ZA9811174B - New crystalline form of omeprazole. - Google Patents

New crystalline form of omeprazole.

Info

Publication number: ZA9811174B
Authority: ZA; South Africa
Prior art keywords: methoxy; crystalline form; omeprazole; methylüsulfinylü; benzimidazole
Prior art date: 1998-11-10

Application number

ZA9811174A

Other languages

English (en)

Inventor

Karin Loevqvist

David Noreland

Gunnel Sunden

Ingvar Ymen

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-10

Filing date

1998-12-07

Publication date

2000-06-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27543202&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA9811174(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-12-07 Application filed by Astra Ab filed Critical Astra Ab

2000-06-07 Publication of ZA9811174B publication Critical patent/ZA9811174B/xx

Links

SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 title abstract 2
229960000381 omeprazole Drugs 0.000 title abstract 2
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA9811174A 1998-11-10 1998-12-07 New crystalline form of omeprazole. ZA9811174B (en)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
EP98957255A EP0969819B1 (fr)	1998-11-10	1998-11-10	Nouvelle forme cristalline d'omeprazole
CA002363810A CA2363810A1 (fr)	1998-11-10	1998-11-10	Nouvelle forme d'omeprazole
PCT/SE1998/002028 WO1999008500A2 (fr)	1998-11-10	1998-11-10	Nouvelle forme cristalline d'omeprazole
DE29823393U DE29823393U1 (de)	1998-11-10	1998-11-10	Neue kristalline Form von Omeprazol
BR9816067-2A BR9816067A (pt)	1998-11-10	1998-11-10	Forma a de omeprazol, omeprazol, processo para a preparação da forma a de omeprazol, formulação farmacêutica, uso de omeprazol, e, método de tratamento de distúrbios gastrointestinais.
US10/076,225 US20020156284A1 (en)	1998-11-10	2002-02-13	Crystalline form of omeprazole

Publications (1)

Publication Number	Publication Date
ZA9811174B true ZA9811174B (en)	2000-06-07

Family

ID=27543202

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9811174A ZA9811174B (en)	1998-11-10	1998-12-07	New crystalline form of omeprazole.

Country Status (33)

Country	Link
US (3)	US6150380A (fr)
EP (2)	EP0969819B1 (fr)
JP (1)	JP3457945B2 (fr)
CN (1)	CN1347413A (fr)
AT (1)	ATE233755T1 (fr)
AU (1)	AU756434B2 (fr)
BR (1)	BR9816067A (fr)
CA (2)	CA2363810A1 (fr)
CZ (1)	CZ301635B6 (fr)
DE (3)	DE969819T1 (fr)
DK (2)	DK0969819T3 (fr)
DZ (1)	DZ2669A1 (fr)
EE (1)	EE04279B1 (fr)
ES (1)	ES2139559T3 (fr)
FI (1)	FI3873U1 (fr)
GR (1)	GR990300034T1 (fr)
HR (1)	HRP20010281B1 (fr)
HU (1)	HUP0104379A3 (fr)
IL (1)	IL142703A0 (fr)
IS (1)	IS2025B (fr)
MA (1)	MA26574A1 (fr)
NO (1)	NO320014B1 (fr)
NZ (1)	NZ511377A (fr)
PL (1)	PL190870B1 (fr)
PT (1)	PT969819E (fr)
RU (1)	RU2207339C2 (fr)
SI (1)	SI0969819T1 (fr)
SK (1)	SK286562B6 (fr)
TR (1)	TR200101282T2 (fr)
TW (1)	TW533203B (fr)
UA (1)	UA72748C2 (fr)
WO (1)	WO1999008500A2 (fr)
ZA (1)	ZA9811174B (fr)

Families Citing this family (40)

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US5840737A (en)	1996-01-04	1998-11-24	The Curators Of The University Of Missouri	Omeprazole solution and method for using same
US6699885B2 (en)	1996-01-04	2004-03-02	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and methods of using same
US6645988B2 (en)	1996-01-04	2003-11-11	Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
US6489346B1 (en)	1996-01-04	2002-12-03	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
SI20019A (sl) *	1998-07-13	2000-02-29	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
IL142703A (en) *	1998-11-10	2006-04-10	Astrazeneca Ab	Crystalline form of omeprazole
US6262085B1 (en) *	1999-08-26	2001-07-17	Robert R. Whittle	Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6262086B1 (en) *	1999-08-26	2001-07-17	Robert R. Whittle	Pharmaceutical unit dosage form
US6780880B1 (en)	1999-08-26	2004-08-24	Robert R. Whittle	FT-Raman spectroscopic measurement
US6750064B2 (en) *	2000-12-28	2004-06-15	S.S.C.I. Inc.	Methods of screening for possible solid forms
SI20875A (sl) *	2001-04-25	2002-10-31	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Kristalna oblika omeprazola
US7855082B1 (en)	2001-10-31	2010-12-21	Astrazeneca Ab	Raman spectroscopic method for determining the ratio of 5-methoxy and 6-methoxy isomers of omeprazole
EP1485373A1 (fr)	2003-02-05	2004-12-15	Teva Pharmaceutical Industries Limited	Procede de stabilisation de lansoprazole
CA2518999A1 (fr) *	2003-03-12	2004-09-23	Teva Pharmaceutical Industries Ltd	Formes solides cristallines et amorphes de pantoprazole et procedes de preparation de ces formes
US8993599B2 (en)	2003-07-18	2015-03-31	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US7892354B2 (en) *	2003-10-06	2011-02-22	Solvias Ag	Process for the parallel detection of crystalline forms of molecular solids
US8815916B2 (en)	2004-05-25	2014-08-26	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en)	2004-05-25	2014-12-09	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20060024362A1 (en)	2004-07-29	2006-02-02	Pawan Seth	Composition comprising a benzimidazole and process for its manufacture
US20060160783A1 (en) *	2004-12-30	2006-07-20	Transform Pharmaceuticals, Inc.	Novel omeprazole forms and related methods
WO2006131338A2 (fr) *	2005-06-08	2006-12-14	Lek Pharmaceuticals D.D.	Solvate cristallin de sodium d'omeprazole
WO2007008588A2 (fr) *	2005-07-07	2007-01-18	Dr. Reddy's Laboratories Ltd.	Omeprazole de forme b
EP1934201A1 (fr) *	2005-10-06	2008-06-25	Auspex Pharmaceuticals Inc.	Inhibiteurs deutériés d'atpase h+,k+ gastrique ayant des propriétés thérapeutiques renforcées
EP2068841B1 (fr)	2006-10-05	2018-09-26	Santarus, Inc.	Nouvelles formulations pour une libération immédiate d'inhibiteurs de pompe à protons et procédés d'utilisation de ces formulations
CA2667682A1 (fr)	2006-10-27	2008-05-15	The Curators Of The University Of Missouri	Compositions comprenant des agents d'inhibition de la pompe a protons labiles d'acide, au moins un autre agent pharmaceutiquement actif et leurs procedes d'utilisation
EP2114919A2 (fr)	2007-01-31	2009-11-11	Krka Tovarna Zdravil, D.D., Novo Mesto	Procédé de préparation d'oméprazole optiquement pur
US8018588B2 (en) *	2007-06-06	2011-09-13	Aptuit, Inc.	Sample holder and sample preparation device
US20090010388A1 (en) *	2007-06-06	2009-01-08	Stahly Barbara C	Microplate and methods of using the same
US20090104236A1 (en) *	2007-10-18	2009-04-23	Pharmaceutics International, Inc.	Pharmaceutical solid hybrids
WO2009137648A1 (fr) *	2008-05-09	2009-11-12	Aptapharma, Inc.	Pastilles multicouches inhibant la pompe à protons
US20090280173A1 (en) *	2008-05-09	2009-11-12	Ishwar Chauhan	Multilayer Omeprazole Tablets
WO2010134099A1 (fr)	2009-05-21	2010-11-25	Cadila Healthcare Limited	Procédé de préparation dans un récipient unique d'oméprazole
EA201290262A1 (ru) *	2009-11-03	2013-01-30	Глэксо Груп Лимитед	Способы получения ингибиторов активирующего 5-липоксигеназу белка и их промежуточных продуктов
GB201001075D0 (en)	2010-01-22	2010-03-10	Cyclacel Ltd	Crystalline forms
RU2501549C1 (ru)	2012-08-30	2013-12-20	Авва Девелопмент Лтд	Фармацевтическая композиция для лечения гастроэзофагеальной рефлюксной болезни
US10076494B2 (en)	2016-06-16	2018-09-18	Dexcel Pharma Technologies Ltd.	Stable orally disintegrating pharmaceutical compositions
RU2726320C1 (ru) *	2020-02-09	2020-07-13	Федеральное государственное бюджетное образовательное учреждение высшего образования "Кемеровский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО КемГМУ)	Способ определения примесных компонентов омепразола
JP2025532389A (ja)	2022-10-04	2025-09-29	ザビリュク，アルセニー	大動脈弁の石灰化の抑制
CN119320380B (zh) *	2024-10-14	2025-11-25	山东益康药业股份有限公司	奥美拉唑与2,6-二羟基苯甲酸的共晶物及其用途
CN119320381B (zh) *	2024-10-14	2025-12-12	山东益康药业股份有限公司	奥美拉唑与3,5-二硝基苯甲酸的共晶物及其用途

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SE7804231L (sv) *	1978-04-14	1979-10-15	Haessle Ab	Magsyrasekretionsmedel
SE8301182D0 (sv)	1983-03-04	1983-03-04	Haessle Ab	Novel compounds
SE9002043D0 (sv) *	1990-06-07	1990-06-07	Astra Ab	Improved method for synthesis
ES2078447T3 (es)	1990-06-15	1995-12-16	Merck & Co Inc	Un procedimiento de cristalizacion para mejorar la estructura y el tamaño de los cristales.
DE4035455A1 (de) *	1990-11-08	1992-05-14	Byk Gulden Lomberg Chem Fab	Enantiomerentrennung
US5877192A (en) *	1993-05-28	1999-03-02	Astra Aktiebolag	Method for the treatment of gastric acid-related diseases and production of medication using (-) enantiomer of omeprazole
SE9301830D0 (sv) *	1993-05-28	1993-05-28	Ab Astra	New compounds
SE9302396D0 (sv) *	1993-07-09	1993-07-09	Ab Astra	A novel compound form
SE9302395D0 (sv) *	1993-07-09	1993-07-09	Ab Astra	New pharmaceutical formulation
WO1995018612A1 (fr) *	1994-01-05	1995-07-13	Aktiebolaget Astra	Procede de traitement du psoriasis par omeprazole ou autres composes apparentes
US5856493A (en) *	1995-02-06	1999-01-05	Smithkline Beecham Corporation	Process for making novel form of paroxeting hydrochloride anhydrate
SE521100C2 (sv) *	1995-12-15	2003-09-30	Astra Ab	Förfarande för framställning av en bensimidazolförening
TW385306B (en)	1996-11-14	2000-03-21	Takeda Chemical Industries Ltd	Method for producing crystals of benzimidazole derivatives
SE510666C2 (sv) *	1996-12-20	1999-06-14	Astra Ab	Nya Kristallmodifikationer
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1998
- 1998-10-11 UA UA2001042925A patent/UA72748C2/uk unknown
- 1998-11-10 HR HR20010281A patent/HRP20010281B1/xx not_active IP Right Cessation
- 1998-11-10 DE DE0969819T patent/DE969819T1/de active Pending
- 1998-11-10 HU HU0104379A patent/HUP0104379A3/hu not_active Application Discontinuation
- 1998-11-10 AU AU13551/99A patent/AU756434B2/en not_active Ceased
- 1998-11-10 DE DE69811868T patent/DE69811868T2/de not_active Expired - Lifetime
- 1998-11-10 RU RU2001111875/04A patent/RU2207339C2/ru not_active IP Right Cessation
- 1998-11-10 US US09/202,251 patent/US6150380A/en not_active Expired - Lifetime
- 1998-11-10 EP EP98957255A patent/EP0969819B1/fr not_active Expired - Lifetime
- 1998-11-10 CZ CZ20011611A patent/CZ301635B6/cs not_active IP Right Cessation
- 1998-11-10 SI SI9830389T patent/SI0969819T1/xx unknown
- 1998-11-10 JP JP2000509263A patent/JP3457945B2/ja not_active Expired - Fee Related
- 1998-11-10 EP EP01128969A patent/EP1221314A1/fr not_active Withdrawn
- 1998-11-10 EE EEP200100248A patent/EE04279B1/xx not_active IP Right Cessation
- 1998-11-10 AT AT98957255T patent/ATE233755T1/de active
- 1998-11-10 DK DK98957255T patent/DK0969819T3/da active
- 1998-11-10 PT PT98957255T patent/PT969819E/pt unknown
- 1998-11-10 DE DE29823393U patent/DE29823393U1/de not_active Expired - Lifetime
- 1998-11-10 SK SK545-2001A patent/SK286562B6/sk not_active IP Right Cessation
- 1998-11-10 IL IL14270398A patent/IL142703A0/xx active IP Right Grant
- 1998-11-10 PL PL348247A patent/PL190870B1/pl not_active IP Right Cessation
- 1998-11-10 ES ES98957255T patent/ES2139559T3/es not_active Expired - Lifetime
- 1998-11-10 CA CA002363810A patent/CA2363810A1/fr not_active Abandoned
- 1998-11-10 CA CA002284470A patent/CA2284470C/fr not_active Expired - Fee Related
- 1998-11-10 WO PCT/SE1998/002028 patent/WO1999008500A2/fr not_active Ceased
- 1998-11-10 BR BR9816067-2A patent/BR9816067A/pt not_active Application Discontinuation
- 1998-11-10 NZ NZ511377A patent/NZ511377A/xx not_active IP Right Cessation
- 1998-11-10 TR TR2001/01282T patent/TR200101282T2/xx unknown
- 1998-11-10 CN CN98814305A patent/CN1347413A/zh active Pending
- 1998-12-04 MA MA25371A patent/MA26574A1/fr unknown
- 1998-12-07 ZA ZA9811174A patent/ZA9811174B/xx unknown
- 1998-12-09 DZ DZ980279A patent/DZ2669A1/fr active
- 1998-12-14 TW TW087120725A patent/TW533203B/zh active
- 1998-12-21 FI FI980578U patent/FI3873U1/fi not_active IP Right Cessation
1999
- 1999-02-19 DK DK199900074U patent/DK199900074U1/da unknown
2000
- 2000-07-31 GR GR990300034T patent/GR990300034T1/el unknown
- 2000-08-15 US US09/640,097 patent/US6384059B1/en not_active Expired - Lifetime
2001
- 2001-05-07 IS IS5935A patent/IS2025B/is unknown
- 2001-05-09 NO NO20012286A patent/NO320014B1/no not_active IP Right Cessation
2002
- 2002-02-13 US US10/076,225 patent/US20020156284A1/en not_active Abandoned

Also Published As

Publication number	Publication date
SK286562B6 (sk)	2009-01-07
BR9816067A (pt)	2001-08-07
IS2025B (is)	2005-08-15
ES2139559T3 (es)	2003-10-01
UA72748C2 (en)	2005-04-15
CA2284470C (fr)	2002-02-26
IL142703A0 (en)	2002-03-10
CA2363810A1 (fr)	1999-02-25
EE200100248A (et)	2002-10-15
FI3873U1 (fi)	1999-03-22
JP3457945B2 (ja)	2003-10-20
NO20012286D0 (no)	2001-05-09
GR990300034T1 (en)	2000-07-31
EE04279B1 (et)	2004-04-15
NZ511377A (en)	2003-04-29
HUP0104379A2 (hu)	2002-04-29
US20020156284A1 (en)	2002-10-24
US6384059B1 (en)	2002-05-07
SI0969819T1 (en)	2003-06-30
WO1999008500A2 (fr)	1999-02-25
EP0969819A2 (fr)	2000-01-12
ES2139559T1 (es)	2000-02-16
TW533203B (en)	2003-05-21
DE29823393U1 (de)	1999-05-27
PT969819E (pt)	2003-06-30
HK1024242A1 (en)	2000-10-05
NO320014B1 (no)	2005-10-10
DE969819T1 (de)	2000-04-06
PL190870B1 (pl)	2006-02-28
EP1221314A1 (fr)	2002-07-10
CN1347413A (zh)	2002-05-01
AU1355199A (en)	1999-03-08
DK0969819T3 (da)	2003-05-19
DE69811868D1 (de)	2003-04-10
IS5935A (is)	2001-05-07
EP0969819B1 (fr)	2003-03-05
HUP0104379A3 (en)	2003-01-28
ATE233755T1 (de)	2003-03-15
DZ2669A1 (fr)	2003-03-22
TR200101282T2 (tr)	2001-11-21
FIU980578U0 (fi)	1998-12-21
JP2001522780A (ja)	2001-11-20
CZ20011611A3 (cs)	2002-01-16
DE69811868T2 (de)	2004-03-04
PL348247A1 (en)	2002-05-20
AU756434B2 (en)	2003-01-16
US6150380A (en)	2000-11-21
WO1999008500A3 (fr)	1999-07-29
HRP20010281A2 (en)	2002-06-30
RU2207339C2 (ru)	2003-06-27
HRP20010281B1 (en)	2004-04-30
SK5452001A3 (en)	2001-11-06
NO20012286L (no)	2001-07-03
MA26574A1 (fr)	2004-12-20
CA2284470A1 (fr)	1999-02-25
DK199900074U1 (da)	2000-02-10
CZ301635B6 (cs)	2010-05-12

Publication	Publication Date	Title
ZA9811174B (en)	2000-06-07	New crystalline form of omeprazole.
SE9702483D0 (sv)	1997-06-27	New compound
CA2357744A1 (fr)	2000-08-03	Sel de potassium, de (s)-omeprazole
CA2290963A1 (fr)	1998-12-03	Trihydrate de magnesium s-omeprazole
WO2002017358A3 (fr)	2002-05-30	Fractions heteroaryle substituees par quinuclidine destinees au traitement de maladies
WO2002015662A3 (fr)	2002-06-13	Fractions heteroaryle substituees par quinuclidine destinees au traitement de maladies
ZA989999B (en)	1999-06-17	New process for the preparation of 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)1H-benzimidazole
MY118724A (en)	2005-01-31	New crystalline form of omeprazole
YU32301A (sh)	2005-07-19	Novi kristalni oblik omeprazola
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