ZA961450B - A process for the preparation of factor ix from biological sources - Google Patents

A process for the preparation of factor ix from biological sources

Info

Publication number
ZA961450B
ZA961450B ZA961450A ZA961450A ZA961450B ZA 961450 B ZA961450 B ZA 961450B ZA 961450 A ZA961450 A ZA 961450A ZA 961450 A ZA961450 A ZA 961450A ZA 961450 B ZA961450 B ZA 961450B
Authority
ZA
South Africa
Prior art keywords
pct
factor
preparation
biological sources
sec
Prior art date
Application number
ZA961450A
Other languages
English (en)
Inventor
Djuro Josic
Lutz Hoffer
Frank Morfeld
Original Assignee
Octapharma A G
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Octapharma A G filed Critical Octapharma A G
Publication of ZA961450B publication Critical patent/ZA961450B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Enzymes And Modification Thereof (AREA)
ZA961450A 1995-02-25 1996-02-23 A process for the preparation of factor ix from biological sources ZA961450B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19506633A DE19506633A1 (de) 1995-02-25 1995-02-25 Verfahren zur Herstellung von Faktor IX aus biologischen Quellen

Publications (1)

Publication Number Publication Date
ZA961450B true ZA961450B (en) 1996-08-27

Family

ID=7755037

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA961450A ZA961450B (en) 1995-02-25 1996-02-23 A process for the preparation of factor ix from biological sources

Country Status (20)

Country Link
US (1) US5919909A (de)
EP (1) EP0811058B1 (de)
JP (1) JPH11500910A (de)
KR (1) KR100436857B1 (de)
CN (1) CN1105779C (de)
AT (1) ATE194167T1 (de)
AU (1) AU697217B2 (de)
CA (1) CA2213577C (de)
DE (2) DE19506633A1 (de)
DK (1) DK0811058T3 (de)
EA (1) EA000222B1 (de)
ES (1) ES2147365T3 (de)
FI (1) FI119377B (de)
GR (1) GR3034035T3 (de)
IL (1) IL117157A (de)
MY (1) MY119366A (de)
PT (1) PT811058E (de)
UA (1) UA46005C2 (de)
WO (1) WO1996027003A1 (de)
ZA (1) ZA961450B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19506633A1 (de) * 1995-02-25 1996-08-29 Octapharma Ag Verfahren zur Herstellung von Faktor IX aus biologischen Quellen
AT405608B (de) * 1997-04-08 1999-10-25 Immuno Ag Verfahren zur inaktivierung von pathogenen, insbesondere von viren, in einem biologischen material
JP4855074B2 (ja) * 2003-09-30 2012-01-18 一般財団法人化学及血清療法研究所 高純度血液凝固ｉｘ因子調製物およびその精製方法
KR100567448B1 (ko) * 2003-11-05 2006-04-04 주식회사 인투젠 형질전환 동물의 유즙 전처리방법 및 이를 통한 인체단백질의 정제방법
US7425539B2 (en) 2004-03-19 2008-09-16 Baxter International Inc. Factor IXa for the treatment of bleeding disorders
US10928366B2 (en) * 2007-01-26 2021-02-23 Sigma-Aldrich Co. Llc Compositions and methods for combining protein precipitation and solid phase extraction
US10434492B2 (en) * 2007-01-26 2019-10-08 Sigma-Aldrich Co. Llc Compositions and methods for solid phase extraction of lipids
AU2011234521B2 (en) * 2010-03-30 2015-04-23 Octapharma Ag A process for purifying Vitamin K dependent proteins such as coagulation factor IX
CN104560925B (zh) * 2014-12-30 2017-11-03 山东泰邦生物制品有限公司 一种从人凝血因子ⅸ层析废液中激活制备人凝血酶的方法
CN107540743A (zh) * 2017-10-11 2018-01-05 南岳生物制药有限公司 一种双层析法制备人纤维蛋白原的方法
CN111378029B (zh) * 2018-12-29 2023-05-05 四川远大蜀阳药业有限责任公司 一种人凝血因子ix的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3473407D1 (en) * 1983-05-02 1988-09-22 Immuno Ag Method of inactivating pathogens
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
EP0317376B2 (de) * 1987-10-23 1996-04-03 Centre Regional De Transfusion Sanguine De Lille Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat
AT402261B (de) * 1991-01-25 1997-03-25 Immuno Ag Komplex enthaltend den gerinnungsfaktor ix
CA2105282C (en) * 1991-03-01 2002-09-24 Centeon L.L.C. Preparation of factor ix
CN1064552C (zh) 1993-02-09 2001-04-18 奥克塔法马有限公司 失活无脂质被膜病毒的方法
DE19506633A1 (de) * 1995-02-25 1996-08-29 Octapharma Ag Verfahren zur Herstellung von Faktor IX aus biologischen Quellen

Also Published As

Publication number Publication date
ATE194167T1 (de) 2000-07-15
EA000222B1 (ru) 1998-12-24
CA2213577C (en) 2005-01-04
KR100436857B1 (ko) 2004-09-21
FI119377B (fi) 2008-10-31
WO1996027003A1 (en) 1996-09-06
JPH11500910A (ja) 1999-01-26
EP0811058A1 (de) 1997-12-10
UA46005C2 (uk) 2002-05-15
ES2147365T3 (es) 2000-09-01
IL117157A0 (en) 1996-06-18
CA2213577A1 (en) 1996-09-06
AU697217B2 (en) 1998-10-01
GR3034035T3 (en) 2000-11-30
EA199700196A1 (ru) 1998-02-26
EP0811058B1 (de) 2000-06-28
FI973469A0 (fi) 1997-08-22
AU4876196A (en) 1996-09-18
DE69609054D1 (de) 2000-08-03
CN1181782A (zh) 1998-05-13
DE19506633A1 (de) 1996-08-29
US5919909A (en) 1999-07-06
FI973469L (fi) 1997-08-22
CN1105779C (zh) 2003-04-16
PT811058E (pt) 2000-10-31
DE69609054T2 (de) 2001-03-08
IL117157A (en) 1999-12-22
MY119366A (en) 2005-05-31
DK0811058T3 (da) 2000-10-16
KR19980702453A (ko) 1998-07-15

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