ZA979268B - L-tartaric acid salt of a(1r) diastereomer of a 2-azadihy-droxybicyclo [2.2.1]heptane compound and the preparation of 2-azabicyclo[2.2.1] heptane compounds - Google Patents

L-tartaric acid salt of a(1r) diastereomer of a 2-azadihy-droxybicyclo [2.2.1]heptane compound and the preparation of 2-azabicyclo[2.2.1] heptane compounds

Info

Publication number: ZA979268B
Authority: ZA; South Africa
Prior art keywords: heptane; droxybicyclo; azadihy; azabicyclo; diastereomer
Prior art date: 1996-10-16

Application number

ZA979268A

Other languages

English (en)

Inventor

Michael O'brien

Patrick Leon

Denis Largeau

Matthew Powers

Thierry Durand

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-16

Filing date

1997-10-16

Publication date

1998-07-27

1997-10-16 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1998-07-27 Publication of ZA979268B publication Critical patent/ZA979268B/xx

Links

GYLMCBOAXJVARF-UHFFFAOYSA-N 3-azabicyclo[2.2.1]heptane Chemical class C1C2CCC1NC2 GYLMCBOAXJVARF-UHFFFAOYSA-N 0.000 title 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical class OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 title 1
IMNFDUFMRHMDMM-UHFFFAOYSA-N anhydrous n-heptane Natural products CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 title 1
-1 heptane compound Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Indole Compounds (AREA)

ZA979268A 1996-10-16 1997-10-16 L-tartaric acid salt of a(1r) diastereomer of a 2-azadihy-droxybicyclo [2.2.1]heptane compound and the preparation of 2-azabicyclo[2.2.1] heptane compounds ZA979268B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/732,024 US5684159A (en)	1995-05-30	1996-10-16	L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds

Publications (1)

Publication Number	Publication Date
ZA979268B true ZA979268B (en)	1998-07-27

Family

ID=24941881

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA979268A ZA979268B (en)	1996-10-16	1997-10-16	L-tartaric acid salt of a(1r) diastereomer of a 2-azadihy-droxybicyclo [2.2.1]heptane compound and the preparation of 2-azabicyclo[2.2.1] heptane compounds

Country Status (21)

Country	Link
US (4)	US5684159A (fr)
EP (1)	EP0934268A4 (fr)
JP (1)	JP2001502329A (fr)
KR (1)	KR20000049195A (fr)
CN (2)	CN1094927C (fr)
AP (1)	AP942A (fr)
AU (1)	AU721965B2 (fr)
BG (2)	BG64701B1 (fr)
BR (1)	BR9711910A (fr)
CA (1)	CA2268652A1 (fr)
CZ (1)	CZ291387B6 (fr)
EA (3)	EA002438B1 (fr)
HU (1)	HUP9903583A3 (fr)
IL (1)	IL129231A (fr)
NO (2)	NO320332B1 (fr)
OA (1)	OA11112A (fr)
PL (1)	PL332827A1 (fr)
SK (1)	SK43799A3 (fr)
UA (1)	UA52702C2 (fr)
WO (1)	WO1998016510A1 (fr)
ZA (1)	ZA979268B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5684159A (en) *	1995-05-30	1997-11-04	Rhone-Poulenc Rorer S.A.	L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
EP0926136B1 (fr) *	1997-12-25	2004-05-12	Kuraray Co., Ltd.	Procédé de préparation et méthode de crystallisation de 2-azabicyclo(2.2.1)hept-5-ène-3-one
TW396337B (en) *	1998-02-13	2000-07-01	Mediatek Inc	The automatic regulating device of cdrom optimum focusing spot and the method thereof
US6057446A (en)	1998-04-02	2000-05-02	Crooks; Peter Anthony	Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds
US5952339A (en) *	1998-04-02	1999-09-14	Bencherif; Merouane	Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
US5986100A (en)	1998-04-02	1999-11-16	Crooks; Peter Anthony	Pharmaceutical compositions and methods for use
PT1140933E (pt)	1998-12-31	2004-12-31	Aventis Pharma Inc	Processo para preparar derivados n6-substituidos de desaza-adenosina
US6387033B1 (en) *	2000-11-22	2002-05-14	Council Of Scientific And Industrial Research	Preparation of new layered double hydroxides exchanged with osmate for asymmetric dihydroxylation of olefins to vicinal diols
EP1392690A2 (fr) *	2001-05-10	2004-03-03	Aventis Pharma Deutschland GmbH	Nouveaux procedes pour la preparation de composes d'adenosine et produits intermediaires de ces derniers
EP1574508A1 (fr) *	2004-01-30	2005-09-14	Lonza AG	Procédé pour la préparation d acetals et cétals de 3-amino-5-(hydroxymethyl)-cyclopentane -1,2-diols et leur derivés sels
JP5118053B2 (ja) *	2006-10-11	2013-01-16	日本曹達株式会社	アザビシクロアルカノール誘導体の製造方法
CN102311440B (zh) *	2010-07-02	2015-01-07	无锡药明康德生物技术有限公司	1-甲氧羰基-3-苄基-8-叔丁氧羰基-3,8-二氮杂双环[3.2.1]辛烷及制备方法

Family Cites Families (11)

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Publication number	Priority date	Publication date	Assignee	Title
SE435499B (sv) *	1974-12-13	1984-10-01	Merck & Co Inc	Diastereomert salt av s-1-t-butylamino-2,3-dihydroxipropan
US4508911A (en) *	1982-06-21	1985-04-02	The Upjohn Company	Amine intermediates for analgesic compounds
US5284769A (en) *	1989-10-16	1994-02-08	Chiros Ltd.	Process for preparing a single enantiomer of a lactam using lactamase
AU641712B2 (en) *	1989-12-13	1993-09-30	Noristan Holdings Limited	Polycyclic nitrile compounds and pharmaceutical compositions thereof
JP2891740B2 (ja) *	1990-03-30	1999-05-17	塩野義製薬株式会社	光学活性ノルボルナン系アミン誘導体の製造方法
AU654507B2 (en) *	1990-09-25	1994-11-10	Rhone-Poulenc Rorer International (Holdings) Inc.	Compounds having antihypertensive and anti-ischemic properties
US5700895A (en) *	1993-08-23	1997-12-23	Sumitomo Chemical Company, Limited	Ethylene-α-olefin copolymer and molded article thereof
US5684159A (en) *	1995-05-30	1997-11-04	Rhone-Poulenc Rorer S.A.	L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
US5670649A (en) *	1995-05-30	1997-09-23	Rhone-Poulenc Rorer S.A.	Derivatives of 2-azabicyclo 2.2.1!heptane, their preparation and their application
FR2734822B1 (fr) *	1995-05-30	1997-07-04	Rhone Poulenc Rorer Sa	Nouveaux derives du 2-azabicyclo(2.2.1)heptane, leur preparation et leur application
US5856497A (en) *	1995-12-11	1999-01-05	Boehringer Ingelheim Pharmaceuticals, Inc.	Asymmetric synthesis of α-cycloalkylalkyl substituted methanamines

1996
- 1996-10-16 US US08/732,024 patent/US5684159A/en not_active Expired - Fee Related
1997
- 1997-06-10 US US08/873,096 patent/US5886192A/en not_active Expired - Fee Related
- 1997-06-10 US US08/873,284 patent/US5831096A/en not_active Expired - Fee Related
- 1997-06-10 US US08/873,285 patent/US5808093A/en not_active Expired - Fee Related
- 1997-10-15 EA EA199900382A patent/EA002438B1/ru not_active IP Right Cessation
- 1997-10-15 CZ CZ19991312A patent/CZ291387B6/cs not_active IP Right Cessation
- 1997-10-15 KR KR1019990703293A patent/KR20000049195A/ko not_active Abandoned
- 1997-10-15 JP JP10518472A patent/JP2001502329A/ja not_active Ceased
- 1997-10-15 SK SK437-99A patent/SK43799A3/sk unknown
- 1997-10-15 HU HU9903583A patent/HUP9903583A3/hu unknown
- 1997-10-15 CN CN97198783A patent/CN1094927C/zh not_active Expired - Fee Related
- 1997-10-15 UA UA99052680A patent/UA52702C2/uk unknown
- 1997-10-15 EP EP97910894A patent/EP0934268A4/fr not_active Withdrawn
- 1997-10-15 PL PL97332827A patent/PL332827A1/xx not_active IP Right Cessation
- 1997-10-15 IL IL12923197A patent/IL129231A/xx unknown
- 1997-10-15 WO PCT/US1997/018365 patent/WO1998016510A1/fr not_active Ceased
- 1997-10-15 AU AU48160/97A patent/AU721965B2/en not_active Ceased
- 1997-10-15 BR BR9711910A patent/BR9711910A/pt not_active Application Discontinuation
- 1997-10-15 EA EA200100660A patent/EA200100660A1/ru unknown
- 1997-10-15 EA EA200100661A patent/EA200100661A1/ru unknown
- 1997-10-15 CA CA002268652A patent/CA2268652A1/fr not_active Abandoned
- 1997-10-15 AP APAP/P/1999/001486A patent/AP942A/en active
- 1997-10-16 ZA ZA979268A patent/ZA979268B/xx unknown
1999
- 1999-03-30 BG BG103296A patent/BG64701B1/bg unknown
- 1999-03-30 BG BG108906A patent/BG64733B1/bg unknown
- 1999-04-09 OA OA9900080A patent/OA11112A/en unknown
- 1999-04-15 NO NO19991800A patent/NO320332B1/no unknown
2002
- 2002-06-05 CN CN02122409A patent/CN1385422A/zh active Pending
2005
- 2005-04-08 NO NO20051757A patent/NO20051757D0/no unknown

Also Published As

Publication number	Publication date
OA11112A (en)	2003-04-04
EP0934268A4 (fr)	2001-04-18
CN1233239A (zh)	1999-10-27
NO20051757L (no)	1999-06-15
EA200100660A1 (ru)	2001-12-24
US5808093A (en)	1998-09-15
WO1998016510A1 (fr)	1998-04-23
IL129231A0 (en)	2000-02-17
CZ291387B6 (cs)	2003-02-12
EA200100661A1 (ru)	2001-12-24
BR9711910A (pt)	1999-08-24
HK1022475A1 (en)	2000-08-11
US5886192A (en)	1999-03-23
NO20051757D0 (no)	2005-04-08
AU4816097A (en)	1998-05-11
NO991800D0 (no)	1999-04-15
AP942A (en)	2001-02-16
EP0934268A1 (fr)	1999-08-11
CZ131299A3 (cs)	2000-06-14
BG64701B1 (bg)	2005-12-30
PL332827A1 (en)	1999-10-11
CN1385422A (zh)	2002-12-18
BG64733B1 (bg)	2006-01-31
HUP9903583A3 (en)	2000-10-30
IL129231A (en)	2003-07-06
JP2001502329A (ja)	2001-02-20
SK43799A3 (en)	2000-04-10
US5831096A (en)	1998-11-03
UA52702C2 (uk)	2003-01-15
AU721965B2 (en)	2000-07-20
CA2268652A1 (fr)	1998-04-23
US5684159A (en)	1997-11-04
KR20000049195A (ko)	2000-07-25
HUP9903583A2 (hu)	2000-04-28
EA199900382A1 (ru)	1999-10-28
BG103296A (en)	2000-11-30
EA002438B1 (ru)	2002-04-25
AP9901486A0 (en)	1999-03-31
NO320332B1 (no)	2005-11-21
CN1094927C (zh)	2002-11-27
NO991800L (no)	1999-06-15

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