ZA996758B - Process for the preparation of mometasone furoate. - Google Patents

Process for the preparation of mometasone furoate.

Info

Publication number: ZA996758B
Authority: ZA; South Africa
Prior art keywords: preparation; mometasone furoate; mometasone; furoate; free
Prior art date: 1999-08-02

Application number

ZA9906758A

Other languages

English (en)

Inventor

William Heggie

Joao Bandarra

Original Assignee

Hovione Int Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-02

Filing date

1999-10-27

Publication date

2000-08-30

1999-10-27 Application filed by Hovione Int Ltd filed Critical Hovione Int Ltd

2000-08-30 Publication of ZA996758B publication Critical patent/ZA996758B/xx

Links

WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 title abstract 2
229960002744 mometasone furoate Drugs 0.000 title 1
OFTKFKYVSBNYEC-UHFFFAOYSA-N 2-furoyl chloride Chemical compound ClC(=O)C1=CC=CO1 OFTKFKYVSBNYEC-UHFFFAOYSA-N 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
239000012442 inert solvent Substances 0.000 abstract 1
QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 abstract 1
229960001664 mometasone Drugs 0.000 abstract 1
150000003512 tertiary amines Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA9906758A 1999-08-02 1999-10-27 Process for the preparation of mometasone furoate. ZA996758B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PT102343A PT102343B (pt)	1999-08-02	1999-08-02	Processo para a preparacao de furoato mometasona

Publications (1)

Publication Number	Publication Date
ZA996758B true ZA996758B (en)	2000-08-30

Family

ID=20085881

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9906758A ZA996758B (en)	1999-08-02	1999-10-27	Process for the preparation of mometasone furoate.

Country Status (22)

Country	Link
US (1)	US6177560B1 (de)
EP (1)	EP1074558B1 (de)
JP (1)	JP3746174B2 (de)
KR (1)	KR100640066B1 (de)
CN (1)	CN1149222C (de)
AT (1)	ATE229970T1 (de)
AU (1)	AU765592B2 (de)
CA (1)	CA2295455C (de)
DE (1)	DE69904585T2 (de)
DK (1)	DK1074558T3 (de)
ES (1)	ES2189354T3 (de)
HR (1)	HRP990341B1 (de)
HU (1)	HU227494B1 (de)
IL (1)	IL133752A (de)
NO (1)	NO321154B1 (de)
NZ (1)	NZ500555A (de)
PL (1)	PL191103B1 (de)
PT (1)	PT102343B (de)
RU (1)	RU2208616C2 (de)
SI (1)	SI1074558T1 (de)
UA (1)	UA60333C2 (de)
ZA (1)	ZA996758B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20070099883A1 (en) *	2005-10-07	2007-05-03	Cheryl Lynn Calis	Anhydrous mometasone furoate formulation
EP1790754A1 (de) *	2005-11-24	2007-05-30	Siemens Aktiengesellschaft	Schichtsystem mit Gadolinium-Mischkristall-Pyrochlorphase
US8021742B2 (en) *	2006-12-15	2011-09-20	Siemens Energy, Inc.	Impact resistant thermal barrier coating system
US8815258B2 (en)	2009-05-29	2014-08-26	Pearl Therapeutics, Inc.	Compositions, methods and systems for respiratory delivery of two or more active agents
AU2010253770B9 (en) *	2009-05-29	2015-02-12	Pearl Therapeutics, Inc.	Compositions for respiratory delivery of active agents and associated methods and systems
PT105139B (pt) *	2010-06-01	2013-01-29	Hovione Farmaciencia S A	Método para a monofluorometilação de substratos orgânicos para preparação de compostos orgânicos biologicamente activos
US20140275517A1 (en)	2013-03-15	2014-09-18	Pearl Therapeutics, Inc.	Methods and systems for conditioning of particulate crystalline materials
MX2015016058A (es)	2013-05-22	2016-12-20	Pearl Therapeutics Inc	Composiciones, metodos y sistemas para el suministro por via respiratoria de tres o mas agentes activos.
CN105481933B (zh) *	2015-12-25	2017-09-19	山东京卫制药有限公司	一种合成糠酸莫米松的方法
CN105566437B (zh) *	2015-12-30	2018-07-20	山东京卫制药有限公司	一种8dm衍生物及利用其合成糠酸莫米松的方法
CN107266518B (zh) *	2016-04-08	2021-03-30	天津金耀集团有限公司	一种糠酸莫米松晶型及其制备方法
MA61888B1 (fr)	2021-07-09	2024-06-28	Astrazeneca Pharmaceuticals Lp	Compositions, procédés et systèmes pour l'administration de médicament en aérosol
WO2023119093A1 (en)	2021-12-20	2023-06-29	Astrazeneca Ab	Compositions, methods and systems for aerosol drug delivery

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CY1359A (en) *	1981-02-02	1987-08-07	Schering Corp	Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them
AU725606B2 (en) *	1996-06-28	2000-10-12	Merck Sharp & Dohme Corp.	Process for the preparation of 17-esters of 9alpha,21- dihalo-pregnane-11beta,17alpha-diol-20-ones
US5886200A (en) *	1996-07-01	1999-03-23	Schering Corporation	Process for the preparation of 17-esters of 9 α, 21-dihalo-pregnane-11 β, 17 α-diol-20-ones

1999
- 1999-08-02 NZ NZ500555A patent/NZ500555A/xx not_active IP Right Cessation
- 1999-08-02 PT PT102343A patent/PT102343B/pt unknown
- 1999-10-21 HU HU9903747A patent/HU227494B1/hu unknown
- 1999-10-22 AU AU56024/99A patent/AU765592B2/en not_active Expired
- 1999-10-25 AT AT99308380T patent/ATE229970T1/de active
- 1999-10-25 SI SI9930173T patent/SI1074558T1/xx unknown
- 1999-10-25 DE DE69904585T patent/DE69904585T2/de not_active Expired - Lifetime
- 1999-10-25 DK DK99308380T patent/DK1074558T3/da active
- 1999-10-25 EP EP99308380A patent/EP1074558B1/de not_active Expired - Lifetime
- 1999-10-25 ES ES99308380T patent/ES2189354T3/es not_active Expired - Lifetime
- 1999-10-26 NO NO19995225A patent/NO321154B1/no not_active IP Right Cessation
- 1999-10-27 ZA ZA9906758A patent/ZA996758B/xx unknown
- 1999-11-03 RU RU99123183/04A patent/RU2208616C2/ru active
- 1999-11-03 KR KR1019990048285A patent/KR100640066B1/ko not_active Expired - Lifetime
- 1999-11-04 UA UA99116069A patent/UA60333C2/uk unknown
- 1999-11-05 HR HR990341A patent/HRP990341B1/xx not_active IP Right Cessation
- 1999-11-05 PL PL336452A patent/PL191103B1/pl unknown
- 1999-11-05 JP JP31523699A patent/JP3746174B2/ja not_active Expired - Lifetime
- 1999-11-26 CN CNB991243803A patent/CN1149222C/zh not_active Expired - Lifetime
- 1999-12-27 IL IL13375299A patent/IL133752A/en not_active IP Right Cessation
- 1999-12-29 US US09/476,004 patent/US6177560B1/en not_active Expired - Lifetime
2000
- 2000-01-14 CA CA002295455A patent/CA2295455C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU5602499A (en)	2001-02-08
JP2001048897A (ja)	2001-02-20
NZ500555A (en)	2000-11-24
PL336452A1 (en)	2001-02-12
HRP990341B1 (en)	2003-10-31
HU9903747D0 (en)	1999-12-28
SI1074558T1 (en)	2003-04-30
AU765592B2 (en)	2003-09-25
CN1149222C (zh)	2004-05-12
CN1282744A (zh)	2001-02-07
NO321154B1 (no)	2006-03-27
DK1074558T3 (da)	2003-04-07
NO995225D0 (no)	1999-10-26
US6177560B1 (en)	2001-01-23
HUP9903747A3 (en)	2001-07-30
HUP9903747A2 (hu)	2001-05-28
UA60333C2 (uk)	2003-10-15
PT102343B (pt)	2003-11-28
EP1074558A1 (de)	2001-02-07
IL133752A0 (en)	2001-04-30
KR20010020094A (ko)	2001-03-15
KR100640066B1 (ko)	2006-10-31
CA2295455A1 (en)	2001-02-02
NO995225L (no)	2001-02-05
JP3746174B2 (ja)	2006-02-15
PT102343A (pt)	2001-02-28
CA2295455C (en)	2008-03-25
PL191103B1 (pl)	2006-03-31
DE69904585T2 (de)	2003-05-15
ATE229970T1 (de)	2003-01-15
RU2208616C2 (ru)	2003-07-20
HU227494B1 (en)	2011-07-28
HRP990341A2 (en)	2001-04-30
ES2189354T3 (es)	2003-07-01
DE69904585D1 (de)	2003-01-30
EP1074558B1 (de)	2002-12-18
IL133752A (en)	2004-02-19

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