AP2126A - Broadspectrum substituted oxindole sulfonamide HIVprotease inhibitors - Google Patents

Broadspectrum substituted oxindole sulfonamide HIVprotease inhibitors

Info

Publication number: AP2126A
Authority: AP; ARIPO
Prior art keywords: hivprotease; sulfonamide; inhibitors; substituted oxindole; broadspectrum
Prior art date: 2002-08-14

Application number

AP2005003245A

Other languages

English (en)

Other versions

AP2005003245A0 (en

Inventor

Abdellah Tahri

Piet Tom Bert Paul Wigerinck

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-14

Filing date

2003-08-14

Publication date

2010-06-03

2003-08-14 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2005-03-31 Publication of AP2005003245A0 publication Critical patent/AP2005003245A0/xx

2010-06-03 Application granted granted Critical

2010-06-03 Publication of AP2126A publication Critical patent/AP2126A/xx

Links

SPKYQJAFIYJJOX-UHFFFAOYSA-N 2-oxo-3h-indole-1-sulfonamide Chemical class C1=CC=C2N(S(=O)(=O)N)C(=O)CC2=C1 SPKYQJAFIYJJOX-UHFFFAOYSA-N 0.000 title 1
239000004030 hiv protease inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AP2005003245A 2002-08-14 2003-08-14 Broadspectrum substituted oxindole sulfonamide HIVprotease inhibitors AP2126A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02078384		2002-08-14
PCT/EP2003/050379 WO2004016619A1 (en)	2002-08-14	2003-08-14	Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors

Publications (2)

Publication Number	Publication Date
AP2005003245A0 AP2005003245A0 (en)	2005-03-31
AP2126A true AP2126A (en)	2010-06-03

Family

ID=31725465

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2005003245A AP2126A (en)	2002-08-14	2003-08-14	Broadspectrum substituted oxindole sulfonamide HIVprotease inhibitors

Country Status (18)

Country	Link
US (1)	US7199148B2 (xx)
EP (1)	EP1546153A1 (xx)
JP (1)	JP4681296B2 (xx)
KR (1)	KR100994759B1 (xx)
CN (1)	CN1688586B (xx)
AP (1)	AP2126A (xx)
AU (1)	AU2003262574B2 (xx)
BR (1)	BR0305771A (xx)
CA (1)	CA2493940C (xx)
EA (1)	EA010486B1 (xx)
HR (1)	HRP20050606B1 (xx)
IL (1)	IL166462A (xx)
MX (1)	MXPA05001792A (xx)
NO (1)	NO331846B1 (xx)
NZ (1)	NZ538714A (xx)
PL (1)	PL375307A1 (xx)
WO (1)	WO2004016619A1 (xx)
ZA (1)	ZA200501223B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7109230B2 (en) *	2002-01-07	2006-09-19	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
WO2005087728A1 (en) *	2004-03-11	2005-09-22	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
AU2005244121B2 (en) *	2004-05-07	2012-01-19	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
AR073248A1 (es)	2008-09-01	2010-10-20	Tibotec Pharm Ltd	Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
US8921415B2 (en)	2009-01-29	2014-12-30	Mapi Pharma Ltd.	Polymorphs of darunavir
PL2528923T3 (pl)	2010-01-28	2015-01-30	Mapi Pharma Ltd	Sposób wytwarzania darunawiru i pochodnych darunawiru
US8580294B2 (en)	2010-10-19	2013-11-12	International Partnership For Microbicides	Platinum-catalyzed intravaginal rings
WO2012092168A1 (en) *	2010-12-27	2012-07-05	Purdue Research Foundation	Fused 6,5 bicyclic ring system p2 ligands, and methods for treating hiv
WO2012092188A1 (en) *	2010-12-27	2012-07-05	Ghosh Arun K	Hydrogen bond forming p1 ligands and methods for treating hiv
US10137031B2 (en)	2013-11-14	2018-11-27	International Partnership For Microbicides, Inc.	Combination therapy intravaginal rings
US20170253607A1 (en) *	2014-09-11	2017-09-07	Shionogi & Co., Ltd.	Long-acting hiv protease inhibitor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996022287A1 (en) *	1995-01-20	1996-07-25	G.D. Searle & Co.	Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
WO1999065870A2 (en) *	1998-06-19	1999-12-23	Vertex Pharmaceuticals Incorporated	Sulfonamide inhibitors of aspartyl protease
WO2001072708A2 (en) *	2000-03-24	2001-10-04	Cor Therapeutics, Inc.	OXINDOLE INHIBITORS OF FACTOR Xa

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5145684A (en)	1991-01-25	1992-09-08	Sterling Drug Inc.	Surface modified drug nanoparticles
PH30929A (en)	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5723490A (en) *	1992-09-08	1998-03-03	Vertex Pharmaceuticals Incorporated	THF-containing sulfonamide inhibitors of aspartyl protease
ES2127938T3 (es)	1993-08-24	1999-05-01	Searle & Co	Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas.
ES2166786T3 (es)	1993-10-01	2002-05-01	Astrazeneca Ab	Procedimiento i.
US5756533A (en)	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en)	1995-03-10	1998-01-06	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
CN1149223C (zh) *	1995-03-10	2004-05-12	G·D·瑟尔公司	杂环羰基氨基酸羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂
US6150556A (en)	1995-03-10	2000-11-21	G. D. Dearle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5753660A (en)	1995-11-15	1998-05-19	G. D. Searle & Co.	Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6509038B2 (en)	1996-05-20	2003-01-21	Janssen Pharmaceutica N.V.	Antifungal compositions with improved bioavailability
CZ295502B6 (cs)	1997-03-26	2005-08-17	Janssen Pharmaceutica N. V.	Antifungální peleta, způsob její přípravy a farmaceutická dávková forma s obsahem těchto pelet
EP1042280A2 (en)	1997-12-24	2000-10-11	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
AU2010299A (en)	1997-12-24	1999-07-19	Vertex Pharmaceuticals Incorporated	Prodrugs os aspartyl protease inhibitors
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
AU2012199A (en)	1997-12-24	1999-07-19	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
PT2336134T (pt)	1998-06-23	2016-10-19	The Board Of Trustees Of The Univ Of Illionis	Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia
AU4828199A (en)	1998-06-23	2000-01-10	Board Of Trustees Of The University Of Illinois, The	Multi-drug resistant retroviral protease inhibitors and associated methods

2003
- 2003-08-14 NZ NZ538714A patent/NZ538714A/en not_active IP Right Cessation
- 2003-08-14 BR BR0305771-2A patent/BR0305771A/pt not_active IP Right Cessation
- 2003-08-14 PL PL03375307A patent/PL375307A1/xx unknown
- 2003-08-14 CA CA2493940A patent/CA2493940C/en not_active Expired - Fee Related
- 2003-08-14 CN CN038240955A patent/CN1688586B/zh not_active Expired - Fee Related
- 2003-08-14 EP EP03787818A patent/EP1546153A1/en not_active Withdrawn
- 2003-08-14 AU AU2003262574A patent/AU2003262574B2/en not_active Ceased
- 2003-08-14 MX MXPA05001792A patent/MXPA05001792A/es active IP Right Grant
- 2003-08-14 WO PCT/EP2003/050379 patent/WO2004016619A1/en not_active Ceased
- 2003-08-14 US US10/524,451 patent/US7199148B2/en not_active Expired - Fee Related
- 2003-08-14 AP AP2005003245A patent/AP2126A/xx active
- 2003-08-14 EA EA200500350A patent/EA010486B1/ru not_active IP Right Cessation
- 2003-08-14 KR KR1020057001812A patent/KR100994759B1/ko not_active Expired - Fee Related
- 2003-08-14 JP JP2004528524A patent/JP4681296B2/ja not_active Expired - Fee Related
- 2003-08-14 HR HRP20050606AA patent/HRP20050606B1/hr not_active IP Right Cessation
2005
- 2005-01-24 IL IL166462A patent/IL166462A/en not_active IP Right Cessation
- 2005-02-10 ZA ZA200501223A patent/ZA200501223B/en unknown
- 2005-03-14 NO NO20051291A patent/NO331846B1/no not_active IP Right Cessation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996022287A1 (en) *	1995-01-20	1996-07-25	G.D. Searle & Co.	Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
WO1999065870A2 (en) *	1998-06-19	1999-12-23	Vertex Pharmaceuticals Incorporated	Sulfonamide inhibitors of aspartyl protease
WO2001072708A2 (en) *	2000-03-24	2001-10-04	Cor Therapeutics, Inc.	OXINDOLE INHIBITORS OF FACTOR Xa

Also Published As

Publication number	Publication date
AP2005003245A0 (en)	2005-03-31
HRP20050606B1 (hr)	2014-04-25
PL375307A1 (en)	2005-11-28
JP2005537305A (ja)	2005-12-08
CA2493940C (en)	2011-11-22
EA200500350A1 (ru)	2005-08-25
HRP20050606A2 (en)	2006-02-28
WO2004016619A1 (en)	2004-02-26
CN1688586A (zh)	2005-10-26
CA2493940A1 (en)	2004-02-26
IL166462A0 (en)	2006-01-15
IL166462A (en)	2012-04-30
NZ538714A (en)	2007-03-30
US7199148B2 (en)	2007-04-03
US20060058368A1 (en)	2006-03-16
BR0305771A (pt)	2004-10-05
KR20050042141A (ko)	2005-05-04
AU2003262574A1 (en)	2004-03-03
EP1546153A1 (en)	2005-06-29
KR100994759B1 (ko)	2010-11-16
CN1688586B (zh)	2012-05-09
ZA200501223B (en)	2006-07-26
NO331846B1 (no)	2012-04-23
MXPA05001792A (es)	2005-04-25
AU2003262574B2 (en)	2009-07-09
EA010486B1 (ru)	2008-10-30
JP4681296B2 (ja)	2011-05-11
NO20051291L (no)	2005-05-18

Publication	Publication Date	Title
DE60336314D1 (de)	2011-04-21	Substituierte indole
EG25482A (en)	2012-01-15	Inhibitors
DK1534290T3 (da)	2012-04-10	Hidtil ukendte kinasehæmmere
NO20034389D0 (no)	2003-10-01	Fremgangsmåte for utledning av data
DK1490355T3 (da)	2011-11-21	Indolylmaleimidderivater
PL373649A1 (en)	2005-09-05	Kinase inhibitors
AU2003290796A8 (en)	2004-06-15	Non-steroidal fxr agonists
DK1501826T3 (da)	2007-01-29	Substituerede indoler som alpha-1-agonister
EP1558609A4 (en)	2008-05-28	KINASE INHIBITORS
AU2003277674A1 (en)	2004-06-03	Novel parp inhibitors
EP1532133A4 (en)	2006-11-15	NF-: B INHIBITORS
IL160752A0 (en)	2004-08-31	Indole derivatives as cox ii inhibitors
EP1569907A4 (en)	2007-10-31	NICOTINAMIDE-BASED KINASE HEMMER
ZA200409686B (en)	2007-09-26	Bicyclic 6-aklylidene-penems as ?-lactamases inhibitors
IL166462A0 (en)	2006-01-15	Broadspectrum substituted oxindole sulfonamide hivproteases inhibitors
AU2003286251A1 (en)	2004-06-15	New bicyclic angiotensin ii agonists
AP2005003242A0 (en)	2005-03-31	Broadspectrum 2-aminobenzothiazole sulfonamide HIVprotease inhibitors.
IL164898A0 (en)	2005-12-18	Heterotricyclyl 6-alkylidene-penems as beta-lactamase inhibitors
IL175889A0 (en)	2006-10-05	Advanced indolinone based protein kinase inhibitors
ZA200410156B (en)	2005-11-30	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
HRP20040936A2 (en)	2005-10-31	Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
GB0318913D0 (en)	2003-09-17	Apoptosis inhibitors
NO20022243D0 (no)	2002-05-10	Fremgangsmåte for rörlegging
ATE405560T1 (de)	2008-09-15	Indolderivaten
HK1079769A (zh)	2006-04-13	取代的羟吲哚磺酰胺类广谱hiv蛋白酶抑制剂