ZA986837B - 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4. - Google Patents

4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4.

Info

Publication number: ZA986837B
Authority: ZA; South Africa
Prior art keywords: vla; amino; type compounds; leukocyte adhesion; adhesion mediated
Prior art date: 1997-07-31

Application number

ZA9806837A

Other languages

English (en)

Inventor

Susan Ashwell

Eugene D Thorsett

Dimitrios Sarantakis

Anthony Kreft

Francine S Grant

Louis John Lombardo

Christopher M Semko

Michael A Pleiss

Andrei W Konradi

Original Assignee

Anthena Neurosciences Inc

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-31

Filing date

1998-07-30

Publication date

2000-05-02

1998-07-30 Application filed by Anthena Neurosciences Inc, American Home Prod filed Critical Anthena Neurosciences Inc

2000-05-02 Publication of ZA986837B publication Critical patent/ZA986837B/xx

Links

CMUHFUGDYMFHEI-QMMMGPOBSA-N 4-amino-L-phenylalanine Chemical class OC(=O)[C@@H](N)CC1=CC=C(N)C=C1 CMUHFUGDYMFHEI-QMMMGPOBSA-N 0.000 title 1
108010008212 Integrin alpha4beta1 Proteins 0.000 title 1
230000023404 leukocyte cell-cell adhesion Effects 0.000 title 1
230000001404 mediated effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)

ZA9806837A 1997-07-31 1998-07-30 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4. ZA986837B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US92035397A	1997-07-31	1997-07-31

Publications (1)

Publication Number	Publication Date
ZA986837B true ZA986837B (en)	2000-05-02

Family

ID=25443597

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9806837A ZA986837B (en)	1997-07-31	1998-07-30	4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4.

Country Status (17)

Country	Link
EP (1)	EP1001974B1 (de)
JP (1)	JP2003517424A (de)
KR (1)	KR20010022414A (de)
CN (1)	CN1265674A (de)
AR (1)	AR014903A1 (de)
AT (1)	ATE327245T1 (de)
AU (1)	AU8584698A (de)
BR (1)	BR9812118A (de)
CA (1)	CA2290750A1 (de)
DE (1)	DE69834642T2 (de)
HU (1)	HUP0004531A3 (de)
IL (1)	IL133638A0 (de)
NO (1)	NO20000411L (de)
NZ (1)	NZ502580A (de)
PL (1)	PL338413A1 (de)
WO (1)	WO1999006434A1 (de)
ZA (1)	ZA986837B (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6903075B1 (en)	1997-05-29	2005-06-07	Merck & Co., Inc.	Heterocyclic amide compounds as cell adhesion inhibitors
JP2002501518A (ja) *	1997-05-30	2002-01-15	セルテックセラピューティックスリミテッド	抗炎症性チロシン誘導体
JP2001517246A (ja)	1997-06-23	2001-10-02	田辺製薬株式会社	α▲下４▼β▲下１▼媒介細胞接着の阻止剤
US6197794B1 (en) *	1998-01-08	2001-03-06	Celltech Therapeutics Limited	Phenylalanine derivatives
MY153569A (en)	1998-01-20	2015-02-27	Mitsubishi Tanabe Pharma Corp	Inhibitors of ?4 mediated cell adhesion
US6329372B1 (en)	1998-01-27	2001-12-11	Celltech Therapeutics Limited	Phenylalanine derivatives
EP1056714B1 (de)	1998-02-26	2004-08-11	Celltech Therapeutics Limited	Phenylalaninderivate als inhibitoren von alpha4 integrinen
US6521626B1 (en)	1998-03-24	2003-02-18	Celltech R&D Limited	Thiocarboxamide derivatives
DE69939165D1 (de)	1998-04-16	2008-09-04	Encysive Pharmaceuticals Inc	N,n-disubstituierte amide welche die bindung von integrinen an ihre rezeptoren hemmen
GB9811159D0 (en)	1998-05-22	1998-07-22	Celltech Therapeutics Ltd	Chemical compounds
GB9811969D0 (en) *	1998-06-03	1998-07-29	Celltech Therapeutics Ltd	Chemical compounds
US6685617B1 (en)	1998-06-23	2004-02-03	Pharmacia & Upjohn Company	Inhibitors of α4β1 mediated cell adhesion
GB9814414D0 (en)	1998-07-03	1998-09-02	Celltech Therapeutics Ltd	Chemical compounds
US6333340B1 (en) *	1998-08-14	2001-12-25	Gpi Nil Holdings, Inc.	Small molecule sulfonamides for vision and memory disorders
US6339101B1 (en) *	1998-08-14	2002-01-15	Gpi Nil Holdings, Inc.	N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
GB9821061D0 (en)	1998-09-28	1998-11-18	Celltech Therapeutics Ltd	Chemical compounds
GB9821222D0 (en)	1998-09-30	1998-11-25	Celltech Therapeutics Ltd	Chemical compounds
GB9825652D0 (en)	1998-11-23	1999-01-13	Celltech Therapeutics Ltd	Chemical compounds
GB9826174D0 (en)	1998-11-30	1999-01-20	Celltech Therapeutics Ltd	Chemical compounds
KR100649819B1 (ko) *	1999-02-18	2007-02-28	에프. 호프만-라 로슈 아게	티오아미드 유도체
US6972296B2 (en)	1999-05-07	2005-12-06	Encysive Pharmaceuticals Inc.	Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
US6723711B2 (en)	1999-05-07	2004-04-20	Texas Biotechnology Corporation	Propanoic acid derivatives that inhibit the binding of integrins to their receptors
US6518283B1 (en)	1999-05-28	2003-02-11	Celltech R&D Limited	Squaric acid derivatives
GEP20053477B (en) *	1999-08-13	2005-03-25	Biogen Inc	Cell Adhesion Inhibitors and Pharmaceutical Compositions Containing Them
US6534513B1 (en)	1999-09-29	2003-03-18	Celltech R&D Limited	Phenylalkanoic acid derivatives
US6455539B2 (en)	1999-12-23	2002-09-24	Celltech R&D Limited	Squaric acid derivates
EP1244656A1 (de)	1999-12-28	2002-10-02	Pfizer Products Inc.	Nicht-peptidische inhibitoren vla-4 abhängiger zellbindung nützlich für die behandlung von entzündungs- autoimmun- und atemwegserkrankungen
AU2001248553A1 (en)	2000-04-17	2001-10-30	Celltech R And D Limited	Enamine derivatives as cell adhesion molecules
US6403608B1 (en)	2000-05-30	2002-06-11	Celltech R&D, Ltd.	3-Substituted isoquinolin-1-yl derivatives
US6545013B2 (en)	2000-05-30	2003-04-08	Celltech R&D Limited	2,7-naphthyridine derivatives
WO2002004426A1 (en)	2000-07-07	2002-01-17	Celltech R & D Limited	Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
EP1305291A1 (de)	2000-08-02	2003-05-02	Celltech R&D Limited	3-substituierte isochinolin-1-yl-derivate
MY129000A (en)	2000-08-31	2007-03-30	Tanabe Seiyaku Co	INHIBITORS OF a4 MEDIATED CELL ADHESION
MY140707A (en)	2002-02-28	2010-01-15	Mitsubishi Tanabe Pharma Corp	Process for preparing a phenylalanine derivative and intermediates thereof
TW200403058A (en) *	2002-04-19	2004-03-01	Bristol Myers Squibb Co	Heterocyclo inhibitors of potassium channel function
CA2514125A1 (en) *	2003-01-24	2004-08-12	Elan Pharmaceuticals, Inc.	Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
AU2003303815A1 (en) *	2003-01-28	2004-08-23	Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	Alanines compounds, method of preparing them and their use
US7196112B2 (en)	2004-07-16	2007-03-27	Biogen Idec Ma Inc.	Cell adhesion inhibitors
KR100646882B1 (ko) *	2004-08-09	2006-11-23	엘지전자 주식회사	전기오븐레인지의 오븐부 배기구조
TW200621244A (en)	2004-08-19	2006-07-01	Vertex Pharma	Modulators of muscarinic receptors
US7786141B2 (en)	2004-08-19	2010-08-31	Vertex Pharmaceuticals Incorporated	Dihydrospiroindene modulators of muscarinic receptors
WO2006022442A1 (ja) *	2004-08-24	2006-03-02	Santen Pharmaceutical Co., Ltd.	ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体
JP2008521825A (ja)	2004-11-29	2008-06-26	バーテックスファーマシューティカルズインコーポレイテッド	ムスカリン受容体のモジュレーター
US7858635B2 (en)	2005-12-22	2010-12-28	Vertex Pharmaceuticals Incorporated	Spiro compounds as modulators of muscarinic receptors
CA2856037C (en)	2005-12-28	2017-03-07	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters
US7671221B2 (en)	2005-12-28	2010-03-02	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
NZ570497A (en)	2006-02-22	2011-09-30	Vertex Pharma	Spiro condensed 4,4'-quinilino-piperidines derivatives as modulators of muscarinic receptors
CN101426499A (zh)	2006-02-22	2009-05-06	弗特克斯药品有限公司	毒蕈碱受体调节剂
CN101500565A (zh)	2006-06-29	2009-08-05	弗特克斯药品有限公司	毒蕈碱性受体的调节剂
EP2051712A2 (de)	2006-08-15	2009-04-29	Vertex Pharmceuticals Incorporated	Modulatoren muskarinischer rezeptoren
WO2008021545A2 (en)	2006-08-18	2008-02-21	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
EP2124996A4 (de)	2007-02-20	2010-03-24	Merrimack Pharmaceuticals Inc	Verfahren zur behandlung von multipler sklerose mittels verabreichung eines alpha-fetoproteins in kombination mit einem integrinantagonisten
MX2010003373A (es)	2007-10-03	2010-04-30	Vertex Pharma	Moduladores de receptores muscarinicos.
CA2721093A1 (en)	2008-04-11	2009-10-15	Merrimack Pharmaceuticals, Inc.	Human serum albumin linkers and conjugates thereof
DE102009058289A1 (de)	2009-12-04	2011-06-09	Vladimir Volchkov	Viertaktmotor und Verfahren zu seinem Betrieb
DE102009058290A1 (de)	2009-12-04	2011-06-09	Vladimir Volchkov	Viertaktmotor, Verfahren zu seinem Betrieb und Kraftstoffeinspritzverfahren
DE102010008225A1 (de)	2010-02-09	2011-08-11	Volchkov, Vladimir, 71638	Viertakt-Gegenkolbenmotor und Verfahren zu seinem Betrieb
AU2019373242B2 (en)	2018-10-30	2023-07-13	Gilead Sciences, Inc.	Compounds for inhibition of alpha 4 beta 7 integrin
EP4541422A3 (de)	2018-10-30	2025-06-25	Gilead Sciences, Inc.	Chinolinderivate als alpha4beta7-integrinhemmer
KR102659859B1 (ko)	2018-10-30	2024-04-25	길리애드 사이언시즈, 인코포레이티드	알파4β7 인테그린의 억제를 위한 화합물
CN112969700B (zh)	2018-10-30	2024-08-20	吉利德科学公司	作为α4β7整合素抑制剂的咪唑并吡啶衍生物
KR102908219B1 (ko)	2019-08-14	2026-01-08	길리애드 사이언시즈, 인코포레이티드	알파 4 베타 7 인테그린의 저해용 화합물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995015973A1 (en) *	1993-12-06	1995-06-15	Cytel Corporation	Cs-1 peptidomimetics, compositions and methods of using the same
US6306840B1 (en) *	1995-01-23	2001-10-23	Biogen, Inc.	Cell adhesion inhibitors
AR016133A1 (es) *	1997-07-31	2001-06-20	Wyeth Corp	Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria

1998
- 1998-07-30 BR BR9812118-9A patent/BR9812118A/pt not_active Application Discontinuation
- 1998-07-30 AR ARP980103777A patent/AR014903A1/es unknown
- 1998-07-30 AT AT98937049T patent/ATE327245T1/de not_active IP Right Cessation
- 1998-07-30 CA CA002290750A patent/CA2290750A1/en not_active Abandoned
- 1998-07-30 WO PCT/US1998/015312 patent/WO1999006434A1/en not_active Ceased
- 1998-07-30 CN CN98807763A patent/CN1265674A/zh active Pending
- 1998-07-30 EP EP98937049A patent/EP1001974B1/de not_active Expired - Lifetime
- 1998-07-30 IL IL13363898A patent/IL133638A0/xx unknown
- 1998-07-30 HU HU0004531A patent/HUP0004531A3/hu unknown
- 1998-07-30 NZ NZ502580A patent/NZ502580A/en unknown
- 1998-07-30 ZA ZA9806837A patent/ZA986837B/xx unknown
- 1998-07-30 AU AU85846/98A patent/AU8584698A/en not_active Abandoned
- 1998-07-30 DE DE69834642T patent/DE69834642T2/de not_active Expired - Fee Related
- 1998-07-30 PL PL98338413A patent/PL338413A1/xx unknown
- 1998-07-30 KR KR1020007000994A patent/KR20010022414A/ko not_active Withdrawn
- 1998-07-30 JP JP2000505189A patent/JP2003517424A/ja active Pending
2000
- 2000-01-27 NO NO20000411A patent/NO20000411L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0004531A3 (en)	2001-12-28
CA2290750A1 (en)	1999-02-11
AR014903A1 (es)	2001-04-11
DE69834642T2 (de)	2007-05-03
NO20000411D0 (no)	2000-01-27
HUP0004531A2 (hu)	2001-04-28
KR20010022414A (ko)	2001-03-15
AU8584698A (en)	1999-02-22
CN1265674A (zh)	2000-09-06
PL338413A1 (en)	2000-11-06
JP2003517424A (ja)	2003-05-27
WO1999006434A1 (en)	1999-02-11
NZ502580A (en)	2001-06-29
IL133638A0 (en)	2001-04-30
EP1001974B1 (de)	2006-05-24
ATE327245T1 (de)	2006-06-15
NO20000411L (no)	2000-03-28
EP1001974A1 (de)	2000-05-24
BR9812118A (pt)	2000-07-18
DE69834642D1 (de)	2006-06-29

Publication	Publication Date	Title
ZA986837B (en)	2000-05-02	4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4.
ZA986834B (en)	2000-05-02	Compounds which inhibit leukocyte adhesion mediated by VLA-4.
ZA986827B (en)	2000-05-02	Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4.
IL133641A0 (en)	2001-04-30	Compounds which inhibit leukocyte adhesion mediated by vla-4
IL133635A0 (en)	2001-04-30	Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4
IL133636A0 (en)	2001-04-30	Carbamyloxy compounds which inhibit leukocyte adhesion mediated by vla-4
IL133637A0 (en)	2001-04-30	Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4
AU2623900A (en)	2000-08-07	Compounds which inhibit leukocyte adhesion mediated by vla-4
IL133639A0 (en)	2001-04-30	Dipeptide and related compounds which inhibit leukocyte adhesion mediated by vla-4
ZA989767B (en)	2000-04-28	Novel compounds.
ZA9711046B (en)	1998-06-22	A novel compound form.
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ZA992899B (en)	2000-03-29	Novel compound.
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AUPP003297A0 (en)	1997-11-20	4,5-diaryloxazole compounds
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AU6904698A (en)	1998-12-03	Herbicidal 3,5-difluoropyridines