ZA96299B - Tricyclic benzazepine vasopressin antagonists - Google Patents

Tricyclic benzazepine vasopressin antagonists

Info

Publication number: ZA96299B
Authority: ZA; South Africa
Prior art keywords: vasopressin antagonists; tricyclic benzazepine; benzazepine vasopressin; tricyclic; antagonists
Prior art date: 1995-01-17

Application number

ZA96299A

Other languages

English (en)

Inventor

Jay D Albright

Xuemei Du

Aranapakam M Venkatesan

Santos Efren G Delos

Marvin F Reich

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-17

Filing date

1996-01-15

Publication date

1997-07-15

1996-01-15 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1997-07-15 Publication of ZA96299B publication Critical patent/ZA96299B/xx

Links

DQFQCHIDRBIESA-UHFFFAOYSA-N 1-benzazepine Chemical compound N1C=CC=CC2=CC=CC=C12 DQFQCHIDRBIESA-UHFFFAOYSA-N 0.000 title 1
229940116211 Vasopressin antagonist Drugs 0.000 title 1
239000003038 vasopressin antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Gastroenterology & Hepatology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA96299A 1995-01-17 1996-01-15 Tricyclic benzazepine vasopressin antagonists ZA96299B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/373,139 US5532235A (en)	1995-01-17	1995-01-17	Tricyclic benzazepine vasopressin antagonists

Publications (1)

Publication Number	Publication Date
ZA96299B true ZA96299B (en)	1997-07-15

Family

ID=23471147

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA96299A ZA96299B (en)	1995-01-17	1996-01-15	Tricyclic benzazepine vasopressin antagonists

Country Status (21)

Country	Link
US (2)	US5532235A (fr)
EP (1)	EP0804440B1 (fr)
JP (1)	JP4219978B2 (fr)
CN (1)	CN1061658C (fr)
AR (1)	AR002268A1 (fr)
AT (1)	ATE381570T1 (fr)
AU (1)	AU4775596A (fr)
BR (1)	BR9607186B1 (fr)
CA (1)	CA2210632A1 (fr)
CZ (1)	CZ224897A3 (fr)
DE (1)	DE69637369T2 (fr)
DK (1)	DK0804440T3 (fr)
EA (1)	EA000607B1 (fr)
ES (1)	ES2297835T3 (fr)
HU (1)	HUP9702219A3 (fr)
IL (1)	IL116773A (fr)
MX (1)	MX9705415A (fr)
NZ (1)	NZ302159A (fr)
TW (1)	TW426684B (fr)
WO (1)	WO1996022295A1 (fr)
ZA (1)	ZA96299B (fr)

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US5532235A (en) *	1995-01-17	1996-07-02	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists
JP2791430B2 (ja)	1995-11-09	1998-08-27	日本たばこ産業株式会社	縮合ヘテロ５員環アゼピン誘導体及びその医薬用途
AU7338796A (en) *	1995-11-09	1997-05-29	Japan Tobacco Inc.	Five-membered fused heterocyclic azepine derivatives and pharmaceutical use thereof
US5880122A (en) *	1996-11-01	1999-03-09	American Home Products Corporation	3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
US6235900B1 (en)	1999-02-04	2001-05-22	American Home Products Corporation	Tricyclic pyridine N-oxides vasopressin agonists
US6297234B1 (en)	1999-02-04	2001-10-02	American Home Products Corporation	Arylthiophene vasopressin agonists
US6437006B1 (en)	1999-09-27	2002-08-20	American Cyanamid Company	Pharmaceutical carrier formulation
US7022699B2 (en)	2001-04-12	2006-04-04	Wyeth	Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
ATE355843T1 (de) *	2001-04-12	2007-03-15	Wyeth Corp	N-biphenylcarbonyl- und n-phenylpyridylcarbonyl substituierte bi- and tricyclische azepine und diazepine als vasopressin-agonisten
MXPA03009159A (es) *	2001-04-12	2004-02-12	Wyeth Corp	Ciclohexilfenilos agonistas de vasopresina.
US6900200B2 (en)	2001-04-12	2005-05-31	Wyeth	Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7202239B2 (en) *	2001-04-12	2007-04-10	Wyeth	Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US7326700B2 (en) *	2001-04-12	2008-02-05	Wyeth	Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US6977254B2 (en) *	2001-04-12	2005-12-20	Wyeth	Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7109193B2 (en)	2001-04-12	2006-09-19	Wyeth	Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7064120B2 (en) *	2001-04-12	2006-06-20	Wyeth	Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
SE0102299D0 (sv)	2001-06-26	2001-06-26	Astrazeneca Ab	Compounds
SE0102764D0 (sv)	2001-08-17	2001-08-17	Astrazeneca Ab	Compounds
US7057046B2 (en) *	2002-05-20	2006-06-06	Bristol-Myers Squibb Company	Lactam glycogen phosphorylase inhibitors and method of use
US7098235B2 (en)	2002-11-14	2006-08-29	Bristol-Myers Squibb Co.	Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
EP1788978B1 (fr) *	2004-09-17	2011-11-09	Codman & Shurtleff, Inc.	Dispositifs a couche mince destines a l'occlusion temporaire ou permanente d'un vaisseau
KR20110084339A (ko)	2005-07-09	2011-07-21	아스트라제네카 아베	당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한 헤테로아릴 벤즈아미드 유도체
AU2011236933A1 (en)	2010-04-05	2013-05-02	Shionogi & Co., Ltd.	Cephem compound having catechol group
JP2019520335A (ja) *	2016-05-25	2019-07-18	アカーナ・セラピューティクス・リミテッドＡｋａｒｎａＴｈｅｒａｐｅｕｔｉｃｓ，Ｌｔｄ．	疾患治療用の縮合二環式化合物
AU2018300150A1 (en)	2017-07-11	2020-01-30	Vertex Pharmaceuticals Incorporated	Carboxamides as modulators of sodium channels
WO2020146612A1 (fr)	2019-01-10	2020-07-16	Vertex Pharmaceuticals Incorporated	Esters et carbamates utilisés en tant que modulateurs de canaux sodiques
WO2020146682A1 (fr)	2019-01-10	2020-07-16	Vertex Pharmaceuticals Incorporated	Carboxamides utilisés en tant que modulateurs de canaux sodiques
KR102954172B1 (ko) *	2021-03-05	2026-04-17	상하이 제유 파마슈티칼 컴퍼니 리미티드	신규 벤자제핀 융합 고리 유도체
KR20250057901A (ko) *	2022-09-05	2025-04-29	상하이 제유 파마슈티칼 컴퍼니 리미티드	벤자제핀 융합 고리 화합물의 염의 형태, 결정형 및 이의 용도

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US4766108A (en) *	1986-12-04	1988-08-23	Smith Kline Beckman Corporation	Tyr-Arg-vasopressin antagonists
US5055448A (en) *	1987-06-25	1991-10-08	Medical College Of Ohio	Linear derivatives of arginine vasopressin antagonists
DK0382185T3 (da) *	1989-02-10	1994-07-04	Otsuka Pharma Co Ltd	Carbostyrilderivater
US5258510A (en) *	1989-10-20	1993-11-02	Otsuka Pharma Co Ltd	Benzoheterocyclic compounds
KR0167349B1 (ko) *	1989-10-20	1999-02-18	오스카 아끼히꼬	벤조헤테로 고리 화합물
US5070187A (en) *	1989-11-03	1991-12-03	Trustees Of Boston University	Pharmacologically effective antagonists of arginine-vasopressin
TW199153B (fr) *	1990-08-07	1993-02-01	Dtsuka Seiyaku Kk
TW198715B (fr) *	1991-04-19	1993-01-21	Dtsuka Seiyaku Kk
EP0533242A3 (en) *	1991-09-16	1993-09-15	Merck & Co. Inc.	Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533240A3 (en) *	1991-09-16	1993-09-29	Merck & Co. Inc.	Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
US5204349A (en) *	1991-09-16	1993-04-20	Merck & Co., Inc.	Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
EP0533243B1 (fr) *	1991-09-16	1997-12-17	Merck & Co. Inc.	Dérivés de spiroindanylcamphorsulfonyl substitués par un radical hydantoine ou succinimide comme antagonists d'oxytocine
TW250481B (fr) *	1992-08-20	1995-07-01	Otsuka Pharma Co Ltd
AU5533894A (en) *	1992-11-25	1994-06-22	Yamanouchi Pharmaceutical Co., Ltd.	Benzanilide derivative
AU5692094A (en) *	1992-12-21	1994-07-19	Yamanouchi Pharmaceutical Co., Ltd.	Novel n-(pyridylcarbonyl)benzazepine derivative and intermediate therefor
WO1994020473A1 (fr) *	1993-03-11	1994-09-15	Yamanouchi Pharmaceutical Co., Ltd.	Compose avec action antagoniste de la vasopressine
GB9307527D0 (en) *	1993-04-13	1993-06-02	Fujisawa Pharmaceutical Co	New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
US5512563A (en) *	1993-07-29	1996-04-30	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists
US5532235A (en) *	1995-01-17	1996-07-02	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists

1995
- 1995-01-17 US US08/373,139 patent/US5532235A/en not_active Expired - Lifetime
1996
- 1996-01-15 AR ARP960101026A patent/AR002268A1/es unknown
- 1996-01-15 ZA ZA96299A patent/ZA96299B/xx unknown
- 1996-01-16 CA CA002210632A patent/CA2210632A1/fr not_active Abandoned
- 1996-01-16 DK DK96903777T patent/DK0804440T3/da active
- 1996-01-16 JP JP52246296A patent/JP4219978B2/ja not_active Expired - Fee Related
- 1996-01-16 CZ CZ972248A patent/CZ224897A3/cs unknown
- 1996-01-16 CN CN96192597A patent/CN1061658C/zh not_active Expired - Fee Related
- 1996-01-16 AU AU47755/96A patent/AU4775596A/en not_active Abandoned
- 1996-01-16 DE DE69637369T patent/DE69637369T2/de not_active Expired - Lifetime
- 1996-01-16 IL IL11677396A patent/IL116773A/xx not_active IP Right Cessation
- 1996-01-16 EA EA199700111A patent/EA000607B1/ru not_active IP Right Cessation
- 1996-01-16 TW TW085100459A patent/TW426684B/zh not_active IP Right Cessation
- 1996-01-16 ES ES96903777T patent/ES2297835T3/es not_active Expired - Lifetime
- 1996-01-16 HU HU9702219A patent/HUP9702219A3/hu unknown
- 1996-01-16 BR BRPI9607186-9A patent/BR9607186B1/pt not_active IP Right Cessation
- 1996-01-16 NZ NZ302159A patent/NZ302159A/xx unknown
- 1996-01-16 EP EP96903777A patent/EP0804440B1/fr not_active Expired - Lifetime
- 1996-01-16 MX MX9705415A patent/MX9705415A/es unknown
- 1996-01-16 WO PCT/US1996/001472 patent/WO1996022295A1/fr not_active Ceased
- 1996-01-16 AT AT96903777T patent/ATE381570T1/de not_active IP Right Cessation
- 1996-05-31 US US08/657,830 patent/US5719278A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
TW426684B (en)	2001-03-21
CN1061658C (zh)	2001-02-07
JPH10512867A (ja)	1998-12-08
US5532235A (en)	1996-07-02
ES2297835T3 (es)	2008-05-01
IL116773A0 (en)	1996-05-14
EP0804440B1 (fr)	2007-12-19
IL116773A (en)	2000-12-06
DE69637369T2 (de)	2009-01-22
CN1181084A (zh)	1998-05-06
CA2210632A1 (fr)	1996-07-25
BR9607186A (pt)	1997-11-11
BR9607186B1 (pt)	2009-01-13
CZ224897A3 (cs)	1998-04-15
EA000607B1 (ru)	1999-12-29
MX9705415A (es)	1997-11-29
DE69637369D1 (de)	2008-01-31
HUP9702219A2 (hu)	1998-07-28
AR002268A1 (es)	1998-03-11
US5719278A (en)	1998-02-17
ATE381570T1 (de)	2008-01-15
NZ302159A (en)	2000-01-28
EP0804440A1 (fr)	1997-11-05
EA199700111A1 (ru)	1997-12-30
JP4219978B2 (ja)	2009-02-04
HUP9702219A3 (en)	1999-05-28
WO1996022295A1 (fr)	1996-07-25
AU4775596A (en)	1996-08-07
DK0804440T3 (da)	2008-03-31

Publication	Publication Date	Title
ZA96297B (en)	1997-07-15	Tricyclic benzazepine vasopressin antagonists
ZA96303B (en)	1997-07-15	Tricyclic benzazepine vasopressin antagonists
ZA96300B (en)	1997-07-15	Tricyclic benzazepine vasopressin antagonists
IL127470A0 (en)	1999-10-28	Tricyclic benzazepine vasopressin antagonists
IL116777A0 (en)	1996-05-14	Tricyclic benzazepine vasopressin antagonists and their preparation
BR9607186A (pt)	1997-11-11	Antagonistas de vasopressina de benzazepina triciclica
ZA96298B (en)	1997-07-15	Tricyclic benzazepine vasopressin antagonists
IL133788A0 (en)	2001-04-30	Tricyclic vasopressin agonists
FI943542L (fi)	1995-01-30	Trisyklisiä bentsatsepiineja, jotka ovat vasopressiiniantagonisteja
PL349778A1 (en)	2002-09-09	Tricyclic benzodiazepines as vasopressin receptor antagonists
HU9601176D0 (en)	1996-06-28	Adhesion-receptor antagonists
AU5844896A (en)	1996-12-18	Tricyclic diazepines useful as gnrh receptor antagonists
AU3641497A (en)	1998-01-14	Tricyclic benzazepine vasopressin antagonists
AU3296597A (en)	1998-01-07	Tricyclic benzazepine vasopressin antagonists
IL118299A0 (en)	1996-09-12	Pharmacological use of AII-receptor antagonists
AU3296497A (en)	1998-01-07	Tricyclic benzazepine vasopressin antagonists
SI0804438T1 (sl)	2006-08-31	Triciklicni benzazepinski antagonisti vazopresina
HK1002959A (en)	1998-09-30	Tricyclic benzazepine vasopressin antagonists
HK1003892A (en)	1998-11-13	Tricyclic benzazepine vasopressin antagonists
HK1019448A (en)	2000-02-11	Tricyclic benzazepine vasopressin antagonists
HK1003264A (en)	1998-10-23	Bicyclic benzazepine derivatives as vasopressin antagonists
HK1018057B (en)	2002-09-27	Tricyclic benzazepine compounds
GB9525388D0 (en)	1996-02-14	Benzazepine derivatives
GB9525365D0 (en)	1996-02-14	Benzazepine derivatives
ZA961293B (en)	1996-08-19	Muscarinic antagonists