ZA96100B - Substituted oxazolidine calpain and/or cathepsin b inhibitors - Google Patents

Substituted oxazolidine calpain and/or cathepsin b inhibitors

Info

Publication number
ZA96100B
ZA96100B ZA96100A ZA96100A ZA96100B ZA 96100 B ZA96100 B ZA 96100B ZA 96100 A ZA96100 A ZA 96100A ZA 96100 A ZA96100 A ZA 96100A ZA 96100 B ZA96100 B ZA 96100B
Authority
ZA
South Africa
Prior art keywords
calpain
cathepsin
inhibitors
substituted oxazolidine
oxazolidine
Prior art date
Application number
ZA96100A
Other languages
English (en)
Inventor
Norton Paul Peet
Shujaath Mehdi
Matthew David Linnik
Michael Richard Angelastro
Hwa-Ok Kim
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of ZA96100B publication Critical patent/ZA96100B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA96100A 1995-01-11 1996-01-08 Substituted oxazolidine calpain and/or cathepsin b inhibitors ZA96100B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37119295A 1995-01-11 1995-01-11

Publications (1)

Publication Number Publication Date
ZA96100B true ZA96100B (en) 1996-07-24

Family

ID=23462894

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA96100A ZA96100B (en) 1995-01-11 1996-01-08 Substituted oxazolidine calpain and/or cathepsin b inhibitors

Country Status (23)

Country Link
US (1) US5691368A (es)
EP (1) EP0802909B1 (es)
JP (1) JP4157601B2 (es)
KR (1) KR100393701B1 (es)
CN (1) CN1088456C (es)
AR (1) AR001787A1 (es)
AT (1) ATE206413T1 (es)
AU (1) AU692044B2 (es)
CA (1) CA2210258C (es)
DE (1) DE69523072T2 (es)
DK (1) DK0802909T3 (es)
ES (1) ES2165441T3 (es)
FI (1) FI972935A0 (es)
HU (1) HUT77649A (es)
IL (1) IL116724A (es)
MX (1) MX9705235A (es)
NO (1) NO309267B1 (es)
NZ (1) NZ298999A (es)
PT (1) PT802909E (es)
SI (1) SI0802909T1 (es)
TW (1) TW454001B (es)
WO (1) WO1996021655A2 (es)
ZA (1) ZA96100B (es)

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WO2000021550A2 (en) * 1998-10-13 2000-04-20 President And Fellows Of Harvard College Methods and compositions for treating neurodegenerative diseases
WO2000027418A2 (en) * 1998-11-12 2000-05-18 Research Corporation Technologies, Inc. A method for treating tissue damaged from ischemia
EP1159273A1 (en) * 1999-03-02 2001-12-05 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cathepsin s
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TW200404789A (en) * 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
HK1039110A1 (zh) 1999-03-15 2002-04-12 Axys Pharmaceuticals, Inc. 以新颖的合成物及组分作为蛋白酶抑制剂
US6420364B1 (en) * 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
FR2800737B1 (fr) * 1999-11-05 2006-06-30 Sod Conseils Rech Applic Nouveaux composes heterocycliques et leur application a titre de medicaments
BR0015315A (pt) * 1999-11-05 2002-06-25 Sod Conseils Rech Applic Compostos, medicamentos, composições farmacêuticas, utilização de compostos e produtos industriais
WO2002010768A2 (en) * 2000-07-31 2002-02-07 The Regents Of The University Of California Model for alzheimer's disease and other neurodegenerative diseases
MXPA03005601A (es) 2000-12-22 2004-12-02 Axys Pharm Inc Nuevos compuestos y composiciones como inhibidores de catepsina.
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
JP2005504078A (ja) 2001-09-14 2005-02-10 アベンティス・ファーマスーティカルズ・インコーポレイテツド カテプシン阻害剤としての新規化合物および組成物
MXPA04004450A (es) 2001-11-14 2004-08-11 Aventis Pharma Inc Nuevos compuestos y composiciones como inhibidores de catepsina s.
WO2004084830A2 (en) * 2003-03-21 2004-10-07 Buck Institute Method for treating alzheimer’s dementia
US7384970B2 (en) * 2003-03-24 2008-06-10 Irm Llc Inhibitors of cathepsin S
US7109243B2 (en) * 2003-03-24 2006-09-19 Irm Llc Inhibitors of cathepsin S
WO2004089395A2 (en) * 2003-04-01 2004-10-21 Aventis Pharmaceuticals Inc. Use of an inhibitor of cathepsin-s or -b to treat or prevent chronic obstructive pulmonary disease
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US7173051B2 (en) * 2003-06-13 2007-02-06 Irm, Llc Inhibitors of cathepsin S
US7256207B2 (en) * 2003-08-20 2007-08-14 Irm Llc Inhibitors of cathepsin S
FR2863268B1 (fr) * 2003-12-09 2006-02-24 Sod Conseils Rech Applic Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
WO2010003092A1 (en) * 2008-07-03 2010-01-07 University Of Massachusetts Methods and compositions for reducing inflammation and treating inflammatory disorders
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
NZ602312A (en) 2010-03-10 2014-02-28 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
WO2024018245A1 (en) 2022-07-22 2024-01-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of calpain inhibitors for the treatment of the diabetic kidney disease
WO2024153744A1 (en) 2023-01-20 2024-07-25 Institut National de la Santé et de la Recherche Médicale Autophagy activators for the treatment of rhabdomyolysis
WO2025153685A1 (en) * 2024-01-18 2025-07-24 Firmenich Sa 3-acyl-oxazolidin-5-one properfumes

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Also Published As

Publication number Publication date
JPH10512257A (ja) 1998-11-24
FI972935L (fi) 1997-07-10
ES2165441T3 (es) 2002-03-16
IL116724A (en) 2000-08-31
WO1996021655A3 (en) 1996-09-06
MX9705235A (es) 1997-10-31
IL116724A0 (en) 1996-05-14
PT802909E (pt) 2002-03-28
SI0802909T1 (en) 2002-02-28
TW454001B (en) 2001-09-11
HUT77649A (hu) 1998-07-28
US5691368A (en) 1997-11-25
NO973216L (no) 1997-09-09
NO309267B1 (no) 2001-01-08
FI972935A7 (fi) 1997-07-10
AR001787A1 (es) 1997-12-10
WO1996021655A2 (en) 1996-07-18
AU4473196A (en) 1996-07-31
DK0802909T3 (da) 2002-01-28
ATE206413T1 (de) 2001-10-15
DE69523072D1 (en) 2001-11-08
FI972935A0 (fi) 1997-07-10
EP0802909B1 (en) 2001-10-04
CN1173174A (zh) 1998-02-11
EP0802909A2 (en) 1997-10-29
KR100393701B1 (ko) 2003-11-28
CA2210258C (en) 2002-10-01
NZ298999A (en) 1999-01-28
NO973216D0 (no) 1997-07-10
AU692044B2 (en) 1998-05-28
DE69523072T2 (de) 2002-06-20
JP4157601B2 (ja) 2008-10-01
CA2210258A1 (en) 1996-07-18
CN1088456C (zh) 2002-07-31

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