ZA962891B - Oxgenated-heterocycle containing sulfonamide inhibitors of aspartyl protease - Google Patents

Oxgenated-heterocycle containing sulfonamide inhibitors of aspartyl protease

Info

Publication number: ZA962891B
Authority: ZA; South Africa
Prior art keywords: oxgenated; heterocycle containing; aspartyl protease; containing sulfonamide; sulfonamide inhibitors
Prior art date: 1995-04-19

Application number

ZA962891A

Other languages

English (en)

Inventor

Roger D Tung

Govinda Rao Bhisetti

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-19

Filing date

1996-04-11

Publication date

1996-10-15

1996-04-11 Application filed by Vertex Pharma filed Critical Vertex Pharma

1996-10-15 Publication of ZA962891B publication Critical patent/ZA962891B/xx

Links

102000004580 Aspartic Acid Proteases Human genes 0.000 title 1
108010017640 Aspartic Acid Proteases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
150000003456 sulfonamides Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Furan Compounds (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)

ZA962891A 1995-04-19 1996-04-11 Oxgenated-heterocycle containing sulfonamide inhibitors of aspartyl protease ZA962891B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/424,810 US5691372A (en)	1995-04-19	1995-04-19	Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease

Publications (1)

Publication Number	Publication Date
ZA962891B true ZA962891B (en)	1996-10-15

Family

ID=23683966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA962891A ZA962891B (en)	1995-04-19	1996-04-11	Oxgenated-heterocycle containing sulfonamide inhibitors of aspartyl protease

Country Status (34)

Country	Link
US (2)	US5691372A (de)
EP (3)	EP1136479B1 (de)
JP (1)	JP4240532B2 (de)
KR (1)	KR100485237B1 (de)
CN (1)	CN1110491C (de)
AP (2)	AP9600827A0 (de)
AR (1)	AR004663A1 (de)
AT (3)	ATE212344T1 (de)
AU (1)	AU712913B2 (de)
BG (1)	BG102041A (de)
BR (1)	BR9608033A (de)
CA (1)	CA2217745C (de)
CO (1)	CO4700433A1 (de)
CZ (1)	CZ329497A3 (de)
DE (3)	DE69638252D1 (de)
DK (1)	DK0833826T3 (de)
EA (1)	EA000906B1 (de)
EE (1)	EE9700254A (de)
ES (3)	ES2351970T3 (de)
GE (1)	GEP20001915B (de)
HU (1)	HUP9801948A3 (de)
IL (1)	IL117962A0 (de)
IS (1)	IS4575A (de)
MY (1)	MY115797A (de)
NO (1)	NO974744L (de)
NZ (1)	NZ307342A (de)
PE (1)	PE43697A1 (de)
PL (1)	PL322904A1 (de)
PT (1)	PT833826E (de)
SK (1)	SK143097A3 (de)
TR (1)	TR199701194T1 (de)
TW (1)	TW404945B (de)
WO (1)	WO1996033187A1 (de)
ZA (1)	ZA962891B (de)

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US7141609B2 (en)	1992-08-25	2006-11-28	G.D. Searle & Co.	α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
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US5945441A (en)	1997-06-04	1999-08-31	Gpi Nil Holdings, Inc.	Pyrrolidine carboxylate hair revitalizing agents
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US6395758B1 (en)	1998-08-14	2002-05-28	Gpi Nil Holdings, Inc.	Small molecule carbamates or ureas for vision and memory disorders
US6399648B1 (en)	1998-08-14	2002-06-04	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US7338976B1 (en)	1998-08-14	2008-03-04	Gpi Nil Holdings, Inc.	Heterocyclic esters or amides for vision and memory disorders
US6462072B1 (en)	1998-09-21	2002-10-08	Gpi Nil Holdings, Inc.	Cyclic ester or amide derivatives
TWI260322B (en) *	1999-02-12	2006-08-21	Vertex Pharma	Inhibitors of aspartyl protease
ES2254156T3 (es) *	1999-02-12	2006-06-16	Vertex Pharmaceuticals Incorporated	Inhibidores de aspartil-proteasa.
AR031520A1 (es) *	1999-06-11	2003-09-24	Vertex Pharma	Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
EP1222192B8 (de) *	1999-10-06	2008-10-01	Tibotec Pharmaceuticals Ltd.	Hexahydrofuro¬2,3-b furan-3-yl-n- 3-¬(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino -1-benzyl-2-hydroxypropyl carbamat als retrovirusproteasehemmer
CN1187052C (zh)	2000-03-30	2005-02-02	布里斯托尔-迈尔斯斯奎布公司	含有司他夫定(stavudine)的持续释放微球
AR035819A1 (es) *	2001-04-09	2004-07-14	Tibotec Pharm Ltd	2-(amino sustituido)-benzoxazol sulfonamidas, inhibidoras de la proteasa del hiv, composiciones farmaceuticas que comprenden dichos compuestos, metodo in vitro para inhibir la replicacion retroviral y uso de dichos compuestos en la fabricacion de medicamentos
AU2003202914A1 (en) *	2002-01-07	2003-07-24	Sequoia Pharmaceuticals	Broad spectrum inhibitors
US7157489B2 (en) *	2002-03-12	2007-01-02	The Board Of Trustees Of The University Of Illinois	HIV protease inhibitors
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WO2006104646A1 (en) *	2005-03-11	2006-10-05	Smithkline Beecham Corporation	Hiv protease inhibitors
JP2007202679A (ja) *	2006-01-31	2007-08-16	Juki Corp	ミシンの糸調子装置
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US9808527B2 (en)	2006-11-21	2017-11-07	Purdue Research Foundation	Methods and compositions for treating HIV infections
WO2009091941A1 (en)	2008-01-17	2009-07-23	Purdue Research Foundation	Small molecule inhibitors of hiv proteases
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1995
- 1995-04-19 US US08/424,810 patent/US5691372A/en not_active Expired - Lifetime
1996
- 1996-04-11 TW TW085104278A patent/TW404945B/zh not_active IP Right Cessation
- 1996-04-11 ZA ZA962891A patent/ZA962891B/xx unknown
- 1996-04-17 AR ARP960102210A patent/AR004663A1/es unknown
- 1996-04-17 AP APAP/P/1996/000827A patent/AP9600827A0/en unknown
- 1996-04-18 SK SK1430-97A patent/SK143097A3/sk unknown
- 1996-04-18 EA EA199700330A patent/EA000906B1/ru not_active IP Right Cessation
- 1996-04-18 HU HU9801948A patent/HUP9801948A3/hu unknown
- 1996-04-18 EP EP01113575A patent/EP1136479B1/de not_active Expired - Lifetime
- 1996-04-18 DE DE69638252T patent/DE69638252D1/de not_active Expired - Lifetime
- 1996-04-18 CN CN96193903A patent/CN1110491C/zh not_active Expired - Fee Related
- 1996-04-18 AU AU56655/96A patent/AU712913B2/en not_active Expired
- 1996-04-18 MY MYPI96001465A patent/MY115797A/en unknown
- 1996-04-18 PT PT96913811T patent/PT833826E/pt unknown
- 1996-04-18 CA CA2217745A patent/CA2217745C/en not_active Expired - Lifetime
- 1996-04-18 AT AT96913811T patent/ATE212344T1/de active
- 1996-04-18 ES ES05028389T patent/ES2351970T3/es not_active Expired - Lifetime
- 1996-04-18 CZ CZ973294A patent/CZ329497A3/cs unknown
- 1996-04-18 DE DE69618779T patent/DE69618779T2/de not_active Expired - Lifetime
- 1996-04-18 AP APAP/P/1997/001104A patent/AP862A/en active
- 1996-04-18 IL IL11796296A patent/IL117962A0/xx unknown
- 1996-04-18 PE PE1996000266A patent/PE43697A1/es not_active Application Discontinuation
- 1996-04-18 PL PL96322904A patent/PL322904A1/xx unknown
- 1996-04-18 AT AT05028389T patent/ATE479674T1/de not_active IP Right Cessation
- 1996-04-18 DK DK96913811T patent/DK0833826T3/da active
- 1996-04-18 TR TR97/01194T patent/TR199701194T1/xx unknown
- 1996-04-18 EE EE9700254A patent/EE9700254A/xx unknown
- 1996-04-18 EP EP96913811A patent/EP0833826B1/de not_active Expired - Lifetime
- 1996-04-18 DE DE69635679T patent/DE69635679T2/de not_active Expired - Lifetime
- 1996-04-18 KR KR1019970707346A patent/KR100485237B1/ko not_active Expired - Lifetime
- 1996-04-18 BR BR9608033A patent/BR9608033A/pt not_active Application Discontinuation
- 1996-04-18 JP JP53195396A patent/JP4240532B2/ja not_active Expired - Lifetime
- 1996-04-18 GE GEAP19963972A patent/GEP20001915B/en unknown
- 1996-04-18 EP EP05028389A patent/EP1637528B1/de not_active Expired - Lifetime
- 1996-04-18 ES ES96913811T patent/ES2171670T3/es not_active Expired - Lifetime
- 1996-04-18 WO PCT/US1996/005473 patent/WO1996033187A1/en not_active Ceased
- 1996-04-18 AT AT01113575T patent/ATE314360T1/de active
- 1996-04-18 ES ES01113575T patent/ES2256117T3/es not_active Expired - Lifetime
- 1996-04-19 CO CO96019067A patent/CO4700433A1/es unknown
1997
- 1997-10-02 IS IS4575A patent/IS4575A/is unknown
- 1997-10-08 NZ NZ307342A patent/NZ307342A/en unknown
- 1997-10-14 NO NO974744A patent/NO974744L/no not_active Application Discontinuation
- 1997-11-13 BG BG102041A patent/BG102041A/xx unknown
- 1997-11-24 US US08/977,365 patent/US5990155A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CO4700433A1 (es)	1998-12-29
EP0833826B1 (de)	2002-01-23
MY115797A (en)	2003-09-30
DE69635679T2 (de)	2006-08-31
ES2171670T3 (es)	2002-09-16
HUP9801948A2 (hu)	1999-09-28
EP1637528A1 (de)	2006-03-22
EA000906B1 (ru)	2000-06-26
DE69618779T2 (de)	2002-08-29
NZ307342A (en)	1999-04-29
BG102041A (en)	1998-09-30
CA2217745A1 (en)	1996-10-24
PT833826E (pt)	2002-06-28
NO974744D0 (no)	1997-10-14
US5990155A (en)	1999-11-23
AU712913B2 (en)	1999-11-18
EP1637528B1 (de)	2010-09-01
ATE212344T1 (de)	2002-02-15
TR199701194T1 (xx)	1998-03-21
BR9608033A (pt)	1999-01-12
ES2256117T3 (es)	2006-07-16
DK0833826T3 (da)	2002-05-06
AP9600827A0 (en)	1997-10-17
ATE314360T1 (de)	2006-01-15
JPH11504628A (ja)	1999-04-27
JP4240532B2 (ja)	2009-03-18
KR100485237B1 (ko)	2005-09-30
DE69635679D1 (de)	2006-02-02
AR004663A1 (es)	1999-03-10
EE9700254A (et)	1998-04-15
CN1110491C (zh)	2003-06-04
IL117962A0 (en)	1996-08-04
CN1184474A (zh)	1998-06-10
DE69638252D1 (de)	2010-10-14
ES2351970T3 (es)	2011-02-14
PE43697A1 (es)	1997-10-11
EP1136479B1 (de)	2005-12-28
EP0833826A1 (de)	1998-04-08
HK1009811A1 (en)	1999-06-11
IS4575A (is)	1997-10-02
HUP9801948A3 (en)	2002-04-29
AP9701104A0 (en)	1997-10-31
PL322904A1 (en)	1998-03-02
KR19990007823A (ko)	1999-01-25
TW404945B (en)	2000-09-11
SK143097A3 (en)	1998-03-04
DE69618779D1 (de)	2002-03-14
EP1136479A1 (de)	2001-09-26
GEP20001915B (en)	2000-01-05
HK1092791A1 (en)	2007-02-16
CA2217745C (en)	2011-07-05
NO974744L (no)	1997-10-14
AU5665596A (en)	1996-11-07
US5691372A (en)	1997-11-25
WO1996033187A1 (en)	1996-10-24
ATE479674T1 (de)	2010-09-15
CZ329497A3 (cs)	1998-03-18
AP862A (en)	2000-08-04
EA199700330A1 (ru)	1998-04-30

Publication	Publication Date	Title
ZA962891B (en)	1996-10-15	Oxgenated-heterocycle containing sulfonamide inhibitors of aspartyl protease
AP9701119A0 (en)	1997-10-31	THF-containing sulfonamide inhibitors of aspartyl protease
AP9300572A0 (en)	1993-10-31	Novel sulfonamide inhibitors of aspartyl protease
AP2000002023A0 (en)	2000-12-31	Sulfonamide inhibitors of aspartyl protease
ZA939285B (en)	1994-09-06	Inhibitors of aspartyl protease
PL323710A1 (en)	1998-04-14	Reversible inhibitors of cysteinic protease
HUP9902083A3 (en)	2000-06-28	Sulfonamide inhibitors of matrix metalloproteinases
PL314838A1 (en)	1996-09-30	Inhibitors of bp-iv-serine protease
PL326508A1 (en)	1998-09-28	Protease inhibitors
IL128378A0 (en)	2000-01-31	Inhibitors of cysteine protease
HUP0101831A3 (en)	2002-08-28	Sulphonamide derivatives as prodrugs of aspartyl protease inhibitors and medicaments containing them
AU5122196A (en)	1996-10-16	Cysteine protease inhibitor
EP0923535A4 (de)	2001-01-10	Inhibitoren der cystein-protease
HUP9802764A3 (en)	2000-03-28	Guanidino protease inhibitors
GB2299583B (en)	1997-08-13	Peptidyl inhibitors of serine proteases
AU7133898A (en)	1998-11-13	Nanosized aspartyl protease inhibitors
SI0846110T1 (en)	2003-04-30	Thf-containing sulfonamide inhibitors of aspartyl protease
ZA938470B (en)	1994-06-20	Sulfonamide inhibitors of aspartyl protease
HK1011864A (en)	1999-07-23	Thf-containing sulfonamide inhibitors of aspartyl protease
ZA969078B (en)	1998-04-29	Inhibitors of cysteine protease.
SI0874836T1 (en)	2002-12-31	Sulfonamide inhibitors of matrix metalloproteinases
GB9521813D0 (en)	1996-01-03	Peptide inhibitors of serine proteinases
GB9500946D0 (en)	1995-03-08	Protease inhibitors
SI0936912T1 (en)	2004-06-30	Inhibitors of cysteine protease
HK1016584A (en)	1999-11-05	Aspartyl protease inhibitors