AP2214A - Pyrrolo [3,4-c] pyrazole derivatives active as kinase inhibitors. - Google Patents

Pyrrolo [3,4-c] pyrazole derivatives active as kinase inhibitors.

Info

Publication number: AP2214A
Authority: AP; ARIPO
Prior art keywords: pyrrolo; kinase inhibitors; pyrazole derivatives; derivatives active; active
Prior art date: 2003-07-09

Application number

AP2006003480A

Other languages

English (en)

Other versions

AP2006003480A0 (en

Inventor

Daniele Fancelli

Barbra Forte

Jurgen Moll

Mario Varasi

Paolo Vianello

Original Assignee

Pharmacia Italia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-09

Filing date

2004-07-08

Publication date

2011-03-04

2004-07-08 Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa

2006-02-28 Publication of AP2006003480A0 publication Critical patent/AP2006003480A0/xx

2011-03-04 Application granted granted Critical

2011-03-04 Publication of AP2214A publication Critical patent/AP2214A/xx

Links

229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
QBMRFAZXVYJCCO-UHFFFAOYSA-N pyrrolo[3,4-c]pyrazole Chemical class N1=NC=C2C=NC=C21 QBMRFAZXVYJCCO-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Virology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AP2006003480A 2003-07-09 2004-07-08 Pyrrolo [3,4-c] pyrazole derivatives active as kinase inhibitors. AP2214A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48581403P	2003-07-09	2003-07-09

Publications (2)

Publication Number	Publication Date
AP2006003480A0 AP2006003480A0 (en)	2006-02-28
AP2214A true AP2214A (en)	2011-03-04

Family

ID=34062099

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2006003480A AP2214A (en)	2003-07-09	2004-07-08	Pyrrolo [3,4-c] pyrazole derivatives active as kinase inhibitors.

Country Status (41)

Country	Link
US (2)	US7141568B2 (xx)
EP (1)	EP1644376B1 (xx)
JP (1)	JP4728232B2 (xx)
KR (1)	KR101075711B1 (xx)
CN (1)	CN100564380C (xx)
AP (1)	AP2214A (xx)
AR (1)	AR050045A1 (xx)
AT (1)	ATE480540T1 (xx)
AU (1)	AU2004255347B2 (xx)
BR (1)	BRPI0411868B8 (xx)
CA (1)	CA2531759C (xx)
CR (1)	CR8171A (xx)
CY (1)	CY1110832T1 (xx)
DE (1)	DE602004029045D1 (xx)
DK (1)	DK1644376T3 (xx)
DO (1)	DOP2004000949A (xx)
EA (1)	EA009462B1 (xx)
EC (1)	ECSP056246A (xx)
ES (1)	ES2349780T3 (xx)
GE (1)	GEP20084395B (xx)
GT (2)	GT200400133AA (xx)
HN (1)	HN2004000232A (xx)
IL (1)	IL172923A (xx)
IS (1)	IS2843B (xx)
MA (1)	MA28064A1 (xx)
ME (1)	MEP51908A (xx)
MX (1)	MXPA06000362A (xx)
MY (1)	MY139072A (xx)
NO (1)	NO332361B1 (xx)
NZ (1)	NZ544514A (xx)
PA (1)	PA8606201A1 (xx)
PE (1)	PE20050325A1 (xx)
PL (1)	PL1644376T3 (xx)
PT (1)	PT1644376E (xx)
RS (2)	RS20060004A (xx)
SI (1)	SI1644376T1 (xx)
TN (1)	TNSN06009A1 (xx)
TW (1)	TWI343382B (xx)
UA (1)	UA81682C2 (xx)
WO (1)	WO2005005427A1 (xx)
ZA (1)	ZA200600095B (xx)

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ES2349762T3 (es) *	2000-08-10	2011-01-11	Pfizer Italia S.R.L.	Biciclo-pirazoles activos como inhibidores de quinasas, procedimientos para su preparación y composiciones farmacéuticas que los comprenden.
ATE546452T1 (de) *	2003-09-23	2012-03-15	Vertex Pharma	Pyrazolopyrrolderivate als proteinkinaseinhibitoren
WO2005061519A1 (en) *	2003-12-19	2005-07-07	Takeda San Diego, Inc.	Kinase inhibitors
WO2005105788A1 (en) *	2004-04-23	2005-11-10	Takeda San Diego, Inc.	Indole derivatives and use thereof as kinase inhibitors
EP1778669A2 (en) *	2004-08-18	2007-05-02	Takeda San Diego, Inc.	Kinase inhibitors
ATE479687T1 (de)	2004-10-15	2010-09-15	Takeda Pharmaceutical	Kinaseinhibitoren
AU2005323797B2 (en)	2005-01-10	2009-07-09	Pfizer Inc.	Pyrrolopyrazoles, potent kinase inhibitors
US8119655B2 (en) *	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
TW200808311A (en) *	2006-03-30	2008-02-16	Nerviano Medical Sciences Srl	Use of a kinase inhibitor for the treatment of particular resistant tumors
WO2008017465A1 (en) *	2006-08-10	2008-02-14	F. Hoffmann-La Roche Ag	Bicyclic lactam derivatives, their manufacture and use as pharmaceutical agents
EP2223925A1 (en) *	2006-10-09	2010-09-01	Takeda Pharmaceutical Company Limited	Kinase inhibitors
SG158147A1 (en)	2006-10-09	2010-01-29	Takeda Pharmaceutical	Kinase inhibitors
JP5547487B2 (ja) *	2006-11-03	2014-07-16	ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ	抗癌化合物の投与方法
CL2009001158A1 (es)	2008-05-15	2009-10-23	Nerviano Medical Sciences Srl	Compuestos derivados de los acidos carboxilicos, tales como 5,6-dihiro-4h-pirrolo[3,4-c]pirazol, furo[3,2-c]pirazol, tieno[2,3-c]pirazol, 4,5,6,7-tetrahidropirazol[4,3-c]piridina e indazol; composicion farmaceutica; y su uso en el tratamiento de trastornos proliferativos celulares asociados a la actividad de proteina quinasa alterada, tal como el cancer.
WO2010009985A2 (en)	2008-07-24	2010-01-28	Nerviano Medical Sciences S.R.L.	Therapeutic combination comprising an aurora kinase inhibitor and antiproliferative agents
US20110117212A1 (en) *	2008-07-24	2011-05-19	Nerviano Medical Sciences S.R.L.	Therapeutic combination comprising an aurora kinase inhibitor and an antineoplastic agent
US20100022553A1 (en) *	2008-07-24	2010-01-28	Nerviano Medical Sciences S.R.L.	Therapeutic Combination Comprising an Aurora Kinase Inhibitor and Imatinib
RU2535032C2 (ru)	2008-12-22	2014-12-10	Милленниум Фармасьютикалз, Инк.	Сочетание ингибиторов аврора киназы и анти-cd 20 антител
KR20140105508A (ko)	2011-12-12	2014-09-01	닥터 레디스 레보러터리즈 리미티드	트로포미오신 수용체 키나제(Trk) 억제제인 치환된 피라졸로[1,5-a]피리딘
CN104072498B (zh) *	2013-03-26	2016-12-28	沈阳药科大学	（R）‑N‑[5‑(2‑甲氧基‑2‑苯基乙酰基)‑1,4,5,6‑四氢吡咯并[3,4‑c]吡唑‑3‑基]‑4‑(4‑甲基哌嗪‑1‑基)苯甲酰胺的合成方法
EP3076963A4 (en)	2013-12-06	2017-09-13	Millennium Pharmaceuticals, Inc.	Combination of aurora kinase inhibitors and anti-cd30 antibodies
EP3157921A1 (en)	2014-06-23	2017-04-26	Dr. Reddy's Laboratories Ltd.	Substituted imidazo[1,2-a]pyridine compounds useful for the treatment of pain
CA2989519C (en)	2015-06-15	2023-09-26	Ube Industries, Ltd.	Substituted dihydropyrrolopyrazole derivative
JP2018524292A (ja)	2015-07-21	2018-08-30	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	オーロラキナーゼインヒビターと化学療法剤の投与
CN107337674B (zh) *	2016-04-29	2019-09-20	江苏吉贝尔药业股份有限公司	用于dpp-iv抑制剂的四氢吡喃胺衍生物、其药物组合物和制剂以及用途
US11874276B2 (en)	2018-04-05	2024-01-16	Dana-Farber Cancer Institute, Inc.	STING levels as a biomarker for cancer immunotherapy
US20220305048A1 (en)	2019-08-26	2022-09-29	Dana-Farber Cancer Institute, Inc.	Use of heparin to promote type 1 interferon signaling
CN113563346A (zh) *	2021-08-19	2021-10-29	守恒(厦门)医疗科技有限公司	吡咯[3,4-c]并吡唑二酰胺类衍生物及其在抗肿瘤药物中的应用
JP2025511697A (ja)	2022-04-07	2025-04-16	イーライリリーアンドカンパニー	Ｋｒａｓｇ１２ｃ阻害剤を作製するための方法
CA3247183A1 (en)	2022-04-08	2023-10-12	Eli Lilly And Company	TREATMENT METHOD INCLUDING KRAS G12C INHIBITORS AND AURORA A INHIBITORS
EP4547251A1 (en)	2022-06-30	2025-05-07	Eli Lilly and Company	Kras g12c inhibitor for treating cancer

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GB9911053D0 (en)	1999-05-12	1999-07-14	Pharmacia & Upjohn Spa	4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents
DE19932144A1 (de) *	1999-07-09	2001-01-11	Basf Ag	Mikrokapselzubereitungen und Mikrokapseln enthaltende Wasch- und Reinigungsmittel
US6387900B1 (en)	1999-08-12	2002-05-14	Pharmacia & Upjohn S.P.A.	3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
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FR2815032B1 (fr)	2000-10-10	2003-08-08	Pf Medicament	Nouveaux derives d'aminophenyle piperazine ou d'amino phenyle piperide inhibiteurs de proteines prenyl transferase ainsi que leurs preparations
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CA2493625A1 (en)	2002-07-25	2004-02-19	Pharmacia Italia S.P.A.	Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them

2004
- 2004-07-01 US US10/882,493 patent/US7141568B2/en not_active Expired - Lifetime
- 2004-07-08 ME MEP-519/08A patent/MEP51908A/xx unknown
- 2004-07-08 PE PE2004000657A patent/PE20050325A1/es not_active Application Discontinuation
- 2004-07-08 SI SI200431502T patent/SI1644376T1/sl unknown
- 2004-07-08 CA CA2531759A patent/CA2531759C/en not_active Expired - Fee Related
- 2004-07-08 EP EP04763132A patent/EP1644376B1/en not_active Expired - Lifetime
- 2004-07-08 AU AU2004255347A patent/AU2004255347B2/en not_active Ceased
- 2004-07-08 MX MXPA06000362A patent/MXPA06000362A/es active IP Right Grant
- 2004-07-08 JP JP2006518148A patent/JP4728232B2/ja not_active Expired - Fee Related
- 2004-07-08 DE DE602004029045T patent/DE602004029045D1/de not_active Expired - Lifetime
- 2004-07-08 PL PL04763132T patent/PL1644376T3/pl unknown
- 2004-07-08 RS YUP-2006/0004A patent/RS20060004A/sr unknown
- 2004-07-08 DK DK04763132.0T patent/DK1644376T3/da active
- 2004-07-08 ES ES04763132T patent/ES2349780T3/es not_active Expired - Lifetime
- 2004-07-08 EA EA200600209A patent/EA009462B1/ru not_active IP Right Cessation
- 2004-07-08 PT PT04763132T patent/PT1644376E/pt unknown
- 2004-07-08 BR BRPI0411868A patent/BRPI0411868B8/pt not_active IP Right Cessation
- 2004-07-08 CN CNB2004800195930A patent/CN100564380C/zh not_active Expired - Fee Related
- 2004-07-08 GE GEAP20049209A patent/GEP20084395B/en unknown
- 2004-07-08 NZ NZ544514A patent/NZ544514A/xx not_active IP Right Cessation
- 2004-07-08 KR KR1020067000310A patent/KR101075711B1/ko not_active Expired - Fee Related
- 2004-07-08 TW TW093120474A patent/TWI343382B/zh not_active IP Right Cessation
- 2004-07-08 AP AP2006003480A patent/AP2214A/xx active
- 2004-07-08 AT AT04763132T patent/ATE480540T1/de active
- 2004-07-08 WO PCT/EP2004/007515 patent/WO2005005427A1/en not_active Ceased
- 2004-07-08 RS RS20060004A patent/RS52155B/sr unknown
- 2004-07-09 DO DO2004000949A patent/DOP2004000949A/es unknown
- 2004-07-09 PA PA20048606201A patent/PA8606201A1/es unknown
- 2004-07-09 HN HN2004000232A patent/HN2004000232A/es unknown
- 2004-07-09 GT GT200400133AK patent/GT200400133AA/es unknown
- 2004-07-09 GT GT200400133A patent/GT200400133A/es unknown
- 2004-07-09 MY MYPI20042753A patent/MY139072A/en unknown
- 2004-07-12 AR ARP040102447A patent/AR050045A1/es active IP Right Grant
- 2004-08-07 UA UAA200601248A patent/UA81682C2/ru unknown
2005
- 2005-12-22 IS IS8192A patent/IS2843B/is unknown
- 2005-12-22 EC EC2005006246A patent/ECSP056246A/es unknown
- 2005-12-29 IL IL172923A patent/IL172923A/en active IP Right Grant
2006
- 2006-01-03 ZA ZA200600095A patent/ZA200600095B/en unknown
- 2006-01-05 CR CR8171A patent/CR8171A/es unknown
- 2006-01-06 NO NO20060113A patent/NO332361B1/no not_active IP Right Cessation
- 2006-01-09 MA MA28721A patent/MA28064A1/fr unknown
- 2006-01-09 TN TNP2006000009A patent/TNSN06009A1/fr unknown
- 2006-08-11 US US11/503,256 patent/US7582628B2/en not_active Expired - Lifetime
2010
- 2010-10-18 CY CY20101100924T patent/CY1110832T1/el unknown

Patent Citations (1)

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Publication number	Priority date	Publication date	Assignee	Title
WO2002012242A2 (en) *	2000-08-10	2002-02-14	Pharmacia Italia S.P.A.	Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number	Publication date
MXPA06000362A (es)	2006-03-28
CY1110832T1 (el)	2015-06-10
IS2843B (is)	2013-08-15
KR20060033001A (ko)	2006-04-18
EP1644376B1 (en)	2010-09-08
US7582628B2 (en)	2009-09-01
GEP20084395B (en)	2008-06-10
TW200510385A (en)	2005-03-16
JP4728232B2 (ja)	2011-07-20
JP2009513525A (ja)	2009-04-02
NZ544514A (en)	2009-07-31
PE20050325A1 (es)	2005-05-17
IL172923A0 (en)	2006-06-11
PA8606201A1 (es)	2005-08-04
BRPI0411868A (pt)	2006-08-08
MA28064A1 (fr)	2006-08-01
NO20060113L (no)	2006-04-05
ES2349780T3 (es)	2011-01-11
RS20060004A (sr)	2008-06-05
SI1644376T1 (sl)	2010-11-30
US20050032839A1 (en)	2005-02-10
BRPI0411868B8 (pt)	2021-05-25
KR101075711B1 (ko)	2011-10-21
IS8192A (is)	2005-12-22
IL172923A (en)	2011-09-27
DE602004029045D1 (de)	2010-10-21
ECSP056246A (es)	2006-04-19
PT1644376E (pt)	2010-09-24
RS52155B (sr)	2012-08-31
CR8171A (es)	2006-08-09
ZA200600095B (en)	2007-01-31
US7141568B2 (en)	2006-11-28
BRPI0411868B1 (pt)	2019-11-12
DOP2004000949A (es)	2005-01-15
ATE480540T1 (de)	2010-09-15
NO332361B1 (no)	2012-09-03
AU2004255347A1 (en)	2005-01-20
CA2531759A1 (en)	2005-01-20
GT200400133A (es)	2005-04-18
AU2004255347B2 (en)	2010-04-08
CN1820009A (zh)	2006-08-16
EA200600209A1 (ru)	2006-06-30
DK1644376T3 (da)	2011-01-03
MEP51908A (en)	2011-05-10
WO2005005427A1 (en)	2005-01-20
MY139072A (en)	2009-08-28
TNSN06009A1 (fr)	2007-10-03
TWI343382B (en)	2011-06-11
US20060276471A1 (en)	2006-12-07
GT200400133AA (es)	2007-07-10
CN100564380C (zh)	2009-12-02
EA009462B1 (ru)	2007-12-28
EP1644376A1 (en)	2006-04-12
CA2531759C (en)	2013-04-02
AP2006003480A0 (en)	2006-02-28
AR050045A1 (es)	2006-09-27
UA81682C2 (xx)	2008-01-25
HK1089769A1 (en)	2006-12-08
PL1644376T3 (pl)	2011-03-31
HN2004000232A (es)	2011-01-17

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PT2671882T (pt)	2018-04-20	Pirrolo[2,3-b]piridin-4-il-aminas e pirrolo[2,3-b]pirimidin-4-il-aminas como inibidores de quinase de janus
AP2005003353A0 (en)	2005-09-30	Diazepinoindole derivatives as kinase inhibitors.
IL188248A0 (en)	2008-04-13	Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors
PL392790A1 (pl)	2011-01-03	Związki pirazolo [3, 4-b] pirydynowe i ich zastosowanie jako inhibitorów fosfodiesterazy
EP1653969A4 (en)	2006-12-20	PYRROLO 1,2-B PYRIDAZINE DERIVATIVES
NO20053955D0 (no)	2005-08-25	Pyrazolo [1,5-A] pyrimidinderivater
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ZA200606179B (en)	2008-02-27	1H-thieno[2,3-c]pyrazole derivatives useful as kinase inhibitors
HK1108880A (en)	2008-05-23	1,4 substituted pyrazolopyrimidines as kinase inhibitors
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HK1112231A (en)	2008-08-29	Pyrazolo [1,5-a] pyrimidines as protein kinase inhibitors
HK1102440A (en)	2007-11-23	Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors
HK1057745A (en)	2004-04-16	Imidazole derivatives as raf kinase inhibitors