ZA964951B - Method for the preparation of taxol and its derivatives - Google Patents
Method for the preparation of taxol and its derivativesInfo
- Publication number
- ZA964951B ZA964951B ZA964951A ZA964951A ZA964951B ZA 964951 B ZA964951 B ZA 964951B ZA 964951 A ZA964951 A ZA 964951A ZA 964951 A ZA964951 A ZA 964951A ZA 964951 B ZA964951 B ZA 964951B
- Authority
- ZA
- South Africa
- Prior art keywords
- formula
- compound
- aryl
- heteroaryl
- chem
- Prior art date
Links
- 229930012538 Paclitaxel Natural products 0.000 title 1
- 229960001592 paclitaxel Drugs 0.000 title 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 11
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 2
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9512471.5A GB9512471D0 (en) | 1995-06-20 | 1995-06-20 | Method for the preparation of taxol and its derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA964951B true ZA964951B (en) | 1997-01-23 |
Family
ID=10776319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA964951A ZA964951B (en) | 1995-06-20 | 1996-06-11 | Method for the preparation of taxol and its derivatives |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5767282A (de) |
| EP (2) | EP0776322B1 (de) |
| JP (1) | JP3889047B2 (de) |
| KR (1) | KR970705552A (de) |
| CN (1) | CN1179955C (de) |
| AT (1) | ATE208381T1 (de) |
| AU (1) | AU712898B2 (de) |
| CA (1) | CA2197467C (de) |
| DE (1) | DE69616719T2 (de) |
| ES (1) | ES2168489T3 (de) |
| GB (1) | GB9512471D0 (de) |
| HU (1) | HUP9702399A3 (de) |
| IL (1) | IL120165A (de) |
| MX (1) | MX9701274A (de) |
| NO (1) | NO970766D0 (de) |
| WO (1) | WO1997000870A1 (de) |
| ZA (1) | ZA964951B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150537A (en) * | 1997-12-12 | 2000-11-21 | Emory University | Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents |
| WO2000047434A1 (en) | 1999-02-10 | 2000-08-17 | Erik Zapletal | Balanced suspension system |
| IT1308636B1 (it) * | 1999-03-02 | 2002-01-09 | Indena Spa | Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii. |
| US6519517B1 (en) | 1999-04-12 | 2003-02-11 | Kinetic Pty. Ltd. | Active ride control for a vehicle suspension system |
| HK1049787B (en) | 1999-10-01 | 2014-07-25 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6143900A (en) * | 1999-10-26 | 2000-11-07 | Dong Kook Pharmaceutical Co., Ltd. | Stereoselective synthesis of oxazoline derivative |
| PL194032B1 (pl) * | 2002-12-19 | 2007-04-30 | Agropharm Sa | Sposób wytwarzania półproduktów użytecznych w syntezie paklitakselu |
| CN101020672B (zh) * | 2006-12-28 | 2010-08-25 | 上海百灵医药科技有限公司 | 多烯紫杉醇的合成方法 |
| CN101007795B (zh) * | 2007-01-26 | 2010-08-18 | 浙江大学 | 紫杉醇及多烯紫杉醇的合成方法 |
| CN115260130A (zh) * | 2022-07-07 | 2022-11-01 | 上海卓鼎生物技术有限公司 | 一种10-脱乙酰基紫杉醇的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9102128A (es) * | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| FR2687151B1 (fr) * | 1992-02-07 | 1994-03-25 | Rhone Poulenc Rorer Sa | Nouveaux derives de la baccatine iii et de la desacetyl-10 baccatine iii, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2696458B1 (fr) * | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
-
1995
- 1995-06-20 GB GBGB9512471.5A patent/GB9512471D0/en active Pending
-
1996
- 1996-06-04 DE DE69616719T patent/DE69616719T2/de not_active Expired - Lifetime
- 1996-06-04 MX MX9701274A patent/MX9701274A/es not_active IP Right Cessation
- 1996-06-04 JP JP50354397A patent/JP3889047B2/ja not_active Expired - Fee Related
- 1996-06-04 WO PCT/EP1996/002409 patent/WO1997000870A1/en not_active Ceased
- 1996-06-04 KR KR1019970701092A patent/KR970705552A/ko not_active Withdrawn
- 1996-06-04 AT AT96920783T patent/ATE208381T1/de not_active IP Right Cessation
- 1996-06-04 HU HU9702399A patent/HUP9702399A3/hu unknown
- 1996-06-04 CA CA002197467A patent/CA2197467C/en not_active Expired - Fee Related
- 1996-06-04 CN CNB961907630A patent/CN1179955C/zh not_active Expired - Fee Related
- 1996-06-04 EP EP96920783A patent/EP0776322B1/de not_active Expired - Lifetime
- 1996-06-04 AU AU62215/96A patent/AU712898B2/en not_active Ceased
- 1996-06-04 IL IL12016596A patent/IL120165A/en not_active IP Right Cessation
- 1996-06-04 ES ES96920783T patent/ES2168489T3/es not_active Expired - Lifetime
- 1996-06-04 US US08/776,607 patent/US5767282A/en not_active Expired - Lifetime
- 1996-06-04 EP EP01201499A patent/EP1116718A3/de not_active Withdrawn
- 1996-06-11 ZA ZA964951A patent/ZA964951B/xx unknown
-
1997
- 1997-02-19 NO NO970766A patent/NO970766D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0776322A1 (de) | 1997-06-04 |
| AU712898B2 (en) | 1999-11-18 |
| JP3889047B2 (ja) | 2007-03-07 |
| CN1158126A (zh) | 1997-08-27 |
| CN1179955C (zh) | 2004-12-15 |
| KR970705552A (ko) | 1997-10-09 |
| ATE208381T1 (de) | 2001-11-15 |
| CA2197467C (en) | 2008-02-12 |
| IL120165A (en) | 2002-02-10 |
| MX9701274A (es) | 1997-05-31 |
| EP1116718A3 (de) | 2001-08-29 |
| EP1116718A2 (de) | 2001-07-18 |
| DE69616719T2 (de) | 2002-08-01 |
| CA2197467A1 (en) | 1997-01-09 |
| GB9512471D0 (en) | 1995-08-23 |
| NO970766L (no) | 1997-02-19 |
| ES2168489T3 (es) | 2002-06-16 |
| IL120165A0 (en) | 1997-06-10 |
| US5767282A (en) | 1998-06-16 |
| JPH10505360A (ja) | 1998-05-26 |
| EP0776322B1 (de) | 2001-11-07 |
| HUP9702399A3 (en) | 1999-12-28 |
| HUP9702399A2 (hu) | 1998-07-28 |
| WO1997000870A1 (en) | 1997-01-09 |
| DE69616719D1 (de) | 2001-12-13 |
| AU6221596A (en) | 1997-01-22 |
| NO970766D0 (no) | 1997-02-19 |
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