BRPI0415710A - formas polimórficas de n-[(r)-2,3-dihidróxi-propóxi]-3,4-diflúor-2-(2-flúor-4-io dofenilamino)-benzamida - Google Patents

formas polimórficas de n-[(r)-2,3-dihidróxi-propóxi]-3,4-diflúor-2-(2-flúor-4-io dofenilamino)-benzamida

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Publication number
BRPI0415710A
BRPI0415710A BRPI0415710-9A BRPI0415710A BRPI0415710A BR PI0415710 A BRPI0415710 A BR PI0415710A BR PI0415710 A BRPI0415710 A BR PI0415710A BR PI0415710 A BRPI0415710 A BR PI0415710A
Authority
BR
Brazil
Prior art keywords
benzamide
dihydroxypropoxy
difluoro
fluoro
dophenylamino
Prior art date
Application number
BRPI0415710-9A
Other languages
English (en)
Inventor
Dainius Macikenas
Thomas Nanninga
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BRPI0415710A publication Critical patent/BRPI0415710A/pt

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    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton

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  • Health & Medical Sciences (AREA)
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Abstract

"FORMAS POLIMóRFICAS DE N-¢(R)-2,3-DIHIDRóXI-PROPóXI!-3,4-DIFLúOR-2-(2-FLúOR-4-IO DOFENILAMINO)-BENZAMIDA". A presente invenção refere-se a uma nova forma polimórfica de N-¢(R)-2,3-dihidróxi-propóxi!3,4-diflúor-2-(2-flúor-4-iodo-fenilamino)-be nzamida, bem como composições farmacêuticas e métodos terapêuticos utilizando a forma polimórfica.
BRPI0415710-9A 2003-10-21 2004-10-11 formas polimórficas de n-[(r)-2,3-dihidróxi-propóxi]-3,4-diflúor-2-(2-flúor-4-io dofenilamino)-benzamida BRPI0415710A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51298003P 2003-10-21 2003-10-21
PCT/IB2004/003309 WO2005040098A1 (en) 2003-10-21 2004-10-11 Polymorphic form of n-[(r)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide

Publications (1)

Publication Number Publication Date
BRPI0415710A true BRPI0415710A (pt) 2006-12-19

Family

ID=34520067

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415710-9A BRPI0415710A (pt) 2003-10-21 2004-10-11 formas polimórficas de n-[(r)-2,3-dihidróxi-propóxi]-3,4-diflúor-2-(2-flúor-4-io dofenilamino)-benzamida

Country Status (18)

Country Link
US (1) US7060856B2 (pt)
EP (1) EP1682495A1 (pt)
JP (1) JP2007509125A (pt)
KR (1) KR101013932B1 (pt)
CN (1) CN100594212C (pt)
AR (1) AR046124A1 (pt)
AU (1) AU2004283148A1 (pt)
BR (1) BRPI0415710A (pt)
CA (1) CA2542210A1 (pt)
CO (1) CO5690569A2 (pt)
IL (1) IL174367A0 (pt)
MX (1) MXPA06004363A (pt)
NO (1) NO20062090L (pt)
NZ (1) NZ546011A (pt)
RU (1) RU2352558C2 (pt)
TW (1) TW200524584A (pt)
WO (1) WO2005040098A1 (pt)
ZA (1) ZA200602250B (pt)

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RU2006113437A (ru) 2006-08-27
NZ546011A (en) 2009-09-25
EP1682495A1 (en) 2006-07-26
US20050085550A1 (en) 2005-04-21
US7060856B2 (en) 2006-06-13
CA2542210A1 (en) 2005-05-06
NO20062090L (no) 2006-07-12
JP2007509125A (ja) 2007-04-12
CN100594212C (zh) 2010-03-17
WO2005040098A1 (en) 2005-05-06
AU2004283148A1 (en) 2005-05-06
ZA200602250B (en) 2007-05-30
MXPA06004363A (es) 2006-06-14
KR20060080230A (ko) 2006-07-07
RU2352558C2 (ru) 2009-04-20
KR101013932B1 (ko) 2011-02-14
HK1093483A1 (en) 2007-03-02
CN1867543A (zh) 2006-11-22
TW200524584A (en) 2005-08-01
AR046124A1 (es) 2005-11-23
IL174367A0 (en) 2006-08-01
CO5690569A2 (es) 2006-10-31

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