IS8192A - Pýrróló[3,4-c] pýrasól afleiður virkar sem kínasahindrar - Google Patents

Pýrróló[3,4-c] pýrasól afleiður virkar sem kínasahindrar

Info

Publication number: IS8192A
Authority: IS; Iceland
Prior art keywords: pyrrolo; kinase inhibitors; pyrazole derivatives; derivatives act; act
Prior art date: 2003-07-09

Application number

IS8192A

Other languages

English (en)

Other versions

IS2843B (is

Inventor

Fancelli Daniele

Forte Barbara

Moll Jurgen

Varasi Mario

Vianello Paola

Original Assignee

Pharmacia Italia S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-09

Filing date

2005-12-22

Publication date

2005-12-22

2005-12-22 Application filed by Pharmacia Italia S.P.A. filed Critical Pharmacia Italia S.P.A.

2005-12-22 Publication of IS8192A publication Critical patent/IS8192A/is

2013-08-15 Publication of IS2843B publication Critical patent/IS2843B/is

Links

229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
QBMRFAZXVYJCCO-UHFFFAOYSA-N pyrrolo[3,4-c]pyrazole Chemical class N1=NC=C2C=NC=C21 QBMRFAZXVYJCCO-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Virology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IS8192A 2003-07-09 2005-12-22 Pýrróló[3,4-c] pýrasólafleiður virkar sem kínasahindrar IS2843B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US48581403P	2003-07-09	2003-07-09
PCT/EP2004/007515 WO2005005427A1 (en)	2003-07-09	2004-07-08	PYRROLO[3,4-c]PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

Publications (2)

Publication Number	Publication Date
IS8192A true IS8192A (is)	2005-12-22
IS2843B IS2843B (is)	2013-08-15

Family

ID=34062099

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS8192A IS2843B (is)	2003-07-09	2005-12-22	Pýrróló[3,4-c] pýrasólafleiður virkar sem kínasahindrar

Country Status (41)

Country	Link
US (2)	US7141568B2 (is)
EP (1)	EP1644376B1 (is)
JP (1)	JP4728232B2 (is)
KR (1)	KR101075711B1 (is)
CN (1)	CN100564380C (is)
AP (1)	AP2214A (is)
AR (1)	AR050045A1 (is)
AT (1)	ATE480540T1 (is)
AU (1)	AU2004255347B2 (is)
BR (1)	BRPI0411868B8 (is)
CA (1)	CA2531759C (is)
CR (1)	CR8171A (is)
CY (1)	CY1110832T1 (is)
DE (1)	DE602004029045D1 (is)
DK (1)	DK1644376T3 (is)
DO (1)	DOP2004000949A (is)
EA (1)	EA009462B1 (is)
EC (1)	ECSP056246A (is)
ES (1)	ES2349780T3 (is)
GE (1)	GEP20084395B (is)
GT (2)	GT200400133AA (is)
HN (1)	HN2004000232A (is)
IL (1)	IL172923A (is)
IS (1)	IS2843B (is)
MA (1)	MA28064A1 (is)
ME (1)	MEP51908A (is)
MX (1)	MXPA06000362A (is)
MY (1)	MY139072A (is)
NO (1)	NO332361B1 (is)
NZ (1)	NZ544514A (is)
PA (1)	PA8606201A1 (is)
PE (1)	PE20050325A1 (is)
PL (1)	PL1644376T3 (is)
PT (1)	PT1644376E (is)
RS (2)	RS20060004A (is)
SI (1)	SI1644376T1 (is)
TN (1)	TNSN06009A1 (is)
TW (1)	TWI343382B (is)
UA (1)	UA81682C2 (is)
WO (1)	WO2005005427A1 (is)
ZA (1)	ZA200600095B (is)

Families Citing this family (31)

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KR100904157B1 (ko) *	2000-08-10	2009-06-23	파마시아 이탈리아 에스.피.에이.	키나제 억제제로서 활성인 비사이클로-피라졸, 이의제조방법 및 이를 포함하는 약제학적 조성물
WO2005030776A1 (en) *	2003-09-23	2005-04-07	Vertex Pharmaceuticals Incorporated	Pyrazolopyrrole derivatives as protein kinase inhibitors
US7572914B2 (en) *	2003-12-19	2009-08-11	Takeda Pharmaceutical Company Limited	Kinase inhibitors
EP1763524A1 (en) *	2004-04-23	2007-03-21	Takeda San Diego, Inc.	Indole derivatives and use thereof as kinase inhibitors
WO2006023931A2 (en) *	2004-08-18	2006-03-02	Takeda San Diego, Inc.	Kinase inhibitors
US7713973B2 (en) *	2004-10-15	2010-05-11	Takeda Pharmaceutical Company Limited	Kinase inhibitors
SI1838718T1 (sl)	2005-01-10	2011-08-31	Pfizer	Pirolopirazoli, zmogljivi inhibitorji kinaze
US8119655B2 (en) *	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
TW200808311A (en) *	2006-03-30	2008-02-16	Nerviano Medical Sciences Srl	Use of a kinase inhibitor for the treatment of particular resistant tumors
WO2008017465A1 (en) *	2006-08-10	2008-02-14	F. Hoffmann-La Roche Ag	Bicyclic lactam derivatives, their manufacture and use as pharmaceutical agents
GEP20135728B (en)	2006-10-09	2013-01-25	Takeda Pharmaceuticals Co	Kinase inhibitors
EP2223925A1 (en) *	2006-10-09	2010-09-01	Takeda Pharmaceutical Company Limited	Kinase inhibitors
US20100256160A1 (en) *	2006-11-03	2010-10-07	Nerviano Medical Sciences S.R.L.	Method of administering an antitumor compound
AR071780A1 (es) *	2008-05-15	2010-07-14	Nerviano Medical Sciences Srl	Derivados de carbamoilo de carbonilamino-pirazoles biciclicos como profarmacos
WO2010009985A2 (en)	2008-07-24	2010-01-28	Nerviano Medical Sciences S.R.L.	Therapeutic combination comprising an aurora kinase inhibitor and antiproliferative agents
CN102105147B (zh) *	2008-07-24	2013-07-03	内尔维阿诺医学科学有限公司	包含aurora激酶抑制剂和抗肿瘤药的治疗组合
US20100022553A1 (en) *	2008-07-24	2010-01-28	Nerviano Medical Sciences S.R.L.	Therapeutic Combination Comprising an Aurora Kinase Inhibitor and Imatinib
MX2011006725A (es)	2008-12-22	2011-09-15	Millennium Pharm Inc	Combinacion de inhibidores de aurora cinasa y anticuerpos anti-cd20.
WO2013088257A1 (en)	2011-12-12	2013-06-20	Dr. Reddy's Laboratories Ltd.	Substituted heterocyclic compounds as tropomyosin receptor kinase a (trka) inhibitors
CN104072498B (zh) *	2013-03-26	2016-12-28	沈阳药科大学	（R）‑N‑[5‑(2‑甲氧基‑2‑苯基乙酰基)‑1,4,5,6‑四氢吡咯并[3,4‑c]吡唑‑3‑基]‑4‑(4‑甲基哌嗪‑1‑基)苯甲酰胺的合成方法
US10335494B2 (en)	2013-12-06	2019-07-02	Millennium Pharmaceuticals, Inc.	Combination of aurora kinase inhibitors and anti-CD30 antibodies
EP3157921A1 (en)	2014-06-23	2017-04-26	Dr. Reddy's Laboratories Ltd.	Substituted imidazo[1,2-a]pyridine compounds useful for the treatment of pain
EP3309163A4 (en)	2015-06-15	2019-01-09	UBE Industries, Ltd.	SUBSTITUTED DIHYDROPYRROLO PYRAZOL DERIVATIVE
JP2018524292A (ja)	2015-07-21	2018-08-30	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	オーロラキナーゼインヒビターと化学療法剤の投与
CN107337674B (zh) *	2016-04-29	2019-09-20	江苏吉贝尔药业股份有限公司	用于dpp-iv抑制剂的四氢吡喃胺衍生物、其药物组合物和制剂以及用途
US11874276B2 (en)	2018-04-05	2024-01-16	Dana-Farber Cancer Institute, Inc.	STING levels as a biomarker for cancer immunotherapy
US20220305048A1 (en)	2019-08-26	2022-09-29	Dana-Farber Cancer Institute, Inc.	Use of heparin to promote type 1 interferon signaling
CN113563346A (zh) *	2021-08-19	2021-10-29	守恒(厦门)医疗科技有限公司	吡咯[3,4-c]并吡唑二酰胺类衍生物及其在抗肿瘤药物中的应用
CA3247864A1 (en)	2022-04-07	2023-10-12	Eli Lilly And Company	Process for making a kras g12c inhibitor
EP4504209A1 (en)	2022-04-08	2025-02-12	Eli Lilly and Company	Method of treatment including kras g12c inhibitors and aurora a inhibitors
IL317823A (en)	2022-06-30	2025-02-01	Lilly Co Eli	KRAS G12C inhibitor for cancer treatment

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FR2717380B1 (fr) *	1994-03-15	1996-04-26	Oreal	Compositions cosmétiques contenant un mélange synergétique de polymères conditionneurs.
GB9911053D0 (en)	1999-05-12	1999-07-14	Pharmacia & Upjohn Spa	4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents
DE19932144A1 (de) *	1999-07-09	2001-01-11	Basf Ag	Mikrokapselzubereitungen und Mikrokapseln enthaltende Wasch- und Reinigungsmittel
GEP20053476B (en)	1999-08-12	2005-03-25	Upjohn Co	3(5)-Amino-Pyrazole Derivatives, Process for Their Preparation and Their Use as Antitumor Agents
US6387900B1 (en)	1999-08-12	2002-05-14	Pharmacia & Upjohn S.P.A.	3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
KR100904157B1 (ko)	2000-08-10	2009-06-23	파마시아 이탈리아 에스.피.에이.	키나제 억제제로서 활성인 비사이클로-피라졸, 이의제조방법 및 이를 포함하는 약제학적 조성물
FR2815032B1 (fr)	2000-10-10	2003-08-08	Pf Medicament	Nouveaux derives d'aminophenyle piperazine ou d'amino phenyle piperide inhibiteurs de proteines prenyl transferase ainsi que leurs preparations
US20040019046A1 (en)	2000-11-27	2004-01-29	Paolo Pevarello	Phenylacetamido-pyrazole derivatives and their use as antitumor agents
EP1379524A2 (en)	2001-01-26	2004-01-14	Pharmacia Italia S.p.A.	Chromane derivatives, process for their preparation and their use as antitumor agents
ES2357502T3 (es)	2001-09-26	2011-04-27	Pfizer Italia S.R.L.	Derivados de aminoindazol activos como inhibidores de quinasa, procedimiento para su preparación y composiciones farmaceuticas que los contienen.
AU2003244632A1 (en)	2002-07-25	2004-02-25	Pharmacia Italia S.P.A.	Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them

2004
- 2004-07-01 US US10/882,493 patent/US7141568B2/en not_active Expired - Lifetime
- 2004-07-08 RS YUP-2006/0004A patent/RS20060004A/sr unknown
- 2004-07-08 MX MXPA06000362A patent/MXPA06000362A/es active IP Right Grant
- 2004-07-08 ME MEP-519/08A patent/MEP51908A/xx unknown
- 2004-07-08 NZ NZ544514A patent/NZ544514A/xx not_active IP Right Cessation
- 2004-07-08 PE PE2004000657A patent/PE20050325A1/es not_active Application Discontinuation
- 2004-07-08 ES ES04763132T patent/ES2349780T3/es not_active Expired - Lifetime
- 2004-07-08 KR KR1020067000310A patent/KR101075711B1/ko not_active Expired - Fee Related
- 2004-07-08 AU AU2004255347A patent/AU2004255347B2/en not_active Ceased
- 2004-07-08 PT PT04763132T patent/PT1644376E/pt unknown
- 2004-07-08 TW TW093120474A patent/TWI343382B/zh not_active IP Right Cessation
- 2004-07-08 RS RS20060004A patent/RS52155B/sr unknown
- 2004-07-08 CN CNB2004800195930A patent/CN100564380C/zh not_active Expired - Fee Related
- 2004-07-08 AT AT04763132T patent/ATE480540T1/de active
- 2004-07-08 EP EP04763132A patent/EP1644376B1/en not_active Expired - Lifetime
- 2004-07-08 SI SI200431502T patent/SI1644376T1/sl unknown
- 2004-07-08 EA EA200600209A patent/EA009462B1/ru not_active IP Right Cessation
- 2004-07-08 DK DK04763132.0T patent/DK1644376T3/da active
- 2004-07-08 WO PCT/EP2004/007515 patent/WO2005005427A1/en not_active Ceased
- 2004-07-08 BR BRPI0411868A patent/BRPI0411868B8/pt not_active IP Right Cessation
- 2004-07-08 AP AP2006003480A patent/AP2214A/xx active
- 2004-07-08 CA CA2531759A patent/CA2531759C/en not_active Expired - Fee Related
- 2004-07-08 GE GEAP20049209A patent/GEP20084395B/en unknown
- 2004-07-08 JP JP2006518148A patent/JP4728232B2/ja not_active Expired - Fee Related
- 2004-07-08 PL PL04763132T patent/PL1644376T3/pl unknown
- 2004-07-08 DE DE602004029045T patent/DE602004029045D1/de not_active Expired - Lifetime
- 2004-07-09 GT GT200400133AK patent/GT200400133AA/es unknown
- 2004-07-09 HN HN2004000232A patent/HN2004000232A/es unknown
- 2004-07-09 PA PA20048606201A patent/PA8606201A1/es unknown
- 2004-07-09 DO DO2004000949A patent/DOP2004000949A/es unknown
- 2004-07-09 GT GT200400133A patent/GT200400133A/es unknown
- 2004-07-09 MY MYPI20042753A patent/MY139072A/en unknown
- 2004-07-12 AR ARP040102447A patent/AR050045A1/es active IP Right Grant
- 2004-08-07 UA UAA200601248A patent/UA81682C2/ru unknown
2005
- 2005-12-22 IS IS8192A patent/IS2843B/is unknown
- 2005-12-22 EC EC2005006246A patent/ECSP056246A/es unknown
- 2005-12-29 IL IL172923A patent/IL172923A/en active IP Right Grant
2006
- 2006-01-03 ZA ZA200600095A patent/ZA200600095B/en unknown
- 2006-01-05 CR CR8171A patent/CR8171A/es unknown
- 2006-01-06 NO NO20060113A patent/NO332361B1/no not_active IP Right Cessation
- 2006-01-09 TN TNP2006000009A patent/TNSN06009A1/fr unknown
- 2006-01-09 MA MA28721A patent/MA28064A1/fr unknown
- 2006-08-11 US US11/503,256 patent/US7582628B2/en not_active Expired - Lifetime
2010
- 2010-10-18 CY CY20101100924T patent/CY1110832T1/el unknown

Also Published As

Publication number	Publication date
AP2214A (en)	2011-03-04
CA2531759C (en)	2013-04-02
AU2004255347A1 (en)	2005-01-20
CY1110832T1 (el)	2015-06-10
DE602004029045D1 (de)	2010-10-21
PE20050325A1 (es)	2005-05-17
MY139072A (en)	2009-08-28
CN100564380C (zh)	2009-12-02
GT200400133AA (es)	2007-07-10
NO332361B1 (no)	2012-09-03
BRPI0411868B8 (pt)	2021-05-25
RS20060004A (sr)	2008-06-05
TNSN06009A1 (fr)	2007-10-03
PL1644376T3 (pl)	2011-03-31
CR8171A (es)	2006-08-09
EA009462B1 (ru)	2007-12-28
US7141568B2 (en)	2006-11-28
ECSP056246A (es)	2006-04-19
CN1820009A (zh)	2006-08-16
AP2006003480A0 (en)	2006-02-28
GEP20084395B (en)	2008-06-10
TW200510385A (en)	2005-03-16
MEP51908A (en)	2011-05-10
US7582628B2 (en)	2009-09-01
JP2009513525A (ja)	2009-04-02
UA81682C2 (en)	2008-01-25
IL172923A (en)	2011-09-27
NZ544514A (en)	2009-07-31
NO20060113L (no)	2006-04-05
DOP2004000949A (es)	2005-01-15
CA2531759A1 (en)	2005-01-20
EA200600209A1 (ru)	2006-06-30
KR20060033001A (ko)	2006-04-18
AR050045A1 (es)	2006-09-27
BRPI0411868A (pt)	2006-08-08
TWI343382B (en)	2011-06-11
IL172923A0 (en)	2006-06-11
US20050032839A1 (en)	2005-02-10
MA28064A1 (fr)	2006-08-01
RS52155B (sr)	2012-08-31
BRPI0411868B1 (pt)	2019-11-12
MXPA06000362A (es)	2006-03-28
HK1089769A1 (en)	2006-12-08
PT1644376E (pt)	2010-09-24
PA8606201A1 (es)	2005-08-04
ES2349780T3 (es)	2011-01-11
SI1644376T1 (sl)	2010-11-30
IS2843B (is)	2013-08-15
KR101075711B1 (ko)	2011-10-21
HN2004000232A (es)	2011-01-17
US20060276471A1 (en)	2006-12-07
EP1644376A1 (en)	2006-04-12
WO2005005427A1 (en)	2005-01-20
EP1644376B1 (en)	2010-09-08
JP4728232B2 (ja)	2011-07-20
AU2004255347B2 (en)	2010-04-08
ZA200600095B (en)	2007-01-31
ATE480540T1 (de)	2010-09-15
DK1644376T3 (da)	2011-01-03
GT200400133A (es)	2005-04-18

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