AP2005003467A0 - N-pyrrolidin-3-YL-amide derivatives as serotonin and noradrenaline reuptake inhibitors. - Google Patents

N-pyrrolidin-3-YL-amide derivatives as serotonin and noradrenaline reuptake inhibitors.

Info

Publication number: AP2005003467A0
Authority: AP; ARIPO
Prior art keywords: serotonin; pyrrolidin; reuptake inhibitors; amide derivatives; noradrenaline reuptake
Prior art date: 2003-06-17

Application number

AP2005003467A

Other languages

English (en)

Inventor

Paul Vincent Fish

Michael Jonathan Fray

Deborah Jane Lovering

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-17

Filing date

2004-06-07

Publication date

2006-12-31

2003-06-17 Priority claimed from GBGB0314048.0A external-priority patent/GB0314048D0/en

2004-06-07 Application filed by Pfizer filed Critical Pfizer

2006-12-31 Publication of AP2005003467A0 publication Critical patent/AP2005003467A0/xx

Links

QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 2
239000002767 noradrenalin uptake inhibitor Substances 0.000 title 1
NGXSWUFDCSEIOO-UHFFFAOYSA-N pyrrolidin-3-amine Chemical class NC1CCNC1 NGXSWUFDCSEIOO-UHFFFAOYSA-N 0.000 title 1
229940076279 serotonin Drugs 0.000 title 1
239000003772 serotonin uptake inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Psychology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Rheumatology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AP2005003467A 2003-06-17 2004-06-07 N-pyrrolidin-3-YL-amide derivatives as serotonin and noradrenaline reuptake inhibitors. AP2005003467A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0314048.0A GB0314048D0 (en)	2003-06-17	2003-06-17	Novel compounds
US49312603P	2003-08-06	2003-08-06
PCT/IB2004/001943 WO2004110995A1 (en)	2003-06-17	2004-06-07	N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors

Publications (1)

Publication Number	Publication Date
AP2005003467A0 true AP2005003467A0 (en)	2006-12-31

Family

ID=33554153

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2005003467A AP2005003467A0 (en)	2003-06-17	2004-06-07	N-pyrrolidin-3-YL-amide derivatives as serotonin and noradrenaline reuptake inhibitors.

Country Status (31)

Country	Link
US (2)	US7378436B2 (pt)
EP (1)	EP1638933B1 (pt)
JP (1)	JP4137159B2 (pt)
KR (1)	KR100803796B1 (pt)
AP (1)	AP2005003467A0 (pt)
AR (1)	AR044715A1 (pt)
AT (1)	ATE398107T1 (pt)
AU (1)	AU2004247487B2 (pt)
BR (1)	BRPI0411594A (pt)
CA (1)	CA2530159C (pt)
CY (1)	CY1110434T1 (pt)
DE (1)	DE602004014372D1 (pt)
DK (1)	DK1638933T3 (pt)
EA (1)	EA009881B1 (pt)
EC (1)	ECSP056232A (pt)
ES (1)	ES2305776T3 (pt)
HR (2)	HRP20050993A2 (pt)
IL (1)	IL172063A0 (pt)
IS (1)	IS8136A (pt)
MA (1)	MA27885A1 (pt)
MX (1)	MXPA05013960A (pt)
NL (1)	NL1026438C2 (pt)
NZ (1)	NZ544046A (pt)
PA (1)	PA8605301A1 (pt)
PE (1)	PE20050631A1 (pt)
PL (1)	PL1638933T3 (pt)
PT (1)	PT1638933E (pt)
SI (1)	SI1638933T1 (pt)
TW (1)	TW200505852A (pt)
UY (1)	UY28360A1 (pt)
WO (1)	WO2004110995A1 (pt)

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JP2008523136A (ja) *	2004-12-14	2008-07-03	ファイザー・リミテッド	セロトニンおよびノルアドレナリン再取り込み阻害剤としてのｎ−ピロリジン−３−イル−アミド誘導体
TWI410406B (zh) *	2005-05-13	2013-10-01	Otsuka Pharma Co Ltd	吡咯烷化合物
EP1893603B1 (en) *	2005-06-02	2009-10-14	F. Hoffmann-La Roche AG	Piperidin-4-yl-amide derivatives and their use as sst receptor subtype 5 antagonists
WO2007135530A2 (en) *	2006-05-22	2007-11-29	Pfizer Limited	Pharmaceutically & veterinarily suitable salt
US20080014152A1 (en) *	2006-07-13	2008-01-17	Di Mauro Thomas M	Intranasal delivery of clenbuterol across the cribriform plate and into the brain
JP5219465B2 (ja) *	2006-11-10	2013-06-26	大塚製薬株式会社	医薬
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JP2010189275A (ja) *	2007-06-14	2010-09-02	Dainippon Sumitomo Pharma Co Ltd	ナフタレン誘導体
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JP5405571B2 (ja)	2008-07-24	2014-02-05	セラヴァンス，インコーポレーテッド	３−（フェノキシフェニルメチル）ピロリジン化合物
SI2358675T1 (sl)	2008-11-14	2013-01-31	Theravance, Inc.	4-(2-(2-fluorofenoksimetil)fenil)piperidinske spojine
US20100267743A1 (en) *	2009-04-15	2010-10-21	Stangeland Eric L	3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds
JP5331883B2 (ja)	2009-06-24	2013-10-30	大日本住友製薬株式会社	Ｎ−置換−環状アミノ誘導体
CN102471258A (zh) *	2009-07-13	2012-05-23	施万制药	3-苯氧基甲基吡咯烷化合物
JP5714580B2 (ja)	2009-07-21	2015-05-07	セラヴァンスバイオファーマアール＆ディーアイピー，エルエルシー	３−フェノキシメチルピロリジン化合物
WO2011085291A1 (en)	2010-01-11	2011-07-14	Theravance, Inc.	1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors
EP2550252B1 (en) *	2010-03-22	2015-05-06	Theravance Biopharma R&D IP, LLC	1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds
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AU2003263393A1 (en)	2002-09-04	2004-03-29	Glenmark Pharmaceuticals Limited	New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
MXPA05006507A (es)	2002-12-20	2006-02-17	Chemocentryx	Inhibidores de ccxckr2 expresado en tumor humano.
ES2305776T3 (es) *	2003-06-17	2008-11-01	Pfizer Inc.	Derivados de n-pirrolidin-3-il-amida como inhibidores de la re-captacion de serotonina y noradrenalina.

2004
- 2004-06-07 ES ES04736241T patent/ES2305776T3/es not_active Expired - Lifetime
- 2004-06-07 NZ NZ544046A patent/NZ544046A/en unknown
- 2004-06-07 CA CA002530159A patent/CA2530159C/en not_active Expired - Fee Related
- 2004-06-07 WO PCT/IB2004/001943 patent/WO2004110995A1/en not_active Ceased
- 2004-06-07 AU AU2004247487A patent/AU2004247487B2/en not_active Expired - Fee Related
- 2004-06-07 SI SI200430767T patent/SI1638933T1/sl unknown
- 2004-06-07 EP EP04736241A patent/EP1638933B1/en not_active Expired - Lifetime
- 2004-06-07 PT PT04736241T patent/PT1638933E/pt unknown
- 2004-06-07 MX MXPA05013960A patent/MXPA05013960A/es active IP Right Grant
- 2004-06-07 JP JP2006516540A patent/JP4137159B2/ja not_active Expired - Fee Related
- 2004-06-07 BR BRPI0411594-5A patent/BRPI0411594A/pt not_active IP Right Cessation
- 2004-06-07 DE DE602004014372T patent/DE602004014372D1/de not_active Expired - Lifetime
- 2004-06-07 AP AP2005003467A patent/AP2005003467A0/xx unknown
- 2004-06-07 PL PL04736241T patent/PL1638933T3/pl unknown
- 2004-06-07 AT AT04736241T patent/ATE398107T1/de not_active IP Right Cessation
- 2004-06-07 DK DK04736241T patent/DK1638933T3/da active
- 2004-06-07 EA EA200501730A patent/EA009881B1/ru not_active IP Right Cessation
- 2004-06-07 KR KR1020057024147A patent/KR100803796B1/ko not_active Expired - Fee Related
- 2004-06-07 HR HR20050993A patent/HRP20050993A2/hr not_active Application Discontinuation
- 2004-06-07 HR HR20080339T patent/HRP20080339T3/xx unknown
- 2004-06-14 UY UY28360A patent/UY28360A1/es not_active Application Discontinuation
- 2004-06-14 PE PE2004000590A patent/PE20050631A1/es not_active Application Discontinuation
- 2004-06-16 PA PA20048605301A patent/PA8605301A1/es unknown
- 2004-06-16 AR ARP040102082A patent/AR044715A1/es not_active Application Discontinuation
- 2004-06-16 TW TW093117317A patent/TW200505852A/zh unknown
- 2004-06-17 US US10/872,160 patent/US7378436B2/en not_active Expired - Fee Related
- 2004-06-17 NL NL1026438A patent/NL1026438C2/nl not_active IP Right Cessation
2005
- 2005-11-20 IL IL172063A patent/IL172063A0/en unknown
- 2005-11-21 IS IS8136A patent/IS8136A/is unknown
- 2005-12-16 EC EC2005006232A patent/ECSP056232A/es unknown
- 2005-12-16 MA MA28674A patent/MA27885A1/fr unknown
2008
- 2008-05-21 US US12/124,755 patent/US20080306123A1/en not_active Abandoned
- 2008-08-14 CY CY20081100869T patent/CY1110434T1/el unknown

Also Published As

Publication number	Publication date
CY1110434T1 (el)	2015-04-29
IL172063A0 (en)	2009-02-11
NL1026438C2 (nl)	2005-09-20
KR20060036927A (ko)	2006-05-02
EP1638933B1 (en)	2008-06-11
UY28360A1 (es)	2005-01-31
BRPI0411594A (pt)	2006-08-29
EA200501730A1 (ru)	2006-08-25
PE20050631A1 (es)	2005-09-14
IS8136A (is)	2005-11-21
TW200505852A (en)	2005-02-16
PT1638933E (pt)	2008-07-22
ES2305776T3 (es)	2008-11-01
US20080306123A1 (en)	2008-12-11
PA8605301A1 (es)	2005-02-04
HRP20080339T3 (en)	2008-08-31
WO2004110995A1 (en)	2004-12-23
SI1638933T1 (sl)	2008-10-31
MA27885A1 (fr)	2006-05-02
PL1638933T3 (pl)	2008-10-31
AU2004247487B2 (en)	2010-05-20
DE602004014372D1 (de)	2008-07-24
NZ544046A (en)	2009-08-28
DK1638933T3 (da)	2008-07-28
US20050137229A1 (en)	2005-06-23
ATE398107T1 (de)	2008-07-15
KR100803796B1 (ko)	2008-02-14
HRP20050993A2 (en)	2006-03-31
CA2530159C (en)	2010-02-02
ECSP056232A (es)	2006-04-19
WO2004110995A8 (en)	2005-04-21
JP4137159B2 (ja)	2008-08-20
US7378436B2 (en)	2008-05-27
MXPA05013960A (es)	2006-02-24
AR044715A1 (es)	2005-09-21
NL1026438A1 (nl)	2004-12-20
EP1638933A1 (en)	2006-03-29
CA2530159A1 (en)	2004-12-23
EA009881B1 (ru)	2008-04-28
JP2006527758A (ja)	2006-12-07
AU2004247487A1 (en)	2004-12-23

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ZA200506744B (en)	2006-06-28	PyrazoloÄ1,5-AÜpyrimidine derivatives
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IL158141A0 (en)	2004-03-28	Phenyl heterocyclyl ether derivatives as serotonin reuptake inhibitors
PL1613594T3 (pl)	2008-09-30	Pochodne 4-(2-fenylosulfanylo-fenylo)-1,2,3,6-tetrahydropirydyny jako inhibitory wychwytu zwrotnego serotoniny
NO20053588D0 (no)	2005-07-22	Acylaminotiazol-derivater, fremstilling og anvendelse derav som beta-amyloidpeptid-produksjonsinhibitorer.
PL376753A1 (pl)	2006-01-09	Podstawione pochodne 3-(benzoiloureido)-tiofenu, sposób ich wytwarzania oraz ich zastosowanie
TWI339658B (en)	2011-04-01	Morpholine derivatives as norepinephrine reuptake inhibitors
ZA200509132B (en)	2007-02-28	N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors
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HK1060563A (en)	2004-08-13	Cyclopropylindole derivatives as selective serotonin reuptake inhibitors
SE0303065D0 (sv)	2003-11-18	New composition, methods and uses thereof
AU2002333414A1 (en)	2003-03-03	2-substituted 1-arylpiperazines as tachykinin antagonists and/or serotonin reuptake inhibitors