ZA97676B - Method for inducing death of neoplastic cells using piperazine derivatives. - Google Patents

Method for inducing death of neoplastic cells using piperazine derivatives.

Info

Publication number: ZA97676B
Authority: ZA; South Africa
Prior art keywords: neoplastic cells; piperazine derivatives; inducing death; death; inducing
Prior art date: 1996-01-26

Application number

ZA9700676A

Other languages

English (en)

Inventor

Gabriel F Eilon

John W Jacobs

Original Assignee

Hitachi Chemical Co Ltd

Hitachi Chemical Res Ct Inc

Nippon Chemiphar Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-26

Filing date

1997-01-27

Publication date

1997-08-25

1997-01-27 Application filed by Hitachi Chemical Co Ltd, Hitachi Chemical Res Ct Inc, Nippon Chemiphar Co filed Critical Hitachi Chemical Co Ltd

1997-08-25 Publication of ZA97676B publication Critical patent/ZA97676B/xx

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA9700676A 1996-01-26 1997-01-27 Method for inducing death of neoplastic cells using piperazine derivatives. ZA97676B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/592,540 US5733911A (en)	1996-01-26	1996-01-26	Method for inducing death of neoplastic cells using piperazne derivatives

Publications (1)

Publication Number	Publication Date
ZA97676B true ZA97676B (en)	1997-08-25

Family

ID=24371096

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9700676A ZA97676B (en)	1996-01-26	1997-01-27	Method for inducing death of neoplastic cells using piperazine derivatives.

Country Status (14)

Country	Link
US (3)	US5733911A (de)
EP (1)	EP0877614B1 (de)
JP (1)	JP4117404B2 (de)
KR (1)	KR100468271B1 (de)
CN (1)	CN1220490C (de)
AR (1)	AR005569A1 (de)
AT (1)	ATE219676T1 (de)
AU (1)	AU731125B2 (de)
CA (1)	CA2242657A1 (de)
DE (1)	DE69713570T2 (de)
ID (1)	ID18975A (de)
TW (1)	TW475897B (de)
WO (1)	WO1997026881A1 (de)
ZA (1)	ZA97676B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0826681B1 (de) *	1995-03-31	2002-10-09	Nippon Chemiphar Co., Ltd.	Derivate der epoxybernsteinsäure
US5733911A (en) *	1996-01-26	1998-03-31	Hitachi Chemical Co., Ltd.	Method for inducing death of neoplastic cells using piperazne derivatives
EP1342720A3 (de) *	1997-09-04	2004-02-11	Nippon Chemiphar Co., Ltd.	Epoxysuccinamid-Derivate
EP1094063A1 (de) *	1999-10-18	2001-04-25	Applied Research Systems ARS Holding N.V.	9-(Piperazinylalkyl)carbazole als Bax-Modulatoren
US6376514B1 (en)	2000-10-17	2002-04-23	The Procter & Gamble Co.	Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en)	2000-10-17	2004-02-17	The Procter & Gamble Company	Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
ATE358672T1 (de) *	2000-10-23	2007-04-15	Arizona Biomedical Res Commiss	Antitumor verbindungen basierend auf der regulierung von protein prenylation
WO2003044535A1 (en) *	2001-11-22	2003-05-30	Mehmet Ozturk	Method, antigen and antibody for distinguishing viable and apoptotic cells
CN112472699A (zh)	2013-07-26	2021-03-12	种族肿瘤学公司	改善比生群及衍生物的治疗益处的组合方法
PL407922A1 (pl) *	2014-04-16	2015-10-26	Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością	Nowe bisfosfoniany i ich zastosowanie

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS55115878A (en) *	1979-02-27	1980-09-06	Taisho Pharmaceut Co Ltd	Epoxysuccinic acid derivative
JPS55153778A (en) *	1979-05-17	1980-11-29	Taisho Pharmaceut Co Ltd	Epoxysuccinylamino acid derivative
US4474800A (en) *	1980-05-13	1984-10-02	Taisho Pharmaceutical Co., Ltd.	Epoxysuccinyl amino acid derivatives
JPS57169478A (en) *	1981-04-10	1982-10-19	Nippon Chemiphar Co Ltd	Piperazine derivative
JPS6276A (ja) *	1985-03-26	1987-01-06	Toyo Jozo Co Ltd	酵素阻害性新規物質
JPH0832698B2 (ja) *	1987-05-08	1996-03-29	日本ケミファ株式会社	ピペラジン誘導体
WO1991009851A1 (fr) *	1989-12-27	1991-07-11	Japan Tobacco Inc.	Derive d'oxyde de 1,3,2-dioxathiolane
WO1993006143A1 (fr) *	1991-09-19	1993-04-01	Cray Valley Sa	Resines de petrole thermiquement stables, leur procede de preparation et leur application a la formulation d'adhesifs thermofusibles
JPH0641067A (ja) *	1992-04-20	1994-02-15	Kitasato Inst:The	新規カルパイン阻害物質ｋｐ−１２４１及びその製造法
DK0603769T3 (da) *	1992-12-25	1999-06-14	Mitsubishi Chem Corp	Alfa-aminoketonderivater
US5733911A (en) *	1996-01-26	1998-03-31	Hitachi Chemical Co., Ltd.	Method for inducing death of neoplastic cells using piperazne derivatives

1996
- 1996-01-26 US US08/592,540 patent/US5733911A/en not_active Expired - Fee Related
1997
- 1997-01-24 DE DE69713570T patent/DE69713570T2/de not_active Expired - Fee Related
- 1997-01-24 KR KR10-1998-0705786A patent/KR100468271B1/ko not_active Expired - Fee Related
- 1997-01-24 AU AU18402/97A patent/AU731125B2/en not_active Ceased
- 1997-01-24 CN CNB971926689A patent/CN1220490C/zh not_active Expired - Fee Related
- 1997-01-24 EP EP97903981A patent/EP0877614B1/de not_active Expired - Lifetime
- 1997-01-24 WO PCT/US1997/001231 patent/WO1997026881A1/en not_active Ceased
- 1997-01-24 AT AT97903981T patent/ATE219676T1/de active
- 1997-01-24 JP JP52706097A patent/JP4117404B2/ja not_active Expired - Fee Related
- 1997-01-24 CA CA002242657A patent/CA2242657A1/en not_active Abandoned
- 1997-01-27 ZA ZA9700676A patent/ZA97676B/xx unknown
- 1997-01-27 ID IDP970229A patent/ID18975A/id unknown
- 1997-01-27 AR ARP970100324A patent/AR005569A1/es not_active Application Discontinuation
- 1997-03-14 TW TW086103221A patent/TW475897B/zh not_active IP Right Cessation
- 1997-12-10 US US08/987,816 patent/US5859013A/en not_active Expired - Fee Related
- 1997-12-10 US US08/988,056 patent/US6054437A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU1840297A (en)	1997-08-20
ATE219676T1 (de)	2002-07-15
JP4117404B2 (ja)	2008-07-16
ID18975A (id)	1998-05-28
AU731125B2 (en)	2001-03-22
JP2000505792A (ja)	2000-05-16
EP0877614B1 (de)	2002-06-26
US6054437A (en)	2000-04-25
EP0877614A1 (de)	1998-11-18
US5733911A (en)	1998-03-31
CN1220490C (zh)	2005-09-28
CN1212623A (zh)	1999-03-31
DE69713570T2 (de)	2003-01-23
TW475897B (en)	2002-02-11
AR005569A1 (es)	1999-06-23
DE69713570D1 (de)	2002-08-01
CA2242657A1 (en)	1997-07-31
WO1997026881A1 (en)	1997-07-31
KR100468271B1 (ko)	2005-07-05
KR19990082064A (ko)	1999-11-15
US5859013A (en)	1999-01-12

Publication	Publication Date	Title
ZA978194B (en)	1999-03-03	Piperazine derivatives
ZA964101B (en)	1996-07-29	Piperazine derivatives
IL117866A0 (en)	1996-08-04	Substituted piperazine derivatives
IS3970A (is)	1993-07-22	Hliðstæð aðferð til framleiðslu á 1,5-benzódíazepín afleiðum
PL338075A1 (en)	2000-09-25	Derivatives of piperazine
GB9514901D0 (en)	1995-09-20	Piperazine derivatives
ZA97676B (en)	1997-08-25	Method for inducing death of neoplastic cells using piperazine derivatives.
GB2277517B (en)	1996-09-11	Piperazine derivatives
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CY2392B1 (en)	2004-09-10	Method for the preparation of alpha-bromolactam derivatives.
ZA941422B (en)	1995-09-01	Method for inducing tumor cell death
GB9405533D0 (en)	1994-05-04	Heterocyclic derivatives
HUP9903870A3 (en)	2002-01-28	Piperazine derivatives and process for the preparation thereof
GB9623283D0 (en)	1997-01-08	Heterocyclic derivatives
GB9820312D0 (en)	1998-11-11	(3-Oxoisoindolin-1-ylidine)propandinitrile derivatives and method for preparing the same
GB9412708D0 (en)	1994-08-17	Piperazine derivatives
IL125936A0 (en)	1999-04-11	Piperazine derivatives
GB9402010D0 (en)	1994-03-30	Piperazine derivatives
GB9525841D0 (en)	1996-02-21	Piperazine derivatives
AUPO268396A0 (en)	1996-10-24	Piperazine derivatives
AUPN989196A0 (en)	1996-06-06	Piperazine derivatives
ZA976543B (en)	1998-04-29	Piperazine derivatives and process for the preparation thereof.
IL112180A0 (en)	1995-03-15	Slippers for all seasons
SI1032557T1 (en)	2004-02-29	Method for preparing bromomethyl-biphenyl derivatives