DK0811058T3 - Fremgangsmåde til fremstilling af faktor IX ud fra biologiske kilder - Google Patents

Fremgangsmåde til fremstilling af faktor IX ud fra biologiske kilder

Info

Publication number
DK0811058T3
DK0811058T3 DK96904778T DK96904778T DK0811058T3 DK 0811058 T3 DK0811058 T3 DK 0811058T3 DK 96904778 T DK96904778 T DK 96904778T DK 96904778 T DK96904778 T DK 96904778T DK 0811058 T3 DK0811058 T3 DK 0811058T3
Authority
DK
Denmark
Prior art keywords
pct
biological sources
factor
sec
preparing factor
Prior art date
Application number
DK96904778T
Other languages
English (en)
Inventor
Djuro Josic
Lutz Hoffer
Frank Morfeld
Original Assignee
Octapharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Octapharma Ag filed Critical Octapharma Ag
Application granted granted Critical
Publication of DK0811058T3 publication Critical patent/DK0811058T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Enzymes And Modification Thereof (AREA)
DK96904778T 1995-02-25 1996-02-14 Fremgangsmåde til fremstilling af faktor IX ud fra biologiske kilder DK0811058T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19506633A DE19506633A1 (de) 1995-02-25 1995-02-25 Verfahren zur Herstellung von Faktor IX aus biologischen Quellen
PCT/EP1996/000636 WO1996027003A1 (en) 1995-02-25 1996-02-14 A process for the preparation of factor ix from biological sources

Publications (1)

Publication Number Publication Date
DK0811058T3 true DK0811058T3 (da) 2000-10-16

Family

ID=7755037

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96904778T DK0811058T3 (da) 1995-02-25 1996-02-14 Fremgangsmåde til fremstilling af faktor IX ud fra biologiske kilder

Country Status (20)

Country Link
US (1) US5919909A (da)
EP (1) EP0811058B1 (da)
JP (1) JPH11500910A (da)
KR (1) KR100436857B1 (da)
CN (1) CN1105779C (da)
AT (1) ATE194167T1 (da)
AU (1) AU697217B2 (da)
CA (1) CA2213577C (da)
DE (2) DE19506633A1 (da)
DK (1) DK0811058T3 (da)
EA (1) EA000222B1 (da)
ES (1) ES2147365T3 (da)
FI (1) FI119377B (da)
GR (1) GR3034035T3 (da)
IL (1) IL117157A (da)
MY (1) MY119366A (da)
PT (1) PT811058E (da)
UA (1) UA46005C2 (da)
WO (1) WO1996027003A1 (da)
ZA (1) ZA961450B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19506633A1 (de) * 1995-02-25 1996-08-29 Octapharma Ag Verfahren zur Herstellung von Faktor IX aus biologischen Quellen
AT405608B (de) * 1997-04-08 1999-10-25 Immuno Ag Verfahren zur inaktivierung von pathogenen, insbesondere von viren, in einem biologischen material
JP4855074B2 (ja) * 2003-09-30 2012-01-18 一般財団法人化学及血清療法研究所 高純度血液凝固ｉｘ因子調製物およびその精製方法
KR100567448B1 (ko) * 2003-11-05 2006-04-04 주식회사 인투젠 형질전환 동물의 유즙 전처리방법 및 이를 통한 인체단백질의 정제방법
WO2005094873A1 (en) * 2004-03-19 2005-10-13 Baxter International Inc. Factor ixa for the treatment of bleeding disorders
US10434492B2 (en) * 2007-01-26 2019-10-08 Sigma-Aldrich Co. Llc Compositions and methods for solid phase extraction of lipids
US10928366B2 (en) * 2007-01-26 2021-02-23 Sigma-Aldrich Co. Llc Compositions and methods for combining protein precipitation and solid phase extraction
CN102858971B (zh) * 2010-03-30 2016-06-01 奥克塔法马股份有限公司 纯化维生素k依赖性蛋白如凝血因子ix的方法
CN104560925B (zh) * 2014-12-30 2017-11-03 山东泰邦生物制品有限公司 一种从人凝血因子ⅸ层析废液中激活制备人凝血酶的方法
CN107540743A (zh) * 2017-10-11 2018-01-05 南岳生物制药有限公司 一种双层析法制备人纤维蛋白原的方法
CN111378029B (zh) * 2018-12-29 2023-05-05 四川远大蜀阳药业有限责任公司 一种人凝血因子ix的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE36457T1 (de) * 1983-05-02 1988-09-15 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen krankheitserregern.
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
ES2045167T5 (es) * 1987-10-23 1996-07-01 Centre Regional De Transfusion Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas.
AT402261B (de) * 1991-01-25 1997-03-25 Immuno Ag Komplex enthaltend den gerinnungsfaktor ix
JP3418621B2 (ja) * 1991-03-01 2003-06-23 アヴェンティス ベーリング エルエルシー Ｉｘ因子の調製
ES2118386T3 (es) 1993-02-09 1998-09-16 Octapharma Ag Procedimiento para la inactivacion de virus que no estan provistos de envolventes lipidicas.
DE19506633A1 (de) * 1995-02-25 1996-08-29 Octapharma Ag Verfahren zur Herstellung von Faktor IX aus biologischen Quellen

Also Published As

Publication number Publication date
MY119366A (en) 2005-05-31
EA199700196A1 (ru) 1998-02-26
ES2147365T3 (es) 2000-09-01
CA2213577C (en) 2005-01-04
CN1181782A (zh) 1998-05-13
FI973469L (fi) 1997-08-22
EP0811058A1 (en) 1997-12-10
PT811058E (pt) 2000-10-31
IL117157A0 (en) 1996-06-18
DE69609054D1 (de) 2000-08-03
WO1996027003A1 (en) 1996-09-06
CN1105779C (zh) 2003-04-16
UA46005C2 (uk) 2002-05-15
AU4876196A (en) 1996-09-18
EA000222B1 (ru) 1998-12-24
DE19506633A1 (de) 1996-08-29
JPH11500910A (ja) 1999-01-26
AU697217B2 (en) 1998-10-01
FI119377B (fi) 2008-10-31
EP0811058B1 (en) 2000-06-28
ATE194167T1 (de) 2000-07-15
IL117157A (en) 1999-12-22
DE69609054T2 (de) 2001-03-08
KR19980702453A (ko) 1998-07-15
CA2213577A1 (en) 1996-09-06
FI973469A0 (fi) 1997-08-22
ZA961450B (en) 1996-08-27
US5919909A (en) 1999-07-06
GR3034035T3 (en) 2000-11-30
KR100436857B1 (ko) 2004-09-21

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