ZA937112B - 17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstaniene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions contning same - Google Patents

17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstaniene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions contning same

Info

Publication number: ZA937112B
Authority: ZA; South Africa
Prior art keywords: androstene; androstane; heterocyclyl; aryl; preparation
Prior art date: 1992-09-29

Application number

ZA937112A

Other languages

English (en)

Inventor

Peiro Melloni

Mara Ferrandi

Marina Mauro

Luigi Bernardi

Marco Frigerio

Luisa Quadri

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-29

Filing date

1993-09-24

Publication date

1995-07-25

1993-09-24 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1995-07-25 Publication of ZA937112B publication Critical patent/ZA937112B/xx

Links

NXQOQNROJJFYCJ-FZFXZXLVSA-N androst-16-ene Chemical compound C1CCC[C@]2(C)[C@H]3CC[C@](C)(C=CC4)[C@@H]4[C@@H]3CCC21 NXQOQNROJJFYCJ-FZFXZXLVSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
210000000748 cardiovascular system Anatomy 0.000 title 1
150000001439 androstadienes Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA937112A 1992-09-29 1993-09-24 17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstaniene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions contning same ZA937112B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4232681A DE4232681C2 (de)	1992-09-29	1992-09-29	17-Phenyl- und 17-Furyl-14beta,5alpha-androstan- und androsten- Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung

Publications (1)

Publication Number	Publication Date
ZA937112B true ZA937112B (en)	1995-07-25

Family

ID=6469164

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA937112A ZA937112B (en)	1992-09-29	1993-09-24	17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstaniene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions contning same

Country Status (11)

Country	Link
US (2)	US5556846A (ja)
EP (1)	EP0590271B1 (ja)
JP (1)	JPH06192287A (ja)
KR (1)	KR940007054A (ja)
AT (1)	ATE145649T1 (ja)
CA (1)	CA2106916A1 (ja)
DE (2)	DE4232681C2 (ja)
DK (1)	DK0590271T3 (ja)
ES (1)	ES2094974T3 (ja)
GR (1)	GR3021789T3 (ja)
ZA (1)	ZA937112B (ja)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1279386B1 (it) *	1994-11-07	1997-12-10	Sigma Tau Ind Farmaceuti	1,5 derivati di 7a-metilperidroinden-3a-oli, attivi sul sistema cardiovascolare, procedimenti per la loro preparazione e composizioni
US5847172A (en) *	1995-06-07	1998-12-08	Magainin Pharmaceuticals Inc.	Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5994334A (en) *	1997-02-05	1999-11-30	University Of Maryland	Androgen synthesis inhibitors
US5994335A (en)	1997-10-17	1999-11-30	The University Of Maryland, Baltimore	17-azolyl steroids useful as androgen synthesis inhibitors
US20100048913A1 (en)	2008-03-14	2010-02-25	Angela Brodie	Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2009137337A1 (en) *	2008-05-05	2009-11-12	The Scripps Research Institute	STEREOSELECTIVE SYNTHESIS OF 17-α -AND 17-β -ARYL STEROIDAL COMPOUNDS
CN102686600A (zh)	2009-02-05	2012-09-19	托凯药业股份有限公司	甾体cyp17抑制剂/抗雄激素物质的新型药物前体
EP2411015B1 (en)	2009-03-23	2015-12-23	SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.	5-beta, 14-beta-androstane derivatives useful for the treatment of proteinuria, glomerulosclerosis and renal failure
WO2011059969A2 (en) *	2009-11-13	2011-05-19	Tokai Pharmaceuticals, Inc.	Mammalian metabolites of steroids
EP3572417B1 (en)	2011-10-14	2025-12-17	Sage Therapeutics, LLC	3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
RU2015137617A (ru)	2013-03-14	2017-04-18	Юниверсити Оф Мэриленд, Балтимор Офис Оф Текнолоджи Трансфер	Агенты, подавляющие андрогенные рецепторы, и их применение
KR102396328B1 (ko)	2013-04-17	2022-05-10	세이지 테라퓨틱스, 인크.	19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
US20160068563A1 (en)	2013-04-17	2016-03-10	Boyd L. Harrison	19-nor neuroactive steroids and methods of use thereof
EP2986624B1 (en)	2013-04-17	2020-03-25	Sage Therapeutics, Inc.	19-nor neuroactive steroids for methods of treatment
US9725481B2 (en)	2013-04-17	2017-08-08	Sage Therapeutics, Inc.	19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
SI3021852T1 (sl)	2013-07-19	2021-07-30	Sage Therapeutics, Inc.	Nevroaktivni steroidi, sestavki in uporabe le-teh
CN105636594A (zh)	2013-08-12	2016-06-01	托凯药业股份有限公司	使用雄激素靶向疗法用于治疗肿瘤性疾病的生物标记物
AU2014308621C1 (en)	2013-08-23	2022-01-06	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
US10246482B2 (en)	2014-06-18	2019-04-02	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
ME03809B (me)	2014-10-16	2021-04-20	Sage Therapeutics Inc	KOMPOZICIJE I POSTUPCI ZA LEČENJE POREMEĆAJA CNS-a
CN117024501A (zh)	2014-10-16	2023-11-10	萨奇治疗股份有限公司	靶向cns障碍的组合物和方法
WO2016082789A1 (en)	2014-11-27	2016-06-02	Sage Therapeutics, Inc.	Compositions and methods for treating cns disorders
RS61530B1 (sr)	2015-01-26	2021-04-29	Sage Therapeutics Inc	Kompozicije i postupci za lečenje poremećaja cns
EP4155314A1 (en)	2015-02-20	2023-03-29	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
WO2018013615A1 (en)	2016-07-11	2018-01-18	Sage Therapeutics, Inc.	C7, c12, and c16 substituted neuroactive steroids and their methods of use
MA45599A (fr)	2016-07-11	2019-05-15	Sage Therapeutics Inc	Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
SG11202112391UA (en)	2019-05-31	2021-12-30	Sage Therapeutics Inc	Neuroactive steroids and compositions thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3405127A (en) *	1965-07-13	1968-10-08	Sterling Drug Inc	12, 17-dioxygenated steroids
DE1768800C3 (de) *	1968-07-02	1978-07-06	Hoechst Ag, 6000 Frankfurt	Verfahren zur Herstellung von 14 ß- Hydroxy-3oxo-5 a-card-20(22)- enoliden
DE2614046C2 (de) *	1976-04-01	1984-08-02	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue 17α-Hydroxy-Cardenolid-Glykoside, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3832303A1 (de) *	1988-09-20	1990-04-12	Schering Ag	11ss-phenyl-14ssh-steroide
IT1250410B (it) *	1991-02-14	1995-04-07	Simes	Composti steroidei attivi sul sistema cardiovascolare
DE4232638C2 (de) *	1992-09-29	1994-11-17	Sigma Tau Ind Farmaceuti	17-Phenyl-5beta-14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

1992
- 1992-09-29 DE DE4232681A patent/DE4232681C2/de not_active Expired - Fee Related
1993
- 1993-08-03 ES ES93112408T patent/ES2094974T3/es not_active Expired - Lifetime
- 1993-08-03 DE DE69306212T patent/DE69306212T2/de not_active Expired - Fee Related
- 1993-08-03 DK DK93112408.5T patent/DK0590271T3/da active
- 1993-08-03 EP EP93112408A patent/EP0590271B1/en not_active Expired - Lifetime
- 1993-08-03 AT AT93112408T patent/ATE145649T1/de not_active IP Right Cessation
- 1993-09-24 CA CA002106916A patent/CA2106916A1/en not_active Abandoned
- 1993-09-24 ZA ZA937112A patent/ZA937112B/xx unknown
- 1993-09-27 KR KR1019930019823A patent/KR940007054A/ko not_active Ceased
- 1993-09-29 JP JP5243361A patent/JPH06192287A/ja active Pending
- 1993-09-29 US US08/128,116 patent/US5556846A/en not_active Expired - Fee Related
1995
- 1995-11-03 US US08/552,796 patent/US5721227A/en not_active Expired - Fee Related
1996
- 1996-11-28 GR GR960402277T patent/GR3021789T3/el unknown

Also Published As

Publication number	Publication date
DE69306212T2 (de)	1997-04-24
EP0590271A2 (en)	1994-04-06
KR940007054A (ko)	1994-04-26
DE4232681A1 (de)	1994-03-31
US5556846A (en)	1996-09-17
HK1005880A1 (en)	1999-01-29
DK0590271T3 (da)	1996-12-16
EP0590271B1 (en)	1996-11-27
GR3021789T3 (en)	1997-02-28
CA2106916A1 (en)	1994-03-30
JPH06192287A (ja)	1994-07-12
US5721227A (en)	1998-02-24
ATE145649T1 (de)	1996-12-15
ES2094974T3 (es)	1997-02-01
DE4232681C2 (de)	1994-11-24
EP0590271A3 (en)	1994-07-06
DE69306212D1 (de)	1997-01-09

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