ZA986784B - Tricyclic vasopressin agonists. - Google Patents

Tricyclic vasopressin agonists.

Info

Publication number
ZA986784B
ZA986784B ZA9806784A ZA986784A ZA986784B ZA 986784 B ZA986784 B ZA 986784B ZA 9806784 A ZA9806784 A ZA 9806784A ZA 986784 A ZA986784 A ZA 986784A ZA 986784 B ZA986784 B ZA 986784B
Authority
ZA
South Africa
Prior art keywords
vasopressin agonists
tricyclic
tricyclic vasopressin
agonists
vasopressin
Prior art date
Application number
ZA9806784A
Other languages
English (en)
Inventor
John Paul Dusza
Jay Donald Albright
Jehan Framroz Bagli
Amedeo Arturo Failli
Mark Anthony Ashwell
Thomas Joseph Caggiano
Eugene John Trybulski
Peter Sinchun Chan
Albert John Molinari
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of ZA986784B publication Critical patent/ZA986784B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA9806784A 1997-07-30 1998-07-29 Tricyclic vasopressin agonists. ZA986784B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90336997A 1997-07-30 1997-07-30

Publications (1)

Publication Number Publication Date
ZA986784B true ZA986784B (en) 2000-06-22

Family

ID=25417392

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9806784A ZA986784B (en) 1997-07-30 1998-07-29 Tricyclic vasopressin agonists.

Country Status (22)

Country Link
EP (1) EP1000062B1 (de)
JP (1) JP4338305B2 (de)
KR (1) KR100580805B1 (de)
CN (1) CN1183134C (de)
AR (1) AR016557A1 (de)
AT (1) ATE277050T1 (de)
AU (1) AU756959B2 (de)
BR (1) BR9811585A (de)
CA (1) CA2297406C (de)
DE (1) DE69826487T2 (de)
DK (1) DK1000062T3 (de)
ES (1) ES2229525T3 (de)
HU (1) HUP0002480A3 (de)
IL (1) IL133788A0 (de)
NO (1) NO315273B1 (de)
NZ (1) NZ502449A (de)
PT (1) PT1000062E (de)
RU (1) RU2213094C2 (de)
SI (1) SI1000062T1 (de)
TW (1) TW502035B (de)
WO (1) WO1999006409A1 (de)
ZA (1) ZA986784B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138393B2 (en) * 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
ES2207333T7 (es) * 1999-01-19 2009-06-18 Orto-Mcneil Pharmaceutical, Inc. Benzodiazepinas triciclicas utilizadas como antagonistas del receptor de la vasopresina.
JP2003510280A (ja) * 1999-09-27 2003-03-18 アメリカン・サイアナミド・カンパニー バソプレッシンアゴニスト処方および製法
US6831079B1 (en) * 1999-09-27 2004-12-14 American Cyanamid Company Vasopressin agonist formulation and process
GB0000079D0 (en) 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
GB0015601D0 (en) * 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents
US7326700B2 (en) 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7064120B2 (en) 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US6900200B2 (en) 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US6903087B2 (en) 2001-04-12 2005-06-07 Wyeth Pyrido cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7202239B2 (en) 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US6977254B2 (en) 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
NZ532033A (en) * 2001-10-12 2006-11-30 Azevan Pharmaceuticals Inc 2-(azetidin-2-on-1-yl)alkanedioic acid derivatives as vasopressin V1a receptor antagonists
RU2338747C2 (ru) * 2003-03-31 2008-11-20 Каунсил Оф Сайентифик Энд Индастриал Рисерч ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ
RU2326868C2 (ru) 2003-04-28 2008-06-20 Астеллас Фарма Инк. Производное 4,4-дифтор-1,2,2,4-тетрагидро-5н-1-бензазепина или его соль
GB0406917D0 (en) 2004-03-26 2004-04-28 Photocure Asa Compounds
EP1627876A1 (de) * 2004-08-20 2006-02-22 Ferring B.V. Kondensierte heterocyclische Verbindungen und ihre Verwendung als antidiuretische Mittel
CA2578370A1 (en) 2004-08-25 2006-03-02 Pfizer Inc. Triazolobenzodiazepines and their use as vasopressin antagonists
EP1868434A4 (de) 2005-03-22 2011-10-26 Azevan Pharmaceuticals Inc Beta-lactamylalkansäuren zur behandlung von prämenstruellen störungen
PE20110537A1 (es) 2008-11-13 2011-08-04 Hoffmann La Roche ESPIRO-5,6-DIHIDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENOS COMO ANTAGONISTAS DE LA V1a
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
US8420633B2 (en) * 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
GB201005623D0 (en) 2010-04-01 2010-05-19 Vantia Ltd New polymorph
US8461151B2 (en) * 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8481528B2 (en) * 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) * 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
ES2662350T3 (es) 2010-07-01 2018-04-06 Azevan Pharmaceuticals, Inc. Procedimientos para el tratamiento del trastorno por estrés postraumático
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
WO2014134391A1 (en) 2013-02-28 2014-09-04 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
AU2015237253B2 (en) 2014-03-28 2019-11-14 Azevan Pharmaceuticals, Inc. Compositions and methods for treating neurodegenerative diseases
MY208313A (en) 2017-09-15 2025-04-30 Azevan Pharmaceuticals Inc Compositions and methods for treating brain injury

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516774A (en) * 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5521173A (en) * 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
TW359669B (en) * 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives

Also Published As

Publication number Publication date
AU8663398A (en) 1999-02-22
NO315273B1 (no) 2003-08-11
RU2213094C2 (ru) 2003-09-27
IL133788A0 (en) 2001-04-30
SI1000062T1 (en) 2004-12-31
TW502035B (en) 2002-09-11
NO20000242D0 (no) 2000-01-18
JP2001512125A (ja) 2001-08-21
CA2297406C (en) 2009-02-24
EP1000062B1 (de) 2004-09-22
HUP0002480A3 (en) 2002-09-30
EP1000062A1 (de) 2000-05-17
CA2297406A1 (en) 1999-02-11
KR20010022398A (ko) 2001-03-15
ATE277050T1 (de) 2004-10-15
KR100580805B1 (ko) 2006-05-17
CN1272111A (zh) 2000-11-01
PT1000062E (pt) 2004-12-31
WO1999006409A1 (en) 1999-02-11
CN1183134C (zh) 2005-01-05
DE69826487T2 (de) 2005-12-01
HUP0002480A2 (hu) 2000-11-28
BR9811585A (pt) 2000-09-26
JP4338305B2 (ja) 2009-10-07
AR016557A1 (es) 2001-07-25
NO20000242L (no) 2000-03-06
ES2229525T3 (es) 2005-04-16
AU756959B2 (en) 2003-01-30
NZ502449A (en) 2002-08-28
DK1000062T3 (da) 2004-11-22
DE69826487D1 (de) 2004-10-28

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