ZA977209B - Thrombin inhibitors. - Google Patents

Thrombin inhibitors.

Info

Publication number: ZA977209B
Authority: ZA; South Africa
Prior art keywords: thrombin inhibitors; thrombin; inhibitors
Prior art date: 1996-08-23

Application number

ZA9707209A

Other languages

English (en)

Inventor

Constant Adriaan Anton Boeckel

Anton Egbert Peter Adang

Jacobus Albertus Maria Peters

Johannes Bernardus Ma Rewinkel

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-23

Filing date

1997-08-12

Publication date

1998-02-20

1997-08-12 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

1998-02-20 Publication of ZA977209B publication Critical patent/ZA977209B/xx

Links

229940122388 Thrombin inhibitor Drugs 0.000 title 1
239000003868 thrombin inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA9707209A 1996-08-23 1997-08-12 Thrombin inhibitors. ZA977209B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP96202336		1996-08-23

Publications (1)

Publication Number	Publication Date
ZA977209B true ZA977209B (en)	1998-02-20

Family

ID=8224306

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9707209A ZA977209B (en)	1996-08-23	1997-08-12	Thrombin inhibitors.

Country Status (10)

Country	Link
EP (1)	EP0956293B1 (de)
AR (1)	AR009302A1 (de)
AT (1)	ATE282629T1 (de)
AU (1)	AU4618197A (de)
DE (1)	DE69731664D1 (de)
ID (1)	ID18075A (de)
IL (1)	IL121474A0 (de)
TW (1)	TW515803B (de)
WO (1)	WO1998007308A2 (de)
ZA (1)	ZA977209B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0884325A1 (de) *	1997-04-24	1998-12-16	Akzo Nobel N.V.	Inhibitoren des Thrombins, die einen peptid-Heterocyclus aufweisen
US5877156A (en) *	1997-04-24	1999-03-02	Akzo Nobel, N.V.	Thrombin inhibitors
GB0507577D0 (en)	2005-04-14	2005-05-18	Novartis Ag	Organic compounds
CA2651762A1 (en)	2006-05-23	2007-11-29	Irm Llc	Compounds and compositions as channel activating protease inhibitors
JP5270538B2 (ja) *	2006-05-23	2013-08-21	アイアールエム・リミテッド・ライアビリティ・カンパニー	チャネル活性化プロテアーゼ阻害剤としての化合物および組成物
AU2008214217B2 (en)	2007-02-09	2011-10-13	Irm Llc	Compounds and compositions as channel activating protease inhibitors
CN117143179B (zh) *	2023-09-18	2024-07-12	安徽峆一药业股份有限公司	一种凝血酶发色底物s-2238的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5672582A (en) *	1993-04-30	1997-09-30	Merck & Co., Inc.	Thrombin inhibitors
SE9301916D0 (sv) *	1993-06-03	1993-06-03	Ab Astra	New peptides derivatives
IL112795A (en) *	1994-03-04	2001-01-28	Astrazeneca Ab	Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them
JPH10513151A (ja) *	1994-12-22	1998-12-15	バイオケムファーマインコーポレイテッド	トロンビン阻害剤としての複素環式ケトアルギニンペプチド
US5827860A (en) *	1995-06-07	1998-10-27	Ortho Pharmaceutical Corporation	Peptidyl heterocycles useful in the treatment of thrombin related disorders
IL119466A (en) *	1995-11-03	2001-08-26	Akzo Nobel Nv	Thrombin inhibitors, their preparation and pharmaceutical compositions containing them

1997
- 1997-08-05 IL IL12147497A patent/IL121474A0/xx unknown
- 1997-08-12 ZA ZA9707209A patent/ZA977209B/xx unknown
- 1997-08-19 AU AU46181/97A patent/AU4618197A/en not_active Abandoned
- 1997-08-19 DE DE69731664T patent/DE69731664D1/de not_active Expired - Lifetime
- 1997-08-19 AT AT97944781T patent/ATE282629T1/de not_active IP Right Cessation
- 1997-08-19 WO PCT/EP1997/004579 patent/WO1998007308A2/en not_active Ceased
- 1997-08-19 EP EP97944781A patent/EP0956293B1/de not_active Expired - Lifetime
- 1997-08-22 AR ARP970103820A patent/AR009302A1/es unknown
- 1997-08-22 ID IDP972947A patent/ID18075A/id unknown
- 1997-08-30 TW TW086112645A patent/TW515803B/zh active

Also Published As

Publication number	Publication date
TW515803B (en)	2003-01-01
EP0956293A1 (de)	1999-11-17
DE69731664D1 (de)	2004-12-23
IL121474A0 (en)	1998-02-08
ID18075A (id)	1998-02-26
ATE282629T1 (de)	2004-12-15
EP0956293B1 (de)	2004-11-17
AR009302A1 (es)	2000-04-12
WO1998007308A3 (en)	2000-08-24
WO1998007308A2 (en)	1998-02-26
AU4618197A (en)	1998-03-06

Publication	Publication Date	Title
PL331338A1 (en)	1999-07-05	Thiosulphonamidic metaloprotease inhibitors
IL128663A0 (en)	2000-01-31	1,4-heterocyclic metalloprotease inhibitors
IL128661A0 (en)	2000-01-31	1,3-diheterocyclic metalloprotease inhibitors
IL127751A0 (en)	1999-10-28	Thrombin inhibitors
PL328307A1 (en)	1999-01-18	Serinic protease inhibitors
ZA9811794B (en)	1999-06-29	Ace inhibitor-MMP inhibitor combinations.
PL331803A1 (en)	1999-08-02	Bidonoric metaloprotease inhibitors
PL328875A1 (en)	1999-03-01	Serinic protease inhibitors
PL328223A1 (en)	1999-01-18	Aspartil protease inhibitors
IL136139A0 (en)	2001-05-20	Thrombin inhibitors
AU3396697A (en)	1998-04-14	Thrombin inhibitor
GB9613718D0 (en)	1996-08-28	Thrombin inhibitors
ZA977209B (en)	1998-02-20	Thrombin inhibitors.
ZA974779B (en)	1997-12-01	Thrombin inhibitors.
EP1027333A4 (de)	2000-11-08	Thrombin-inhibitoren
ZA968968B (en)	1997-10-31	Selective thrombin inhibitors.
GB9624292D0 (en)	1997-01-08	Thrombin inhibitors
GB9624319D0 (en)	1997-01-08	Thrombin inhibitors
GB9625311D0 (en)	1997-01-22	Thrombin inhibitors
GB9605163D0 (en)	1996-05-15	Thrombin inhibitors
GB9624278D0 (en)	1997-01-08	Thrombin inhibitors
SI0956294T1 (en)	2004-10-31	Thrombin inhibitors
ZA973437B (en)	1997-10-23	Pyrazinone thrombin inhibitors.
ZA961276B (en)	1997-08-19	Novel thrombin inhibitors.
ZA941932B (en)	1994-10-18	Guanidinyl-substituted heterocyclic thrombin inhibitors.