AP2014008179A0 - 3-Substituted estra-1,3,5(10), 16-tetraene derivativess, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments - Google Patents

3-Substituted estra-1,3,5(10), 16-tetraene derivativess, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments

Info

Publication number: AP2014008179A0
Authority: AP; ARIPO
Prior art keywords: production; derivativess; tetraene; medicaments; methods
Prior art date: 2012-07-10

Application number

AP2014008179A

Other languages

English (en)

Inventor

Christian Fischer Oliver Martin Stegmann

Matthias Busemann

Original Assignee

Bayer Pharma AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-07-10

Filing date

2013-07-05

Publication date

2014-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48748225&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2014008179(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-07-05 Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG

2014-12-31 Publication of AP2014008179A0 publication Critical patent/AP2014008179A0/xx

Links

238000004519 manufacturing process Methods 0.000 title 2
239000003814 drug Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Gynecology & Obstetrics (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AP2014008179A 2012-07-10 2013-07-05 3-Substituted estra-1,3,5(10), 16-tetraene derivativess, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments AP2014008179A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102012211970		2012-07-10
PCT/EP2013/064257 WO2014009274A1 (fr)	2012-07-10	2013-07-05	Dérivés d'oestra-1,3,5 (10), 16-tétraène substitués en position 3, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour la fabrication de médicaments

Publications (1)

Publication Number	Publication Date
AP2014008179A0 true AP2014008179A0 (en)	2014-12-31

Family

ID=48748225

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2014008179A AP2014008179A0 (en)	2012-07-10	2013-07-05	3-Substituted estra-1,3,5(10), 16-tetraene derivativess, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments

Country Status (27)

Country	Link
US (1)	US9512169B2 (fr)
EP (1)	EP2872524B1 (fr)
JP (1)	JP6196302B2 (fr)
KR (1)	KR20150036319A (fr)
CN (1)	CN104428309B (fr)
AP (1)	AP2014008179A0 (fr)
AR (1)	AR092025A1 (fr)
AU (1)	AU2013289344A1 (fr)
BR (1)	BR112015000443A2 (fr)
CA (1)	CA2878485A1 (fr)
CL (1)	CL2015000039A1 (fr)
CO (1)	CO7160008A2 (fr)
CR (1)	CR20150007A (fr)
DO (1)	DOP2015000005A (fr)
EA (1)	EA201500112A1 (fr)
EC (1)	ECSP15000868A (fr)
ES (1)	ES2603258T3 (fr)
IL (1)	IL236581A0 (fr)
MA (1)	MA37742B1 (fr)
MX (1)	MX2015000347A (fr)
PE (1)	PE20150353A1 (fr)
PH (1)	PH12015500062A1 (fr)
TN (1)	TN2015000007A1 (fr)
TW (1)	TW201402596A (fr)
UY (1)	UY34899A (fr)
WO (1)	WO2014009274A1 (fr)
ZA (1)	ZA201500920B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2901632C (fr) *	2013-02-21	2017-11-07	Bayer Pharma Aktiengesellschaft	stra-1,3,5(10),16-tetraeno-3-carboxamide pour inhiber la 17-beta-hydroxysteroide deshydrogenase (akr1c3)
ES2696848T3 (es) *	2014-09-11	2019-01-18	Bayer Pharma AG	Inhibidores de oestra-1,3,5(10),16-tetraeno AKR1C3 sustituido con 3-nitrógeno o azufre
US10167293B2 (en)	2016-05-26	2019-01-01	Bayer Pharma Aktiengesellschaft	[8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
CZ307437B6 (cs)	2016-06-07	2018-08-22	Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i.	15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz
EP3269373A1 (fr)	2016-07-11	2018-01-17	Bayer Pharma Aktiengesellschaft	Formes posologiques orales à faible dosage d'un inhibiteur de akr1c3 pour le traitement des maladies
CA3047191A1 (fr)	2016-12-19	2018-06-28	Bayer Pharma Aktiengesellschaft	[4-(phenylsulfonyl)piperazin-1-yl](1h-1,2,3-triazol-4-yl)methanones
TW201825478A (zh)	2016-12-19	2018-07-16	德商拜耳製藥公司	［４－（苯基磺醯基）哌嗪－１－-基］（１ｈ－１，２，３－三唑－４-基）甲酮
EP3555101A2 (fr)	2016-12-19	2019-10-23	Bayer Pharma Aktiengesellschaft	[(phénylsulfonyl)octahydro-épiminoisoindol-yl](1h-1,2,3-triazol-5-yl)méthanones
EP3421483A1 (fr)	2017-06-29	2019-01-02	Bayer Pharma Aktiengesellschaft	Nouveaux dérivés 17-beta-hétéroaryle des stéroïdes comme inhibiteurs de akr1c3
CN110693892A (zh) *	2018-07-09	2020-01-17	深圳艾欣达伟医药科技有限公司	化合物用于制备预防、治疗或改善疼痛的药物的用途
CN110272465A (zh) *	2019-07-15	2019-09-24	成都贝诺科成生物科技有限公司	阿比特龙衍生物、其制备方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2265624B (en) *	1992-03-31	1995-04-19	British Tech Group	17-substituted steroids useful in cancer treatment
US5604213A (en)	1992-03-31	1997-02-18	British Technology Group Limited	17-substituted steroids useful in cancer treatment
IL122740A (en)	1997-01-15	2003-09-17	Akzo Nobel Nv	16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
BR9809748A (pt)	1997-04-07	2000-06-20	American Home Prod	Estra-5(10), 7-dienos com atividade estrogênica
RU2000125533A (ru)	1998-03-11	2002-10-20	Эндорешерш, Инк. (Ca)	Ингибиторы 17-бета-гидроксистероиддегидрогеназ 5 и 3 типа и способы их применения
CA2339368A1 (fr) *	1998-08-07	2000-02-17	Endorecherche, Inc.	Inhibition de la 3$g(a)-hydroxysteroid-deshydrogenase de type 3
EP1284272A4 (fr) *	2000-04-24	2003-09-10	Kyowa Hakko Kogyo Kk	Derives d'estra-1,3,5(10)-triene
EP1756139A4 (fr)	2004-03-12	2009-07-29	Entremed Inc	Agents anti-angiogeniques
MX2008011127A (es)	2006-03-02	2008-10-31	Astellas Pharma Inc	INHIBIDOR DE 17ß HSD TIPO 5.
CA2671075A1 (fr)	2006-11-30	2008-06-05	Solvay Pharmaceuticals Gmbh	Derives oestatrienes substitues en tant qu'inhibiteurs de la 17beta hsd
MX2009006454A (es)	2006-12-22	2009-06-26	Hoffmann La Roche	Derivados de espiro-piperidina.
CA2694216A1 (fr)	2007-07-24	2009-01-29	Astellas Pharma Inc.	Derive de benzimidazole
DE102011083725A1 (de) *	2011-09-29	2013-04-04	Bayer Pharma AG	Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln

2013
- 2013-07-05 US US14/414,386 patent/US9512169B2/en not_active Expired - Fee Related
- 2013-07-05 WO PCT/EP2013/064257 patent/WO2014009274A1/fr not_active Ceased
- 2013-07-05 EA EA201500112A patent/EA201500112A1/ru unknown
- 2013-07-05 KR KR20157002707A patent/KR20150036319A/ko not_active Withdrawn
- 2013-07-05 PE PE2015000018A patent/PE20150353A1/es not_active Application Discontinuation
- 2013-07-05 EP EP13734744.9A patent/EP2872524B1/fr active Active
- 2013-07-05 MX MX2015000347A patent/MX2015000347A/es unknown
- 2013-07-05 CN CN201380036684.4A patent/CN104428309B/zh not_active Expired - Fee Related
- 2013-07-05 BR BR112015000443A patent/BR112015000443A2/pt not_active IP Right Cessation
- 2013-07-05 AU AU2013289344A patent/AU2013289344A1/en not_active Abandoned
- 2013-07-05 CA CA2878485A patent/CA2878485A1/fr not_active Abandoned
- 2013-07-05 ES ES13734744.9T patent/ES2603258T3/es active Active
- 2013-07-05 JP JP2015520927A patent/JP6196302B2/ja not_active Expired - Fee Related
- 2013-07-05 AP AP2014008179A patent/AP2014008179A0/xx unknown
- 2013-07-10 AR ARP130102438A patent/AR092025A1/es unknown
- 2013-07-10 UY UY0001034899A patent/UY34899A/es not_active Application Discontinuation
- 2013-07-10 TW TW102124795A patent/TW201402596A/zh unknown
2015
- 2015-01-05 IL IL236581A patent/IL236581A0/en unknown
- 2015-01-07 MA MA37742A patent/MA37742B1/fr unknown
- 2015-01-07 TN TNP2015000007A patent/TN2015000007A1/fr unknown
- 2015-01-08 CL CL2015000039A patent/CL2015000039A1/es unknown
- 2015-01-09 CO CO15004249A patent/CO7160008A2/es unknown
- 2015-01-09 CR CR20150007A patent/CR20150007A/es unknown
- 2015-01-09 DO DO2015000005A patent/DOP2015000005A/es unknown
- 2015-01-09 PH PH12015500062A patent/PH12015500062A1/en unknown
- 2015-01-09 EC ECIEPI2015868A patent/ECSP15000868A/es unknown
- 2015-02-09 ZA ZA2015/00920A patent/ZA201500920B/en unknown

Also Published As

Publication number	Publication date
AR092025A1 (es)	2015-03-18
CA2878485A1 (fr)	2014-01-16
JP6196302B2 (ja)	2017-09-13
CO7160008A2 (es)	2015-01-15
EP2872524A1 (fr)	2015-05-20
AU2013289344A1 (en)	2015-02-05
HK1205743A1 (en)	2015-12-24
US20150210734A1 (en)	2015-07-30
JP2015522050A (ja)	2015-08-03
KR20150036319A (ko)	2015-04-07
CR20150007A (es)	2015-03-13
MA37742B1 (fr)	2016-12-30
IL236581A0 (en)	2015-02-26
TN2015000007A1 (en)	2016-06-29
EP2872524B1 (fr)	2016-08-24
CL2015000039A1 (es)	2015-03-27
DOP2015000005A (es)	2015-02-15
EA201500112A1 (ru)	2015-07-30
CN104428309B (zh)	2016-09-14
ES2603258T3 (es)	2017-02-24
PH12015500062A1 (en)	2015-03-02
UY34899A (es)	2014-02-28
MA37742A1 (fr)	2016-05-31
ECSP15000868A (es)	2016-01-29
CN104428309A (zh)	2015-03-18
BR112015000443A2 (pt)	2017-06-27
TW201402596A (zh)	2014-01-16
MX2015000347A (es)	2015-04-14
PE20150353A1 (es)	2015-03-28
ZA201500920B (en)	2017-01-25
US9512169B2 (en)	2016-12-06
WO2014009274A1 (fr)	2014-01-16

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ZA201401568B (en)	2016-11-30	Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, process for preparation thereof, pharmaceutical preparations comprising them, and use thereof for production of medicaments
ZA201300100B (en)	2014-03-26	Indolizine derivatives,process for the preparation thereof and therapeutic use thereof
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ZA201506675B (en)	2017-02-22	New stable pentadecapeptide salts, a process for preparation thereof, a use thereof in the manufacture of pharmaceutical preparations and a use thereof in therapy
EP2875814A4 (fr)	2016-05-25	Composition liquide contenant un principe actif à base de taxane, son procédé de fabrication et préparation médicinale liquide
PT2662382T (pt)	2016-07-13	Método de preparação de derivados de esterois, composições farmacêuticas contendo os mesmos e sua utilização no tratamento de vários glioblastomas
ZA201209674B (en)	2013-09-25	Pharmaceutical compositions comprising paracetamol and process for preparing the same
GB201202149D0 (en)	2012-03-21	Anti-aging mixtures, pure substance and drug called "laundrin"
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