ZA953673B - Stable crystalline (6S)- and (6R)- tetrahydrofolic acid - Google Patents

Stable crystalline (6S)- and (6R)- tetrahydrofolic acid

Info

Publication number: ZA953673B
Authority: ZA; South Africa
Prior art keywords: tetrahydrofolic acid; stable crystalline; crystalline; stable; tetrahydrofolic
Prior art date: 1994-05-09

Application number

ZA953673A

Other languages

English (en)

Inventor

Hans Rudolf Mueller

Martin Ulmann

Rudolf Moser

Thomas Ammann

Original Assignee

Eprova Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-09

Filing date

1995-05-08

Publication date

1996-01-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4210562&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA953673(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-05-08 Application filed by Eprova Ag filed Critical Eprova Ag

1996-01-12 Publication of ZA953673B publication Critical patent/ZA953673B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Hematology (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Obesity (AREA)
Toxicology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Nutrition Science (AREA)
Tropical Medicine & Parasitology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA953673A 1994-05-09 1995-05-08 Stable crystalline (6S)- and (6R)- tetrahydrofolic acid ZA953673B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH144294A CH686369A5 (de)	1994-05-09	1994-05-09	Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.

Publications (1)

Publication Number	Publication Date
ZA953673B true ZA953673B (en)	1996-01-12

Family

ID=4210562

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA953673A ZA953673B (en)	1994-05-09	1995-05-08	Stable crystalline (6S)- and (6R)- tetrahydrofolic acid

Country Status (19)

Country	Link
US (2)	US6271374B1 (fr)
EP (1)	EP0682026B2 (fr)
JP (2)	JP3419585B2 (fr)
KR (1)	KR950032192A (fr)
CN (1)	CN1063444C (fr)
AT (1)	ATE188699T1 (fr)
AU (1)	AU704363B2 (fr)
CA (1)	CA2148671C (fr)
CH (1)	CH686369A5 (fr)
DE (1)	DE59507591D1 (fr)
DK (1)	DK0682026T4 (fr)
ES (1)	ES2144066T5 (fr)
FI (1)	FI120585B (fr)
GR (1)	GR3032984T3 (fr)
HU (1)	HUT71612A (fr)
NO (1)	NO313673B1 (fr)
PT (1)	PT682026E (fr)
RU (1)	RU2165422C2 (fr)
ZA (1)	ZA953673B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH689831A5 (de) *	1995-11-07	1999-12-15	Eprova Ag	Stabile kristalline Tetrahydrofolsaeure-Salze.
CH693905A5 (de)	1999-04-15	2004-04-15	Eprova Ag	Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH695217A5 (de) *	1999-07-14	2006-01-31	Merck Eprova Ag	Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure.
CH694251A5 (de)	1999-07-14	2004-10-15	Eprova Ag	Herstellung von Tetrahydropterin und Derivaten.
ITMI20020132A1 (it)	2002-01-25	2003-07-25	Gmt Fine Chemicals Sa	Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico
KR20070005550A (ko)	2003-11-17	2007-01-10	바이오마린 파머수티컬 인크.	대사 장애 치료를 위한 조성물 및 방법
KR20060051135A (ko) *	2004-09-15	2006-05-19	니프로 가부시키가이샤	안정화된 주사용 수용액 제재
CA2588994A1 (fr) *	2004-12-08	2006-06-15	Biomarin Pharmaceutical Inc.	Methodes et compositions de traitement de l'hypertension pulmonaire du nouveau-ne
BR112012000614B1 (pt)	2009-07-10	2022-05-24	Linzy O. Scott Iii	Usos de folato no tratamento de hipotireoidismo e composições farmacêuticas compreendendo folato
US8372451B2 (en) *	2010-02-12	2013-02-12	Alexander Vuckovic, M.D., Llc	Compositions and methods for treating depression
JP5925381B2 (ja) *	2012-04-13	2016-05-25	▲連雲▼港金康和信▲薬業▼有限公司ＬｉａｎｙｕｎｇａｎｇＪｉｎｋａｎｇＨｅｘｉｎＰｈａｒｍａｃｅｕｔｉｃａｌＣｏ．，Ｌｔｄ．	化合物［４−（２−アミノ−１０−メチル−４−オキソ−６，７，８，９−テトラヒドロ−４ａ，７−エピミノピリミド［４，５−ｂ］［１，４］ジアゼピン−５（４Ｈ）−イル）ベンゾイル］−グルタメート及びその製造
US9629846B1 (en)	2013-11-14	2017-04-25	Argent Development Group, Llc	Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women
US9492421B1 (en)	2013-11-14	2016-11-15	Argent Development Group, Llc	Nutritional supplements for treatment of iron deficiency anemia
WO2016185413A1 (fr)	2015-05-20	2016-11-24	Nestec S.A.	Formulations à libération modifiée
US10059710B2 (en)	2016-02-17	2018-08-28	Merck & Cie	Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
AU2017397463B2 (en)	2016-11-03	2022-01-06	HedoniaUSA, Inc.	Compositions and methods for treating depression
US11185545B2 (en)	2017-03-31	2021-11-30	Merck Patent Gmbh	Crystalline monosodium salt of 5-methyl-(6S)-tetrahydrofolic acid
RU2019134064A (ru)	2017-03-31	2021-04-30	Мерк Патент Гмбх	Кристаллическая натриевая соль 5-метил-(6s)-тетрагидрофолиевой кислоты
EP4501315A1 (fr)	2023-08-04	2025-02-05	Lesaffre et Compagnie	Formulations liquides de folates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS497416A (fr) *	1972-05-12	1974-01-23
US4665176A (en) *	1984-10-23	1987-05-12	Mitsui Toatsu Chemicals, Incorporated	Process for the preparation of 5,6,7,8-tetrahydrofolic acid
GB8621268D0 (en) *	1986-09-03	1986-10-08	Univ Strathclyde	Separation of substances
CH673459A5 (fr) *	1987-05-15	1990-03-15	Eprova Ag
DE3821875C1 (fr) *	1988-06-29	1990-02-15	Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
DK0432441T3 (da) *	1989-12-11	1996-07-29	American Cyanamid Co	Fremgangsmåde til fremstilling af optisk rene diastereoisomere af tetrahydrofolatforbindelser
CH680731A5 (fr) *	1990-04-12	1992-10-30	Sapec Fine Chemicals
CH681303A5 (fr) *	1991-01-16	1993-02-26	Eprova Ag
CH683261A5 (it) *	1991-10-10	1994-02-15	Applied Pharma Res	Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
US5198547A (en) *	1992-03-16	1993-03-30	South Alabama Medical Science Foundation, Usa	Process for N5-formylating tetrahydropteridines
US5698693A (en) *	1992-11-16	1997-12-16	The United States Of America As Represented By The Department Of Health And Human Services	Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
CH686672A5 (de) *	1992-12-01	1996-05-31	Cerbios Pharma Sa	Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
AU2001268035A1 (en)	2000-03-21	2001-10-03	Bbj Environmental Solutions Inc.	Aqueous cleaning composition with controlled ph

1994
- 1994-05-09 CH CH144294A patent/CH686369A5/de not_active IP Right Cessation
1995
- 1995-04-27 DK DK95106285T patent/DK0682026T4/da active
- 1995-04-27 EP EP95106285A patent/EP0682026B2/fr not_active Expired - Lifetime
- 1995-04-27 DE DE59507591T patent/DE59507591D1/de not_active Expired - Lifetime
- 1995-04-27 ES ES95106285T patent/ES2144066T5/es not_active Expired - Lifetime
- 1995-04-27 PT PT95106285T patent/PT682026E/pt unknown
- 1995-04-27 AT AT95106285T patent/ATE188699T1/de active
- 1995-05-02 JP JP10888195A patent/JP3419585B2/ja not_active Expired - Fee Related
- 1995-05-04 CA CA002148671A patent/CA2148671C/fr not_active Expired - Lifetime
- 1995-05-05 RU RU95107144/04A patent/RU2165422C2/ru active
- 1995-05-08 CN CN95106005A patent/CN1063444C/zh not_active Expired - Lifetime
- 1995-05-08 HU HU9501348A patent/HUT71612A/hu unknown
- 1995-05-08 NO NO19951796A patent/NO313673B1/no not_active IP Right Cessation
- 1995-05-08 FI FI952198A patent/FI120585B/fi not_active IP Right Cessation
- 1995-05-08 ZA ZA953673A patent/ZA953673B/xx unknown
- 1995-05-08 AU AU17931/95A patent/AU704363B2/en not_active Ceased
- 1995-05-09 KR KR1019950011214A patent/KR950032192A/ko not_active Ceased
1998
- 1998-01-26 US US09/013,266 patent/US6271374B1/en not_active Expired - Lifetime
2000
- 2000-03-16 GR GR20000400684T patent/GR3032984T3/el not_active IP Right Cessation
2001
- 2001-01-08 US US09/755,072 patent/US6596721B2/en not_active Expired - Fee Related
2003
- 2003-01-28 JP JP2003019261A patent/JP4898081B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR950032192A (ko)	1995-12-20
EP0682026B1 (fr)	2000-01-12
FI120585B (fi)	2009-12-15
CA2148671C (fr)	2000-08-15
JP3419585B2 (ja)	2003-06-23
ES2144066T3 (es)	2000-06-01
JP2003201291A (ja)	2003-07-18
JPH0841062A (ja)	1996-02-13
CH686369A5 (de)	1996-03-15
NO951796L (no)	1995-11-10
NO951796D0 (no)	1995-05-08
JP4898081B2 (ja)	2012-03-14
HUT71612A (en)	1996-01-29
DK0682026T3 (da)	2000-04-17
ATE188699T1 (de)	2000-01-15
CN1122337A (zh)	1996-05-15
ES2144066T5 (es)	2003-11-01
DK0682026T4 (da)	2003-02-24
CN1063444C (zh)	2001-03-21
EP0682026A1 (fr)	1995-11-15
FI952198L (fi)	1995-11-10
NO313673B1 (no)	2002-11-11
DE59507591D1 (de)	2000-02-17
US20010002398A1 (en)	2001-05-31
GR3032984T3 (en)	2000-07-31
AU704363B2 (en)	1999-04-22
CA2148671A1 (fr)	1995-11-10
RU95107144A (ru)	1997-03-20
US6596721B2 (en)	2003-07-22
AU1793195A (en)	1995-11-16
PT682026E (pt)	2000-05-31
FI952198A0 (fi)	1995-05-08
US6271374B1 (en)	2001-08-07
RU2165422C2 (ru)	2001-04-20
EP0682026B2 (fr)	2003-02-05

Publication	Publication Date	Title
ZA953673B (en)	1996-01-12	Stable crystalline (6S)- and (6R)- tetrahydrofolic acid
AU1803092A (en)	1993-01-07	7-azaisoindolinyl-quinolone- and-naphthyridonecarboxylic acid derivatives
AU591745B2 (en)	1989-12-14	2-cyanoacrylate composition
AU1071288A (en)	1988-07-28	Polyolefin stabilising composition
AU1739192A (en)	1992-12-24	7-isoindolinyl-quinolone- and -naphthyridonecarboxylic acid derivatives
FI920180L (fi)	1992-07-17	Foerfarande foer framstaellning av (6s) - och (6r)-tetrahydrofolsyra.
AU5184193A (en)	1994-06-09	Diaminobenzoic acid derivatives
AU2156088A (en)	1989-03-02	Arylenediamino substituted triazine
AU2052188A (en)	1989-02-16	Toothbrush for controlling brushing-stroke
AU2030988A (en)	1989-02-23	Pyrimidine derivatives
AU646762B2 (en)	1994-03-03	Cyclic-substituted imidazolyl-propenoic acid derivatives
AU646977B2 (en)	1994-03-10	Imidazolyl-propenoic acid derivatives
AU4791993A (en)	1994-03-03	Diamino acid derivatives as antihypertensives
AU7273187A (en)	1987-12-10	Diastereoisomeric tetrahydropyrido (2,3-d) pyrimidine derivatives
AU3057192A (en)	1993-06-07	Method for extending produce shelf life
AU2979892A (en)	1993-06-10	Thiazolyl-substituted quinolylmethoxphenylacetic acid derivatives
AU2065688A (en)	1989-02-16	Rifamycin derivatives
AU2294088A (en)	1989-04-06	Can carrier composition
AU580186B2 (en)	1989-01-05	Rubber-modified nylon composition
AU1116692A (en)	1992-08-27	Lampholder
AU1980888A (en)	1989-02-13	Toothbrush
GB8811237D0 (en)	1988-06-15	3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives
AU2700988A (en)	1989-06-22	N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
EP0548895A3 (en)	1993-08-11	Process for the preparation of pure diasteroisomers of tetrahydrofolates
AU638486B2 (en)	1993-07-01	Opposed spindles lathe