ZA979997B - Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents. - Google Patents
Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents.Info
- Publication number
- ZA979997B ZA979997B ZA9709997A ZA979997A ZA979997B ZA 979997 B ZA979997 B ZA 979997B ZA 9709997 A ZA9709997 A ZA 9709997A ZA 979997 A ZA979997 A ZA 979997A ZA 979997 B ZA979997 B ZA 979997B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzoheterocyclic
- antitumor
- preparing
- antiviral agents
- distamycin derivatives
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 239000003443 antiviral agent Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical class CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9623522.1A GB9623522D0 (en) | 1996-11-11 | 1996-11-11 | Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA979997B true ZA979997B (en) | 1998-05-25 |
Family
ID=10802813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9709997A ZA979997B (en) | 1996-11-11 | 1997-11-06 | Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6153642A (fr) |
| EP (1) | EP0937070B1 (fr) |
| JP (1) | JP2001504109A (fr) |
| AR (1) | AR009413A1 (fr) |
| AU (1) | AU5121698A (fr) |
| CA (1) | CA2271299A1 (fr) |
| DE (1) | DE69726593T2 (fr) |
| ES (1) | ES2212138T3 (fr) |
| GB (1) | GB9623522D0 (fr) |
| WO (1) | WO1998021202A1 (fr) |
| ZA (1) | ZA979997B (fr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9806692D0 (en) | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents |
| ATE314854T1 (de) * | 1999-02-04 | 2006-02-15 | Joern Bullerdiek | Mittel zur prävention und/oder behandlung einer gewebeveränderung mesenchymalen ursprungs |
| US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
| GB0011059D0 (en) * | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
| GB0015447D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| GB0015446D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
| GB0015444D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors |
| GB0016447D0 (en) | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| IT1318696B1 (it) | 2000-09-15 | 2003-08-27 | Pharmacia & Upjohn Spa | Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale. |
| GB0029004D0 (en) | 2000-11-28 | 2001-01-10 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| US20030236198A1 (en) | 2001-06-13 | 2003-12-25 | Genesoft, Inc. | Antipathogenic benzamide compounds |
| WO2002101073A2 (fr) * | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc. | Composes aryl-benzimidazole presentant une activite anti-infectieuse |
| EP1470119A4 (fr) * | 2001-06-13 | 2005-10-19 | Genesoft Pharmaceuticals Inc | Composes benzothiophene presentant une activite anti-infectieuse |
| ITTO20010633A1 (it) | 2001-07-02 | 2003-01-02 | Univ Ferrara | Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale distamicina a. |
| US6969592B2 (en) | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
| GB0130868D0 (en) | 2001-12-24 | 2002-02-06 | Univ Strathclyde | New compounds |
| ATE425753T1 (de) | 2002-08-02 | 2009-04-15 | Genesoft Pharmaceuticals Inc | Biaryl-verbindungen mit antiinfektiver wirkung |
| AU2003275225A1 (en) | 2002-09-20 | 2004-04-08 | Genelabs Technologies, Inc. | Novel aromatic compounds possessing antifungal or antibacterial activity |
| WO2004035571A1 (fr) * | 2002-10-15 | 2004-04-29 | Rigel Pharmaceuticals, Inc. | Indoles substitues et leur utilisation en tant qu'inhibiteurs du virus de l'hepatite c (vhc) |
| EP1562931A2 (fr) * | 2002-10-25 | 2005-08-17 | Genesoft Pharmaceuticals, Inc. | Composes biaryle anti-infectieux |
| JP2006509027A (ja) | 2002-12-10 | 2006-03-16 | オーシェント ファーマシューティカルズ コーポレーション | （ピロールカルボキサミド）−（ベンズアミド）−（イミダゾールカルボキサミド）モチーフを有する抗菌化合物 |
| DE102006026764A1 (de) * | 2006-06-09 | 2007-12-13 | Comsort Gmbh | Verfahren zum Ausschleusen von auf einem Sortiertisch einer Fördervorrichtung angeordnetem Stückgut sowie Sortiertisch und Vorrichtung zum Transportieren und Vereinzeln von Stückgut |
| GB0619325D0 (en) | 2006-09-30 | 2006-11-08 | Univ Strathclyde | New compounds |
| CN102807540A (zh) * | 2012-09-06 | 2012-12-05 | 无锡万全医药技术有限公司 | 一种新的5-氨基苯并呋喃-2-甲酸的制备方法 |
| CN104845967B (zh) | 2015-04-15 | 2020-12-11 | 苏州新海生物科技股份有限公司 | 寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用 |
| WO2018047148A1 (fr) | 2016-09-12 | 2018-03-15 | Novartis Ag | Composés pour inhibition du miarn |
| EP3963085A4 (fr) * | 2019-05-01 | 2022-09-14 | The University of North Carolina at Chapel Hill | Inhibiteurs de protéines de liaison à l'arn, compositions de ceux-ci et leurs utilisations thérapeutiques |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8612218D0 (en) * | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
| IT1262921B (it) * | 1992-01-10 | 1996-07-22 | Federico Arcamone | Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono |
| IT1271456B (it) * | 1993-03-01 | 1997-05-28 | Menarini Farma Ind | Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono |
| GB9416005D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
| GB9514993D0 (en) * | 1995-07-21 | 1995-09-20 | Pharmacia Spa | Site specific phenyl nitrogen mustards |
-
1996
- 1996-11-11 GB GBGB9623522.1A patent/GB9623522D0/en active Pending
-
1997
- 1997-10-23 JP JP52210098A patent/JP2001504109A/ja not_active Ceased
- 1997-10-23 AU AU51216/98A patent/AU5121698A/en not_active Abandoned
- 1997-10-23 CA CA002271299A patent/CA2271299A1/fr not_active Abandoned
- 1997-10-23 US US09/284,958 patent/US6153642A/en not_active Expired - Fee Related
- 1997-10-23 EP EP97945879A patent/EP0937070B1/fr not_active Expired - Lifetime
- 1997-10-23 DE DE1997626593 patent/DE69726593T2/de not_active Expired - Fee Related
- 1997-10-23 WO PCT/EP1997/005986 patent/WO1998021202A1/fr not_active Ceased
- 1997-10-23 ES ES97945879T patent/ES2212138T3/es not_active Expired - Lifetime
- 1997-11-06 ZA ZA9709997A patent/ZA979997B/xx unknown
- 1997-11-10 AR ARP970105209A patent/AR009413A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0937070B1 (fr) | 2003-12-03 |
| US6153642A (en) | 2000-11-28 |
| DE69726593T2 (de) | 2004-11-18 |
| EP0937070A1 (fr) | 1999-08-25 |
| DE69726593D1 (de) | 2004-01-15 |
| ES2212138T3 (es) | 2004-07-16 |
| JP2001504109A (ja) | 2001-03-27 |
| GB9623522D0 (en) | 1997-01-08 |
| WO1998021202A1 (fr) | 1998-05-22 |
| CA2271299A1 (fr) | 1998-05-22 |
| AU5121698A (en) | 1998-06-03 |
| AR009413A1 (es) | 2000-04-12 |
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