ZA947006B - Method of inhibiting binding of reticulocytes to endothelium by interfering with vla-4/vcam-1 interactions - Google Patents

Method of inhibiting binding of reticulocytes to endothelium by interfering with vla-4/vcam-1 interactions

Info

Publication number
ZA947006B
ZA947006B ZA947006A ZA947006A ZA947006B ZA 947006 B ZA947006 B ZA 947006B ZA 947006 A ZA947006 A ZA 947006A ZA 947006 A ZA947006 A ZA 947006A ZA 947006 B ZA947006 B ZA 947006B
Authority
ZA
South Africa
Prior art keywords
reticulocytes
vcam
vla
endothelium
interfering
Prior art date
Application number
ZA947006A
Other languages
English (en)
Inventor
Robert A Swerlick
James R Eckman
Timothy M Wick
Original Assignee
Univ Emory
Georgia Tech Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory, Georgia Tech Res Inst filed Critical Univ Emory
Publication of ZA947006B publication Critical patent/ZA947006B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70542—CD106
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ZA947006A 1993-09-15 1994-09-12 Method of inhibiting binding of reticulocytes to endothelium by interfering with vla-4/vcam-1 interactions ZA947006B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12222893A 1993-09-15 1993-09-15

Publications (1)

Publication Number Publication Date
ZA947006B true ZA947006B (en) 1995-05-02

Family

ID=22401460

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA947006A ZA947006B (en) 1993-09-15 1994-09-12 Method of inhibiting binding of reticulocytes to endothelium by interfering with vla-4/vcam-1 interactions

Country Status (5)

Country Link
EP (1) EP0720486A1 (fr)
AP (1) AP9400679A0 (fr)
AU (1) AU7835294A (fr)
WO (1) WO1995007717A1 (fr)
ZA (1) ZA947006B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11560433B2 (en) * 2016-05-27 2023-01-24 Albert Einstein College Of Medicine Methods of treatment by targeting VCAM1 and MAEA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL113261A (en) * 1989-09-01 1996-10-16 Hutchinson Fred Cancer Res Inhibition by peptides of lymphocyte adherence to vascular endothelium utilizing an extracellular matrix receptor-ligand interaction and pharmaceutical compositions containing said peptides
CA2127462C (fr) * 1992-01-13 1999-03-23 Roy R. Lobb Traitement de l'asthme
JPH07506566A (ja) * 1992-02-12 1995-07-20 バイオゲン　インコーポレイテッド 炎症性胃腸病の処置

Also Published As

Publication number Publication date
WO1995007717A1 (fr) 1995-03-23
EP0720486A1 (fr) 1996-07-10
AU7835294A (en) 1995-04-03
AP9400679A0 (en) 1996-03-13

Similar Documents

Publication Publication Date Title
IL107512A0 (en) Composition and method for enhanced fertilizer uptake by plants
ZA918478B (en) Agents and methods for binding to elam-1
DE69500773D1 (de) Verfahren zur Vorbehandlung von H2S-haltigem Erdgas
GB2179382B (en) Recovering oil by injecting ammoniated seawater
GB2009133B (en) Method and a composition for inhibiting corrosion
EP0503703A3 (en) Laser-welding of galvanized steel
IL111869A0 (en) Improvements to ordnance
HU9503369D0 (en) 4-amino-17beta(cyclopropyloxy)androst-4-en-3-one, 4-amino-17beta(cyclopropylamino)androst-4-en-3-one and related compounds as c17-20 lyase and 5alfa-reductase inhibitors
PL306543A1 (en) Method of protecting wood against being undesirably affected by micro-organisms
GB9016270D0 (en) Process for reducing the metal content of a hydrocarbon mixture
GB9315709D0 (en) Improvements relating to closure arrangements
GB9408449D0 (en) Improved method for detection of sulfides
HUT72180A (en) Method of cultivation of coal and lignite infields formed by uncovering
GB2279388B (en) Method for forming a cellular structure for containing loose material to stabilize and reinforce soils
DE3372788D1 (en) A method of zinc smelting by injection smelting
EP0160152A3 (en) A compound containing ferric ferrous salt and a producing method thereof
AU2804584A (en) Amine inhibitor to protect ferrous based cans
HU9301169D0 (en) Method for improving flame-proofness of plastics by means of addition of guanidine-barbiturates and/or guanidine-thiobarbiturates as burning inhibitors, flame-proof plastics containing said compounds as well as these compounds
GB9326109D0 (en) Improvements relating to finger rings
AP9400679A0 (en) Method of inhibiting binding of reticulocytes to endothelium by interfering with VLA-4/VCAM-1 interactions.
HU9203660D0 (en) New nitrogen containing compounds, preparatives containing them and method to produce said compounds
AU4175389A (en) Method of inhibiting sulfide attack
EP0728008A4 (fr) Oligo-elements pour animaux
GB2009134B (en) Method and a composition for inhibiting corrosion
AU4757085A (en) A compound containing ferric ferrous salt and a producing method thereof