BRPI0816806A2 - Derivados de azaciclil-isoquinolinona e isoindolinona como antagonista de histamina-3 - Google Patents
Derivados de azaciclil-isoquinolinona e isoindolinona como antagonista de histamina-3Info
- Publication number
- BRPI0816806A2 BRPI0816806A2 BRPI0816806-7A2A BRPI0816806A BRPI0816806A2 BR PI0816806 A2 BRPI0816806 A2 BR PI0816806A2 BR PI0816806 A BRPI0816806 A BR PI0816806A BR PI0816806 A2 BRPI0816806 A2 BR PI0816806A2
- Authority
- BR
- Brazil
- Prior art keywords
- azaciclil
- histamin
- isoquinolinone
- antagonist
- isoindolinone derivatives
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical class C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99355407P | 2007-09-12 | 2007-09-12 | |
| PCT/US2008/075942 WO2009036117A1 (en) | 2007-09-12 | 2008-09-11 | Azacyclylisoquinolinone and isoindolinone derivatives as histamine-3 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0816806A2 true BRPI0816806A2 (pt) | 2015-03-10 |
Family
ID=40261508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0816806-7A2A BRPI0816806A2 (pt) | 2007-09-12 | 2008-09-11 | Derivados de azaciclil-isoquinolinona e isoindolinona como antagonista de histamina-3 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20090069370A1 (pt) |
| EP (1) | EP2200998A1 (pt) |
| JP (1) | JP2010539178A (pt) |
| KR (1) | KR20100054852A (pt) |
| CN (1) | CN101842366A (pt) |
| AP (1) | AP2010005199A0 (pt) |
| AU (1) | AU2008298983A1 (pt) |
| BR (1) | BRPI0816806A2 (pt) |
| CA (1) | CA2699383A1 (pt) |
| CL (1) | CL2008002708A1 (pt) |
| CO (1) | CO6300951A2 (pt) |
| CR (1) | CR11309A (pt) |
| DO (1) | DOP2010000078A (pt) |
| EA (1) | EA201000319A1 (pt) |
| EC (1) | ECSP10010032A (pt) |
| MA (1) | MA31700B1 (pt) |
| MX (1) | MX2010002899A (pt) |
| NI (1) | NI201000035A (pt) |
| PA (1) | PA8795601A1 (pt) |
| PE (1) | PE20090679A1 (pt) |
| TN (1) | TN2010000107A1 (pt) |
| TW (1) | TW200918062A (pt) |
| WO (1) | WO2009036117A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200823204A (en) * | 2006-10-17 | 2008-06-01 | Arena Pharm Inc | Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto |
| JP2011213700A (ja) * | 2010-04-02 | 2011-10-27 | Nishizaki Soyaku Kenkyusho:Kk | 認知症改善用組成物 |
| TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
| WO2011143161A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
| JP5766278B2 (ja) * | 2010-05-11 | 2015-08-19 | サノフイ | 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用 |
| AR081034A1 (es) | 2010-05-11 | 2012-05-30 | Sanofi Aventis | Derivados de n-heteroaril tetrahidro-isoquinolina sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central |
| AR081908A1 (es) | 2010-05-11 | 2012-10-31 | Sanofi Aventis | N-heteroaril-espirolactama-bipirrolidinas sustituidas, preparacion y usos terapeuticos de las mismas |
| EP2569294B1 (en) | 2010-05-11 | 2015-03-11 | Sanofi | Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| US9295531B2 (en) | 2011-06-13 | 2016-03-29 | Dentsply International Inc. | Collagen coated article |
| EP2535062A1 (en) | 2011-06-13 | 2012-12-19 | Dentsply IH AB | Collagen coated article |
| MX350717B (es) * | 2011-11-30 | 2017-09-14 | Hoffmann La Roche | Nuevos derivados biciclicos de dihidroisoquinolin-1-ona. |
| JO3442B1 (ar) | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
| PL3063139T3 (pl) | 2013-10-29 | 2019-05-31 | Takeda Pharmaceuticals Co | Związek heterocykliczny |
| CN112209876B (zh) * | 2020-10-15 | 2022-08-26 | 华侨大学 | 一种3-三氟甲基异喹啉酮衍生物的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3933829A (en) * | 1974-08-22 | 1976-01-20 | John Wyeth & Brother Limited | 4-Aminoquinoline derivatives |
| US4159331A (en) * | 1978-05-05 | 1979-06-26 | The Upjohn Company | Antihypertensive 4-aminoquinolines |
| US4166853A (en) * | 1978-05-05 | 1979-09-04 | The Upjohn Company | Antihypertensive 7-trifluoromethyl-4-aminoquinolones |
| SE7907121L (sv) * | 1979-08-27 | 1981-02-28 | Astra Laekemedel Ab | Ftalimidinderivat |
| US5491148A (en) * | 1991-04-26 | 1996-02-13 | Syntex (U.S.A.) Inc. | Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists |
| US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
| US5739135A (en) * | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
| AU4319797A (en) * | 1996-09-25 | 1998-04-17 | Yamanouchi Pharmaceutical Co., Ltd. | 2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline derivatives or medicinal compositions thereof |
| ATE253359T1 (de) * | 1997-05-01 | 2003-11-15 | Lilly Co Eli | Antithrombotische mittel |
| US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
| KR101792651B1 (ko) * | 2004-05-14 | 2017-11-20 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 아우로라 키나아제의 억제에 의해 유사분열 진행을 억제하기 위한 화합물 및 그 화합물을 포함하는 약학적 조성물 |
| US20060014733A1 (en) * | 2004-07-19 | 2006-01-19 | Pfizer Inc | Histamine-3 agonists and antagonists |
| SE0401970D0 (sv) | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Novel compounds |
| US7381732B2 (en) * | 2004-10-26 | 2008-06-03 | Bristol-Myers Squibb Company | Pyrazolobenzamides and derivatives as factor Xa inhibitors |
| EP1848696A1 (en) * | 2005-01-21 | 2007-10-31 | Schering Corporation | Imidazole and benzimidazole derivates useful as histamine h3 antagonists |
| US20070032475A1 (en) * | 2005-04-15 | 2007-02-08 | Ye Xiaocong M | Novel compounds useful for bradykinin B1 receptor antagonism |
| US8143284B2 (en) * | 2006-10-05 | 2012-03-27 | Abbott Laboratories | Poly(ADP-ribose)polymerase inhibitors |
| US7799806B2 (en) * | 2007-04-04 | 2010-09-21 | Hoffmann-La Roche Inc. | Substituted n-benzyl piperidines as somatostatin receptor modulators |
-
2008
- 2008-09-10 TW TW097134761A patent/TW200918062A/zh unknown
- 2008-09-11 AP AP2010005199A patent/AP2010005199A0/xx unknown
- 2008-09-11 EA EA201000319A patent/EA201000319A1/ru unknown
- 2008-09-11 PE PE2008001588A patent/PE20090679A1/es not_active Application Discontinuation
- 2008-09-11 CL CL200802708A patent/CL2008002708A1/es unknown
- 2008-09-11 WO PCT/US2008/075942 patent/WO2009036117A1/en not_active Ceased
- 2008-09-11 CA CA2699383A patent/CA2699383A1/en not_active Abandoned
- 2008-09-11 AU AU2008298983A patent/AU2008298983A1/en not_active Abandoned
- 2008-09-11 EP EP08830104A patent/EP2200998A1/en not_active Withdrawn
- 2008-09-11 JP JP2010524972A patent/JP2010539178A/ja not_active Withdrawn
- 2008-09-11 CN CN200880113557A patent/CN101842366A/zh active Pending
- 2008-09-11 MX MX2010002899A patent/MX2010002899A/es unknown
- 2008-09-11 BR BRPI0816806-7A2A patent/BRPI0816806A2/pt not_active IP Right Cessation
- 2008-09-11 KR KR1020107007636A patent/KR20100054852A/ko not_active Ceased
- 2008-09-11 US US12/208,780 patent/US20090069370A1/en not_active Abandoned
- 2008-09-12 PA PA20088795601A patent/PA8795601A1/es unknown
-
2010
- 2010-03-11 CR CR11309A patent/CR11309A/es not_active Application Discontinuation
- 2010-03-11 TN TNP2010000107A patent/TN2010000107A1/fr unknown
- 2010-03-11 NI NI201000035A patent/NI201000035A/es unknown
- 2010-03-11 DO DO2010000078A patent/DOP2010000078A/es unknown
- 2010-03-12 MA MA32689A patent/MA31700B1/fr unknown
- 2010-03-12 EC EC2010010032A patent/ECSP10010032A/es unknown
- 2010-03-15 CO CO10030401A patent/CO6300951A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TN2010000107A1 (fr) | 2011-09-26 |
| EP2200998A1 (en) | 2010-06-30 |
| DOP2010000078A (es) | 2010-04-15 |
| EA201000319A1 (ru) | 2010-10-29 |
| JP2010539178A (ja) | 2010-12-16 |
| ECSP10010032A (es) | 2010-08-31 |
| MX2010002899A (es) | 2010-04-09 |
| CR11309A (es) | 2010-04-07 |
| WO2009036117A1 (en) | 2009-03-19 |
| AP2010005199A0 (en) | 2010-04-30 |
| PA8795601A1 (es) | 2009-05-15 |
| US20090069370A1 (en) | 2009-03-12 |
| TW200918062A (en) | 2009-05-01 |
| CL2008002708A1 (es) | 2008-10-10 |
| PE20090679A1 (es) | 2009-05-28 |
| CO6300951A2 (es) | 2011-07-21 |
| AU2008298983A1 (en) | 2009-03-19 |
| CA2699383A1 (en) | 2009-03-19 |
| MA31700B1 (fr) | 2010-09-01 |
| NI201000035A (es) | 2010-07-15 |
| KR20100054852A (ko) | 2010-05-25 |
| CN101842366A (zh) | 2010-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A, 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |