ZA971183B - Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants. - Google Patents

Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants.

Info

Publication number: ZA971183B
Authority: ZA; South Africa
Prior art keywords: derivatives; coagulants; amino acid; benzamidine; hydroxy acid
Prior art date: 1996-02-12

Application number

ZA9701183A

Other languages

English (en)

Inventor

Monica Kochanny

Raju Mohan

Michael M Morrissey

Howard P Ng

Weiya Yun

Original Assignee

Berlex Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-12

Filing date

1997-02-12

Publication date

1997-09-18

1997-02-12 Application filed by Berlex Lab filed Critical Berlex Lab

1997-09-18 Publication of ZA971183B publication Critical patent/ZA971183B/xx

Links

125000003275 alpha amino acid group Chemical class 0.000 title abstract 2
239000003146 anticoagulant agent Substances 0.000 title abstract 2
229940127219 anticoagulant drug Drugs 0.000 title abstract 2
PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical group NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 title abstract 2
150000001261 hydroxy acids Chemical class 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001732 thrombotic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/20—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with no nitrogen atoms directly attached to a ring carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/38—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Saccharide Compounds (AREA)

ZA9701183A 1996-02-12 1997-02-12 Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants. ZA971183B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/599,834 US5994375A (en)	1996-02-12	1996-02-12	Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants

Publications (1)

Publication Number	Publication Date
ZA971183B true ZA971183B (en)	1997-09-18

Family

ID=24401285

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9701183A ZA971183B (en)	1996-02-12	1997-02-12	Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants.

Country Status (23)

Country	Link
US (4)	US5994375A (de)
EP (1)	EP0888271B1 (de)
JP (1)	JP3762790B2 (de)
KR (1)	KR19990082480A (de)
CN (1)	CN1211232A (de)
AT (1)	ATE265409T1 (de)
AU (1)	AU715992B2 (de)
CA (1)	CA2245925A1 (de)
CZ (1)	CZ255098A3 (de)
DE (1)	DE69728869T2 (de)
DK (1)	DK0888271T3 (de)
ES (1)	ES2221032T3 (de)
HU (1)	HU223604B1 (de)
IL (1)	IL125285A (de)
NO (1)	NO312834B1 (de)
NZ (1)	NZ326452A (de)
PL (1)	PL186474B1 (de)
PT (1)	PT888271E (de)
RU (1)	RU98117078A (de)
SK (1)	SK283306B6 (de)
UA (1)	UA51694C2 (de)
WO (1)	WO1997029067A1 (de)
ZA (1)	ZA971183B (de)

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ATE251141T1 (de)	1995-03-10	2003-10-15	Berlex Lab	Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
US5753635A (en) *	1996-08-16	1998-05-19	Berlex Laboratories, Inc.	Purine derivatives and their use as anti-coagulants
ATE228513T1 (de) *	1996-09-12	2002-12-15	Schering Ag	Durch cyclische aminosäuren oder cyclische hydroxysäuren substituierte benzamidinderivate und deren verwendung als antikoagulantien
US6004985A (en) *	1996-10-09	1999-12-21	Berlex Laboratories, Inc.	Thio acid derived monocylic N-heterocyclics as anticoagulants
US6686364B2 (en)	1997-12-08	2004-02-03	Berlex Laboratories, Inc.	Benzamidine derivatives and their use as anti-coagulants
US6140351A (en) *	1997-12-19	2000-10-31	Berlex Laboratories, Inc.	Ortho-anthranilamide derivatives as anti-coagulants
EP1040108B1 (de) *	1997-12-19	2004-02-25	Schering Aktiengesellschaft	Ortho-anthranilamide derivate als antikoagulantien
US6262088B1 (en) *	1998-11-19	2001-07-17	Berlex Laboratories, Inc.	Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6127376A (en) *	1998-12-04	2000-10-03	Berlex Laboratories, Inc.	Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
WO2000038683A1 (en) *	1998-12-23	2000-07-06	Du Pont Pharmaceuticals Company	THROMBIN OR FACTOR Xa INHIBITORS
US6350761B1 (en)	1999-07-30	2002-02-26	Berlex Laboratories, Inc.	Benzenamine derivatives as anti-coagulants
US6844367B1 (en)	1999-09-17	2005-01-18	Millennium Pharmaceuticals, Inc.	Benzamides and related inhibitors of factor Xa
AU2001250783A1 (en)	2000-02-29	2001-09-12	Cor Therapeutics, Inc.	Benzamides and related inhibitors of factor xa
EP1323189A2 (de) *	2000-09-13	2003-07-02	Shipley Company LLC	Herstellung einer elektronischen vorrichtung
JP4087577B2 (ja)	2001-03-30	2008-05-21	富士フイルム株式会社	ヘテロ環連結体を含有する写真処理組成物及び画像形成方法
US7482366B2 (en)	2001-12-21	2009-01-27	X-Ceptor Therapeutics, Inc.	Modulators of LXR
WO2003059884A1 (en)	2001-12-21	2003-07-24	X-Ceptor Therapeutics, Inc.	Modulators of lxr
AR040456A1 (es) *	2002-06-27	2005-04-06	Bristol Myers Squibb Co	Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana
AU2003302238A1 (en)	2002-12-03	2004-06-23	Axys Pharmaceuticals, Inc.	2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
ES2550057T3 (es)	2006-11-02	2015-11-04	Millennium Pharmaceuticals, Inc.	Métodos para sintetizar sales farmacéuticas de un inhibidor del Factor Xa
CN105367503A (zh)	2007-10-19	2016-03-02	阿维拉制药公司	杂芳基化合物和其用途
US7989465B2 (en) *	2007-10-19	2011-08-02	Avila Therapeutics, Inc.	4,6-disubstituted pyrimidines useful as kinase inhibitors
US12595251B2 (en)	2018-06-14	2026-04-07	Georgia State University Research Foundation, Inc.	Amidines and amidine analogs for the treatment of bacterial infections and potentiation antibiotics
CN119837855A (zh)	2019-12-19	2025-04-18	乔治亚州大学研究基金会	用于治疗细菌感染和增强抗生素的化合物

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GB824908A (en) *	1958-06-03	1959-12-09	May & Baker Ltd	Improvements in or relating to triazine derivatives
JPS5922697B2 (ja) *	1976-01-13	1984-05-28	エーザイ株式会社	ビス−（メタ−アミジノフエノキシ）−化合物
JPH0813834B2 (ja) *	1990-08-01	1996-02-14	日東紡績株式会社	トリペプチド誘導体及びそれを有効成分とする蛋白分解酵素阻害剤
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DE4213919A1 (de)	1992-04-28	1993-11-04	Thomae Gmbh Dr K	Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
TW234077B (de)	1992-07-17	1994-11-11	Shell Internat Res Schappej B V
AU675981B2 (en)	1992-12-02	1997-02-27	Bristol-Myers Squibb Company	Guanidinyl-substituted heterocyclic thrombin inhibitors
CA2151044A1 (en) *	1992-12-15	1994-06-23	Terence K. Brunck	Novel inhibitors for factor xa
US5332822A (en) *	1992-12-24	1994-07-26	Bristol-Myers Squibb Company	Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors
ATE181334T1 (de) *	1993-02-12	1999-07-15	Corvas Int Inc	Inhibitoren gegen thrombose
US5633381A (en) *	1994-07-05	1997-05-27	Berlex Laboratories, Inc.	(Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones
IL115420A0 (en) *	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
US5691364A (en) *	1995-03-10	1997-11-25	Berlex Laboratories, Inc.	Benzamidine derivatives and their use as anti-coagulants
ATE251141T1 (de)	1995-03-10	2003-10-15	Berlex Lab	Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
US5612363A (en) *	1995-06-02	1997-03-18	Berlex Laboratories, Inc.	N,N-di(aryl) cyclic urea derivatives as anti-coagulants
US5849759A (en) *	1995-12-08	1998-12-15	Berlex Laboratories, Inc.	Naphthyl-substituted benzimidazole derivatives as anti-coagulants
US5753635A (en) *	1996-08-16	1998-05-19	Berlex Laboratories, Inc.	Purine derivatives and their use as anti-coagulants
US5693641A (en) *	1996-08-16	1997-12-02	Berlex Laboratories Inc.	Bicyclic pyrimidine derivatives and their use as anti-coagulants
ATE228513T1 (de) *	1996-09-12	2002-12-15	Schering Ag	Durch cyclische aminosäuren oder cyclische hydroxysäuren substituierte benzamidinderivate und deren verwendung als antikoagulantien
US6004985A (en) *	1996-10-09	1999-12-21	Berlex Laboratories, Inc.	Thio acid derived monocylic N-heterocyclics as anticoagulants

1996
- 1996-02-12 US US08/599,834 patent/US5994375A/en not_active Expired - Fee Related
1997
- 1997-02-07 PT PT97901221T patent/PT888271E/pt unknown
- 1997-02-07 JP JP52833697A patent/JP3762790B2/ja not_active Expired - Fee Related
- 1997-02-07 CZ CZ982550A patent/CZ255098A3/cs unknown
- 1997-02-07 ES ES97901221T patent/ES2221032T3/es not_active Expired - Lifetime
- 1997-02-07 AU AU14548/97A patent/AU715992B2/en not_active Ceased
- 1997-02-07 HU HU9902017A patent/HU223604B1/hu not_active IP Right Cessation
- 1997-02-07 RU RU98117078/04A patent/RU98117078A/ru not_active Application Discontinuation
- 1997-02-07 NZ NZ326452A patent/NZ326452A/en unknown
- 1997-02-07 AT AT97901221T patent/ATE265409T1/de not_active IP Right Cessation
- 1997-02-07 IL IL12528597A patent/IL125285A/en not_active IP Right Cessation
- 1997-02-07 DK DK97901221T patent/DK0888271T3/da active
- 1997-02-07 KR KR1019980706213A patent/KR19990082480A/ko not_active Abandoned
- 1997-02-07 EP EP97901221A patent/EP0888271B1/de not_active Expired - Lifetime
- 1997-02-07 WO PCT/IB1997/000098 patent/WO1997029067A1/en not_active Ceased
- 1997-02-07 SK SK1092-98A patent/SK283306B6/sk unknown
- 1997-02-07 DE DE69728869T patent/DE69728869T2/de not_active Expired - Fee Related
- 1997-02-07 CN CN97192215A patent/CN1211232A/zh active Pending
- 1997-02-07 CA CA002245925A patent/CA2245925A1/en not_active Abandoned
- 1997-02-07 PL PL97328412A patent/PL186474B1/pl not_active IP Right Cessation
- 1997-02-12 ZA ZA9701183A patent/ZA971183B/xx unknown
- 1997-07-02 UA UA98094782A patent/UA51694C2/uk unknown
1998
- 1998-08-11 NO NO19983671A patent/NO312834B1/no not_active IP Right Cessation
1999
- 1999-09-09 US US09/393,180 patent/US6166088A/en not_active Expired - Fee Related
- 1999-09-09 US US09/394,458 patent/US6071912A/en not_active Expired - Fee Related
- 1999-09-09 US US09/393,198 patent/US6242454B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6242454B1 (en)	2001-06-05
CA2245925A1 (en)	1997-08-14
IL125285A0 (en)	1999-03-12
CZ255098A3 (cs)	1999-01-13
NO312834B1 (no)	2002-07-08
IL125285A (en)	2002-11-10
HUP9902017A2 (hu)	1999-09-28
DK0888271T3 (da)	2004-08-16
HU223604B1 (hu)	2004-10-28
US6166088A (en)	2000-12-26
DE69728869T2 (de)	2005-01-05
CN1211232A (zh)	1999-03-17
US6071912A (en)	2000-06-06
NZ326452A (en)	2000-02-28
RU98117078A (ru)	2000-06-10
EP0888271A1 (de)	1999-01-07
DE69728869D1 (de)	2004-06-03
KR19990082480A (ko)	1999-11-25
PT888271E (pt)	2004-09-30
SK109298A3 (en)	1999-02-11
AU1454897A (en)	1997-08-28
PL186474B1 (pl)	2004-01-30
US5994375A (en)	1999-11-30
PL328412A1 (en)	1999-01-18
SK283306B6 (sk)	2003-05-02
EP0888271A4 (de)	2000-03-15
ES2221032T3 (es)	2004-12-16
HUP9902017A3 (en)	2000-06-28
JP3762790B2 (ja)	2006-04-05
NO983671D0 (no)	1998-08-11
UA51694C2 (uk)	2002-12-16
ATE265409T1 (de)	2004-05-15
WO1997029067A1 (en)	1997-08-14
EP0888271B1 (de)	2004-04-28
JP2000505431A (ja)	2000-05-09
NO983671L (no)	1998-09-11
AU715992B2 (en)	2000-02-17

Publication	Publication Date	Title
IL128691A0 (en)	2000-01-31	Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
ZA971183B (en)	1997-09-18	Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants.
IL128062A0 (en)	1999-11-30	Bicyclic pyrimidine derivatives and pharmaceutical compositions containing the same
IL129056A0 (en)	2000-02-17	Monocyclic N-heterocyclics substituted by thio acid derivatives and pharmaceutical compositions containing same
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IL128666A0 (en)	2000-01-31	Substituted cyclic amine metalloprotease inhibitors
IL104154A0 (en)	1993-05-13	Saccharin derivatives,their preparation and pharmaceutical compositions containing them
MY106202A (en)	1995-03-31	Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof.
UA66865C2 (uk)	2004-06-15	Інденопіролокарбазоли, фармацевтична композиція, спосіб інгібування кіназної активності та спосіб лікування (варіанти)
AU2443184A (en)	1984-08-16	Benzazocinones and benzazoninones
IL144199A0 (en)	2002-05-23	Novel bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions
AU7028798A (en)	1998-09-22	Use of 2-methylthiazolidine-2,4-dicarboxylic acid as mucolytic agent
AU2596195A (en)	1996-01-15	Substituted alkyldiamine derivatives and their use as tachykinin antagonists