ZA974886B - Novel dibenzo-oxazepine and -dioxepine derivatives. - Google Patents

Novel dibenzo-oxazepine and -dioxepine derivatives.

Info

Publication number: ZA974886B
Authority: ZA; South Africa
Prior art keywords: lower alkyl; oxazepine; substituted; unsubstituted; dioxepine
Prior art date: 1996-06-07

Application number

ZA9704886A

Other languages

English (en)

Inventor

Urvashi Hooda Dhingra

Haruyoshi Shirai

Yuki Takehana

Peter Michael Wovkulich

Nami Yabuki

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-07

Filing date

1997-06-03

Publication date

1997-12-08

1997-06-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1997-12-08 Publication of ZA974886B publication Critical patent/ZA974886B/xx

Links

125000000217 alkyl group Chemical group 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
241000228257 Aspergillus sp. Species 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
125000000524 functional group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D267/20—[b, f]-condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Motorcycle And Bicycle Frame (AREA)
Rehabilitation Tools (AREA)

ZA9704886A 1996-06-07 1997-06-03 Novel dibenzo-oxazepine and -dioxepine derivatives. ZA974886B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP96109115		1996-06-07

Publications (1)

Publication Number	Publication Date
ZA974886B true ZA974886B (en)	1997-12-08

Family

ID=8222857

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9704886A ZA974886B (en)	1996-06-07	1997-06-03	Novel dibenzo-oxazepine and -dioxepine derivatives.

Country Status (29)

Country	Link
US (1)	US5811420A (de)
EP (1)	EP0906295B1 (de)
JP (1)	JP3199752B2 (de)
KR (1)	KR100300152B1 (de)
CN (1)	CN1072650C (de)
AT (1)	ATE207471T1 (de)
AU (1)	AU725649B2 (de)
BR (1)	BR9709773A (de)
CA (1)	CA2257422A1 (de)
CO (1)	CO4940487A1 (de)
CZ (1)	CZ397498A3 (de)
DE (1)	DE69707672T2 (de)
DK (1)	DK0906295T3 (de)
ES (1)	ES2166087T3 (de)
HR (1)	HRP970313A2 (de)
HU (1)	HUP0001792A3 (de)
IL (1)	IL127137A0 (de)
MA (1)	MA24197A1 (de)
NO (1)	NO985685L (de)
NZ (1)	NZ332997A (de)
PE (1)	PE69598A1 (de)
PL (1)	PL330346A1 (de)
PT (1)	PT906295E (de)
RU (1)	RU2167871C2 (de)
TR (1)	TR199802517T2 (de)
UY (1)	UY24578A1 (de)
WO (1)	WO1997047611A1 (de)
YU (1)	YU55898A (de)
ZA (1)	ZA974886B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AUPQ307399A0 (en) *	1999-09-24	1999-10-21	Luminis Pty Limited	Cell cycle control
CA2404540A1 (en) *	2002-09-20	2004-03-20	Institut Pasteur	A method for measuring a marker indicative of the exposure of a patient to nicotine; a kit for measuring such a marker
KR100794856B1 (ko) *	2003-11-07	2008-01-14	에프. 호프만-라 로슈 아게	벤조[ｂ][1,4]다이옥세핀 유도체
WO2012012498A2 (en)	2010-07-20	2012-01-26	Pulmatrix, Inc.	Use of trp channel agonists to treat infections
CN109722389B (zh) *	2017-10-31	2021-05-14	鲁南新时代生物技术有限公司	一种烟曲霉菌液体培养基
CN108165590B (zh) *	2017-12-20	2021-11-23	河南科技学院	一种烟曲霉发酵产烟曲霉素的培养基及培养方法
WO2022187611A1 (en) *	2021-03-04	2022-09-09	Lifemine Therapeutics	Cdk inhibitor compounds for use in methods of treatment
WO2025221647A1 (en) *	2024-04-17	2025-10-23	Lifemine Therapeutics, Inc.	Tricyclic compounds and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5173486A (en) *	1991-08-26	1992-12-22	Bristol-Myers Squibb Company	Dibenz[b,f][1,4]oxazepin-11(10H)-ones for multidrug resistance reversing agents
GB9120640D0 (en) *	1991-09-27	1991-11-06	Ici Plc	Tricyclic heterocycles
US5350763A (en) *	1993-06-11	1994-09-27	Merck & Co., Inc.	Unguinol and analogs are animal growth permittants
JPH0769882A (ja) *	1993-08-27	1995-03-14	Nippon Paint Co Ltd	エプスタイン−バーウィルス活性化抑制剤
ZA947969B (en) *	1993-10-15	1996-07-12	Schering Corp	Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

1997
- 1997-05-30 WO PCT/EP1997/002806 patent/WO1997047611A1/en not_active Ceased
- 1997-05-30 DE DE69707672T patent/DE69707672T2/de not_active Expired - Fee Related
- 1997-05-30 RU RU99100107/04A patent/RU2167871C2/ru not_active IP Right Cessation
- 1997-05-30 AU AU31696/97A patent/AU725649B2/en not_active Ceased
- 1997-05-30 HU HU0001792A patent/HUP0001792A3/hu unknown
- 1997-05-30 CA CA002257422A patent/CA2257422A1/en not_active Abandoned
- 1997-05-30 PL PL97330346A patent/PL330346A1/xx unknown
- 1997-05-30 YU YU55898A patent/YU55898A/sh unknown
- 1997-05-30 ES ES97927080T patent/ES2166087T3/es not_active Expired - Lifetime
- 1997-05-30 DK DK97927080T patent/DK0906295T3/da active
- 1997-05-30 NZ NZ332997A patent/NZ332997A/xx unknown
- 1997-05-30 CN CN97195242A patent/CN1072650C/zh not_active Expired - Fee Related
- 1997-05-30 CZ CZ983974A patent/CZ397498A3/cs unknown
- 1997-05-30 PT PT97927080T patent/PT906295E/pt unknown
- 1997-05-30 EP EP97927080A patent/EP0906295B1/de not_active Expired - Lifetime
- 1997-05-30 PE PE1997000457A patent/PE69598A1/es not_active Application Discontinuation
- 1997-05-30 TR TR1998/02517T patent/TR199802517T2/xx unknown
- 1997-05-30 KR KR1019980710016A patent/KR100300152B1/ko not_active Expired - Fee Related
- 1997-05-30 BR BR9709773A patent/BR9709773A/pt not_active Application Discontinuation
- 1997-05-30 IL IL12713797A patent/IL127137A0/xx not_active IP Right Cessation
- 1997-05-30 AT AT97927080T patent/ATE207471T1/de not_active IP Right Cessation
- 1997-05-30 JP JP50112498A patent/JP3199752B2/ja not_active Expired - Fee Related
- 1997-06-03 ZA ZA9704886A patent/ZA974886B/xx unknown
- 1997-06-05 UY UY24578A patent/UY24578A1/es unknown
- 1997-06-05 CO CO97031203A patent/CO4940487A1/es unknown
- 1997-06-05 MA MA24647A patent/MA24197A1/fr unknown
- 1997-06-06 US US08/870,798 patent/US5811420A/en not_active Expired - Fee Related
- 1997-06-06 HR HR96109115.4A patent/HRP970313A2/xx not_active Application Discontinuation
1998
- 1998-12-04 NO NO985685A patent/NO985685L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2166087T3 (es)	2002-04-01
CZ397498A3 (cs)	1999-03-17
JP3199752B2 (ja)	2001-08-20
WO1997047611A1 (en)	1997-12-18
EP0906295B1 (de)	2001-10-24
UY24578A1 (es)	2000-12-29
JPH11511760A (ja)	1999-10-12
NO985685D0 (no)	1998-12-04
KR20000016432A (ko)	2000-03-25
HUP0001792A3 (en)	2001-10-29
US5811420A (en)	1998-09-22
TR199802517T2 (xx)	1999-02-22
CO4940487A1 (es)	2000-07-24
AU3169697A (en)	1998-01-07
KR100300152B1 (ko)	2001-09-06
CN1072650C (zh)	2001-10-10
MA24197A1 (fr)	1997-12-31
PT906295E (pt)	2002-04-29
IL127137A0 (en)	1999-09-22
CN1221409A (zh)	1999-06-30
HK1019063A1 (en)	2000-01-21
EP0906295A1 (de)	1999-04-07
HRP970313A2 (en)	1998-04-30
NZ332997A (en)	2000-05-26
PL330346A1 (en)	1999-05-10
CA2257422A1 (en)	1997-12-18
YU55898A (sh)	2001-12-26
NO985685L (no)	1999-02-04
ATE207471T1 (de)	2001-11-15
PE69598A1 (es)	1998-11-14
DE69707672D1 (de)	2001-11-29
HUP0001792A2 (hu)	2000-12-28
DK0906295T3 (da)	2002-02-11
RU2167871C2 (ru)	2001-05-27
BR9709773A (pt)	1999-08-10
DE69707672T2 (de)	2002-08-08
AU725649B2 (en)	2000-10-19

Publication	Publication Date	Title
AU563960B2 (en)	1987-07-30	Substituted 1-hydroxyethyl-triazolyl derivatives
DK0923554T3 (da)	2002-04-29	N-Benzylpiperidin- og tetrahydropyridinderivater
PL343439A1 (en)	2001-08-13	Semi-synthetic ecteinascidins
TR199902897T2 (xx)	2000-05-22	S�v� benz-izo-kuinolin t�revleri.
EA200200558A1 (ru)	2002-12-26	2-( 1h-индол-3-ил)-2-оксоацетамиды, обладающие противоопухолевой активностью
PL309874A1 (en)	1996-02-05	Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
FI922561A0 (fi)	1992-06-03	Derivat av 1-metylkarbapenem, deras framstaellning och anvaendning som antibiotika.
DE69529619D1 (en)	2003-03-20	Pyrimidinylpyrazolderivate
ZA974886B (en)	1997-12-08	Novel dibenzo-oxazepine and -dioxepine derivatives.
AU576887B2 (en)	1988-09-08	1,6-naphthyridine derivatives
NO994104L (no)	1999-10-26	5-hydroksymetyl-2-aminotetraliner i form av kardiovaskulaere midler
ZA879186B (en)	1988-06-06	2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene pgi2 derivatives
ES479444A1 (es)	1979-11-16	Un procedimiento para preparar derivados de pirrolidincarbo-xaldehido y piperidicarboxaldehido.
AU2971997A (en)	1998-01-07	Intermediates for oligonucleotide synthesis
EP0273017A3 (en)	1989-03-01	N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline, process for their preparation and pharmaceutical compositions having antihypertensive activity containing same
AU8714082A (en)	1983-03-03	N-substituted-tetrahydroisophthalimide derivatives