AP2001002249A0 - Process for making N-ARYL-ANTHRANILIC acids and their derivatives. - Google Patents
Process for making N-ARYL-ANTHRANILIC acids and their derivatives.Info
- Publication number
- AP2001002249A0 AP2001002249A0 APAP/P/2001/002249A AP2001002249A AP2001002249A0 AP 2001002249 A0 AP2001002249 A0 AP 2001002249A0 AP 2001002249 A AP2001002249 A AP 2001002249A AP 2001002249 A0 AP2001002249 A0 AP 2001002249A0
- Authority
- AP
- ARIPO
- Prior art keywords
- aryl
- derivatives
- making
- anthranilic acids
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22820600P | 2000-08-25 | 2000-08-25 | |
| PCT/US2001/022948 WO2002018319A1 (en) | 2000-08-25 | 2001-07-20 | Process for making n-aryl-anthranilic acids and their derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AP2001002249A0 true AP2001002249A0 (en) | 2001-09-30 |
Family
ID=22856235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/2001/002249A AP2001002249A0 (en) | 2000-08-25 | 2001-07-20 | Process for making N-ARYL-ANTHRANILIC acids and their derivatives. |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP1313694A1 (es) |
| JP (1) | JP2004507518A (es) |
| KR (1) | KR20030059115A (es) |
| CN (1) | CN1458921A (es) |
| AP (1) | AP2001002249A0 (es) |
| AR (1) | AR032175A1 (es) |
| AU (1) | AU2001277044A1 (es) |
| BG (1) | BG107635A (es) |
| BR (1) | BR0113520A (es) |
| CA (1) | CA2420003A1 (es) |
| CZ (1) | CZ2003477A3 (es) |
| DO (1) | DOP2001000238A (es) |
| EA (1) | EA200300187A1 (es) |
| GT (1) | GT200100174A (es) |
| HN (1) | HN2001000216A (es) |
| HU (1) | HUP0300828A2 (es) |
| IL (1) | IL154507A0 (es) |
| IS (1) | IS6724A (es) |
| MA (1) | MA26949A1 (es) |
| MX (1) | MXPA03001654A (es) |
| NO (1) | NO20030844L (es) |
| PA (1) | PA8526501A1 (es) |
| PE (1) | PE20020393A1 (es) |
| PL (1) | PL360699A1 (es) |
| PY (1) | PY0120841A (es) |
| SK (1) | SK2072003A3 (es) |
| SV (1) | SV2002000601A (es) |
| TN (1) | TNSN01127A1 (es) |
| UY (1) | UY26908A1 (es) |
| WO (1) | WO2002018319A1 (es) |
| YU (1) | YU14303A (es) |
| ZA (1) | ZA200301182B (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI343377B (en) | 2002-03-13 | 2011-06-11 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| US7538120B2 (en) | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
| US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| BRPI0415710A (pt) | 2003-10-21 | 2006-12-19 | Warner Lambert Co | formas polimórficas de n-[(r)-2,3-dihidróxi-propóxi]-3,4-diflúor-2-(2-flúor-4-io dofenilamino)-benzamida |
| NZ547481A (en) | 2003-11-19 | 2009-12-24 | Array Biopharma Inc | Heterocyclic inhibitors of mek and methods of use thereof |
| US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
| US20050130954A1 (en) | 2003-11-21 | 2005-06-16 | Mitchell Ian S. | AKT protein kinase inhibitors |
| UA89035C2 (ru) * | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
| US20080306054A1 (en) | 2005-04-13 | 2008-12-11 | Astex Therapeutics Limited | Pharmaceutical Compounds |
| CN102898364A (zh) | 2005-05-18 | 2013-01-30 | 阵列生物制药公司 | Mek的杂环抑制剂及其使用方法 |
| US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
| WO2008006032A1 (en) | 2006-07-06 | 2008-01-10 | Array Biopharma Inc. | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
| US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| CN101511842B (zh) | 2006-07-06 | 2012-10-31 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的二氢呋喃并嘧啶 |
| ATE532789T1 (de) | 2006-07-06 | 2011-11-15 | Array Biopharma Inc | Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren |
| JP5721949B2 (ja) | 2006-10-12 | 2015-05-20 | アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | 複合薬剤 |
| JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| WO2008044041A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| WO2008044027A2 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical compounds having hsp90 inhibitory or modulating activity |
| US8618097B2 (en) | 2007-07-05 | 2013-12-31 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| SI2173723T1 (sl) | 2007-07-05 | 2011-12-30 | Array Biopharma Inc | Pirimidil ciklopentani kot inhibitorji AKT-protein-kinaze |
| US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
| EP2240455B1 (en) | 2008-01-09 | 2012-12-26 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor |
| JP5346345B2 (ja) | 2008-01-09 | 2013-11-20 | アレイ バイオファーマ、インコーポレイテッド | Ａｋｔタンパク質キナーゼ阻害剤としての水酸化されたピリミジルシクロペンタン類 |
| GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| CN101985428B (zh) * | 2009-07-29 | 2014-02-12 | 杭州民生药业有限公司 | 邻苯胺基苯甲酸衍生物或其药学上可接受的盐、其制备方法及其用途 |
| WO2011101599A1 (fr) * | 2010-02-19 | 2011-08-25 | Centre National De La Recherche Scientifique | Procédé de préparation de composés chimiques d'intérêt par substitution nucléophile aromatique |
| CN102985399A (zh) * | 2010-02-19 | 2013-03-20 | 国家科学研究中心 | 通过对携带至少一个吸电子基团的芳香族羧酸衍生物进行亲核芳香族取代来制备目的化合物的方法 |
| ES2620644T3 (es) | 2011-04-01 | 2017-06-29 | Genentech, Inc. | Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso |
| KR20140022053A (ko) | 2011-04-01 | 2014-02-21 | 제넨테크, 인크. | Akt 및 mek 억제제 화합물의 조합물, 및 사용 방법 |
| HRP20180670T1 (hr) * | 2012-10-12 | 2018-07-13 | Exelixis Inc. | Novi postupak dobivanja spojeva namijenjenih upotrebi u liječenju raka |
| CN112745237B (zh) * | 2019-10-29 | 2023-06-20 | 中国科学院上海药物研究所 | 2-芳基胺类化合物及其制备方法和应用 |
| CN119948008B (zh) * | 2022-07-15 | 2026-04-28 | 南方科技大学 | 一种以异腈和环丙烯为原料制备稠环芳胺的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3138636A (en) * | 1960-06-23 | 1964-06-23 | Parke Davis & Co | Anthranilic acid derivatives |
| WO1998037881A1 (en) * | 1997-02-28 | 1998-09-03 | Warner Lambert Company | Method of treating or preventing septic shock by administering a mek inhibitor |
| AU757046B2 (en) * | 1997-07-01 | 2003-01-30 | Warner-Lambert Company | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors |
| JP2002509536A (ja) * | 1997-07-01 | 2002-03-26 | ワーナー−ランバート・カンパニー | ２−（４−ブロモ又は４−ヨードフェニルアミノ）安息香酸誘導体及びｍｅｋ阻害物質としてのそれらの使用 |
| CA2348236A1 (en) * | 1999-01-13 | 2000-07-20 | Stephen Douglas Barrett | 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors |
| PL351085A1 (en) * | 1999-04-21 | 2003-03-24 | Warner Lambert Co | Method for making 2-(n-phenylamino)benzoic acids |
-
2001
- 2001-07-20 KR KR10-2003-7002675A patent/KR20030059115A/ko not_active Withdrawn
- 2001-07-20 YU YU14303A patent/YU14303A/sh unknown
- 2001-07-20 JP JP2002523437A patent/JP2004507518A/ja active Pending
- 2001-07-20 MX MXPA03001654A patent/MXPA03001654A/es unknown
- 2001-07-20 AU AU2001277044A patent/AU2001277044A1/en not_active Abandoned
- 2001-07-20 WO PCT/US2001/022948 patent/WO2002018319A1/en not_active Ceased
- 2001-07-20 AP APAP/P/2001/002249A patent/AP2001002249A0/en unknown
- 2001-07-20 BR BR0113520-1A patent/BR0113520A/pt not_active Application Discontinuation
- 2001-07-20 IL IL15450701A patent/IL154507A0/xx unknown
- 2001-07-20 CZ CZ2003477A patent/CZ2003477A3/cs unknown
- 2001-07-20 HU HU0300828A patent/HUP0300828A2/hu unknown
- 2001-07-20 CA CA002420003A patent/CA2420003A1/en not_active Abandoned
- 2001-07-20 PL PL36069901A patent/PL360699A1/xx unknown
- 2001-07-20 SK SK207-2003A patent/SK2072003A3/sk unknown
- 2001-07-20 CN CN01815869A patent/CN1458921A/zh active Pending
- 2001-07-20 EP EP01954824A patent/EP1313694A1/en not_active Withdrawn
- 2001-07-20 EA EA200300187A patent/EA200300187A1/ru unknown
- 2001-08-15 SV SV2001000601A patent/SV2002000601A/es not_active Application Discontinuation
- 2001-08-22 TN TNTNSN01127A patent/TNSN01127A1/en unknown
- 2001-08-22 PY PY200100120841A patent/PY0120841A/es unknown
- 2001-08-23 PA PA20018526501A patent/PA8526501A1/es unknown
- 2001-08-24 GT GT200100174A patent/GT200100174A/es unknown
- 2001-08-24 DO DO2001000238A patent/DOP2001000238A/es unknown
- 2001-08-24 UY UY26908A patent/UY26908A1/es not_active Application Discontinuation
- 2001-08-24 PE PE2001000853A patent/PE20020393A1/es not_active Application Discontinuation
- 2001-08-24 AR ARP010104047A patent/AR032175A1/es unknown
- 2001-09-26 HN HN2001000216A patent/HN2001000216A/es unknown
-
2003
- 2003-02-12 ZA ZA200301182A patent/ZA200301182B/en unknown
- 2003-02-20 IS IS6724A patent/IS6724A/is unknown
- 2003-02-24 NO NO20030844A patent/NO20030844L/no not_active Application Discontinuation
- 2003-03-13 BG BG107635A patent/BG107635A/bg unknown
- 2003-03-14 MA MA27069A patent/MA26949A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HN2001000216A (es) | 2002-05-22 |
| JP2004507518A (ja) | 2004-03-11 |
| KR20030059115A (ko) | 2003-07-07 |
| SV2002000601A (es) | 2002-04-03 |
| PL360699A1 (en) | 2004-09-20 |
| UY26908A1 (es) | 2001-11-30 |
| TNSN01127A1 (en) | 2005-11-10 |
| NO20030844L (no) | 2003-02-25 |
| IS6724A (is) | 2003-02-20 |
| EA200300187A1 (ru) | 2003-08-28 |
| PY0120841A (es) | 2004-06-01 |
| PE20020393A1 (es) | 2002-05-09 |
| MXPA03001654A (es) | 2004-09-10 |
| AU2001277044A1 (en) | 2002-03-13 |
| EP1313694A1 (en) | 2003-05-28 |
| DOP2001000238A (es) | 2003-01-31 |
| CZ2003477A3 (cs) | 2003-10-15 |
| IL154507A0 (en) | 2003-09-17 |
| NO20030844D0 (no) | 2003-02-24 |
| SK2072003A3 (en) | 2004-01-08 |
| AR032175A1 (es) | 2003-10-29 |
| BR0113520A (pt) | 2003-06-24 |
| WO2002018319A1 (en) | 2002-03-07 |
| CA2420003A1 (en) | 2002-03-07 |
| YU14303A (sh) | 2006-08-17 |
| ZA200301182B (en) | 2004-05-12 |
| MA26949A1 (fr) | 2004-12-20 |
| PA8526501A1 (es) | 2002-07-30 |
| CN1458921A (zh) | 2003-11-26 |
| BG107635A (bg) | 2004-09-30 |
| GT200100174A (es) | 2002-07-18 |
| HUP0300828A2 (hu) | 2003-09-29 |
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