ATE327245T1 - Verbindungen mit einer 4-amino-phenylalaningruppe,die die vla-4 vermittelte adhäsion von leukozyten inhibieren - Google Patents

Verbindungen mit einer 4-amino-phenylalaningruppe,die die vla-4 vermittelte adhäsion von leukozyten inhibieren

Info

Publication number: ATE327245T1
Authority: AT; Austria
Prior art keywords: leukocytes; amino; compounds containing; mediated adhesion; phenylalanine group
Prior art date: 1997-07-31

Application number

AT98937049T

Other languages

English (en)

Inventor

Susan Ashwell

Francine S Grant

Andrei W Konradi

Anthony Kreft

Louis John Lombardo

Michael A Pleiss

Dimitrios Sarantakis

Christopher M Semko

Eugene D Thorsett

Original Assignee

Elan Pharm Inc

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-31

Filing date

1998-07-30

Publication date

2006-06-15

1998-07-30 Application filed by Elan Pharm Inc, Wyeth Corp filed Critical Elan Pharm Inc

2006-06-15 Application granted granted Critical

2006-06-15 Publication of ATE327245T1 publication Critical patent/ATE327245T1/de

Links

CMUHFUGDYMFHEI-QMMMGPOBSA-N 4-amino-L-phenylalanine Chemical group OC(=O)[C@@H](N)CC1=CC=C(N)C=C1 CMUHFUGDYMFHEI-QMMMGPOBSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
210000000265 leukocyte Anatomy 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Oncology (AREA)
Transplantation (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)

AT98937049T 1997-07-31 1998-07-30 Verbindungen mit einer 4-amino-phenylalaningruppe,die die vla-4 vermittelte adhäsion von leukozyten inhibieren ATE327245T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US92035397A	1997-07-31	1997-07-31

Publications (1)

Publication Number	Publication Date
ATE327245T1 true ATE327245T1 (de)	2006-06-15

Family

ID=25443597

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98937049T ATE327245T1 (de)	1997-07-31	1998-07-30	Verbindungen mit einer 4-amino-phenylalaningruppe,die die vla-4 vermittelte adhäsion von leukozyten inhibieren

Country Status (17)

Country	Link
EP (1)	EP1001974B1 (de)
JP (1)	JP2003517424A (de)
KR (1)	KR20010022414A (de)
CN (1)	CN1265674A (de)
AR (1)	AR014903A1 (de)
AT (1)	ATE327245T1 (de)
AU (1)	AU8584698A (de)
BR (1)	BR9812118A (de)
CA (1)	CA2290750A1 (de)
DE (1)	DE69834642T2 (de)
HU (1)	HUP0004531A3 (de)
IL (1)	IL133638A0 (de)
NO (1)	NO20000411L (de)
NZ (1)	NZ502580A (de)
PL (1)	PL338413A1 (de)
WO (1)	WO1999006434A1 (de)
ZA (1)	ZA986837B (de)

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US6333340B1 (en) *	1998-08-14	2001-12-25	Gpi Nil Holdings, Inc.	Small molecule sulfonamides for vision and memory disorders
US6339101B1 (en) *	1998-08-14	2002-01-15	Gpi Nil Holdings, Inc.	N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
GB9821061D0 (en)	1998-09-28	1998-11-18	Celltech Therapeutics Ltd	Chemical compounds
GB9821222D0 (en)	1998-09-30	1998-11-25	Celltech Therapeutics Ltd	Chemical compounds
GB9825652D0 (en)	1998-11-23	1999-01-13	Celltech Therapeutics Ltd	Chemical compounds
GB9826174D0 (en)	1998-11-30	1999-01-20	Celltech Therapeutics Ltd	Chemical compounds
CA2362831C (en) *	1999-02-18	2008-10-07	F. Hoffmann-La Roche Ag	Thioamide derivatives
US6723711B2 (en)	1999-05-07	2004-04-20	Texas Biotechnology Corporation	Propanoic acid derivatives that inhibit the binding of integrins to their receptors
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US6518283B1 (en)	1999-05-28	2003-02-11	Celltech R&D Limited	Squaric acid derivatives
DK1265606T3 (da)	1999-08-13	2007-02-12	Biogen Idec Inc	Celleadhæsionsinhibitorer
US6534513B1 (en)	1999-09-29	2003-03-18	Celltech R&D Limited	Phenylalkanoic acid derivatives
US6455539B2 (en)	1999-12-23	2002-09-24	Celltech R&D Limited	Squaric acid derivates
AP2002002565A0 (en)	1999-12-28	2002-06-30	Pfizer Prod Inc	Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases.
WO2001079173A2 (en)	2000-04-17	2001-10-25	Celltech R & D Limited	Enamine derivatives as cell adhesion molecules
US6403608B1 (en)	2000-05-30	2002-06-11	Celltech R&D, Ltd.	3-Substituted isoquinolin-1-yl derivatives
US6545013B2 (en)	2000-05-30	2003-04-08	Celltech R&D Limited	2,7-naphthyridine derivatives
EP1301488A1 (de)	2000-07-07	2003-04-16	Celltech R&D Limited	Bicyclische heteroaromatische ring enthaltende quadratsäure-derivate als integrin-antagonisten
EP1305291A1 (de)	2000-08-02	2003-05-02	Celltech R&D Limited	3-substituierte isochinolin-1-yl-derivate
MY129000A (en)	2000-08-31	2007-03-30	Tanabe Seiyaku Co	INHIBITORS OF a4 MEDIATED CELL ADHESION
MY140707A (en)	2002-02-28	2010-01-15	Mitsubishi Tanabe Pharma Corp	Process for preparing a phenylalanine derivative and intermediates thereof
TW200403058A (en) *	2002-04-19	2004-03-01	Bristol Myers Squibb Co	Heterocyclo inhibitors of potassium channel function
KR20050114212A (ko) *	2003-01-24	2005-12-05	엘란 파마슈티칼스, 인크.	수초재생제의 투여에 의한 탈수초성 질환 및 마비의 치료및 조성물
EP1591440A4 (de) *	2003-01-28	2006-03-29	Shanghai Inst Materia Medica	Alaninverbindungen, herstellungsverfahren und verwendung
US7196112B2 (en)	2004-07-16	2007-03-27	Biogen Idec Ma Inc.	Cell adhesion inhibitors
KR100646882B1 (ko) *	2004-08-09	2006-11-23	엘지전자 주식회사	전기오븐레인지의 오븐부 배기구조
US7786141B2 (en)	2004-08-19	2010-08-31	Vertex Pharmaceuticals Incorporated	Dihydrospiroindene modulators of muscarinic receptors
CN101031296A (zh)	2004-08-19	2007-09-05	弗特克斯药品有限公司	毒蕈碱受体调节剂
WO2006022442A1 (ja) *	2004-08-24	2006-03-02	Santen Pharmaceutical Co., Ltd.	ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体
CN101155587A (zh)	2004-11-29	2008-04-02	弗特克斯药品有限公司	毒蕈碱受体调节剂
JP2009521483A (ja)	2005-12-22	2009-06-04	バーテックスファーマシューティカルズインコーポレイテッド	ムスカリン受容体のモジュレーター
US7671221B2 (en)	2005-12-28	2010-03-02	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
US7691902B2 (en)	2005-12-28	2010-04-06	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
US8003660B2 (en)	2006-02-22	2011-08-23	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
WO2007100670A1 (en)	2006-02-22	2007-09-07	Vertex Pharmaceuticals Incorporated	Spiro condensed piperidnes as modulators of muscarinic receptors
WO2008005295A2 (en)	2006-06-29	2008-01-10	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
US7696201B2 (en)	2006-08-15	2010-04-13	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
CA2660974A1 (en)	2006-08-18	2008-02-21	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
AU2008219007A1 (en)	2007-02-20	2008-08-28	Merrimack Pharmaceuticals, Inc.	Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
MX2010003373A (es)	2007-10-03	2010-04-30	Vertex Pharma	Moduladores de receptores muscarinicos.
ES2525065T3 (es)	2008-04-11	2014-12-17	Merrimack Pharmaceuticals, Inc.	Ligadores de seroalbúmina humana y sus conjugados
DE102009058290A1 (de)	2009-12-04	2011-06-09	Vladimir Volchkov	Viertaktmotor, Verfahren zu seinem Betrieb und Kraftstoffeinspritzverfahren
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US6306840B1 (en) *	1995-01-23	2001-10-23	Biogen, Inc.	Cell adhesion inhibitors
AR016133A1 (es) *	1997-07-31	2001-06-20	Wyeth Corp	Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria

1998
- 1998-07-30 CN CN98807763A patent/CN1265674A/zh active Pending
- 1998-07-30 KR KR1020007000994A patent/KR20010022414A/ko not_active Withdrawn
- 1998-07-30 AT AT98937049T patent/ATE327245T1/de not_active IP Right Cessation
- 1998-07-30 ZA ZA9806837A patent/ZA986837B/xx unknown
- 1998-07-30 EP EP98937049A patent/EP1001974B1/de not_active Expired - Lifetime
- 1998-07-30 DE DE69834642T patent/DE69834642T2/de not_active Expired - Fee Related
- 1998-07-30 PL PL98338413A patent/PL338413A1/xx unknown
- 1998-07-30 AR ARP980103777A patent/AR014903A1/es unknown
- 1998-07-30 NZ NZ502580A patent/NZ502580A/en unknown
- 1998-07-30 CA CA002290750A patent/CA2290750A1/en not_active Abandoned
- 1998-07-30 WO PCT/US1998/015312 patent/WO1999006434A1/en not_active Ceased
- 1998-07-30 BR BR9812118-9A patent/BR9812118A/pt not_active Application Discontinuation
- 1998-07-30 IL IL13363898A patent/IL133638A0/xx unknown
- 1998-07-30 HU HU0004531A patent/HUP0004531A3/hu unknown
- 1998-07-30 JP JP2000505189A patent/JP2003517424A/ja active Pending
- 1998-07-30 AU AU85846/98A patent/AU8584698A/en not_active Abandoned
2000
- 2000-01-27 NO NO20000411A patent/NO20000411L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20000411L (no)	2000-03-28
AR014903A1 (es)	2001-04-11
IL133638A0 (en)	2001-04-30
ZA986837B (en)	2000-05-02
CA2290750A1 (en)	1999-02-11
HUP0004531A3 (en)	2001-12-28
KR20010022414A (ko)	2001-03-15
DE69834642D1 (de)	2006-06-29
AU8584698A (en)	1999-02-22
DE69834642T2 (de)	2007-05-03
EP1001974A1 (de)	2000-05-24
NO20000411D0 (no)	2000-01-27
NZ502580A (en)	2001-06-29
WO1999006434A1 (en)	1999-02-11
CN1265674A (zh)	2000-09-06
HUP0004531A2 (hu)	2001-04-28
EP1001974B1 (de)	2006-05-24
PL338413A1 (en)	2000-11-06
BR9812118A (pt)	2000-07-18
JP2003517424A (ja)	2003-05-27

Legal Events

Date	Code	Title	Description
2006-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE327245T1 (de)	2006-06-15	Verbindungen mit einer 4-amino-phenylalaningruppe,die die vla-4 vermittelte adhäsion von leukozyten inhibieren
DE60036918D1 (de)	2007-12-13	Verbindungen die die vla-4 vermittelte adhäsion von leukozyten inhibieren
ZA986834B (en)	2000-05-02	Compounds which inhibit leukocyte adhesion mediated by VLA-4.
IL133641A0 (en)	2001-04-30	Compounds which inhibit leukocyte adhesion mediated by vla-4
ZA986827B (en)	2000-05-02	Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4.
NO20000414D0 (no)	2000-01-27	Benzylforbindelser som inhiberer leukocytt adhesjon mediert av VLA-4
IL133636A0 (en)	2001-04-30	Carbamyloxy compounds which inhibit leukocyte adhesion mediated by vla-4
IL133637A0 (en)	2001-04-30	Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4
AR244740A1 (es)	1993-11-30	Una composicion de polipropileno.
DE69520347D1 (de)	2001-04-19	Borsäure-Verbindungen mit einer Binaphthyl-Gruppe
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