ZA948060B - Galanthamide derivatives,a process for their preparation and their use as medicaments - Google Patents

Galanthamide derivatives,a process for their preparation and their use as medicaments

Info

Publication number: ZA948060B
Authority: ZA; South Africa
Prior art keywords: galanthamide; medicaments; derivatives; preparation; alkylaminocarbonyloxy
Prior art date: 1993-10-15

Application number

ZA948060A

Other languages

English (en)

Inventor

Raymond W Kosley Jr

Larry Davis

Veronica Taberna

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-15

Filing date

1994-10-14

Publication date

1995-06-09

1994-10-14 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1995-06-09 Publication of ZA948060B publication Critical patent/ZA948060B/xx

Links

239000003814 drug Substances 0.000 title 1
125000005195 alkyl amino carbonyloxy group Chemical group 0.000 abstract 3
125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA948060A 1993-10-15 1994-10-14 Galanthamide derivatives,a process for their preparation and their use as medicaments ZA948060B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/137,443 US6323196B1 (en)	1993-10-15	1993-10-15	Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (1)

Publication Number	Publication Date
ZA948060B true ZA948060B (en)	1995-06-09

Family

ID=22477457

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA948060A ZA948060B (en)	1993-10-15	1994-10-14	Galanthamide derivatives,a process for their preparation and their use as medicaments

Country Status (24)

Country	Link
US (1)	US6323196B1 (pt)
EP (2)	EP0648771B1 (pt)
JP (1)	JP2718637B2 (pt)
KR (1)	KR100189043B1 (pt)
CN (1)	CN1039011C (pt)
AT (1)	ATE201687T1 (pt)
AU (1)	AU679560B2 (pt)
CA (1)	CA2118171C (pt)
CZ (1)	CZ283561B6 (pt)
DE (1)	DE69427332T2 (pt)
DK (1)	DK0648771T3 (pt)
EG (1)	EG20747A (pt)
ES (1)	ES2158876T3 (pt)
FI (1)	FI108724B (pt)
GR (1)	GR3036068T3 (pt)
IL (1)	IL111273A (pt)
NO (1)	NO307463B1 (pt)
NZ (1)	NZ264681A (pt)
PL (1)	PL177754B1 (pt)
PT (1)	PT648771E (pt)
RO (1)	RO114132B1 (pt)
RU (1)	RU2113438C1 (pt)
TW (1)	TW375615B (pt)
ZA (1)	ZA948060B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT403803B (de)	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
AU1738800A (en) *	1998-11-23	2000-06-13	Bonnie Davis	Dosage formulations for acetylcholinesterase inhibitors
AU775914B2 (en)	1998-12-24	2004-08-19	Janssen Pharmaceutica N.V.	Controlled release galantamine composition
JP2003516947A (ja) *	1999-12-10	2003-05-20	デイビス、ボニー	ニコチン様物質受容体のモジュレーターとしてのガランタミンおよびリコラミンの類似物
NZ516302A (en)	2000-03-31	2004-02-27	Sanochemia Pharmazeutika Ag	Novel derivatives and analogues of galanthamin
US20030162770A1 (en) *	2002-02-22	2003-08-28	Davis Bonnie M.	Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
AU2003287433A1 (en) *	2002-11-01	2004-06-07	Oregon Health And Science University	Treatment of hyperkinetic movement disorder with donepezil
US20050048543A1 (en) *	2003-07-11	2005-03-03	Jeroen Aerssens	CHRNA2 genetic markers associated with galantamine response
WO2005042762A2 (en) *	2003-10-28	2005-05-12	Genaissance Pharmaceuticals, Inc.	Lrpap1 genetic markers associated with galantamine response
US20050143350A1 (en) *	2003-11-19	2005-06-30	Seed John C.	Combination drug therapy to treat obesity
US7250258B2 (en) *	2003-12-15	2007-07-31	Pgxhealth Llc	CDK5 genetic markers associated with galantamine response
US20050191349A1 (en) *	2003-12-31	2005-09-01	Garth Boehm	Galantamine formulations
US20050142193A1 (en) *	2003-12-31	2005-06-30	Lijuan Tang	Galantamine formulations
EP1779867A4 (en) *	2004-07-01	2009-12-02	Eisai R&D Man Co Ltd	MEANS FOR PROMOTING NERVE REVENERATION
ATE478659T1 (de) *	2005-05-13	2010-09-15	Alza Corp	Mehrlagiges arzneimittelausbringsystem mit sperre gegen reservoirmaterialfluss
US20080188510A1 (en) *	2005-05-23	2008-08-07	Eisai R & D Management Co., Ltd.	Novel methods using zonisamide
EP1777222A1 (en) *	2005-09-22	2007-04-25	Galantos Pharma GmbH	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
US20090253654A1 (en)	2005-09-22	2009-10-08	Galantos Pharma Gmbh	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
WO2007035941A2 (en) *	2005-09-23	2007-03-29	Alza Corporation	Transdermal galantamine delivery system
KR100786371B1 (ko) *	2006-12-07	2007-12-17	한국화학연구원	갈란타민의 제조방법
CA2721007C (en)	2008-04-14	2014-04-29	Galantos Pharma Gmbh	Derivatives of galantamine as pro-drugs for the treatment of human brain diseases
US20120184532A1 (en) *	2009-07-23	2012-07-19	Shire Llc	Galantamine amino acid and peptide prodrugs and uses thereof
US12551491B1 (en) *	2025-07-23	2026-02-17	Alpha Cognition Inc.	Dosage regimens for benzgalantamine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL122665B1 (en)	1978-11-21	1982-08-31	Edinen Zentar Chim	Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en)	1986-01-15	1987-05-05	Bonnie Davis	Method of treating Alzheimer's disease
EP0363415B1 (en) *	1987-05-04	2008-10-15	Davis, Bonnie	Compounds for the treatment of alzheimer's disease
US6150354A (en) *	1987-01-15	2000-11-21	Bonnie Davis	Compounds for the treatment of Alzheimer's disease
NL8800350A (nl)	1988-02-12	1989-09-01	Stichting Biomedical Research	Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
US5336675A (en) *	1991-05-14	1994-08-09	Ernir Snorrason	Method of treating mania in humans
WO1992020327A1 (en) *	1991-05-14	1992-11-26	Ernir Snorrason	Treatment of fatigue syndrome with cholinesterase inhibitors
US5153193A (en)	1991-10-01	1992-10-06	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5231093A (en) *	1991-10-01	1993-07-27	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

1993
- 1993-10-15 US US08/137,443 patent/US6323196B1/en not_active Expired - Lifetime
1994
- 1994-10-10 DK DK94115960T patent/DK0648771T3/da active
- 1994-10-10 AT AT94115960T patent/ATE201687T1/de active
- 1994-10-10 ES ES94115960T patent/ES2158876T3/es not_active Expired - Lifetime
- 1994-10-10 EP EP94115960A patent/EP0648771B1/en not_active Expired - Lifetime
- 1994-10-10 DE DE69427332T patent/DE69427332T2/de not_active Expired - Lifetime
- 1994-10-10 EP EP00107569A patent/EP1020469A3/en not_active Withdrawn
- 1994-10-10 PT PT94115960T patent/PT648771E/pt unknown
- 1994-10-12 EG EG63794A patent/EG20747A/xx active
- 1994-10-13 FI FI944822A patent/FI108724B/fi not_active IP Right Cessation
- 1994-10-13 IL IL111273A patent/IL111273A/en not_active IP Right Cessation
- 1994-10-13 RU RU94036761A patent/RU2113438C1/ru active
- 1994-10-13 NZ NZ264681A patent/NZ264681A/en not_active IP Right Cessation
- 1994-10-14 CA CA002118171A patent/CA2118171C/en not_active Expired - Lifetime
- 1994-10-14 ZA ZA948060A patent/ZA948060B/xx unknown
- 1994-10-14 NO NO943894A patent/NO307463B1/no not_active IP Right Cessation
- 1994-10-14 TW TW083109528A patent/TW375615B/zh not_active IP Right Cessation
- 1994-10-14 CZ CZ942547A patent/CZ283561B6/cs not_active IP Right Cessation
- 1994-10-14 AU AU75812/94A patent/AU679560B2/en not_active Expired
- 1994-10-14 RO RO94-01668A patent/RO114132B1/ro unknown
- 1994-10-14 CN CN94117061A patent/CN1039011C/zh not_active Expired - Lifetime
- 1994-10-14 KR KR1019940026304A patent/KR100189043B1/ko not_active Expired - Lifetime
- 1994-10-14 PL PL94305455A patent/PL177754B1/pl unknown
- 1994-10-17 JP JP6250776A patent/JP2718637B2/ja not_active Expired - Fee Related
2001
- 2001-06-19 GR GR20010400911T patent/GR3036068T3/el unknown

Also Published As

Publication number	Publication date
EP1020469A2 (en)	2000-07-19
RU2113438C1 (ru)	1998-06-20
GR3036068T3 (en)	2001-09-28
FI944822L (fi)	1995-04-16
AU7581294A (en)	1995-05-04
CZ283561B6 (cs)	1998-05-13
JP2718637B2 (ja)	1998-02-25
CZ254794A3 (en)	1995-05-17
NO307463B1 (no)	2000-04-10
NO943894D0 (no)	1994-10-14
EP0648771A1 (en)	1995-04-19
US6323196B1 (en)	2001-11-27
JPH07188238A (ja)	1995-07-25
CN1039011C (zh)	1998-07-08
KR950011444A (ko)	1995-05-15
CA2118171C (en)	1999-12-28
DE69427332D1 (de)	2001-07-05
NO943894L (no)	1995-04-18
RO114132B1 (ro)	1999-01-29
CA2118171A1 (en)	1995-04-16
AU679560B2 (en)	1997-07-03
RU94036761A (ru)	1996-09-10
ATE201687T1 (de)	2001-06-15
NZ264681A (en)	1997-12-19
DE69427332T2 (de)	2001-10-11
IL111273A (en)	1998-04-05
EP1020469A3 (en)	2000-07-26
FI944822A0 (fi)	1994-10-13
PT648771E (pt)	2001-09-28
FI108724B (fi)	2002-03-15
CN1108658A (zh)	1995-09-20
PL177754B1 (pl)	2000-01-31
EG20747A (en)	2000-01-31
KR100189043B1 (ko)	1999-06-01
TW375615B (en)	1999-12-01
EP0648771B1 (en)	2001-05-30
ES2158876T3 (es)	2001-09-16
PL305455A1 (en)	1995-04-18
IL111273A0 (en)	1994-12-29
DK0648771T3 (da)	2001-08-27

Publication	Publication Date	Title
ZA948060B (en)	1995-06-09	Galanthamide derivatives,a process for their preparation and their use as medicaments
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