTEN ERKRANKUNGEN
JPH0959151A (ja) *	1995-08-24	1997-03-04	Kao Corp	ＮＦ−κＢ活性化抑制剤
SE9602300D0 (sv) *	1996-06-11	1996-06-11	Karolinska Innovations Ab	New composition and methods
WO1999001579A1 (en)	1997-07-01	1999-01-14	Isis Pharmaceuticals, Inc.	Compositions and methods for the delivery of oligonucleotides via the alimentary canal
CN1057301C (zh) *	1997-12-30	2000-10-11	杭州赛狮生物技术开发有限公司北京分公司	抑制人体肿瘤细胞生长的反义寡核苷酸
WO1999060012A1 (en) *	1998-05-21	1999-11-25	Isis Pharmaceuticals, Inc.	Compositions and methods for non-parenteral delivery of oligonucleotides
US6069008A (en) *	1998-11-25	2000-05-30	Isis Pharmaceuticals Inc.	Antisense modulation of NF-kappa-B p65 subunit expression
GB9930616D0 (en) *	1999-12-24	2000-02-16	Mathilda & Terence Kennedy Ins	Activation and inhibition of the immune system
US7069580B1 (en)	2000-06-16	2006-06-27	Fisher-Rosemount Systems, Inc.	Function-based process control verification and security in a process control system
WO2002066071A2 (en) *	2001-01-03	2002-08-29	Thomas Jefferson University	Treatment of tissue fibrosis by blocking the sp1 transcription factor
IL159722A0 (en) *	2001-07-10	2004-06-20	Oligos Etc Inc	Pharmaceutical compositions containing oligonucleotides
US20060257380A1 (en) *	2002-09-19	2006-11-16	Inst.Nat. De La Sante Et De La Recherche MED	Use of sirnas for gene silencing in antigen presenting cells
US7585848B2 (en)	2005-01-11	2009-09-08	Rush University Medical Center	Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc
EP1904077B1 (de)	2005-07-01	2009-08-12	Index Pharmaceuticals AB	Modulierung der reaktion auf steroide
DK2380584T3 (da)	2005-07-01	2014-01-20	Index Pharmaceuticals Ab	Immunstimulerende fremgangsmåde
WO2007050034A1 (en)	2005-10-28	2007-05-03	Index Pharmaceuticals Ab	Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease
US9550827B2 (en)	2007-10-19	2017-01-24	The Regents Of The University Of California	Methods for ameliorating and preventing central nervous system inflammation
WO2018130581A1 (en)	2017-01-13	2018-07-19	Roche Innovation Center Copenhagen A/S	Antisense oligonucleotides for modulating rela expression
WO2018130583A1 (en)	2017-01-13	2018-07-19	Roche Innovation Center Copenhagen A/S	Antisense oligonucleotides for modulating nfkb1 expression

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1341091C (en) *	1983-10-20	2000-09-05	Masayori Inouye	Regulation of gene expression by employing translational inhibition utilizaing mrna interfering complementary rna
WO1989007614A1 (en) *	1988-02-12	1989-08-24	Massachusetts Institute Of Technology	Nuclear factors associated with transcriptional regulation
WO1989008147A1 (en) *	1988-03-01	1989-09-08	Whitehead Institute For Biomedical Research	ACTIVITION OF NF-kB PRECURSOR
US5225326A (en) *	1988-08-31	1993-07-06	Research Development Foundation	One step in situ hybridization assay
ZA902912B (en) *	1989-04-21	1991-01-30	Cornell Res Foundation Inc	Method of inhibiting induction of latent or chronic viral infection
US5138045A (en) *	1990-07-27	1992-08-11	Isis Pharmaceuticals	Polyamine conjugated oligonucleotides
CA2089476A1 (en) *	1990-08-15	1992-02-16	Bernard Roizman	Inhibition of herpesviridae infection by antisense oligonucleotides
WO1992005284A1 (en) *	1990-09-21	1992-04-02	University Of Maryland	Compositions and methods for inhibiting growth or replication of viruses
WO1992020795A1 (en) *	1991-05-17	1992-11-26	Cetus Oncology Corporation	INHIBITOR OF NF-λB TRANSCRIPTIONAL ACTIVATOR AND USES THEREOF

1993
- 1993-09-07 CA CA002105595A patent/CA2105595A1/en not_active Abandoned
- 1993-09-14 EP EP93114721A patent/EP0589330A3/de not_active Withdrawn
- 1993-09-16 ZA ZA936838A patent/ZA936838B/xx unknown
- 1993-09-17 AU AU47430/93A patent/AU673537B2/en not_active Ceased
- 1993-09-17 NZ NZ248691A patent/NZ248691A/xx unknown
- 1993-09-22 JP JP5236828A patent/JPH06209778A/ja active Pending
- 1993-09-22 CN CN93117831A patent/CN1084564A/zh active Pending
1994
- 1994-10-25 US US08/328,592 patent/US5591840A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0589330A3 (de)	1995-04-05
US5591840A (en)	1997-01-07
NZ248691A (en)	1995-01-27
CN1084564A (zh)	1994-03-30
AU4743093A (en)	1994-03-31
AU673537B2 (en)	1996-11-14
CA2105595A1 (en)	1994-03-24
JPH06209778A (ja)	1994-08-02
EP0589330A2 (de)	1994-03-30

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DE69307690D1 (en)	1997-03-06	Implantierbare penis-prothese
AU115931S (en)	1992-12-11	Cuff-link
DE59302394D1 (en)	1996-05-30	Linearlagerelement
DE69306746D1 (en)	1997-01-30	Schlichtmittelzusammensetzung
GB9224640D0 (en)	1993-01-13	Stable oligonucleotides
AU116869S (en)	1993-04-27	Bottle-cooler
AU4743093A (en)	1994-03-31	Antisense polynucleotides
DE69310500D1 (en)	1997-06-12	Racemisierungsverfahren
AP9300599A0 (en)	1994-01-31	Substituted 6-azaandrostenones
DE69318966D1 (en)	1998-07-09	Chemilumineszenzverstärker
DE69315037D1 (en)	1997-12-11	Phasendifferenz-kompensationsfilm
AU116434S (en)	1993-03-01	Sponge-squeegee
GB9221872D0 (en)	1992-12-02	Improved cord-lock
GB9117138D0 (en)	1991-09-25	Polynucleotides
GB9100962D0 (en)	1991-02-27	Polynucleotides
GB9112801D0 (en)	1991-07-31	Polynucleotides
AU499P (en)	1995-11-29	BAYAMO Desmanthus virgatus
CA70408S (en)	1992-04-14	Hairsetter
AU940P (en)	1997-12-09	KISMET Chamelaucium uncinatum
CA71063S (en)	1992-07-14	Montre-chronographe
GB9214762D0 (en)	1992-08-26	Improvements
GB9220763D0 (en)	1992-11-18	Distributor
GB9109020D0 (en)	1991-06-12	Modified antisense oligonucleotides
GB9204196D0 (en)	1992-04-08	Single ended striplight
GB9308212D0 (en)	1993-06-02	Improved carry-pack