ES2166786T3 - Procedimiento i. - Google Patents

Procedimiento i.

Info

Publication number
ES2166786T3
ES2166786T3 ES94929076T ES94929076T ES2166786T3 ES 2166786 T3 ES2166786 T3 ES 2166786T3 ES 94929076 T ES94929076 T ES 94929076T ES 94929076 T ES94929076 T ES 94929076T ES 2166786 T3 ES2166786 T3 ES 2166786T3
Authority
ES
Spain
Prior art keywords
medicinal product
size
screw feeder
themselves
finally divided
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94929076T
Other languages
English (en)
Inventor
Eva Trofast
Johan Falk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9303214A external-priority patent/SE9303214D0/xx
Priority claimed from SE9304271A external-priority patent/SE9304271D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2166786T3 publication Critical patent/ES2166786T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/20—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Control Of Multiple Motors (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Glanulating (AREA)
  • Exchange Systems With Centralized Control (AREA)
  • Stereophonic System (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DE ACUERDO CON LA INVENCION, SE PROPORCIONA UN METODO DE TRATAMIENTO DE UN MEDICAMENTO EN POLVO FINAMENTE DIVIDIDO CON UN TAMAÑO DE PARTICULA MENOR A 10{MI}M Y POBRES PROPIEDADES DE FLUJO PARA FORMAR, DE MANERA CONTROLADA, AGLOMERADOS O BOLITAS QUE FLUYEN LIBREMENTE Y QUE SON CAPACES DE ROMPERSE PARA PROPORCIONAR EL MEDICAMENTO FINAMENTE DIVIDIDO, QUE INCLUYE LOS PASOS DE LA AGLOMERACION DEL MEDICAMENTO EN POLVO, ALIMENTANDO EL MATERIAL A UN ALIMENTADOR DE TORNILLO, DEJANDOLO PASAR A TRAVES DEL MISMO , OBTENIENDO ASI AGLOMERADOS, FORMANDO AGLOMERADOS RESULTANTES EN FORMA DE ESFERA PARA OBTENER AGLOMERADOS MAS ESFERICOS, MAS DENSOS Y COMPACTOS QUE AQUELLOS OBTENIDOS DEL PROCESO DE AGLOMERACION EN EL ALIMENTADOR DE TORNILLO, Y DANDO UN TAMAÑO A LOS MISMOS PARA OBTENER UN TAMAÑO UNIFORME DEL PRODUCTO FINAL. DE ACUERDO CON LA INVENCION, TAMBIEN SE PROPORCIONA UN APARATO PARA LLEVAR A CABO EL METODO.
ES94929076T 1993-10-01 1994-09-29 Procedimiento i. Expired - Lifetime ES2166786T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9303214A SE9303214D0 (sv) 1993-10-01 1993-10-01 Process I
SE9304271A SE9304271D0 (sv) 1993-12-22 1993-12-22 Process I
US08/317,033 US5551489A (en) 1993-10-01 1994-10-03 Agglomeration of finely divided powders

Publications (1)

Publication Number Publication Date
ES2166786T3 true ES2166786T3 (es) 2002-05-01

Family

ID=27355730

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94929076T Expired - Lifetime ES2166786T3 (es) 1993-10-01 1994-09-29 Procedimiento i.

Country Status (23)

Country Link
US (1) US5551489A (es)
EP (1) EP0721331B1 (es)
JP (1) JP3732508B2 (es)
CN (1) CN1110300C (es)
AT (1) ATE209903T1 (es)
AU (1) AU679789B2 (es)
BR (1) BR9407686A (es)
CZ (1) CZ289214B6 (es)
DE (1) DE69429357T2 (es)
DK (1) DK0721331T3 (es)
EG (1) EG20677A (es)
ES (1) ES2166786T3 (es)
FI (1) FI116364B (es)
HU (1) HU222355B1 (es)
IL (1) IL111080A (es)
NO (1) NO314836B1 (es)
NZ (1) NZ274277A (es)
PL (1) PL175564B1 (es)
PT (1) PT721331E (es)
RU (1) RU2170082C2 (es)
SG (1) SG48049A1 (es)
SK (1) SK283569B6 (es)
WO (1) WO1995009615A1 (es)

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Also Published As

Publication number Publication date
NO961290L (no) 1996-03-29
CN1110300C (zh) 2003-06-04
EG20677A (en) 1999-11-30
PL313765A1 (en) 1996-07-22
HUT74519A (en) 1997-01-28
RU2170082C2 (ru) 2001-07-10
AU7826194A (en) 1995-05-01
CZ94296A3 (en) 1996-06-12
WO1995009615A1 (en) 1995-04-13
AU679789B2 (en) 1997-07-10
BR9407686A (pt) 1997-02-04
US5551489A (en) 1996-09-03
FI961430L (fi) 1996-03-29
JP3732508B2 (ja) 2006-01-05
NO961290D0 (no) 1996-03-29
HU222355B1 (hu) 2003-06-28
CZ289214B6 (cs) 2001-12-12
SG48049A1 (en) 1998-04-17
DE69429357T2 (de) 2002-08-14
ATE209903T1 (de) 2001-12-15
PL175564B1 (pl) 1999-01-29
NO314836B1 (no) 2003-06-02
IL111080A0 (en) 1994-11-28
EP0721331B1 (en) 2001-12-05
CN1132476A (zh) 1996-10-02
NZ274277A (en) 1998-01-26
DK0721331T3 (da) 2002-02-11
SK39196A3 (en) 1997-06-04
SK283569B6 (sk) 2003-09-11
DE69429357D1 (de) 2002-01-17
FI961430A0 (fi) 1996-03-29
FI116364B (fi) 2005-11-15
JPH09504224A (ja) 1997-04-28
EP0721331A1 (en) 1996-07-17
IL111080A (en) 1999-08-17
PT721331E (pt) 2002-05-31
HU9600821D0 (en) 1996-05-28

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