AP179A - 5 11-Dihydro-6H-Dipyrido (3, 2-b:2', 3'-e) (1,4) Diazepines and their use in the prevention and treatment of HIV infection. - Google Patents

5 11-Dihydro-6H-Dipyrido (3, 2-b:2', 3'-e) (1,4) Diazepines and their use in the prevention and treatment of HIV infection. Download PDF

Info

Publication number: AP179A
Authority: AP; ARIPO
Prior art keywords: carbon atoms; hydrogen; methyl; formula; alkyl
Prior art date: 1989-11-17

Application number

APAP/P/1990/000224A

Other languages

English (en)

Other versions

AP9000224A0 (en

Inventor

Schmidt Gunther Dr

Engel Wolfhard Dr

Trummlitz Gunther Dr

Eberlein Wolfgang Dr

Hargrave Karl D Dr

Original Assignee

Boehringer Ingelheim Pharmaceuticals Inc

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-17

Filing date

1990-11-16

Publication date

1992-04-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27412005&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP179(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-11-16 Application filed by Boehringer Ingelheim Pharmaceuticals Inc, Thomae Gmbh Dr K filed Critical Boehringer Ingelheim Pharmaceuticals Inc

1991-01-31 Publication of AP9000224A0 publication Critical patent/AP9000224A0/xx

1992-04-30 Application granted granted Critical

1992-04-30 Publication of AP179A publication Critical patent/AP179A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

APAP/P/1990/000224A 1989-11-17 1990-11-16 5 11-Dihydro-6H-Dipyrido (3, 2-b:2', 3'-e) (1,4) Diazepines and their use in the prevention and treatment of HIV infection. AP179A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US43892389A	1989-11-17	1989-11-17
US57900190A	1990-09-06	1990-09-06
US60039090A	1990-10-19	1990-10-19

Publications (2)

Publication Number	Publication Date
AP9000224A0 AP9000224A0 (en)	1991-01-31
AP179A true AP179A (en)	1992-04-30

Family

ID=27412005

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1990/000224A AP179A (en)	1989-11-17	1990-11-16	5 11-Dihydro-6H-Dipyrido (3, 2-b:2', 3'-e) (1,4) Diazepines and their use in the prevention and treatment of HIV infection.

Country Status (20)

Country	Link
EP (1)	EP0429987B1 (fr)
AP (1)	AP179A (fr)
AT (1)	ATE177744T1 (fr)
AU (1)	AU630251B2 (fr)
CA (1)	CA2030056C (fr)
DE (2)	DE19975051I2 (fr)
DK (1)	DK0429987T3 (fr)
ES (1)	ES2130114T3 (fr)
FI (1)	FI94529C (fr)
GR (1)	GR3030100T3 (fr)
IE (1)	IE904141A1 (fr)
IL (1)	IL96367A (fr)
LU (1)	LU90393I2 (fr)
NL (1)	NL990022I2 (fr)
NO (2)	NO175478C (fr)
NZ (1)	NZ236105A (fr)
OA (1)	OA09852A (fr)
PT (1)	PT95919B (fr)
RU (1)	RU2040527C1 (fr)
UA (1)	UA34420C2 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5366972A (en) *	1989-04-20	1994-11-22	Boehringer Ingelheim Pharmaceuticals, Inc.	5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
GB9109557D0 (en) *	1991-05-02	1991-06-26	Wellcome Found	Chemical compounds
JP3133331B2 (ja) *	1991-06-11	2001-02-05	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	３―アミノ―２―クロロ―４―アルキルピリジン類の製造方法
US5200522A (en) *	1991-06-11	1993-04-06	Boehringer Ingelheim Pharmaceuticals, Inc.	Method for preparing 3-amino-2-chloro-4-alkylpyridines
DE4138908A1 (de) *	1991-11-27	1993-06-03	Bayer Ag	6-thiono-dibenz(b,e)azepine
DE4138853A1 (de) *	1991-11-27	1993-06-03	Bayer Ag	5,6-dihydro-dibenz(b,e)azepin-6,11-dion-11- oxime
DK0598396T3 (da) *	1992-11-18	1998-11-23	Boehringer Ingelheim Pharma	Forbedret fremgangsmåde til fremstilling af 3-amino-2-chlor-4-alkylpyridiner
WO1994017075A1 (fr) *	1993-01-20	1994-08-04	A. Menarini Industrie Farmaceutiche Riunite S.R.L.	Derives de diazepine et compositions antivirales
DE4333697A1 (de) *	1993-10-02	1995-04-06	Merck Patent Gmbh	Verfahren zur Herstellung von 3-Aminopyridinen aus 3-Nitropyridinen
DE4403311C1 (de) *	1994-02-03	1995-04-20	Boehringer Ingelheim Kg	Verfahren zur Herstellung von Nevirapine (11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4-diazepin]-6-on)
PL181323B1 (pl) *	1994-02-18	2001-07-31	Boehringer Ingelheim Pharma	2-heteroarylo-5,11-dihydro-6H-dipirydo[3,2-b:2’,3'-e][1,4] diazepinyi ich zastosowanie w zapobieganiu i leczeniu zakazen HIV PL PL PL
DE69525978T2 (de) *	1995-06-06	2002-12-19	Pfizer	Trizyclische 5,6-dihydro-9h-pyrazolo(3,4-c)-1,2,4-triazolo(4,3-alpha)pyridine
US5917033A (en) *	1995-10-31	1999-06-29	University Of Medicine & Dentistry Of New Jersey	Structure based design of inhibitors of HIV-1 reverse transcriptase
US5747488A (en) *	1996-01-30	1998-05-05	Boehringer Ingelheim Pharmaceuticals, Inc.	2-aryl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-E! 1, 4!diazepines and their use in the treatment of HIV infection
IL134185A (en) *	1997-08-25	2005-11-20	Boehringer Ingelheim Pharma	Preparation of nevirapine hemihydrate and pharmaceutical suspensions containing it
DE10023492A1 (de) *	2000-05-09	2001-11-22	Schering Ag	Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel
US6878714B2 (en)	2001-01-12	2005-04-12	Amgen Inc.	Substituted alkylamine derivatives and methods of use
US7102009B2 (en)	2001-01-12	2006-09-05	Amgen Inc.	Substituted amine derivatives and methods of use
US7105682B2 (en)	2001-01-12	2006-09-12	Amgen Inc.	Substituted amine derivatives and methods of use
US6995162B2 (en)	2001-01-12	2006-02-07	Amgen Inc.	Substituted alkylamine derivatives and methods of use
US7307088B2 (en)	2002-07-09	2007-12-11	Amgen Inc.	Substituted anthranilic amide derivatives and methods of use
WO2006008119A1 (fr)	2004-07-16	2006-01-26	Proteosys Ag	Antagonistes muscariniques avec activite modulatrice parp et sin en tant qu'agents contre les maladies inflammatoires
US8247556B2 (en)	2005-10-21	2012-08-21	Amgen Inc.	Method for preparing 6-substituted-7-aza-indoles
DK2155169T3 (en)	2007-06-08	2016-06-13	Boehringer Ingelheim Int	Formulation of nevirapine extended release
EP2387405A2 (fr)	2009-01-13	2011-11-23	ProteoSys AG	Pirenzépine en tant qu'agent utilisé dans le traitement du cancer
JP2017535573A (ja)	2014-11-25	2017-11-30	バイエルファーマアクチエンゲゼルシャフト	置換されたピリドベンゾジアゼピノン誘導体およびそれの使用
EP3153157A1 (fr)	2015-10-09	2017-04-12	Teva Pharmaceutical Works Private Limited Company	Composition pharmaceutique à libération prolongée de névirapine
CN107382848A (zh) *	2017-07-15	2017-11-24	河北蓝泰化工科技有限公司	一种烟酰胺化合物及其制备方法和应用
CN116606243A (zh) *	2023-05-19	2023-08-18	中科苏州药物研究院	一种安全高效合成奈伟拉平中间体的新工艺

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Publication date	Assignee	Title
CA554134A (fr) *	1958-03-11	Hoffmann Karl	Composes thia-aza-cycloheptadiene et procede pour leur fabrication
CA658624A (en) *	1963-02-26	Schmutz Jean	Diazepine derivatives
CA783570A (en) *	1968-04-23	Schmidt Gunther	5,6-dihydro-6-oxo-11h-pyrido (2,3-b) (1,4)-benzodiazepines

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3643666A1 (de) *	1986-12-20	1988-06-30	Thomae Gmbh Dr K	Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3726908A1 (de) *	1987-08-13	1989-02-23	Thomae Gmbh Dr K	Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3735895A1 (de) *	1987-10-23	1989-05-03	Thomae Gmbh Dr K	Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE69031845T2 (de) *	1989-04-20	1998-05-07	Boehringer Ingelheim Pharma	6,11-Dihydro-5H-pyrido(2,3-b)(1,5)benzodiazepin-5-one und Thione und ihre Verwendung für die Vorbeugung oder Behandlung von AIDS
ES2058656T3 (es) *	1989-04-20	1994-11-01	Boehringer Ingelheim Pharma	5,11-dihidro-6h-dipirido(3,2-b:2',3'-e)(1,4)diazepin-6-onas y su uso en la prevencion o tratamiento del sida.
ES2063202T3 (es) *	1989-06-28	1995-01-01	Boehringer Ingelheim Pharma	Nuevas 5,11-dihidro-6h-dipirido(3,2-b:2',3'-e)(1,4)diazepin-6-onas y -tionas y su uso en la prevencion o tratamiento del sida.

1990
- 1990-11-15 CA CA002030056A patent/CA2030056C/fr not_active Expired - Lifetime
- 1990-11-16 NZ NZ236105A patent/NZ236105A/en unknown
- 1990-11-16 EP EP90121954A patent/EP0429987B1/fr not_active Expired - Lifetime
- 1990-11-16 ES ES90121954T patent/ES2130114T3/es not_active Expired - Lifetime
- 1990-11-16 AP APAP/P/1990/000224A patent/AP179A/en active
- 1990-11-16 OA OA59896A patent/OA09852A/en unknown
- 1990-11-16 IE IE414190A patent/IE904141A1/en not_active IP Right Cessation
- 1990-11-16 DK DK90121954T patent/DK0429987T3/da active
- 1990-11-16 AT AT90121954T patent/ATE177744T1/de active
- 1990-11-16 FI FI905674A patent/FI94529C/fi active IP Right Grant
- 1990-11-16 IL IL9636790A patent/IL96367A/xx active IP Right Grant
- 1990-11-16 UA UA5011559A patent/UA34420C2/uk unknown
- 1990-11-16 PT PT95919A patent/PT95919B/pt not_active IP Right Cessation
- 1990-11-16 NO NO904986A patent/NO175478C/no not_active IP Right Cessation
- 1990-11-16 DE DE1999175051 patent/DE19975051I2/de active Active
- 1990-11-16 DE DE69033003T patent/DE69033003T2/de not_active Expired - Lifetime
- 1990-11-19 AU AU66732/90A patent/AU630251B2/en not_active Expired
1992
- 1992-05-06 RU SU925011559A patent/RU2040527C1/ru active
1999
- 1999-04-30 GR GR990401182T patent/GR3030100T3/el unknown
- 1999-04-30 LU LU90393C patent/LU90393I2/fr unknown
- 1999-06-29 NO NO1999013C patent/NO1999013I1/no unknown
- 1999-07-27 NL NL990022C patent/NL990022I2/nl unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Publication date	Assignee	Title
CA554134A (fr) *	1958-03-11	Hoffmann Karl	Composes thia-aza-cycloheptadiene et procede pour leur fabrication
CA658624A (en) *	1963-02-26	Schmutz Jean	Diazepine derivatives
CA783570A (en) *	1968-04-23	Schmidt Gunther	5,6-dihydro-6-oxo-11h-pyrido (2,3-b) (1,4)-benzodiazepines

Also Published As

Publication number	Publication date
AP9000224A0 (en)	1991-01-31
DK0429987T3 (da)	1999-10-11
UA34420C2 (uk)	2001-03-15
IL96367A (en)	1997-02-18
HK1011025A1 (en)	1999-07-02
DE69033003D1 (de)	1999-04-22
NO1999013I1 (no)	1999-06-29
NZ236105A (en)	1994-04-27
RU2040527C1 (ru)	1995-07-25
ATE177744T1 (de)	1999-04-15
NO904986D0 (no)	1990-11-16
CA2030056A1 (fr)	1991-05-18
EP0429987A2 (fr)	1991-06-05
DE19975051I2 (de)	2004-05-06
AU630251B2 (en)	1992-10-22
FI94529C (fi)	1995-09-25
PT95919A (pt)	1991-09-13
LU90393I2 (fr)	1999-06-30
NO904986L (no)	1991-05-21
FI94529B (fi)	1995-06-15
NO175478C (no)	1994-10-19
CA2030056C (fr)	1995-10-17
GR3030100T3 (en)	1999-07-30
FI905674A0 (fi)	1990-11-16
OA09852A (en)	1994-08-15
AU6673290A (en)	1991-05-23
ES2130114T3 (es)	1999-07-01
NL990022I2 (nl)	2007-11-01
DE69033003T2 (de)	1999-09-16
IE904141A1 (en)	1991-05-22
PT95919B (pt)	1998-01-30
NO175478B (no)	1994-07-11
EP0429987B1 (fr)	1999-03-17
NL990022I1 (nl)	1999-10-01
EP0429987A3 (en)	1992-01-22
FI905674A7 (fi)	1991-05-18

Publication	Publication Date	Title
EP0429987B1 (fr)	1999-03-17	5,11-Dihydro-6H-dipyrido[3,2-b:2'3'-e] [1,4]diazépines et leur utilisation pour prévenir ou traiter l'infection par le VIH
US5366972A (en)	1994-11-22	5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
US5571809A (en)	1996-11-05	The treatment of HIV-1 infection using certain pyridodiazepines
CA2019812C (fr)	2000-11-21	Nouveau 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-ones et leur utilisation dans la prevention et le traitement du sida
CA2014771C (fr)	2000-08-01	5,11-dihydro-6h-dipyrido[3,2-b:2'3'-e][1,4]diazepine-6-ones et leur utilisation pour la prevention ou le traitement du sida
CA2014885C (fr)	2000-12-26	6,11-dihydro-5h-pyrido[2,3-b] [1,5] benzodiazepin-5-ones et thiones et leur utilisation dans la prevention et le traitement du sida
US5087625A (en)	1992-02-11	Pyridodiazepines and their use in the prevention or treatment of HIV infection
EP0745083B1 (fr)	1998-05-20	2-HETEROARYL-5,11-DIHYDRO-6H-DIPYRIDO[3,2-b:2',3'-e][1,4] DIAZEPINES ET LEUR UTILISATION DANS LA PREVENTION OU LE TRAITEMENT DE L'INFECTION A VIH
DE69213777T2 (de)	1997-03-13	Pyridobenzodiazepine, Dipyrido-[3,2-b:2',3'-3] [1,4]-diazepine und deren Verwendung in der Vorbeugung und Behandlung von AIDS
HK1011025B (en)	2000-04-20	5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the preventionor treatment of hiv infection
US5837704A (en)	1998-11-17	2-heteroaryl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-E! 1,4!diazepines and their use in the prevention or treatment of HIV infection
JP2912007B2 (ja)	1999-06-28	５，１１―ジヒドロ―６Ｈ―ジピリド〔３，２―ｂ：２′，３′―ｅ〕〔１，４〕ジアゼピンおよび該化合物を含有するＨＩＶ感染の予防又は治療用組成物
AP190A (en)	1992-05-04	Pyrido(2,3-b) (1.5) benzoxazepin (and thiazepin)-5 (6H)-ones and thiones and prevention or treatment of HIV infection.
KR0168427B1 (ko)	1999-01-15	5,11-디하이드로-6H-디피리도[3,2-b:2',3'-e][1,4]디아제핀 및 HIV 감염의 예방 또는 치료를 위한 이를 함유하는 약제학적 조성물
JP2539116B2 (ja)	1996-10-02	５，１１−ジヒドロ−６Ｈ−ジピリド〔３，２−ｂ：２′，３′−ｅ〕〔１，４〕ジアゼピンおよび該化合物を含有するＨＩＶ感染の予防又は治療用組成物
IE71935B1 (en)	1997-03-12	Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection