ZA968183B - 13-Substituted milbemycin 5-oxime derivatives their preparation and their use against insects and other pests - Google Patents

13-Substituted milbemycin 5-oxime derivatives their preparation and their use against insects and other pests

Info

Publication number: ZA968183B
Authority: ZA; South Africa
Prior art keywords: alkyl; chem; cycloalkyl; carbocyclic aryl; pests
Prior art date: 1995-09-29

Application number

ZA968183A

Other languages

English (en)

Inventor

Kazuo Sato

Akio Saito

Toshimitsu Toyama

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-29

Filing date

1996-09-27

Publication date

1997-04-25

1996-09-27 Application filed by Sankyo Co filed Critical Sankyo Co

1997-04-25 Publication of ZA968183B publication Critical patent/ZA968183B/xx

Links

241000238631 Hexapoda Species 0.000 title 1
241000607479 Yersinia pestis Species 0.000 title 1
FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Natural products COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 9
125000000753 cycloalkyl group Chemical group 0.000 abstract 4
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
230000000895 acaricidal effect Effects 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
230000000507 anthelmentic effect Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000000749 insecticidal effect Effects 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
-1 nitro, amino Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Dentistry (AREA)
Oncology (AREA)
Agronomy & Crop Science (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Communicable Diseases (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

ZA968183A 1995-09-29 1996-09-27 13-Substituted milbemycin 5-oxime derivatives their preparation and their use against insects and other pests ZA968183B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP25296595		1995-09-29

Publications (1)

Publication Number	Publication Date
ZA968183B true ZA968183B (en)	1997-04-25

Family

ID=17244627

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA968183A ZA968183B (en)	1995-09-29	1996-09-27	13-Substituted milbemycin 5-oxime derivatives their preparation and their use against insects and other pests

Country Status (18)

Country	Link
US (1)	US5861429A (de)
EP (1)	EP0765879B1 (de)
KR (1)	KR100300376B1 (de)
AT (1)	ATE199154T1 (de)
AU (1)	AU707152B2 (de)
CA (1)	CA2186650A1 (de)
CZ (1)	CZ288178B6 (de)
DE (1)	DE69611773T2 (de)
DK (1)	DK0765879T3 (de)
ES (1)	ES2155172T3 (de)
GR (1)	GR3035565T3 (de)
HU (1)	HU225226B1 (de)
IL (1)	IL119321A (de)
NO (1)	NO317090B1 (de)
NZ (1)	NZ299460A (de)
PT (1)	PT765879E (de)
RU (1)	RU2128181C1 (de)
ZA (1)	ZA968183B (de)

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* Cited by examiner, † Cited by third party
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ATE455106T1 (de) *	1999-01-22	2010-01-15	Elan Pharm Inc	Acyl derivate zur behandlung von krankheiten die in zusammenhang mit vla-4 stehen
HK1043794A1 (zh) *	1999-01-22	2002-09-27	依兰制药公司	抑制vla-4介导的白细胞粘附的稠合环杂芳基和杂环化合物
US6465513B1 (en)	1999-01-22	2002-10-15	Elan Pharmaceuticals, Inc.	Multicyclic compounds which inhibit leukocyte adhesion mediated by VLA-4
US6436904B1 (en)	1999-01-25	2002-08-20	Elan Pharmaceuticals, Inc.	Compounds which inhibit leukocyte adhesion mediated by VLA-4
JP2002538135A (ja)	1999-03-01	2002-11-12	エランファーマシューティカルズ，インコーポレイテッド	α４β７レセプターアンタゴニストとして有用なα−アミノ酢酸誘導体
DK1276748T3 (da)	2000-04-27	2006-03-20	Sankyo Lifetech Company Ltd	13-substituerede milbemycinderivater, deres fremstilling og deres anvendelse over for insekter og andre skadedyr
RU2195280C1 (ru) *	2001-05-21	2002-12-27	Всероссийский научно-исследовательский институт гельминтологии им. К.И. Скрябина	Антигельминтное средство
CA2464403A1 (en)	2001-10-25	2003-05-01	Novartis Animal Health K.K.	Anthelmintic composition
TWI281470B (en) *	2002-05-24	2007-05-21	Elan Pharm Inc	Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en) *	2002-05-24	2003-12-16	Elan Pharm Inc	Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
JP4373080B2 (ja) *	2002-12-24	2009-11-25	三井化学アグロ株式会社	ミルベマイシン類の精製法
WO2005075070A1 (ja) *	2004-02-05	2005-08-18	Nippon Shokubai Co., Ltd.	粒子状吸水剤及びその製造方法並びに吸水性物品
RU2355370C2 (ru) *	2004-02-05	2009-05-20	Ниппон Шокубаи Ко., Лтд.	Твердый водопоглощающий реагент и способ его изготовления, и водопоглощающее изделие
TWI353360B (en)	2005-04-07	2011-12-01	Nippon Catalytic Chem Ind	Production process of polyacrylic acid (salt) wate
BRPI0616687A2 (pt) *	2005-09-29	2011-06-28	Elan Pharm Inc	compostos de pirimidinil amida que inibem a adesão leucocitária mediada por vla-4
CA2624524C (en) *	2005-09-29	2014-07-08	Elan Pharmaceuticals, Inc.	Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4
TWI394789B (zh)	2005-12-22	2013-05-01	Nippon Catalytic Chem Ind	吸水性樹脂組成物及其製造方法、吸收性物品
CA2643838A1 (en) *	2006-02-27	2007-09-07	Elan Pharmaceuticals, Inc.	Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4
EP1837348B9 (de)	2006-03-24	2020-01-08	Nippon Shokubai Co.,Ltd.	Wasserabsorbierendes Harz und Verfahren zu seiner Herstellung
WO2010126914A1 (en) *	2009-04-27	2010-11-04	Elan Pharmaceuticals, Inc.	Pyridinone antagonists of alpha-4 integrins
JP5801203B2 (ja)	2009-09-29	2015-10-28	株式会社日本触媒	粒子状吸水剤及びその製造方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4914624A (de) *	1972-06-08	1974-02-08
US3950360A (en) *	1972-06-08	1976-04-13	Sankyo Company Limited	Antibiotic substances
US4206205A (en) *	1977-10-03	1980-06-03	Merck & Co., Inc.	Monosaccharide and aglycone derivatives of C-076
US4201861A (en) *	1977-10-03	1980-05-06	Merck & Co., Inc.	Acyl derivatives of C-076 compounds
US4173571A (en) *	1977-12-19	1979-11-06	Merck & Co., Inc.	13-Halo and 13-deoxy derivatives of C-076 compounds
US4171314A (en) *	1977-12-19	1979-10-16	Merck & Co., Inc.	13-Halo and 13-deoxy C-076 compounds
US4203976A (en) *	1978-08-02	1980-05-20	Merck & Co., Inc.	Sugar derivatives of C-076 compounds
JPS5632481A (en) *	1979-08-23	1981-04-01	Sankyo Co Ltd	Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent
US4289760A (en) *	1980-05-02	1981-09-15	Merck & Co., Inc.	23-Keto derivatives of C-076 compounds
US4457920A (en) *	1981-09-03	1984-07-03	Merck & Co., Inc.	4a-Substituted avermectin compounds
US4423209A (en) *	1982-02-26	1983-12-27	Merck & Co., Inc.	Processes for the interconversion of avermectin compounds
JPS59108785A (ja) *	1982-11-25	1984-06-23	Sankyo Co Ltd	ミルベマイシン類の５−オキシム誘導体
US4579864A (en) *	1984-06-11	1986-04-01	Merck & Co., Inc.	Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
US4547491A (en) *	1984-07-18	1985-10-15	Merck & Co., Inc.	C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical compositions and method of use
IL78621A (en) *	1985-04-30	1991-06-30	American Cyanamid Co	Mylbemycin analogs,their preparation and pesticidal compositions containing them
JPS6289685A (ja) *	1985-05-31	1987-04-24	Sankyo Co Ltd	１３−ハロゲンミルベマイシン誘導体
US4668696A (en) *	1985-07-29	1987-05-26	Merck & Co., Inc.	Novel averonectin fermentation product of a microorganism with anthelmintic activity
US4778809A (en) *	1985-08-23	1988-10-18	Ciba-Geigy Corporation	5-esters of milbemycins for controlling parasitic pests
EP0342710B1 (de) *	1986-03-25	1993-05-19	Sankyo Company Limited	Makrolid-Derivate, ihre Herstellung und ihre Verwendung
GB8815967D0 (en) *	1988-07-05	1988-08-10	Pfizer Ltd	Antiparasitic agents
US5428034A (en) *	1988-09-02	1995-06-27	Sankyo Co., Ltd.	Milbemycin derivatives, their preparation and their use
RU2086552C1 (ru) *	1991-12-18	1997-08-10	Санкио Компани Лимитед	Производные 13-(замещенного тио)ацетоксимилбемицина, способ их получения, инсектицидная композиция и способ защиты растений
GB9201505D0 (en) *	1992-01-24	1992-03-11	Pfizer Ltd	Antiparasitic agents
GB9205051D0 (en) *	1992-03-09	1992-04-22	Cancer Res Campaign Tech	Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them
US5614470A (en) *	1994-04-01	1997-03-25	Sankyo Company, Limited	13-substituted milbemycin derivatives, their preparation and their use
AU3935495A (en) *	1994-11-24	1996-06-17	Sankyo Company Limited	13-etherified milbemycin derivative with insecticidal activity

1996
- 1996-09-27 PT PT96307092T patent/PT765879E/pt unknown
- 1996-09-27 DE DE69611773T patent/DE69611773T2/de not_active Expired - Lifetime
- 1996-09-27 AT AT96307092T patent/ATE199154T1/de not_active IP Right Cessation
- 1996-09-27 DK DK96307092T patent/DK0765879T3/da active
- 1996-09-27 AU AU65861/96A patent/AU707152B2/en not_active Ceased
- 1996-09-27 EP EP96307092A patent/EP0765879B1/de not_active Expired - Lifetime
- 1996-09-27 NZ NZ299460A patent/NZ299460A/en unknown
- 1996-09-27 CA CA002186650A patent/CA2186650A1/en not_active Abandoned
- 1996-09-27 CZ CZ19962862A patent/CZ288178B6/cs not_active IP Right Cessation
- 1996-09-27 ZA ZA968183A patent/ZA968183B/xx unknown
- 1996-09-27 NO NO19964090A patent/NO317090B1/no not_active IP Right Cessation
- 1996-09-27 HU HU9602678A patent/HU225226B1/hu not_active IP Right Cessation
- 1996-09-27 ES ES96307092T patent/ES2155172T3/es not_active Expired - Lifetime
- 1996-09-29 IL IL11932196A patent/IL119321A/en not_active IP Right Cessation
- 1996-09-30 US US08/723,835 patent/US5861429A/en not_active Expired - Fee Related
- 1996-09-30 RU RU96120138/04A patent/RU2128181C1/ru not_active IP Right Cessation
- 1996-09-30 KR KR1019960042886A patent/KR100300376B1/ko not_active Expired - Fee Related
2001
- 2001-03-13 GR GR20010400411T patent/GR3035565T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU9602678D0 (en)	1996-11-28
HU225226B1 (en)	2006-08-28
HK1003937A1 (en)	1998-11-13
AU707152B2 (en)	1999-07-01
KR970015592A (ko)	1997-04-28
CA2186650A1 (en)	1997-03-30
EP0765879B1 (de)	2001-02-14
US5861429A (en)	1999-01-19
EP0765879A1 (de)	1997-04-02
DK0765879T3 (da)	2001-03-19
NO964090L (no)	1997-04-01
PT765879E (pt)	2001-05-31
DE69611773T2 (de)	2001-09-13
ES2155172T3 (es)	2001-05-01
KR100300376B1 (ko)	2001-10-22
IL119321A0 (en)	1996-12-05
NO964090D0 (no)	1996-09-27
RU2128181C1 (ru)	1999-03-27
CZ286296A3 (en)	1997-04-16
IL119321A (en)	2001-05-20
NO317090B1 (no)	2004-08-02
NZ299460A (en)	1997-12-19
CZ288178B6 (en)	2001-05-16
ATE199154T1 (de)	2001-02-15
HUP9602678A1 (en)	1997-11-28
GR3035565T3 (en)	2001-06-29
AU6586196A (en)	1997-04-10
DE69611773D1 (de)	2001-03-22

Publication	Publication Date	Title
ZA968183B (en)	1997-04-25	13-Substituted milbemycin 5-oxime derivatives their preparation and their use against insects and other pests
LV10864A (lv)	1995-10-20	Triazinu atvasinajumi to iegusanas panemiens un herbicids kas tos iesledz sevi ka aktivu ingredientu
DK433982A (da)	1983-03-31	Biologisk aktive amidderivater
GR3005022T3 (de)	1993-05-24
IE870315L (en)	1987-08-08	Pyridazinone derivatives.
GB2189484B (en)	1990-05-23	Derivatives of acrylic acid useful in agriculture
MY104174A (en)	1994-02-28	Insecticidal compounds.
AU689808B2 (en)	1998-04-09	Dithiocarbonimide derivative, fungicidal/insecticidal/ acaricidal agent containing said derivative as active ingredient, intermediate for use in production of said derivative and process for producing said derivative from said intermediate
WO2001083500A8 (en)	2003-05-08	13-substituted milbemycin derivatives, their preparation and their use against insects and other pests
AU623500B2 (en)	1992-05-14	Carboxylimino benzothiazole derivatives
MX9207464A (es)	1993-07-30	Derivados de acetoximilbemicina 13-(tiosubstituida), su preparacion y sus usos aeroquimicos.
AR001113A1 (es)	1997-09-24	1-alqueniltetrazolinonas un procedimiento para su preparación composiciones herbicidas y procedimientos para su preparación procedimiento para combatir malas hierbas y compuestos intermediarios
NO890996L (no)	1989-09-11	Fremgangsmaate for fremstilling av cefemforbindelser.
BR9306625A (pt)	1998-12-08	Métodos de proteção de uma cultura e composição ovicida
CA2027542A1 (en)	1990-08-24	Uv-absorbing cyclic enaminoketones
BR8603928A (pt)	1987-03-24	Compostos de hidrazino-eteres difenilicos,processo para sua preparacao,composicao herbicida e processo para combater o crescimento de plantas indesejaveis
IL110590A0 (en)	1994-11-11	Amidothiophosphate derivatives and insecticides, nematocides and acaricides containing the same as active ingredient
TH19555A (th)	1996-07-16	อนุพันธ์ของ 13-ซับสทิทิวเทด มิลบีไมซิน การเตรียมสารเหล่านี้และการใช้ประโยชน์ของสารเหล่านี้
MX9604511A (es)	1998-01-31	Derivados de 5-oxima de milbencina 13-sustituida, su preparacion y su uso contra insectos y otras plagas.
TH13795A (th)	1994-04-15	อนุพันธ์กวานิดีน