AP2010005199A0 - Azacyclylisoquinolinone and isoindolinone derivatives as histamine-3 antagonists - Google Patents

Azacyclylisoquinolinone and isoindolinone derivatives as histamine-3 antagonists

Info

Publication number: AP2010005199A0
Authority: AP; ARIPO
Prior art keywords: azacyclylisoquinolinone; histamine; antagonists; isoindolinone derivatives; isoindolinone
Prior art date: 2007-09-12

Application number

AP2010005199A

Other languages

English (en)

Inventor

Albert Jean Robichaud

Jonathan Laird Gross

Original Assignee

Wyeth Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-09-12

Filing date

2008-09-11

Publication date

2010-04-30

2008-09-11 Application filed by Wyeth Llc filed Critical Wyeth Llc

2010-04-30 Publication of AP2010005199A0 publication Critical patent/AP2010005199A0/xx

Links

239000005557 antagonist Substances 0.000 title 1
PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical class C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AP2010005199A 2007-09-12 2008-09-11 Azacyclylisoquinolinone and isoindolinone derivatives as histamine-3 antagonists AP2010005199A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US99355407P	2007-09-12	2007-09-12
PCT/US2008/075942 WO2009036117A1 (en)	2007-09-12	2008-09-11	Azacyclylisoquinolinone and isoindolinone derivatives as histamine-3 antagonists

Publications (1)

Publication Number	Publication Date
AP2010005199A0 true AP2010005199A0 (en)	2010-04-30

Family

ID=40261508

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2010005199A AP2010005199A0 (en)	2007-09-12	2008-09-11	Azacyclylisoquinolinone and isoindolinone derivatives as histamine-3 antagonists

Country Status (23)

Country	Link
US (1)	US20090069370A1 (es)
EP (1)	EP2200998A1 (es)
JP (1)	JP2010539178A (es)
KR (1)	KR20100054852A (es)
CN (1)	CN101842366A (es)
AP (1)	AP2010005199A0 (es)
AU (1)	AU2008298983A1 (es)
BR (1)	BRPI0816806A2 (es)
CA (1)	CA2699383A1 (es)
CL (1)	CL2008002708A1 (es)
CO (1)	CO6300951A2 (es)
CR (1)	CR11309A (es)
DO (1)	DOP2010000078A (es)
EA (1)	EA201000319A1 (es)
EC (1)	ECSP10010032A (es)
MA (1)	MA31700B1 (es)
MX (1)	MX2010002899A (es)
NI (1)	NI201000035A (es)
PA (1)	PA8795601A1 (es)
PE (1)	PE20090679A1 (es)
TN (1)	TN2010000107A1 (es)
TW (1)	TW200918062A (es)
WO (1)	WO2009036117A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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TW200823204A (en) *	2006-10-17	2008-06-01	Arena Pharm Inc	Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
JP2011213700A (ja) *	2010-04-02	2011-10-27	Nishizaki Soyaku Kenkyusho:Kk	認知症改善用組成物
EP2569280B1 (en)	2010-05-11	2015-02-25	Sanofi	Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof
EP2569297A1 (en)	2010-05-11	2013-03-20	Sanofi	Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof
WO2011143148A1 (en)	2010-05-11	2011-11-17	Sanofi	Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof
AR081498A1 (es) *	2010-05-11	2012-09-19	Sanofi Aventis	Derivados de n-alquil -y n-acil-tetrahidroisoquinolina sustituidos, preparacion y su uso terapeutico de los mismos
EP2569294B1 (en)	2010-05-11	2015-03-11	Sanofi	Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof
TW201206444A (en)	2010-05-11	2012-02-16	Sanofi Aventis	Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
EP2535062A1 (en)	2011-06-13	2012-12-19	Dentsply IH AB	Collagen coated article
US9295531B2 (en)	2011-06-13	2016-03-29	Dentsply International Inc.	Collagen coated article
AR088989A1 (es) *	2011-11-30	2014-07-23	Hoffmann La Roche	Derivados biciclicos de dihidroisoquinolin-1-ona
JO3442B1 (ar) *	2013-10-07	2019-10-20	Takeda Pharmaceuticals Co	مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5)
AR098215A1 (es)	2013-10-29	2016-05-18	Takeda Pharmaceuticals Co	Compuesto heterocíclico
CN112209876B (zh) *	2020-10-15	2022-08-26	华侨大学	一种3-三氟甲基异喹啉酮衍生物的制备方法

Family Cites Families (19)

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US3933829A (en) *	1974-08-22	1976-01-20	John Wyeth & Brother Limited	4-Aminoquinoline derivatives
US4159331A (en) *	1978-05-05	1979-06-26	The Upjohn Company	Antihypertensive 4-aminoquinolines
US4166853A (en) *	1978-05-05	1979-09-04	The Upjohn Company	Antihypertensive 7-trifluoromethyl-4-aminoquinolones
SE7907121L (sv) *	1979-08-27	1981-02-28	Astra Laekemedel Ab	Ftalimidinderivat
US5491148A (en) *	1991-04-26	1996-02-13	Syntex (U.S.A.) Inc.	Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists
US5595872A (en) *	1992-03-06	1997-01-21	Bristol-Myers Squibb Company	Nucleic acids encoding microsomal trigyceride transfer protein
US5739135A (en) *	1993-09-03	1998-04-14	Bristol-Myers Squibb Company	Inhibitors of microsomal triglyceride transfer protein and method
IL117149A0 (en) *	1995-02-23	1996-06-18	Schering Corp	Muscarinic antagonists
WO1998013364A1 (en) *	1996-09-25	1998-04-02	Yamanouchi Pharmaceutical Co., Ltd.	2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline derivatives or medicinal compositions thereof
ES2210747T3 (es) *	1997-05-01	2004-07-01	Eli Lilly And Company	Agentes antitromboticos.
US7320992B2 (en) *	2003-08-25	2008-01-22	Amgen Inc.	Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
AU2005243175B2 (en) *	2004-05-14	2011-12-01	Millennium Pharmaceuticals, Inc.	Compounds and methods for inhibiting mitotic progression by inhibition of Aurora kinase
US20060014733A1 (en) *	2004-07-19	2006-01-19	Pfizer Inc	Histamine-3 agonists and antagonists
SE0401970D0 (sv)	2004-08-02	2004-08-02	Astrazeneca Ab	Novel compounds
US7381732B2 (en) *	2004-10-26	2008-06-03	Bristol-Myers Squibb Company	Pyrazolobenzamides and derivatives as factor Xa inhibitors
EP1848696A1 (en) *	2005-01-21	2007-10-31	Schering Corporation	Imidazole and benzimidazole derivates useful as histamine h3 antagonists
JP2008537953A (ja) *	2005-04-15	2008-10-02	エランファーマシューティカルズ，インコーポレイテッド	ブラジキニンｂ１受容体拮抗作用に有用な新規化合物
US8143284B2 (en) *	2006-10-05	2012-03-27	Abbott Laboratories	Poly(ADP-ribose)polymerase inhibitors
US7799806B2 (en) *	2007-04-04	2010-09-21	Hoffmann-La Roche Inc.	Substituted n-benzyl piperidines as somatostatin receptor modulators

2008
- 2008-09-10 TW TW097134761A patent/TW200918062A/zh unknown
- 2008-09-11 AP AP2010005199A patent/AP2010005199A0/xx unknown
- 2008-09-11 MX MX2010002899A patent/MX2010002899A/es unknown
- 2008-09-11 KR KR1020107007636A patent/KR20100054852A/ko not_active Ceased
- 2008-09-11 WO PCT/US2008/075942 patent/WO2009036117A1/en not_active Ceased
- 2008-09-11 US US12/208,780 patent/US20090069370A1/en not_active Abandoned
- 2008-09-11 CA CA2699383A patent/CA2699383A1/en not_active Abandoned
- 2008-09-11 BR BRPI0816806-7A2A patent/BRPI0816806A2/pt not_active IP Right Cessation
- 2008-09-11 EA EA201000319A patent/EA201000319A1/ru unknown
- 2008-09-11 PE PE2008001588A patent/PE20090679A1/es not_active Application Discontinuation
- 2008-09-11 CL CL200802708A patent/CL2008002708A1/es unknown
- 2008-09-11 AU AU2008298983A patent/AU2008298983A1/en not_active Abandoned
- 2008-09-11 JP JP2010524972A patent/JP2010539178A/ja not_active Withdrawn
- 2008-09-11 EP EP08830104A patent/EP2200998A1/en not_active Withdrawn
- 2008-09-11 CN CN200880113557A patent/CN101842366A/zh active Pending
- 2008-09-12 PA PA20088795601A patent/PA8795601A1/es unknown
2010
- 2010-03-11 NI NI201000035A patent/NI201000035A/es unknown
- 2010-03-11 DO DO2010000078A patent/DOP2010000078A/es unknown
- 2010-03-11 CR CR11309A patent/CR11309A/es not_active Application Discontinuation
- 2010-03-11 TN TNP2010000107A patent/TN2010000107A1/fr unknown
- 2010-03-12 MA MA32689A patent/MA31700B1/fr unknown
- 2010-03-12 EC EC2010010032A patent/ECSP10010032A/es unknown
- 2010-03-15 CO CO10030401A patent/CO6300951A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
NI201000035A (es)	2010-07-15
CO6300951A2 (es)	2011-07-21
WO2009036117A1 (en)	2009-03-19
TW200918062A (en)	2009-05-01
US20090069370A1 (en)	2009-03-12
CR11309A (es)	2010-04-07
TN2010000107A1 (fr)	2011-09-26
ECSP10010032A (es)	2010-08-31
CA2699383A1 (en)	2009-03-19
BRPI0816806A2 (pt)	2015-03-10
DOP2010000078A (es)	2010-04-15
MA31700B1 (fr)	2010-09-01
PE20090679A1 (es)	2009-05-28
MX2010002899A (es)	2010-04-09
AU2008298983A1 (en)	2009-03-19
CN101842366A (zh)	2010-09-22
JP2010539178A (ja)	2010-12-16
PA8795601A1 (es)	2009-05-15
KR20100054852A (ko)	2010-05-25
EA201000319A1 (ru)	2010-10-29
EP2200998A1 (en)	2010-06-30
CL2008002708A1 (es)	2008-10-10

Publication	Publication Date	Title
AP2010005199A0 (en)	2010-04-30	Azacyclylisoquinolinone and isoindolinone derivatives as histamine-3 antagonists
IL210412A0 (en)	2011-03-31	Heterocyclic derivatives and uses thereof
ZA201308294B (en)	2014-07-30	Heterocyclic compounds and their uses
EP2152079A4 (en)	2011-03-09	HETEROCYCLIC COMPOUNDS AND USES THEREOF
IL211042A0 (en)	2011-04-28	Imidazopyridin-2-one derivatives and uses thereof
ZA201103635B (en)	2012-10-31	Azaquinolinone derivatives and uses thereof
IL218078A0 (en)	2012-04-30	Heterocyclic compounds and uses thereof
IL216973A0 (en)	2012-02-29	Heterocyclic compounds and their uses
IL208203A0 (en)	2010-12-30	Heterocyclic derivatives
ZA201009073B (en)	2012-03-28	Heterocyclic compound and use thereof
ZA201001751B (en)	2010-11-24	Isoquinolinyl and isoindolinyl derivatives as histamine-3 antagonists
IL208771A0 (en)	2010-12-30	Iminopyridine derivatives and use thereof
EP2121703A4 (en)	2011-12-28	THIENOPYRIMIDIN-4-ON- AND THIENOPYRIDAZIN-7-ONDERIVATES AS MCH-RL ANTAGONISTS
ZA200807614B (en)	2009-10-28	Buprenorphine derivatives and uses thereof
ZA201002580B (en)	2010-12-29	Heterocyclic derivatives
IL229560A0 (en)	2014-01-30	Dibenzothiazepine history and use
IL202339A0 (en)	2010-06-30	Azacyclylbenzamide derivatives as histamine-3 antagonists
EP2274294A4 (en)	2011-08-10	5-DIMETHOXY FUMAGILLOL AND ITS DERIVATIVES
PL2297089T3 (pl)	2013-12-31	Pochodne benzocykloheptanu i benzoksepiny
IL206951A0 (en)	2010-12-30	3-alkyl-piperazine derivatives and uses thereof
ZA200906568B (en)	2018-11-28	Heterocyclic compounds and their uses
IL206950A0 (en)	2010-12-30	Aminopiperidinyl derivatives and uses thereof
IL196823A0 (en)	2009-11-18	Tetraarylporphine derivatives and uses thereof
IL200457A0 (en)	2010-04-29	Isoflavone derivatives and uses thereof
HK1152934A (en)	2012-03-16	Benzazepine derivatives and their use as hstamine h3 antagonists