MA37742A1 - Dérivés d'oestra-1,3,5 (10), 16-tétraène substitués en position 3, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour la fabrication de médicaments - Google Patents

Dérivés d'oestra-1,3,5 (10), 16-tétraène substitués en position 3, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour la fabrication de médicaments

Info

Publication number
MA37742A1
MA37742A1 MA37742A MA37742A MA37742A1 MA 37742 A1 MA37742 A1 MA 37742A1 MA 37742 A MA37742 A MA 37742A MA 37742 A MA37742 A MA 37742A MA 37742 A1 MA37742 A1 MA 37742A1
Authority
MA
Morocco
Prior art keywords
preparation
medicaments
tetraene
derivatives
manufacture
Prior art date
Application number
MA37742A
Other languages
Arabic (ar)
English (en)
Other versions
MA37742B1 (fr
Inventor
Ulrich Bothe
Naomi Barak
Matthias Busemann
Oliver Martin Fischer
Andrea Rotgeri
Tobias Marquardt
Christian Stegmann
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48748225&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA37742(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MA37742A1 publication Critical patent/MA37742A1/fr
Publication of MA37742B1 publication Critical patent/MA37742B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des inhibiteurs de akr1c3 et des procédés pour les préparer, ainsi que leur utilisation pour traiter et/ou prévenir des maladies et pour fabriquer des médicaments destinés à traiter et/ou à prévenir des maladies, en particulier les troubles hémorragiques et l'endométriose.
MA37742A 2012-07-10 2015-01-07 Dérivés d'oestra-1,3,5 (10), 16-tétraène substitués en position 3, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour la fabrication de médicaments MA37742B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012211970 2012-07-10
PCT/EP2013/064257 WO2014009274A1 (fr) 2012-07-10 2013-07-05 Dérivés d'oestra-1,3,5 (10), 16-tétraène substitués en position 3, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour la fabrication de médicaments

Publications (2)

Publication Number Publication Date
MA37742A1 true MA37742A1 (fr) 2016-05-31
MA37742B1 MA37742B1 (fr) 2016-12-30

Family

ID=48748225

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37742A MA37742B1 (fr) 2012-07-10 2015-01-07 Dérivés d'oestra-1,3,5 (10), 16-tétraène substitués en position 3, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour la fabrication de médicaments

Country Status (27)

Country Link
US (1) US9512169B2 (fr)
EP (1) EP2872524B1 (fr)
JP (1) JP6196302B2 (fr)
KR (1) KR20150036319A (fr)
CN (1) CN104428309B (fr)
AP (1) AP2014008179A0 (fr)
AR (1) AR092025A1 (fr)
AU (1) AU2013289344A1 (fr)
BR (1) BR112015000443A2 (fr)
CA (1) CA2878485A1 (fr)
CL (1) CL2015000039A1 (fr)
CO (1) CO7160008A2 (fr)
CR (1) CR20150007A (fr)
DO (1) DOP2015000005A (fr)
EA (1) EA201500112A1 (fr)
EC (1) ECSP15000868A (fr)
ES (1) ES2603258T3 (fr)
IL (1) IL236581A0 (fr)
MA (1) MA37742B1 (fr)
MX (1) MX2015000347A (fr)
PE (1) PE20150353A1 (fr)
PH (1) PH12015500062A1 (fr)
TN (1) TN2015000007A1 (fr)
TW (1) TW201402596A (fr)
UY (1) UY34899A (fr)
WO (1) WO2014009274A1 (fr)
ZA (1) ZA201500920B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2901632C (fr) * 2013-02-21 2017-11-07 Bayer Pharma Aktiengesellschaft ƒstra-1,3,5(10),16-tetraeno-3-carboxamide pour inhiber la 17-beta-hydroxysteroide deshydrogenase (akr1c3)
ES2696848T3 (es) * 2014-09-11 2019-01-18 Bayer Pharma AG Inhibidores de oestra-1,3,5(10),16-tetraeno AKR1C3 sustituido con 3-nitrógeno o azufre
US10167293B2 (en) 2016-05-26 2019-01-01 Bayer Pharma Aktiengesellschaft [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
CZ307437B6 (cs) 2016-06-07 2018-08-22 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz
EP3269373A1 (fr) 2016-07-11 2018-01-17 Bayer Pharma Aktiengesellschaft Formes posologiques orales à faible dosage d'un inhibiteur de akr1c3 pour le traitement des maladies
CA3047191A1 (fr) 2016-12-19 2018-06-28 Bayer Pharma Aktiengesellschaft [4-(phenylsulfonyl)piperazin-1-yl](1h-1,2,3-triazol-4-yl)methanones
TW201825478A (zh) 2016-12-19 2018-07-16 德商拜耳製藥公司 ［４－（苯基磺醯基）哌嗪－１－-基］（１ｈ－１，２，３－三唑－４-基）甲酮
EP3555101A2 (fr) 2016-12-19 2019-10-23 Bayer Pharma Aktiengesellschaft [(phénylsulfonyl)octahydro-épiminoisoindol-yl](1h-1,2,3-triazol-5-yl)méthanones
EP3421483A1 (fr) 2017-06-29 2019-01-02 Bayer Pharma Aktiengesellschaft Nouveaux dérivés 17-beta-hétéroaryle des stéroïdes comme inhibiteurs de akr1c3
CN110693892A (zh) * 2018-07-09 2020-01-17 深圳艾欣达伟医药科技有限公司 化合物用于制备预防、治疗或改善疼痛的药物的用途
CN110272465A (zh) * 2019-07-15 2019-09-24 成都贝诺科成生物科技有限公司 阿比特龙衍生物、其制备方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2265624B (en) * 1992-03-31 1995-04-19 British Tech Group 17-substituted steroids useful in cancer treatment
US5604213A (en) 1992-03-31 1997-02-18 British Technology Group Limited 17-substituted steroids useful in cancer treatment
IL122740A (en) 1997-01-15 2003-09-17 Akzo Nobel Nv 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
BR9809748A (pt) 1997-04-07 2000-06-20 American Home Prod Estra-5(10), 7-dienos com atividade estrogênica
RU2000125533A (ru) 1998-03-11 2002-10-20 Эндорешерш, Инк. (Ca) Ингибиторы 17-бета-гидроксистероиддегидрогеназ 5 и 3 типа и способы их применения
CA2339368A1 (fr) * 1998-08-07 2000-02-17 Endorecherche, Inc. Inhibition de la 3$g(a)-hydroxysteroid-deshydrogenase de type 3
EP1284272A4 (fr) * 2000-04-24 2003-09-10 Kyowa Hakko Kogyo Kk Derives d'estra-1,3,5(10)-triene
EP1756139A4 (fr) 2004-03-12 2009-07-29 Entremed Inc Agents anti-angiogeniques
MX2008011127A (es) 2006-03-02 2008-10-31 Astellas Pharma Inc INHIBIDOR DE 17ß HSD TIPO 5.
CA2671075A1 (fr) 2006-11-30 2008-06-05 Solvay Pharmaceuticals Gmbh Derives oestatrienes substitues en tant qu'inhibiteurs de la 17beta hsd
MX2009006454A (es) 2006-12-22 2009-06-26 Hoffmann La Roche Derivados de espiro-piperidina.
CA2694216A1 (fr) 2007-07-24 2009-01-29 Astellas Pharma Inc. Derive de benzimidazole
DE102011083725A1 (de) * 2011-09-29 2013-04-04 Bayer Pharma AG Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln

Also Published As

Publication number Publication date
AR092025A1 (es) 2015-03-18
AP2014008179A0 (en) 2014-12-31
CA2878485A1 (fr) 2014-01-16
JP6196302B2 (ja) 2017-09-13
CO7160008A2 (es) 2015-01-15
EP2872524A1 (fr) 2015-05-20
AU2013289344A1 (en) 2015-02-05
HK1205743A1 (en) 2015-12-24
US20150210734A1 (en) 2015-07-30
JP2015522050A (ja) 2015-08-03
KR20150036319A (ko) 2015-04-07
CR20150007A (es) 2015-03-13
MA37742B1 (fr) 2016-12-30
IL236581A0 (en) 2015-02-26
TN2015000007A1 (en) 2016-06-29
EP2872524B1 (fr) 2016-08-24
CL2015000039A1 (es) 2015-03-27
DOP2015000005A (es) 2015-02-15
EA201500112A1 (ru) 2015-07-30
CN104428309B (zh) 2016-09-14
ES2603258T3 (es) 2017-02-24
PH12015500062A1 (en) 2015-03-02
UY34899A (es) 2014-02-28
ECSP15000868A (es) 2016-01-29
CN104428309A (zh) 2015-03-18
BR112015000443A2 (pt) 2017-06-27
TW201402596A (zh) 2014-01-16
MX2015000347A (es) 2015-04-14
PE20150353A1 (es) 2015-03-28
ZA201500920B (en) 2017-01-25
US9512169B2 (en) 2016-12-06
WO2014009274A1 (fr) 2014-01-16

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