ZA974050B - 2,4-Diaminopyrimidine derivatives - Google Patents

2,4-Diaminopyrimidine derivatives

Info

Publication number: ZA974050B
Authority: ZA; South Africa
Prior art keywords: aryl; hydrogen; dihydro; heteroaryl; naphthyl
Prior art date: 1996-05-10

Application number

ZA974050A

Other languages

English (en)

Inventor

Jean-Paul Rene Marie A Bosmans

Guy Rosalia Eugene Van Lommen

Christopher John Love

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-10

Filing date

1997-05-09

Publication date

1998-11-09

1997-05-09 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1998-11-09 Publication of ZA974050B publication Critical patent/ZA974050B/xx

Links

YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical class NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 title 1
-1 2,3-dihydro-1,4-benzodioxinyl Chemical group 0.000 abstract 3
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
125000001072 heteroaryl group Chemical group 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001624 naphthyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
102000003962 Dopamine D4 receptors Human genes 0.000 abstract 1
108090000357 Dopamine D4 receptors Proteins 0.000 abstract 1
125000000815 N-oxide group Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical group C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
238000003384 imaging method Methods 0.000 abstract 1
125000001041 indolyl group Chemical group 0.000 abstract 1
125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
230000002285 radioactive effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

ZA974050A 1996-05-10 1997-05-09 2,4-Diaminopyrimidine derivatives ZA974050B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP96201283		1996-05-10

Publications (1)

Publication Number	Publication Date
ZA974050B true ZA974050B (en)	1998-11-09

Family

ID=8223971

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA974050A ZA974050B (en)	1996-05-10	1997-05-09	2,4-Diaminopyrimidine derivatives

Country Status (19)

Country	Link
US (2)	US6159982A (de)
EP (1)	EP0912552B1 (de)
JP (1)	JP4264135B2 (de)
KR (1)	KR100462524B1 (de)
CN (1)	CN1134431C (de)
AT (1)	ATE264853T1 (de)
CA (1)	CA2253429C (de)
CZ (1)	CZ289250B6 (de)
DE (1)	DE69728768T2 (de)
ES (1)	ES2221052T3 (de)
HU (1)	HUP9903445A3 (de)
IL (1)	IL126969A (de)
MY (1)	MY116114A (de)
NO (1)	NO317179B1 (de)
NZ (1)	NZ332308A (de)
PL (1)	PL187769B1 (de)
TW (1)	TW504510B (de)
WO (1)	WO1997043279A1 (de)
ZA (1)	ZA974050B (de)

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PL338947A1 (en) *	1997-08-15	2000-12-04	Pfizer Prod Inc	Derivatives of 2-(4-aryl or heteroaryl piperazin-1-ylmethyl)-1h-indole
WO2000018763A2 (en) *	1998-09-29	2000-04-06	Neurogen Corporation	2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands
US6288230B1 (en)	1998-09-29	2001-09-11	Neurogen Corporation	2-(2, 3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands
US6284759B1 (en)	1998-09-30	2001-09-04	Neurogen Corporation	2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
US6107313A (en) *	1998-10-02	2000-08-22	Combichem, Inc.	Dopamine receptor antagonists
GB9915616D0 (en) *	1999-07-05	1999-09-01	Knoll Ag	Therapeutic agents
KR100394083B1 (ko) *	2000-12-04	2003-08-06	학교법인 성신학원	도파민 ｄ3 및 ｄ4 수용체의 선택적 활성을 지닌 신규4,5-디히드로이소옥사졸릴알킬피페라진 유도체와, 이의제조방법
WO2002066468A2 (en) *	2001-02-16	2002-08-29	Aventis Pharmaceuticals Inc.	Heterocyclic urea derivatives and their use as dopamine d3 receptor ligands
IL157412A0 (en) *	2001-02-16	2004-03-28	Aventis Pharmaceuticals Inc Av	Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands
PL364625A1 (en) *	2001-02-23	2004-12-13	Merck & Co, Inc.	N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
AU2003236720A1 (en) *	2002-06-14	2003-12-31	Altana Pharma Ag	Substituted diaminopyrimidines
US20070179161A1 (en) *	2003-03-31	2007-08-02	Vernalis (Cambridge) Limited.	Pyrazolopyrimidine compounds and their use in medicine
US7592360B2 (en)	2003-06-04	2009-09-22	Merck & Co., Inc.	3-fluoro-piperidines as NMDA/NR2B antagonists
US7196928B2 (en) *	2005-04-05	2007-03-27	Sandisk Corporation	Compensating for coupling during read operations of non-volatile memory
JO2769B1 (en)	2005-10-26	2014-03-15	جانسين فارماسوتيكا ان. في	Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
US7855194B2 (en) *	2006-03-27	2010-12-21	Hoffmann-La Roche Inc.	Pyrimidine, quinazoline, pteridine and triazine derivatives
CN101553256B (zh)	2006-11-01	2013-01-30	普渡制药公司	苯基丙酰胺化合物及其用途
JO2642B1 (en) *	2006-12-08	2012-06-17	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en)	2007-02-13	2015-03-15	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
WO2008128994A1 (en) *	2007-04-23	2008-10-30	Janssen Pharmaceutica N.V.	Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists
AU2008240729B2 (en) *	2007-04-23	2012-08-23	Janssen Pharmaceutica N.V.	Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
KR20100016620A (ko)	2007-04-23	2010-02-12	얀센 파마슈티카 엔.브이.	속해리성 도파민 2 수용체 길항제로서의 4-알콕시피리다진 유도체
CA2730774C (en)	2008-07-31	2016-09-13	Janssen Pharmaceutica Nv	Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists
JP2013517273A (ja) *	2010-01-13	2013-05-16	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー	化合物および方法
KR102043337B1 (ko)	2014-08-28	2019-11-11	아셰뉴론 에스아	글리코시다제 저해제
CN106243088B (zh)	2015-06-03	2019-01-04	广东东阳光药业有限公司	取代的哌嗪化合物及其使用方法和用途
KR20180132629A (ko)	2016-02-25	2018-12-12	아셰뉴론 에스아	글리코시다제 저해제
CA3014572C (en)	2016-02-25	2023-10-03	Asceneuron S.A.	Acid addition salts of piperazine derivatives
AU2017222964B2 (en)	2016-02-25	2020-01-02	Asceneuron S. A.	Glycosidase inhibitors
US11261183B2 (en)	2016-02-25	2022-03-01	Asceneuron Sa	Sulfoximine glycosidase inhibitors
US11542248B2 (en) *	2017-06-08	2023-01-03	Kura Oncology, Inc.	Methods and compositions for inhibiting the interaction of menin with MLL proteins
US11213525B2 (en)	2017-08-24	2022-01-04	Asceneuron Sa	Linear glycosidase inhibitors
US11649251B2 (en)	2017-09-20	2023-05-16	Kura Oncology, Inc.	Substituted inhibitors of menin-MLL and methods of use
WO2020039027A1 (en)	2018-08-22	2020-02-27	Asceneuron S. A.	Pyrrolidine glycosidase inhibitors
WO2020039029A1 (en)	2018-08-22	2020-02-27	Asceneuron S. A.	Spiro compounds as glycosidase inhibitors
JP7407171B2 (ja)	2018-08-22	2023-12-28	エースニューロン・ソシエテ・アノニム	グリコシダーゼ阻害剤として有用なピペラジン誘導体のコハク酸付加塩及びフマル酸付加塩
WO2020039028A1 (en)	2018-08-22	2020-02-27	Asceneuron S. A.	Tetrahydro-benzoazepine glycosidase inhibitors
TWI716107B (zh) *	2018-09-26	2021-01-11	美商美國禮來大藥廠	6-氟-2-甲基苯并[d]噻唑-5-基化合物
EP4087574A4 (de) *	2020-03-06	2024-01-17	National Health Research Institutes	Pyrimidinverbindungen und deren pharmazeutische verwendungen

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HU206337B (en) *	1988-12-29	1992-10-28	Mitsui Petrochemical Ind	Process for producing pyrimidine derivatives and pharmaceutical compositions
US5681956A (en) *	1990-12-28	1997-10-28	Neurogen Corporation	4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
GB9216298D0 (en) *	1991-08-15	1992-09-16	Ici Plc	Piperidine derivatives
SI9300097B (en) *	1992-02-27	2001-12-31	Janssen Pharmaceutica Nv	(benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines

1997
- 1997-05-01 TW TW086105766A patent/TW504510B/zh active
- 1997-05-02 HU HU9903445A patent/HUP9903445A3/hu unknown
- 1997-05-02 JP JP54053697A patent/JP4264135B2/ja not_active Expired - Lifetime
- 1997-05-02 US US09/180,364 patent/US6159982A/en not_active Expired - Lifetime
- 1997-05-02 EP EP97923914A patent/EP0912552B1/de not_active Expired - Lifetime
- 1997-05-02 CA CA002253429A patent/CA2253429C/en not_active Expired - Fee Related
- 1997-05-02 IL IL12696997A patent/IL126969A/xx not_active IP Right Cessation
- 1997-05-02 PL PL97329850A patent/PL187769B1/pl not_active IP Right Cessation
- 1997-05-02 WO PCT/EP1997/002506 patent/WO1997043279A1/en not_active Ceased
- 1997-05-02 DE DE69728768T patent/DE69728768T2/de not_active Expired - Lifetime
- 1997-05-02 NZ NZ332308A patent/NZ332308A/xx unknown
- 1997-05-02 ES ES97923914T patent/ES2221052T3/es not_active Expired - Lifetime
- 1997-05-02 KR KR10-1998-0707915A patent/KR100462524B1/ko not_active Expired - Fee Related
- 1997-05-02 AT AT97923914T patent/ATE264853T1/de not_active IP Right Cessation
- 1997-05-02 CN CNB971945160A patent/CN1134431C/zh not_active Expired - Lifetime
- 1997-05-02 CZ CZ19983627A patent/CZ289250B6/cs not_active IP Right Cessation
- 1997-05-07 MY MYPI97002019A patent/MY116114A/en unknown
- 1997-05-09 ZA ZA974050A patent/ZA974050B/xx unknown
1998
- 1998-11-09 NO NO19985228A patent/NO317179B1/no unknown
2000
- 2000-09-22 US US09/667,458 patent/US6395742B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69728768D1 (de)	2004-05-27
NO985228D0 (no)	1998-11-09
IL126969A0 (en)	1999-09-22
AU2956197A (en)	1997-12-05
MY116114A (en)	2003-11-28
CA2253429C (en)	2006-08-08
ATE264853T1 (de)	2004-05-15
JP2000512623A (ja)	2000-09-26
IL126969A (en)	2003-01-12
ES2221052T3 (es)	2004-12-16
CZ289250B6 (cs)	2001-12-12
JP4264135B2 (ja)	2009-05-13
HUP9903445A3 (en)	2002-01-28
CZ362798A3 (cs)	1999-02-17
TW504510B (en)	2002-10-01
US6159982A (en)	2000-12-12
CN1218466A (zh)	1999-06-02
EP0912552B1 (de)	2004-04-21
HUP9903445A2 (hu)	2000-05-28
NO317179B1 (no)	2004-09-06
CN1134431C (zh)	2004-01-14
NZ332308A (en)	1999-08-30
KR100462524B1 (ko)	2005-06-13
PL329850A1 (en)	1999-04-12
CA2253429A1 (en)	1997-11-20
US6395742B1 (en)	2002-05-28
AU708344B2 (en)	1999-08-05
KR20000005228A (ko)	2000-01-25
WO1997043279A1 (en)	1997-11-20
EP0912552A1 (de)	1999-05-06
PL187769B1 (pl)	2004-10-29
DE69728768T2 (de)	2005-04-28
NO985228L (no)	1999-01-11

Publication	Publication Date	Title
ZA974050B (en)	1998-11-09	2,4-Diaminopyrimidine derivatives
TW257757B (de)	1995-09-21
EG20281A (en)	1998-07-30	Process for preparing heterocyclic cyclic amine derivatives useful in enhancing memory in patients suffering from dementia and alzheimer's disease
ZA919181B (en)	1992-08-26	Oxazolopyridine derivatives,processes for preparing these and pharmaceutical compositions containing them
HUP0204283A2 (hu)	2003-04-28	(Kinolil-propil)-piperidin-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
DK282188A (da)	1988-11-26	Cykliske aminderivater, laegemidler indeholdende forbindelserne og fremgangsmaader til deres fremstilling
IL83629A0 (en)	1988-01-31	Alpha-alkyl-4-amino-3-quinoline-methanols and 1-(4-aralkylamino-3-quinolinyl)alkanones,a process for their preparation and pharmaceutical compositions containing them
TR200101155T2 (tr)	2001-09-21	4-Aroil Piperidin CCR-3 Reseptör Antagonistleri III
PL322768A1 (en)	1998-02-16	Novel derivatives of aryloglysinamide, methods of obtaining them and pharmaceutic compositions containing such compounds
ES8402559A1 (es)	1984-02-01	Un procedimiento para preparar nuevos compuestos peptidicos.
IL107961A0 (en)	1994-04-12	Phenoxy- and phenoxyalkyl-piperidines and pharmaceutical compositions containing them
MY117852A (en)	2004-08-30	Alkylaminobenzothiazole and- benzoxazole derivatives
BG104069A (en)	2001-05-31	2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor
NO158578C (no)	1988-10-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3,1-benzoksazin-2-on-derivater.
IL63381A0 (en)	1981-10-30	5-substituted 5,10-dihydro-11h-dibenzo(b,e)(1,4)diazepin-11-one derivatives,their preparation and pharmaceutical compositions containing them
DK669187A (da)	1988-06-21	Kondenserede diazepinoner, fremgangsmaade til deresfremstilling og laegemidler indeholdende forbindelserne
IL71068A (en)	1988-05-31	N-(3-trifluoromethylphenyl)-n'-propargyl-piperazine,its preparation and pharmaceutical compositions containing it
NZ215439A (en)	1990-03-27	Benzo(c) 1,5 naphthyridines and pharmaceutical compositions
GB9908021D0 (en)	1999-06-02	Pharmaceutical compounds
CS548987A2 (en)	1988-09-16	Process for preparing new tetracycline derivatives of indole
ZA909557B (en)	1991-09-25	Substituted benzothiazolinones,process for preparing these and pharmaceutical compositions containing them
HUT59399A (en)	1992-05-28	Process for producing substituted 3-aminosydnone imine derivatives and pharmaceutical compositions comprising same