ZA9811231B - New pyridylalkane alkene and alkine carboxamides substituted with a cyclic imide - Google Patents
New pyridylalkane alkene and alkine carboxamides substituted with a cyclic imideInfo
- Publication number
- ZA9811231B ZA9811231B ZA9811231A ZA9811231A ZA9811231B ZA 9811231 B ZA9811231 B ZA 9811231B ZA 9811231 A ZA9811231 A ZA 9811231A ZA 9811231 A ZA9811231 A ZA 9811231A ZA 9811231 B ZA9811231 B ZA 9811231B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyridylalkane
- alkene
- new
- cyclic imide
- carboxamides substituted
- Prior art date
Links
- 150000001336 alkenes Chemical class 0.000 title abstract 2
- -1 cyclic imide Chemical class 0.000 title abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract 1
- 150000003949 imides Chemical class 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19756212A DE19756212A1 (de) | 1997-12-17 | 1997-12-17 | Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA9811231B true ZA9811231B (en) | 1999-06-08 |
Family
ID=7852321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9811231A ZA9811231B (en) | 1997-12-17 | 1998-12-08 | New pyridylalkane alkene and alkine carboxamides substituted with a cyclic imide |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7192967B1 (de) |
| EP (1) | EP1042315B1 (de) |
| JP (1) | JP4527877B2 (de) |
| AT (1) | ATE264321T1 (de) |
| AU (1) | AU2414699A (de) |
| DE (2) | DE19756212A1 (de) |
| DK (1) | DK1042315T3 (de) |
| ES (1) | ES2218881T3 (de) |
| PT (1) | PT1042315E (de) |
| WO (1) | WO1999031087A1 (de) |
| ZA (1) | ZA9811231B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1031564A1 (de) | 1999-02-26 | 2000-08-30 | Klinge Pharma GmbH | Hemmer der Nicotinamidmonononukleotide-Bildung und deren Verwendung zur Krebstherapie |
| EP1348434A1 (de) * | 2002-03-27 | 2003-10-01 | Fujisawa Deutschland GmbH | Verwendung von Pyridylamiden als Inhibitoren von Angiogenese |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| EP2098231A1 (de) | 2008-03-05 | 2009-09-09 | Topotarget Switzerland SA | Verwendung von NAD Synthesis Hemmern zur Behandlung von ischämischen Reperfusionsschäden |
| CN102186822A (zh) | 2008-08-29 | 2011-09-14 | 顶标公司 | 新脲和硫脲衍生物 |
| WO2010066709A1 (en) * | 2008-12-09 | 2010-06-17 | Topotarget A/S | Novel pyridinyl acrylamide derivatives |
| EP2453883A1 (de) | 2009-07-17 | 2012-05-23 | Topo Target A/S | Verfahren zur prognose des nutzens der verabreichung von nikotinsäure bzw. einem vorläufer oder prodrug daraus zur minderung des schweregrades der nebenwirkungen einer krebsbehandlung mit nikotinamid-phosphoribosyltransferase-hemmern |
| RU2593759C2 (ru) | 2010-09-03 | 2016-08-10 | ФОРМА ТиЭм, ЭлЭлСИ | Гуанидиновые соединения и композиции для ингибирования nampt |
| WO2012031197A1 (en) | 2010-09-03 | 2012-03-08 | Forma Therapeutics, Inc. | Novel compounds and compositions for the inhibition of nampt |
| JP6038792B2 (ja) | 2010-09-03 | 2016-12-07 | フォーマ ティーエム， エルエルシー． | 癌などの疾患の治療のためのｎａｍｐｔ阻害剤としての４−｛［（ピリジン−３−イル−メチル）アミノカルボニル］アミノ｝ベンゼン−スルホン誘導体 |
| CA2834746A1 (en) | 2011-05-04 | 2012-11-08 | Forma Tm, Llc | Novel compounds and compositions for the inhibition of nampt |
| US9555039B2 (en) | 2011-05-09 | 2017-01-31 | Forma Tm, Llc. | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) |
| JP6450323B2 (ja) | 2013-01-07 | 2019-01-09 | ユニバーシティ オブ サザン カリフォルニア | デオキシウリジントリホスファターゼ阻害剤 |
| GB201507937D0 (en) | 2015-05-08 | 2015-06-24 | Univ Hertfordshire Higher Education Corp | Compounds for treatment of pancreatic cancer |
| SI3319939T1 (sl) | 2015-07-08 | 2025-04-30 | Cv6 Therapeutics (Ni) Limited | Zaviralci deoksiuridin trifosfataze, ki vsebujejo hidantoin |
| WO2017006271A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
| WO2017006270A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| WO2017006283A1 (en) | 2015-07-08 | 2017-01-12 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| US11168059B2 (en) | 2016-11-23 | 2021-11-09 | Cv6 Therapeutics (Ni) Limited | Amino sulfonyl compounds |
| US11174271B2 (en) | 2016-11-23 | 2021-11-16 | Cv6 Therapeutics (Ni) Limited | 6-membered uracil isosteres |
| WO2018098208A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Nitrogen ring linked deoxyuridine triphosphatase inhibitors |
| US11247984B2 (en) | 2017-01-05 | 2022-02-15 | Cv6 Therapeutics (Ni) Limited | Uracil containing compounds |
| CN116332823B (zh) * | 2022-07-01 | 2024-09-03 | 湘潭大学 | 一种异吲哚-二酮衍生物的制备方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4283541A (en) | 1980-05-27 | 1981-08-11 | Usv Pharmaceutical Corporation | Pyridylacyl-hydroxamates |
| NL8005133A (nl) | 1980-09-12 | 1982-04-01 | Duphar Int Res | Fenylpiperazinederivaten met antiagressieve werking. |
| JPS57136518A (en) | 1981-02-18 | 1982-08-23 | Eisai Co Ltd | Immunoregulator |
| US5326772A (en) | 1984-09-28 | 1994-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Diaryl compounds for their use |
| US4778796A (en) | 1985-07-19 | 1988-10-18 | Dainippon Pharmaceutical Co., Ltd. | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same |
| DE3641822A1 (de) | 1986-12-06 | 1988-06-16 | Goedecke Ag | Verwendung von dihydrophenylaminosaeurederivaten und diese enthaltende arzneimittel zur immunmodulation und cytostase |
| JPS63179869A (ja) | 1987-01-20 | 1988-07-23 | Dainippon Pharmaceut Co Ltd | ピペリジン誘導体 |
| JP2832979B2 (ja) | 1988-02-15 | 1998-12-09 | 武田薬品工業株式会社 | 不飽和カルボン酸アミド誘導体 |
| WO1989007443A1 (fr) | 1988-02-19 | 1989-08-24 | Byk Gulden Lomberg Chemische Fabrik Gmbh | R-(-)-niguldipine optiquement pure et ses derives pour traiter des affections tumorales |
| EP0343307A1 (de) | 1988-05-26 | 1989-11-29 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. | 4-Piperidinalkanamin-Derivate |
| IE903196A1 (en) | 1989-09-05 | 1991-03-13 | Searle & Co | Substituted n-benzylpiperidine amides |
| IE903957A1 (en) | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| WO1991015485A1 (de) * | 1990-04-10 | 1991-10-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue pyridinester |
| CA2080127A1 (en) | 1990-04-10 | 1991-10-11 | Peter Zimmermann | Pyridines as medicaments |
| US5260323A (en) | 1990-06-28 | 1993-11-09 | Hoechst Aktiengesellschaft | 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use |
| DE4020570A1 (de) | 1990-06-28 | 1992-01-02 | Hoechst Ag | 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung |
| ES2069137T3 (es) | 1990-07-30 | 1995-05-01 | Takeda Chemical Industries Ltd | Derivados de imidazopiridina y su uso. |
| DE69131842T2 (de) | 1990-10-05 | 2000-07-27 | Ajinomoto Co., Inc. | Piperidinderivate und ihre Verwendung als antiarrhythmische Wirkstoffe |
| FR2676053B1 (fr) | 1991-05-03 | 1993-08-27 | Sanofi Elf | Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| JPH05125048A (ja) * | 1991-05-10 | 1993-05-21 | Takeda Chem Ind Ltd | ピリジン誘導体、その製造方法およびそれを含有する医薬製剤 |
| US5246948A (en) * | 1991-05-10 | 1993-09-21 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, their production and use |
| US5208247A (en) | 1991-08-01 | 1993-05-04 | American Cyanamid Company | Pyridinium compounds which are useful as antagonists of platelet activating factor |
| CA2085954A1 (en) | 1991-12-24 | 1993-06-25 | Klaus Weidmann | Substituted pyridine n-oxides, processes for their preparation, and their use |
| EP0619814A1 (de) | 1991-12-31 | 1994-10-19 | Fujisawa Pharmaceutical Co., Ltd. | Oxadiazolderivate mit acetycholinesterase-hemmender und muscarin-agonistischer wirkung |
| FR2686084B1 (fr) | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| GB9200535D0 (en) | 1992-01-10 | 1992-02-26 | Fujisawa Pharmaceutical Co | New compound |
| AU4713293A (en) | 1992-07-13 | 1994-01-31 | Merck Sharp & Dohme Limited | Heterocyclic amide derivatives as tachykinin derivatives |
| SG48750A1 (en) * | 1993-10-15 | 1998-05-18 | Schering Corp | Tricyclic carbonate compounds useful for inhabition of g-protein function for treatment of proliferative diseases |
| EP0723539B1 (de) * | 1993-10-15 | 2001-12-12 | Schering Corporation | Tricyclische sulfonamide-derivate zur inhibierung der g-protein funktion und fur die bekandlung von proliferativen erkrantungen |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| EP0750496A1 (de) | 1994-03-14 | 1997-01-02 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Verwendung von lipoxygenase-hemmet als therapeutische und interventions- antikrebsmittel |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| US5712280A (en) * | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| FR2738245B1 (fr) | 1995-08-28 | 1997-11-21 | Sanofi Sa | Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant |
| DE19624668A1 (de) * | 1996-06-20 | 1998-02-19 | Klinge Co Chem Pharm Fab | Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden |
| DE19624704A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalkansäureamide |
| DE19624659A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
-
1997
- 1997-12-17 DE DE19756212A patent/DE19756212A1/de not_active Ceased
-
1998
- 1998-12-08 ZA ZA9811231A patent/ZA9811231B/xx unknown
- 1998-12-16 AT AT98966634T patent/ATE264321T1/de active
- 1998-12-16 WO PCT/EP1998/008267 patent/WO1999031087A1/en not_active Ceased
- 1998-12-16 JP JP2000539011A patent/JP4527877B2/ja not_active Expired - Fee Related
- 1998-12-16 DK DK98966634T patent/DK1042315T3/da active
- 1998-12-16 EP EP98966634A patent/EP1042315B1/de not_active Expired - Lifetime
- 1998-12-16 ES ES98966634T patent/ES2218881T3/es not_active Expired - Lifetime
- 1998-12-16 PT PT98966634T patent/PT1042315E/pt unknown
- 1998-12-16 AU AU24146/99A patent/AU2414699A/en not_active Abandoned
- 1998-12-16 DE DE69823229T patent/DE69823229T2/de not_active Expired - Lifetime
-
2000
- 2000-06-16 US US09/595,218 patent/US7192967B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE264321T1 (de) | 2004-04-15 |
| AU2414699A (en) | 1999-07-05 |
| ES2218881T3 (es) | 2004-11-16 |
| DE69823229D1 (de) | 2004-05-19 |
| EP1042315A1 (de) | 2000-10-11 |
| DE19756212A1 (de) | 1999-07-01 |
| US7192967B1 (en) | 2007-03-20 |
| JP4527877B2 (ja) | 2010-08-18 |
| PT1042315E (pt) | 2004-08-31 |
| EP1042315B1 (de) | 2004-04-14 |
| JP2002508367A (ja) | 2002-03-19 |
| WO1999031087A1 (en) | 1999-06-24 |
| DK1042315T3 (da) | 2004-07-12 |
| DE69823229T2 (de) | 2005-03-10 |
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