AP2006003849A0 - 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors - Google Patents

3-Aminocyclopentanecarboxamides as modulators of chemokine receptors

Info

Publication number: AP2006003849A0
Authority: AP; ARIPO
Prior art keywords: aminocyclopentanecarboxamides; modulators; chemokine receptors; chemokine; receptors
Prior art date: 2004-06-28

Application number

AP2006003849A

Other languages

English (en)

Inventor

Chu-Biao Xue

Chang-Sheng Zheng

Michael Xia

Original Assignee

Incyte Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-28

Filing date

2005-06-27

Publication date

2006-12-31

2005-06-27 Application filed by Incyte Corp filed Critical Incyte Corp

2006-12-31 Publication of AP2006003849A0 publication Critical patent/AP2006003849A0/xx

Links

OLHSXPNNEJJDLQ-UHFFFAOYSA-N 3-aminocyclopentane-1-carboxamide Chemical class NC1CCC(C(N)=O)C1 OLHSXPNNEJJDLQ-UHFFFAOYSA-N 0.000 title 1
102000009410 Chemokine receptor Human genes 0.000 title 1
108050000299 Chemokine receptor Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Pulmonology (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AP2006003849A 2004-06-28 2005-06-27 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors AP2006003849A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US58348204P	2004-06-28	2004-06-28
US62437404P	2004-11-01	2004-11-01
PCT/US2005/022793 WO2006004684A2 (en)	2004-06-28	2005-06-27	3-aminocyclopentanecarboxamides as modulators of chemokine receptors

Publications (1)

Publication Number	Publication Date
AP2006003849A0 true AP2006003849A0 (en)	2006-12-31

Family

ID=35783293

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2006003849A AP2006003849A0 (en)	2004-06-28	2005-06-27	3-Aminocyclopentanecarboxamides as modulators of chemokine receptors

Country Status (21)

Country	Link
US (2)	US7449467B2 (pt)
EP (1)	EP1763351B9 (pt)
JP (2)	JP4116670B2 (pt)
KR (1)	KR100856156B1 (pt)
AP (1)	AP2006003849A0 (pt)
AR (1)	AR049559A1 (pt)
AU (1)	AU2005260013A1 (pt)
BR (1)	BRPI0512352A (pt)
CA (1)	CA2571019C (pt)
CR (1)	CR8775A (pt)
EA (1)	EA011487B1 (pt)
EC (1)	ECSP067120A (pt)
ES (1)	ES2614117T3 (pt)
GE (1)	GEP20094843B (pt)
IL (1)	IL179910A0 (pt)
MA (1)	MA28680B1 (pt)
MX (1)	MXPA06014672A (pt)
NO (1)	NO20070487L (pt)
SG (1)	SG156691A1 (pt)
TW (1)	TW200608966A (pt)
WO (1)	WO2006004684A2 (pt)

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PL376925A1 (pl) *	2002-11-27	2006-01-09	Incyte Corporation	Pochodne 3-aminopirolidyny jako modulatory receptorów chemokiny
AU2005234596B8 (en) *	2004-04-13	2011-06-16	Incyte Holdings Corporation	Piperazinylpiperidine derivatives as chemokine receptor antagonists
GEP20094843B (en) *	2004-06-28	2009-11-25	Incyte Corp	3-aminocyclopentane carboxamides as modulators of chemokine receptors
EP1763347A4 (en) *	2004-06-28	2009-05-20	Incyte Corp	3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS
WO2007053499A2 (en)	2005-11-01	2007-05-10	Millennium Pharmaceuticals, Inc.	Compounds useful as antagonists of ccr2
US8067457B2 (en)	2005-11-01	2011-11-29	Millennium Pharmaceuticals, Inc.	Compounds useful as antagonists of CCR2
MEP1008A (xx) *	2005-12-21	2010-02-10	Incyte Corp	3-aminociklopentankarboksamidi kao modulatori receptora hemokina
US7910108B2 (en)	2006-06-05	2011-03-22	Incyte Corporation	Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases
US20080076120A1 (en) *	2006-09-14	2008-03-27	Millennium Pharmaceuticals, Inc.	Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
WO2008109238A1 (en) *	2007-03-02	2008-09-12	Janssen Pharmaceutica N.V.	Substituted cyclopentyl piperidine ccr2 antagonists
JP5292400B2 (ja)	2007-07-24	2013-09-18	ブリストル−マイヤーズスクイブカンパニー	ケモカイン受容体活性のモジュレーターとしてのピペリジン誘導体
TWI433838B (zh)	2008-06-25	2014-04-11	必治妥美雅史谷比公司	作為趨化因子受體活性調節劑之六氫吡啶衍生物
CA2743030C (en)	2008-11-26	2013-10-22	Pfizer Inc.	3-aminocyclopentanecarboxamides as chemokine receptor modulators
CN101555616B (zh) *	2009-05-13	2012-11-07	大连理工大学	镍钛合金表面羟基磷灰石/二氧化钛复合涂层的制备方法
WO2011143422A1 (en)	2010-05-12	2011-11-17	Vertex Pharmaceuticals Incorporated	2 -aminopyridine derivatives useful as inhibitors of atr kinase
JP5786258B2 (ja) *	2011-07-15	2015-09-30	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新規かつ選択的なｃｃｒ２拮抗薬
CR20170076A (es)	2014-08-04	2017-06-26	Nuevolution As	Derivados de pirimidima sustituidos con heterociclilo opcionalmente condensados útiles para el tratamiento de enfermedades inflamatorias, metabólicas, oncológicas y autoinmunitarias
US10403890B2 (en) *	2015-11-10	2019-09-03	Nissan Motor Co., Ltd.	Negative electrode active material for electric device and electric device using the same
AU2020408107B2 (en)	2019-12-20	2026-04-23	Nuevolution A/S	Compounds active towards nuclear receptors
AU2020405446A1 (en)	2019-12-20	2022-05-26	Nuevolution A/S	Compounds active towards nuclear receptors
US11613532B2 (en)	2020-03-31	2023-03-28	Nuevolution A/S	Compounds active towards nuclear receptors
EP4126874A1 (en)	2020-03-31	2023-02-08	Nuevolution A/S	Compounds active towards nuclear receptors
CN116710090A (zh) *	2020-10-09	2023-09-05	Napa医疗有限公司	Cd38的杂芳基酰胺抑制剂
JP7720044B2 (ja)	2020-11-19	2025-08-07	グリアセルテック・インコーポレイテッド	ジダノシンを含む神経炎症性疾患の予防または治療用組成物

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CA2503844A1 (en)	2002-10-30	2004-05-21	Merck & Co., Inc.	Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity
EP1558576A4 (en)	2002-10-30	2008-04-16	Merck & Co Inc	PIPERIDINYLCYCLOPENTYLARYLBENZYLAMIDE MODULATORS OF CHEMOKIN RECEPTORACTIVITY
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JP2006514003A (ja) *	2002-10-30	2006-04-27	メルク　エンド　カムパニー　インコーポレーテッド	ケモカイン受容体活性のテトラヒドロピラニルシクロペンチルベンジルアミド調節剤
PL376925A1 (pl) *	2002-11-27	2006-01-09	Incyte Corporation	Pochodne 3-aminopirolidyny jako modulatory receptorów chemokiny
JP2006510688A (ja) *	2002-12-20	2006-03-30	レオ・ファーマ・アクティーゼルスカブ	新規アミノベンゾフェノン化合物
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CA2551869A1 (en)	2004-01-02	2005-07-28	Merck & Co., Inc.	Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
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JP2007519734A (ja)	2004-01-28	2007-07-19	メルク　エンド　カムパニー　インコーポレーテッド	アミノシクロペンチルピリドピラジノン系ケモカイン受容体活性調節剤
EP1742919A4 (en)	2004-04-26	2010-04-28	Merck Sharp & Dohme	TETRAHYDROPYRANYL-CYCLOPENTYL-1-SUBSTITUTED AND 1,1-DISUBSTITUTED TETRAHYDROISOCHINOLINE MODULATORS OF CHEMOKIN RECEPTOR ACTIVITY
JP2007537264A (ja) *	2004-05-11	2007-12-20	インサイトコーポレイション	ケモカインレセプタのモジュレータとしての３−（４−ヘテロアリールシクロヘキシルアミノ）シクロペンタンカルボキサミド
EP1763347A4 (en)	2004-06-28	2009-05-20	Incyte Corp	3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS
GEP20094843B (en) *	2004-06-28	2009-11-25	Incyte Corp	3-aminocyclopentane carboxamides as modulators of chemokine receptors
PA8653301A1 (es) *	2004-11-22	2006-11-09	Incyte Corp Incyte Corp	Sales de la n-[2-({(3r)-1-[trans-4-hidroxi-4-(6-metoxipiridin-3-il) ciclohexil)pirrolidin
MEP1008A (xx) *	2005-12-21	2010-02-10	Incyte Corp	3-aminociklopentankarboksamidi kao modulatori receptora hemokina

2005
- 2005-06-27 GE GEAP20059758A patent/GEP20094843B/en unknown
- 2005-06-27 ES ES05790938.4T patent/ES2614117T3/es not_active Expired - Lifetime
- 2005-06-27 KR KR1020067027464A patent/KR100856156B1/ko not_active Expired - Fee Related
- 2005-06-27 SG SG200907284-4A patent/SG156691A1/en unknown
- 2005-06-27 CA CA2571019A patent/CA2571019C/en not_active Expired - Fee Related
- 2005-06-27 BR BRPI0512352-6A patent/BRPI0512352A/pt not_active IP Right Cessation
- 2005-06-27 US US11/167,816 patent/US7449467B2/en not_active Expired - Lifetime
- 2005-06-27 EA EA200602242A patent/EA011487B1/ru not_active IP Right Cessation
- 2005-06-27 AU AU2005260013A patent/AU2005260013A1/en not_active Abandoned
- 2005-06-27 JP JP2007518357A patent/JP4116670B2/ja not_active Expired - Fee Related
- 2005-06-27 AP AP2006003849A patent/AP2006003849A0/xx unknown
- 2005-06-27 EP EP05790938.4A patent/EP1763351B9/en not_active Expired - Lifetime
- 2005-06-27 TW TW094121454A patent/TW200608966A/zh unknown
- 2005-06-27 WO PCT/US2005/022793 patent/WO2006004684A2/en not_active Ceased
- 2005-06-27 MX MXPA06014672A patent/MXPA06014672A/es unknown
- 2005-06-28 AR ARP050102676A patent/AR049559A1/es unknown
2006
- 2006-11-28 CR CR8775A patent/CR8775A/es not_active Application Discontinuation
- 2006-12-07 IL IL179910A patent/IL179910A0/en unknown
- 2006-12-27 EC EC2006007120A patent/ECSP067120A/es unknown
- 2006-12-28 MA MA29560A patent/MA28680B1/fr unknown
2007
- 2007-01-25 NO NO20070487A patent/NO20070487L/no not_active Application Discontinuation
- 2007-12-12 JP JP2007321252A patent/JP2008074877A/ja active Pending
2008
- 2008-09-25 US US12/238,121 patent/US8470827B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
TW200608966A (en)	2006-03-16
GEP20094843B (en)	2009-11-25
WO2006004684A8 (en)	2007-01-04
ECSP067120A (es)	2007-01-26
WO2006004684A3 (en)	2006-10-05
SG156691A1 (en)	2009-11-26
EP1763351B9 (en)	2017-05-31
CA2571019A1 (en)	2006-01-12
JP4116670B2 (ja)	2008-07-09
MA28680B1 (fr)	2007-06-01
JP2008504293A (ja)	2008-02-14
BRPI0512352A (pt)	2008-03-04
ES2614117T3 (es)	2017-05-29
AU2005260013A1 (en)	2006-01-12
WO2006004684A2 (en)	2006-01-12
EP1763351A4 (en)	2009-08-12
US8470827B2 (en)	2013-06-25
US20060004018A1 (en)	2006-01-05
CR8775A (es)	2007-01-04
MXPA06014672A (es)	2007-03-26
CA2571019C (en)	2012-06-05
IL179910A0 (en)	2007-05-15
NO20070487L (no)	2007-03-05
KR100856156B1 (ko)	2008-09-03
AR049559A1 (es)	2006-08-16
EP1763351B1 (en)	2016-11-30
KR20070026660A (ko)	2007-03-08
EA200602242A1 (ru)	2007-04-27
EP1763351A2 (en)	2007-03-21
EA011487B1 (ru)	2009-04-28
US20100119503A1 (en)	2010-05-13
JP2008074877A (ja)	2008-04-03
US7449467B2 (en)	2008-11-11

Publication	Publication Date	Title
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