ZA9811128B - 1,3,8-Triaza-spiro(4,5)decan-4-on derivatives - Google Patents

1,3,8-Triaza-spiro(4,5)decan-4-on derivatives

Info

Publication number: ZA9811128B
Authority: ZA; South Africa
Prior art keywords: triaza; decan; spiro; derivatives
Prior art date: 1997-12-05

Application number

ZA9811128A

Other languages

English (en)

Inventor

Geo Adam

Andrea Cesura

Guido Galley

Francois Jenck

Stephan Roever

Juergen Wichmann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-05

Filing date

1998-12-04

Publication date

1999-06-07

1998-12-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1999-06-07 Publication of ZA9811128B publication Critical patent/ZA9811128B/xx

Links

JRKPNHLSQGAUDY-UHFFFAOYSA-N 1,3,8-triazaspiro[4.5]decan-4-one Chemical class O=C1NCNC11CCNCC1 JRKPNHLSQGAUDY-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Color Printing (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

ZA9811128A 1997-12-05 1998-12-04 1,3,8-Triaza-spiro(4,5)decan-4-on derivatives ZA9811128B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97121427		1997-12-05

Publications (1)

Publication Number	Publication Date
ZA9811128B true ZA9811128B (en)	1999-06-07

Family

ID=8227753

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9811128A ZA9811128B (en)	1997-12-05	1998-12-04	1,3,8-Triaza-spiro(4,5)decan-4-on derivatives

Country Status (29)

Country	Link
US (1)	US6043366A (de)
JP (1)	JP3366868B2 (de)
KR (1)	KR19990062800A (de)
CN (1)	CN1118467C (de)
AR (1)	AR016428A1 (de)
AT (1)	ATE212635T1 (de)
AU (1)	AU744338B2 (de)
BR (1)	BR9805297B1 (de)
CA (1)	CA2255171C (de)
CO (1)	CO4990965A1 (de)
CZ (1)	CZ399698A3 (de)
DE (1)	DE69803653T2 (de)
DK (1)	DK0921125T3 (de)
ES (1)	ES2170446T3 (de)
HR (1)	HRP980613A2 (de)
HU (1)	HUP9802807A3 (de)
ID (1)	ID21413A (de)
IL (1)	IL127399A0 (de)
MA (1)	MA26573A1 (de)
NO (1)	NO312161B1 (de)
NZ (1)	NZ333159A (de)
PE (1)	PE135299A1 (de)
PL (1)	PL330062A1 (de)
PT (1)	PT921125E (de)
SG (1)	SG71173A1 (de)
TR (1)	TR199802520A2 (de)
TW (1)	TW408123B (de)
YU (1)	YU55198A (de)
ZA (1)	ZA9811128B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0997464B1 (de) *	1998-10-23	2005-02-16	Pfizer Inc.	1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten
JP3989247B2 (ja) *	1999-12-06	2007-10-10	ユーロ−セルティークエス．エイ．	ノシセプチン受容体親和性を有するトリアゾスピロ化合物
CA2454785C (en) *	2001-07-23	2010-09-07	Banyu Pharmaceutical Co., Ltd.	4-oxoimidazolidine-2-spiropiperidine derivatives
US7566728B2 (en)	2002-03-29	2009-07-28	Mitsubishi Tanabe Pharma Corporation	Remedy for sleep disturbance
AU2003268512A1 (en) *	2002-09-09	2004-03-29	Janssen Pharmaceutica N.V.	Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
WO2004058727A1 (en) *	2002-12-20	2004-07-15	Bayer Pharmaceuticals Corporation	Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity
ZA200510329B (en) *	2003-05-23	2007-04-25	Zealand Pharma As	Triaza-spiro compounds as nociceptin analogues and uses thereof
RU2006117368A (ru) *	2003-10-23	2007-12-10	Ф.Хоффманн-Ля Рош Аг (Ch)	Производные триазаспиропипередина, предназначенные для применения в качестве ингибиторов glyt-1 при лечении неврологических и психоневрологических нарушений
US20060178390A1 (en) *	2004-08-02	2006-08-10	Alfonzo Jordan	1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
CN101146801A (zh) *	2005-03-22	2008-03-19	霍夫曼-拉罗奇有限公司	新型的dpp-iv抑制剂的盐和多晶型物
WO2007149873A2 (en) *	2006-06-20	2007-12-27	Wyeth	Kv1.5 potassium channel inhibitors
CN103202840B (zh) *	2006-11-28	2015-02-11	詹森药业有限公司	3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
CN101622241B (zh)	2007-03-01	2013-05-22	田边三菱制药株式会社	苯并咪唑化合物及其医药用途
EP2150552B1 (de) *	2007-04-09	2013-01-02	Janssen Pharmaceutica NV	1,3,8-trisubstituierte-1,3,8-triaza-spiro[4.5]decan-4-on derivate als liganden des orl-1 rezeptors zur behandlung von angst und depression
PA8801401A1 (es) *	2007-10-25	2009-05-15	Janssen Pharmaceutica Nv	Arilindenopirimidinas y su uso como adenosina a2a
TW201016675A (en) *	2008-09-16	2010-05-01	Mitsubishi Tanabe Pharma Corp	Crystalline benzoimidazole compound and salt thereof
US20100076003A1 (en) *	2008-09-19	2010-03-25	Kathleen Battista	5-oxazolidin-2-one substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful as orl-1 receptor modulators
WO2010037081A1 (en) *	2008-09-29	2010-04-01	Palatin Technologies, Inc.	Melanocortin receptor-specific spiro-piperidine compounds
WO2010147776A1 (en)	2009-06-16	2010-12-23	Merck Sharp & Dohme Corp.	Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones
CN107849044B (zh) *	2015-07-03	2021-06-25	豪夫迈·罗氏有限公司	作为ddr1抑制剂的三氮杂-螺癸酮类化合物
US20230357168A1 (en) *	2022-04-15	2023-11-09	The Chinese University Of Hong Kong	Carbobicyclic nucleosides for treatment of viral infection

Family Cites Families (15)

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Publication number	Priority date	Publication date	Assignee	Title
US3155669A (en) *	1962-06-22	1964-11-03	Res Lab Dr C Janssen N V	2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US3161644A (en) *	1962-06-22	1964-12-15	Res Lab Dr C Janssen N V	1-benzyl-4-substituted piperidines
US3155670A (en) *	1962-06-22	1964-11-03	Res Lab Dr C Janssen N V	1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes
US3238216A (en) *	1963-06-20	1966-03-01	Res Lab Dr C Janssen N V	Substituted 1, 3, 8-triaza-spiro (4, 5) decanes
JPS51100084A (de) *	1975-02-28	1976-09-03	Yoshitomi Pharmaceutical
JPS5212171A (en) *	1975-07-17	1977-01-29	Yoshitomi Pharmaceut Ind Ltd	Process for preparation of cyclohexane derivatives
GB1486546A (en) *	1975-02-28	1977-09-21	Yoshitomo Pharma Ind Ltd	4,4-diphenyl-cyclohexylpiperidine compounds and analogues thereof
JPS5934713B2 (ja) *	1976-01-05	1984-08-24	ウェルファイド株式会社	脂環式誘導体
US4076821A (en) *	1976-02-27	1978-02-28	Yoshitomi Pharmaceutical Industries, Ltd.	4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
GR73633B (de) *	1980-03-10	1984-03-26	Janssen Pharmaceutica Nv
MA19091A1 (fr) *	1980-03-10	1981-10-01	Janssen Pharmaceutica Nv	Nouveaux derives de i-(4-aryl-cyclohexyl)piperidine .
US4329353A (en) *	1980-10-22	1982-05-11	Janssen Pharmaceutica, N.V.	1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
ATE67769T1 (de) *	1983-01-25	1991-10-15	Ciba Geigy Ag	Neue peptidderivate.
JPS6012357B2 (ja) *	1984-01-23	1985-04-01	吉富製薬株式会社	脂環式誘導体
CA2226058C (en) *	1997-01-30	2008-01-29	F. Hoffmann-La Roche Ag	8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives

1998
- 1998-11-27 DE DE69803653T patent/DE69803653T2/de not_active Expired - Lifetime
- 1998-11-27 ES ES98122511T patent/ES2170446T3/es not_active Expired - Lifetime
- 1998-11-27 PT PT98122511T patent/PT921125E/pt unknown
- 1998-11-27 DK DK98122511T patent/DK0921125T3/da active
- 1998-11-27 AT AT98122511T patent/ATE212635T1/de active
- 1998-12-03 PL PL98330062A patent/PL330062A1/xx unknown
- 1998-12-03 YU YU55198A patent/YU55198A/sh unknown
- 1998-12-03 PE PE1998001176A patent/PE135299A1/es not_active Application Discontinuation
- 1998-12-03 US US09/204,184 patent/US6043366A/en not_active Expired - Fee Related
- 1998-12-03 CA CA002255171A patent/CA2255171C/en not_active Expired - Fee Related
- 1998-12-03 AR ARP980106141A patent/AR016428A1/es active IP Right Grant
- 1998-12-03 ID IDP981576A patent/ID21413A/id unknown
- 1998-12-03 NZ NZ333159A patent/NZ333159A/en unknown
- 1998-12-03 SG SG1998005141A patent/SG71173A1/en unknown
- 1998-12-04 IL IL12739998A patent/IL127399A0/xx unknown
- 1998-12-04 AU AU96087/98A patent/AU744338B2/en not_active Ceased
- 1998-12-04 TR TR1998/02520A patent/TR199802520A2/xx unknown
- 1998-12-04 CO CO98072457A patent/CO4990965A1/es unknown
- 1998-12-04 HU HU9802807A patent/HUP9802807A3/hu unknown
- 1998-12-04 CZ CZ983996A patent/CZ399698A3/cs unknown
- 1998-12-04 ZA ZA9811128A patent/ZA9811128B/xx unknown
- 1998-12-04 TW TW087120132A patent/TW408123B/zh not_active IP Right Cessation
- 1998-12-04 HR HR97121427.5A patent/HRP980613A2/hr not_active Application Discontinuation
- 1998-12-04 BR BRPI9805297-7A patent/BR9805297B1/pt not_active IP Right Cessation
- 1998-12-04 NO NO19985684A patent/NO312161B1/no not_active IP Right Cessation
- 1998-12-04 MA MA25369A patent/MA26573A1/fr unknown
- 1998-12-04 KR KR1019980053080A patent/KR19990062800A/ko not_active Ceased
- 1998-12-04 JP JP34527898A patent/JP3366868B2/ja not_active Expired - Fee Related
- 1998-12-04 CN CN98122759A patent/CN1118467C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69803653D1 (de)	2002-03-14
DK0921125T3 (da)	2002-05-13
CN1222521A (zh)	1999-07-14
HRP980613A2 (en)	1999-08-31
AU744338B2 (en)	2002-02-21
TR199802520A3 (tr)	1999-06-21
AR016428A1 (es)	2001-07-04
JP3366868B2 (ja)	2003-01-14
IL127399A0 (en)	1999-10-28
ATE212635T1 (de)	2002-02-15
CO4990965A1 (es)	2000-12-26
NO985684L (no)	1999-06-07
HUP9802807A2 (hu)	1999-08-30
CA2255171C (en)	2009-09-29
HUP9802807A3 (en)	2000-01-28
CN1118467C (zh)	2003-08-20
TW408123B (en)	2000-10-11
DE69803653T2 (de)	2002-08-29
NO985684D0 (no)	1998-12-04
TR199802520A2 (xx)	1999-06-21
MA26573A1 (fr)	2004-12-20
JPH11228575A (ja)	1999-08-24
HU9802807D0 (en)	1999-02-01
CZ399698A3 (cs)	1999-06-16
AU9608798A (en)	1999-06-24
YU55198A (sh)	2001-12-26
BR9805297B1 (pt)	2010-07-13
US6043366A (en)	2000-03-28
SG71173A1 (en)	2000-03-21
PE135299A1 (es)	2000-01-18
ES2170446T3 (es)	2002-08-01
ID21413A (id)	1999-06-10
BR9805297A (pt)	2000-02-01
NZ333159A (en)	2000-06-23
PL330062A1 (en)	1999-06-07
KR19990062800A (ko)	1999-07-26
NO312161B1 (no)	2002-04-02
CA2255171A1 (en)	1999-06-05
PT921125E (pt)	2002-06-28

Publication	Publication Date	Title
HU9800138D0 (en)	1998-03-30	8-substituted-1,3,8-triaza-spiro [4,5]-decan-4-on derivatives
EG24081A (en)	2008-05-11	4-Substituted-9-deoxo-9a-aza-9a-homerythromycin derivatives
SI0921125T1 (en)	2002-04-30	1,3,8-Triazaspiro(4,5)decan-4-on derivatives
GB9702194D0 (en)	1997-03-26	Sulphonide derivatives
HUP0003642A3 (en)	2001-11-28	N-alkanoylphenylalanine derivatives
ZA987602B (en)	1999-05-04	N-alkanoylphenylalanine derivatives
PL334847A1 (en)	2000-03-27	Substituted 3-heterocyclyl-benzoyl derivatives
SI0891978T1 (en)	2002-06-30	5H-Thiazolo (3,2-a) pyrimidine derivatives
IL125226A0 (en)	1999-03-12	Heterocycle-condensed morphinoid derivatives (II)
IL127399A0 (en)	1999-10-28	1,3,8-Triaza-spiro (4,5) decan-4-on derivatives
HU9801168D0 (en)	1998-08-28	Triazinylaminostilbene derivatives
IL128701A0 (en)	2000-01-31	1,2,3,4-Tetrahydro-benzofuro (3,2-c)pyridine derivatives
GB2321457B (en)	2001-02-28	5-Aroylnaphthalene derivatives
IL132982A0 (en)	2001-03-19	Cis-disubstituted aminocycloalkyl-pyrrolidine derivatives
ZA982436B (en)	1999-09-23	Thiazolimine derivatives.
GB9715821D0 (en)	1997-10-01	Amidino-camptothecin derivatives
GB9725541D0 (en)	1998-02-04	Amino-benzothiazole derivatives
ZA98611B (en)	1998-08-17	Imino-aza-anthracyclinone derivatives
ZA983116B (en)	1998-10-21	Arylsecocholadiene derivatives
HRP970162A2 (en)	1998-04-30	1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives
HU9800889D0 (en)	1998-06-29	New naphtylpiperazine derivatives
IL131159A0 (en)	2001-01-28	4-Aminoethoxyindazole derivatives
GB9706753D0 (en)	1997-05-21	Aralkoxy-morphinan derivatives
SI1005445T1 (en)	2004-12-31	N-alkanoylphenylalanine derivatives
GB9720329D0 (en)	1997-11-26	4-cyano-4-deformylsordarin derivatives