ZA993364B - Novel 4-phenylpiperidines for the treatment of pruritic dermatoses. - Google Patents
Novel 4-phenylpiperidines for the treatment of pruritic dermatoses.Info
- Publication number
- ZA993364B ZA993364B ZA9903364A ZA993364A ZA993364B ZA 993364 B ZA993364 B ZA 993364B ZA 9903364 A ZA9903364 A ZA 9903364A ZA 993364 A ZA993364 A ZA 993364A ZA 993364 B ZA993364 B ZA 993364B
- Authority
- ZA
- South Africa
- Prior art keywords
- phenylpiperidines
- novel
- treatment
- pruritic dermatoses
- pruritic
- Prior art date
Links
- UTBULQCHEUWJNV-UHFFFAOYSA-N 4-phenylpiperidine Chemical class C1CNCCC1C1=CC=CC=C1 UTBULQCHEUWJNV-UHFFFAOYSA-N 0.000 title 1
- 230000001823 pruritic effect Effects 0.000 title 1
- 208000017520 skin disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9810671.9A GB9810671D0 (en) | 1998-05-18 | 1998-05-18 | Anti-pruritic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA993364B true ZA993364B (en) | 2000-12-01 |
Family
ID=10832267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9903364A ZA993364B (en) | 1998-05-18 | 1999-05-17 | Novel 4-phenylpiperidines for the treatment of pruritic dermatoses. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6610711B2 (de) |
| EP (1) | EP1077940B1 (de) |
| JP (1) | JP2002515486A (de) |
| AP (1) | AP9901535A0 (de) |
| AT (1) | ATE271038T1 (de) |
| AU (1) | AU3531299A (de) |
| BR (1) | BR9910609A (de) |
| CA (1) | CA2332538C (de) |
| DE (1) | DE69918687T2 (de) |
| DK (1) | DK1077940T3 (de) |
| ES (1) | ES2230846T3 (de) |
| GB (1) | GB9810671D0 (de) |
| GT (1) | GT199900067A (de) |
| MA (1) | MA26630A1 (de) |
| PT (1) | PT1077940E (de) |
| TN (1) | TNSN99095A1 (de) |
| WO (1) | WO1999059971A1 (de) |
| ZA (1) | ZA993364B (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9912417D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912415D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912410D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912416D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| MXPA03011886A (es) * | 2001-07-05 | 2005-03-07 | Lundbeck & Co As H | Piperidinias anilinicas sustituidas como antagonistas selectivos de mch. |
| US6727264B1 (en) | 2001-07-05 | 2004-04-27 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as MCH selective antagonists |
| JP4155522B2 (ja) * | 2001-10-22 | 2008-09-24 | ファイザー・プロダクツ・インク | オピオイド受容体アンタゴニストとしての３−アザビシクロ（３．１．０）ヘキサン誘導体 |
| BR0214295A (pt) * | 2001-11-19 | 2004-11-09 | Elan Pharm Inc | Composto, método para tratar um paciente que tem ou prevenir um paciente de adquirir uma doença ou condição, e, método para produzir um composto |
| ES2201908B1 (es) * | 2002-05-29 | 2005-02-16 | Laboratorios Del Dr. Esteve, S.A. | Pienso suplementado con ketoprofeno y su empleo en el tratamiento de procesos que cursan con fiebre, inflamacion y/o dolor, en un colectivo de animales, de forma simultanea. |
| BRPI0409307A (pt) * | 2003-04-14 | 2006-04-25 | Pfizer Prod Inc | derivados de 3-azabiciclo[3.2.1]octano |
| FR2872416B1 (fr) * | 2004-07-01 | 2006-09-22 | Oreal | Utilisation de derives de piperidine pour lutter contre les rides |
| EP2767163A1 (de) * | 2005-02-17 | 2014-08-20 | Abbott Laboratories | Transmukosale Verabreichung von Arzneimittelzusammensetzungen zur Behandlung und Vorbeugung von Erkrankungen bei Tieren |
| CA2632030A1 (en) * | 2005-12-15 | 2007-06-21 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| WO2008014199A2 (en) * | 2006-07-28 | 2008-01-31 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the cb2 receptor |
| KR20090069318A (ko) * | 2006-09-25 | 2009-06-30 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｃｂ2 수용체를 조절하는 화합물 |
| TWI409067B (zh) | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
| US7947710B2 (en) * | 2007-08-27 | 2011-05-24 | Theravance, Inc. | Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| TWI423801B (zh) | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物 |
| ES2465621T3 (es) * | 2007-08-27 | 2014-06-06 | Theravance, Inc. | Compuestos de heteroarilalquil-8-azabiciclo[3.2.1]octano, como antagonistas de los receptores opiodes mu |
| US7902221B2 (en) * | 2007-08-27 | 2011-03-08 | Theravance, Inc. | Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| EP2217565B1 (de) * | 2007-11-07 | 2013-05-22 | Boehringer Ingelheim International GmbH | Cb2 rezeptor-modulierende verbindungen |
| EP2326629B1 (de) * | 2008-07-10 | 2013-10-02 | Boehringer Ingelheim International GmbH | Den cb2-rezeptor modulierende sulfonverbindungen |
| CA2737645A1 (en) * | 2008-09-25 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
| US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| WO2010147791A1 (en) | 2009-06-16 | 2010-12-23 | Boehringer Ingelheim International Gmbh | Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor |
| EP2480544A1 (de) * | 2009-09-22 | 2012-08-01 | Boehringer Ingelheim International GmbH | Verbindungen für selektive cb2-rezeptormodulation |
| EP2523936A1 (de) | 2010-01-15 | 2012-11-21 | Boehringer Ingelheim International GmbH | Cb2 rezeptor-modulierende verbindungen |
| US8329735B2 (en) | 2010-03-05 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the CB2 receptor |
| WO2012012307A1 (en) | 2010-07-22 | 2012-01-26 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the cb2 rece |
| EP2803668A1 (de) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Neuartige (Cyano-dimethyl-methyl)-isoxazole und -[1,3,4]-thiadiazole |
| CN106278914B (zh) * | 2016-08-19 | 2018-04-13 | 四川福思达生物技术开发有限责任公司 | 一种增产胺的合成工艺 |
| CN116440882B (zh) * | 2023-01-16 | 2024-09-20 | 浙江纽龙合成材料制造有限公司 | 一种基于端烯基活化的疏水分离层析介质及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR206937A1 (es) * | 1974-09-06 | 1976-08-31 | Lilly Co Eli | Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina |
| NZ224236A (en) | 1987-04-16 | 1990-08-28 | Lilly Co Eli | Trans 3,4 pyridine derivatives and pharmaceutical compositions |
| US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| CZ284993B6 (cs) | 1991-03-29 | 1999-04-14 | Eli Lilly And Company | Derivát piperidinu |
| GB9507203D0 (en) * | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
| DZ2376A1 (fr) * | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| US6159979A (en) * | 1997-04-18 | 2000-12-12 | Smithkline Beecham P.L.C. | Bicyclic aryl or a bicyclic heterocyclic ring containing compounds having a combined 5HT1A, 5HT1B and 5HT1D receptor antagonistic activity |
-
1998
- 1998-05-18 GB GBGB9810671.9A patent/GB9810671D0/en not_active Ceased
-
1999
- 1999-05-13 AP APAP/P/1999/001535A patent/AP9901535A0/en unknown
- 1999-05-14 GT GT199900067A patent/GT199900067A/es unknown
- 1999-05-17 BR BR9910609-4A patent/BR9910609A/pt not_active IP Right Cessation
- 1999-05-17 MA MA25582A patent/MA26630A1/fr unknown
- 1999-05-17 DK DK99917038T patent/DK1077940T3/da active
- 1999-05-17 EP EP99917038A patent/EP1077940B1/de not_active Expired - Lifetime
- 1999-05-17 CA CA002332538A patent/CA2332538C/en not_active Expired - Fee Related
- 1999-05-17 DE DE69918687T patent/DE69918687T2/de not_active Expired - Fee Related
- 1999-05-17 ZA ZA9903364A patent/ZA993364B/xx unknown
- 1999-05-17 JP JP2000549590A patent/JP2002515486A/ja active Pending
- 1999-05-17 WO PCT/IB1999/000886 patent/WO1999059971A1/en not_active Ceased
- 1999-05-17 TN TNTNSN99095A patent/TNSN99095A1/fr unknown
- 1999-05-17 PT PT99917038T patent/PT1077940E/pt unknown
- 1999-05-17 AT AT99917038T patent/ATE271038T1/de not_active IP Right Cessation
- 1999-05-17 US US09/646,255 patent/US6610711B2/en not_active Expired - Fee Related
- 1999-05-17 ES ES99917038T patent/ES2230846T3/es not_active Expired - Lifetime
- 1999-05-17 AU AU35312/99A patent/AU3531299A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2230846T3 (es) | 2005-05-01 |
| EP1077940B1 (de) | 2004-07-14 |
| WO1999059971A1 (en) | 1999-11-25 |
| MA26630A1 (fr) | 2004-12-20 |
| AP9901535A0 (en) | 1999-06-30 |
| US6610711B2 (en) | 2003-08-26 |
| CA2332538C (en) | 2005-08-02 |
| DE69918687D1 (de) | 2004-08-19 |
| GB9810671D0 (en) | 1998-07-15 |
| DK1077940T3 (da) | 2004-11-01 |
| JP2002515486A (ja) | 2002-05-28 |
| US20030078282A1 (en) | 2003-04-24 |
| ATE271038T1 (de) | 2004-07-15 |
| AU3531299A (en) | 1999-12-06 |
| BR9910609A (pt) | 2001-01-09 |
| GT199900067A (es) | 2000-11-04 |
| CA2332538A1 (en) | 1999-11-25 |
| PT1077940E (pt) | 2004-10-29 |
| EP1077940A1 (de) | 2001-02-28 |
| DE69918687T2 (de) | 2005-07-28 |
| TNSN99095A1 (fr) | 2005-11-10 |
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