BRPI0417605B8 - “n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende”. - Google Patents

“n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende”.

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Publication number
BRPI0417605B8
BRPI0417605B8 BRPI0417605A BRPI0417605A BRPI0417605B8 BR PI0417605 B8 BRPI0417605 B8 BR PI0417605B8 BR PI0417605 A BRPI0417605 A BR PI0417605A BR PI0417605 A BRPI0417605 A BR PI0417605A BR PI0417605 B8 BRPI0417605 B8 BR PI0417605B8
Authority
BR
Brazil
Prior art keywords
ylpyridin
oxoethyl
pyrrolidin
benzamide
pyrimidin
Prior art date
Application number
BRPI0417605A
Other languages
English (en)
Inventor
Qi Han Amy
Wang Anlai
Metcalf Brian
Zheng Changsheng
Xue Chu-Biao
J Robinson Darius
Zhang Yingxin
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of BRPI0417605A publication Critical patent/BRPI0417605A/pt
Publication of BRPI0417605B1 publication Critical patent/BRPI0417605B1/pt
Publication of BRPI0417605B8 publication Critical patent/BRPI0417605B8/pt

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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

derivados de 3-cicloalquilaminopirrolidina como moduladores de receptores de quimiocina. a presente invenção está relacionada com derivados de 3-cicloalquilaminopirrolidina de fórmula i: (na qual r1, r2, r3, r4, r5, r6, r7, x, y, e z são como definido nesta) que são úteis como moduladores da atividade dos receptores de quimiocina. em particular, esses compostos são úteis como moduladores de receptores de quimiocinas e mais especificamente como moduladores dos receptores ccr2 e/ou ccr5. os compostos e composições da invenção podem se ligar aos receptores de quimiocina, por exemplo, os receptores ccr2 e/ou ccr5, e são úteis para o tratamento de doenças associadas a quimiocina, por exemplo, atividade de ccr2 e/ou ccr5, tais como aterosclerose, restenose, lúpus, rejeição ao transplante de órgãos e artrite reumatóide.
BRPI0417605A 2003-12-18 2004-12-16 “n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende”. BRPI0417605B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53127003P 2003-12-18 2003-12-18
US60/531.270 2003-12-18
PCT/US2004/042321 WO2005060665A2 (en) 2003-12-18 2004-12-16 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors

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BRPI0417605A BRPI0417605A (pt) 2007-03-27
BRPI0417605B1 BRPI0417605B1 (pt) 2020-05-12
BRPI0417605B8 true BRPI0417605B8 (pt) 2021-05-25

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EP1696919A4 (en) 2009-07-01
US20140155377A1 (en) 2014-06-05
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