PL360699A1 - Process for making n-aryl-anthranilic acids and their derivatives - Google Patents

Process for making n-aryl-anthranilic acids and their derivatives

Info

Publication number
PL360699A1
PL360699A1 PL36069901A PL36069901A PL360699A1 PL 360699 A1 PL360699 A1 PL 360699A1 PL 36069901 A PL36069901 A PL 36069901A PL 36069901 A PL36069901 A PL 36069901A PL 360699 A1 PL360699 A1 PL 360699A1
Authority
PL
Poland
Prior art keywords
aryl
derivatives
making
anthranilic acids
anthranilic
Prior art date
Application number
PL36069901A
Other languages
Polish (pl)
Inventor
Michael Huai Gu Chen
Edward Mark Davis
Javier Magano
Thomas Norman Nanninga
Derick Dale Winkle
Original Assignee
Warner-Lambert Company Llc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company Llc. filed Critical Warner-Lambert Company Llc.
Publication of PL360699A1 publication Critical patent/PL360699A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
PL36069901A 2000-08-25 2001-07-20 Process for making n-aryl-anthranilic acids and their derivatives PL360699A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22820600P 2000-08-25 2000-08-25
PCT/US2001/022948 WO2002018319A1 (en) 2000-08-25 2001-07-20 Process for making n-aryl-anthranilic acids and their derivatives

Publications (1)

Publication Number Publication Date
PL360699A1 true PL360699A1 (en) 2004-09-20

Family

ID=22856235

Family Applications (1)

Application Number Title Priority Date Filing Date
PL36069901A PL360699A1 (en) 2000-08-25 2001-07-20 Process for making n-aryl-anthranilic acids and their derivatives

Country Status (32)

Country Link
EP (1) EP1313694A1 (en)
JP (1) JP2004507518A (en)
KR (1) KR20030059115A (en)
CN (1) CN1458921A (en)
AP (1) AP2001002249A0 (en)
AR (1) AR032175A1 (en)
AU (1) AU2001277044A1 (en)
BG (1) BG107635A (en)
BR (1) BR0113520A (en)
CA (1) CA2420003A1 (en)
CZ (1) CZ2003477A3 (en)
DO (1) DOP2001000238A (en)
EA (1) EA200300187A1 (en)
GT (1) GT200100174A (en)
HN (1) HN2001000216A (en)
HU (1) HUP0300828A2 (en)
IL (1) IL154507A0 (en)
IS (1) IS6724A (en)
MA (1) MA26949A1 (en)
MX (1) MXPA03001654A (en)
NO (1) NO20030844L (en)
PA (1) PA8526501A1 (en)
PE (1) PE20020393A1 (en)
PL (1) PL360699A1 (en)
PY (1) PY0120841A (en)
SK (1) SK2072003A3 (en)
SV (1) SV2002000601A (en)
TN (1) TNSN01127A1 (en)
UY (1) UY26908A1 (en)
WO (1) WO2002018319A1 (en)
YU (1) YU14303A (en)
ZA (1) ZA200301182B (en)

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TWI343377B (en) 2002-03-13 2011-06-11 Array Biopharma Inc N3 alkylated benzimidazole derivatives as mek inhibitors
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
BRPI0415710A (en) 2003-10-21 2006-12-19 Warner Lambert Co polymorphic forms of n - [(r) -2,3-dihydroxypropoxy] -3,4-difluoro-2- (2-fluoro-4-yl dophenylamino) benzamide
NZ547481A (en) 2003-11-19 2009-12-24 Array Biopharma Inc Heterocyclic inhibitors of mek and methods of use thereof
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
US20050130954A1 (en) 2003-11-21 2005-06-16 Mitchell Ian S. AKT protein kinase inhibitors
UA89035C2 (en) * 2003-12-03 2009-12-25 Лео Фарма А/С Hydroxamic acid esters and pharmaceutical use thereof
US20080306054A1 (en) 2005-04-13 2008-12-11 Astex Therapeutics Limited Pharmaceutical Compounds
CN102898364A (en) 2005-05-18 2013-01-30 阵列生物制药公司 Heterocyclic inhibitors of MEK and methods of use thereof
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
WO2008006032A1 (en) 2006-07-06 2008-01-10 Array Biopharma Inc. Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN101511842B (en) 2006-07-06 2012-10-31 阵列生物制药公司 Dihydrofuro pyrimidines as AKT protein kinase inhibitors
ATE532789T1 (en) 2006-07-06 2011-11-15 Array Biopharma Inc DIHYDROTHIENOPYRIMIDINES AS ACT PROTEIN KINASE INHIBITORS
JP5721949B2 (en) 2006-10-12 2015-05-20 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ Compound drug
JP5518478B2 (en) 2006-10-12 2014-06-11 アステックス、セラピューティックス、リミテッド Pharmaceutical compounds
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
WO2008044027A2 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical compounds having hsp90 inhibitory or modulating activity
US8618097B2 (en) 2007-07-05 2013-12-31 Array Biopharma, Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
SI2173723T1 (en) 2007-07-05 2011-12-30 Array Biopharma Inc Pyrimidyl cyclopentanes as akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
EP2240455B1 (en) 2008-01-09 2012-12-26 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
JP5346345B2 (en) 2008-01-09 2013-11-20 アレイ バイオファーマ、インコーポレイテッド Hydroxylated pyrimidylcyclopentanes as AKT protein kinase inhibitors
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CN101985428B (en) * 2009-07-29 2014-02-12 杭州民生药业有限公司 O-anilino benzoic acid derivatives or pharmaceutically acceptable salts thereof as well as preparation method and application thereof
WO2011101599A1 (en) * 2010-02-19 2011-08-25 Centre National De La Recherche Scientifique Method for preparing chemical compounds of interest by aromatic nucleophilic substitution
CN102985399A (en) * 2010-02-19 2013-03-20 国家科学研究中心 Method for preparing chemical compounds of interest by nucleophilic aromatic substitution of aromatic carboxylic acid derivatives supporting at least one electro-attractive group
ES2620644T3 (en) 2011-04-01 2017-06-29 Genentech, Inc. Combinations of AKT inhibitor compounds and chemotherapeutic agents, and methods of use
KR20140022053A (en) 2011-04-01 2014-02-21 제넨테크, 인크. Combinations of akt and mek inhibitor compounds, and methods of use
HRP20180670T1 (en) * 2012-10-12 2018-07-13 Exelixis Inc. NEW PROCEDURE FOR OBTAINING COMPOUNDS FOR THE USE OF CANCER TREATMENT
CN112745237B (en) * 2019-10-29 2023-06-20 中国科学院上海药物研究所 2-arylamine compound and its preparation method and application
CN119948008B (en) * 2022-07-15 2026-04-28 南方科技大学 A method for preparing polycyclic aromatic amines from isonitriles and cyclopropenes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138636A (en) * 1960-06-23 1964-06-23 Parke Davis & Co Anthranilic acid derivatives
WO1998037881A1 (en) * 1997-02-28 1998-09-03 Warner Lambert Company Method of treating or preventing septic shock by administering a mek inhibitor
AU757046B2 (en) * 1997-07-01 2003-01-30 Warner-Lambert Company 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
JP2002509536A (en) * 1997-07-01 2002-03-26 ワーナー−ランバート・カンパニー 2- (4-bromo or 4-iodophenylamino) benzoic acid derivatives and their use as MEK inhibitors
CA2348236A1 (en) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
PL351085A1 (en) * 1999-04-21 2003-03-24 Warner Lambert Co Method for making 2-(n-phenylamino)benzoic acids

Also Published As

Publication number Publication date
HN2001000216A (en) 2002-05-22
JP2004507518A (en) 2004-03-11
KR20030059115A (en) 2003-07-07
SV2002000601A (en) 2002-04-03
UY26908A1 (en) 2001-11-30
TNSN01127A1 (en) 2005-11-10
NO20030844L (en) 2003-02-25
IS6724A (en) 2003-02-20
EA200300187A1 (en) 2003-08-28
PY0120841A (en) 2004-06-01
PE20020393A1 (en) 2002-05-09
MXPA03001654A (en) 2004-09-10
AP2001002249A0 (en) 2001-09-30
AU2001277044A1 (en) 2002-03-13
EP1313694A1 (en) 2003-05-28
DOP2001000238A (en) 2003-01-31
CZ2003477A3 (en) 2003-10-15
IL154507A0 (en) 2003-09-17
NO20030844D0 (en) 2003-02-24
SK2072003A3 (en) 2004-01-08
AR032175A1 (en) 2003-10-29
BR0113520A (en) 2003-06-24
WO2002018319A1 (en) 2002-03-07
CA2420003A1 (en) 2002-03-07
YU14303A (en) 2006-08-17
ZA200301182B (en) 2004-05-12
MA26949A1 (en) 2004-12-20
PA8526501A1 (en) 2002-07-30
CN1458921A (en) 2003-11-26
BG107635A (en) 2004-09-30
GT200100174A (en) 2002-07-18
HUP0300828A2 (en) 2003-09-29

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