AP2014007953A0 - Diacylglycerol acyltransferase 2 inhibitors - Google Patents

Diacylglycerol acyltransferase 2 inhibitors

Info

Publication number
AP2014007953A0
AP2014007953A0 AP2014007953A AP2014007953A AP2014007953A0 AP 2014007953 A0 AP2014007953 A0 AP 2014007953A0 AP 2014007953 A AP2014007953 A AP 2014007953A AP 2014007953 A AP2014007953 A AP 2014007953A AP 2014007953 A0 AP2014007953 A0 AP 2014007953A0
Authority
AP
ARIPO
Prior art keywords
inhibitors
diacylglycerol acyltransferase
acyltransferase
diacylglycerol
Prior art date
Application number
AP2014007953A
Other languages
English (en)
Inventor
Kay Ahn
Markus Boehm
Shawn Cabral
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48428540&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2014007953(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of AP2014007953A0 publication Critical patent/AP2014007953A0/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
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    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
AP2014007953A 2012-04-06 2013-03-26 Diacylglycerol acyltransferase 2 inhibitors AP2014007953A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261621144P 2012-04-06 2012-04-06
PCT/IB2013/052404 WO2013150416A1 (en) 2012-04-06 2013-03-26 Diacylglycerol acyltransferase 2 inhibitors

Publications (1)

Publication Number Publication Date
AP2014007953A0 true AP2014007953A0 (en) 2014-09-30

Family

ID=48428540

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2014007953A AP2014007953A0 (en) 2012-04-06 2013-03-26 Diacylglycerol acyltransferase 2 inhibitors

Country Status (27)

Country Link
US (1) US9296745B2 (mo)
EP (1) EP2834238B1 (mo)
JP (1) JP2015515472A (mo)
KR (1) KR20140137404A (mo)
CN (1) CN104334557A (mo)
AP (1) AP2014007953A0 (mo)
AU (1) AU2013245353A1 (mo)
CA (1) CA2869587A1 (mo)
CL (1) CL2014002541A1 (mo)
CO (1) CO7160030A2 (mo)
CR (1) CR20140468A (mo)
CU (1) CU20140115A7 (mo)
DO (1) DOP2014000225A (mo)
EA (1) EA201400990A1 (mo)
EC (1) ECSP14021251A (mo)
GT (1) GT201400213A (mo)
HK (1) HK1206735A1 (mo)
IL (1) IL234928A0 (mo)
MA (1) MA37385B1 (mo)
MD (1) MD20140103A2 (mo)
MX (1) MX2014011373A (mo)
NI (1) NI201400120A (mo)
PE (1) PE20142164A1 (mo)
PH (1) PH12014502057A1 (mo)
SG (1) SG11201405477XA (mo)
TN (1) TN2014000419A1 (mo)
WO (1) WO2013150416A1 (mo)

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UA129065C2 (uk) 2019-12-23 2025-01-01 Елджі Кем, Лтд. Аміноарильна похідна сполука, корисна як інгібітор діацилгліцеролацилтрансферази-2, та її використання
CN115362003B (zh) * 2019-12-24 2024-03-22 卡尔那生物科学株式会社 二酰基甘油激酶调节化合物
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
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TWI817191B (zh) * 2020-09-04 2023-10-01 南韓商Ｌｇ化學股份有限公司 新穎聯芳基衍生物及其作為針對二醯基甘油醯基轉移酶２之抑制劑之用途
KR102993831B1 (ko) 2020-10-08 2026-07-23 머크 샤프 앤드 돔 엘엘씨 신규 디아실글리세리드 o-아실트랜스퍼라제 2 억제제로서의 옥스인돌 유도체의 제조
AU2021356589A1 (en) 2020-10-08 2023-05-25 Merck Sharp & Dohme Llc Preparation of benzimidazolone derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors
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AU2021409234A1 (en) 2020-12-22 2023-06-29 Merck Sharp & Dohme Llc Preparation of tetrahydroindazole derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide
MX2024009441A (es) * 2022-02-18 2024-08-14 Bristol Myers Squibb Co Compuestos de imidazopiridinilo sustituidos utiles como inhibidores del receptor tipo toll 9 (tlr9).
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PE20142164A1 (es) 2014-12-27
CN104334557A (zh) 2015-02-04
JP2015515472A (ja) 2015-05-28
KR20140137404A (ko) 2014-12-02
AU2013245353A1 (en) 2014-09-25
MA37385A3 (fr) 2016-12-30
HK1206735A1 (en) 2016-01-15
CU20140115A7 (es) 2014-11-27
EP2834238B1 (en) 2017-02-01
GT201400213A (es) 2015-06-02
MD20140103A2 (mo) 2015-01-31
MA201637385A2 (fr) 2016-03-31
EP2834238A1 (en) 2015-02-11
US20150087585A1 (en) 2015-03-26
MA37385B1 (fr) 2019-09-30
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CL2014002541A1 (es) 2015-01-16
IL234928A0 (en) 2014-12-31
CR20140468A (es) 2014-11-17
EA201400990A1 (ru) 2015-01-30
DOP2014000225A (es) 2014-11-30
US9296745B2 (en) 2016-03-29
TN2014000419A1 (fr) 2016-03-30
WO2013150416A1 (en) 2013-10-10
SG11201405477XA (en) 2014-11-27
ECSP14021251A (es) 2015-09-30
CA2869587A1 (en) 2013-10-10
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PH12014502057A1 (en) 2014-12-10

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